25 relations: Antidepressant, Blood–brain barrier, Central nervous system, Clinic, Clinical trial, Competitive antagonist, Depression (mood), Drug, Evans Blue (dye), Excitatory amino acid reuptake inhibitor, Glutamic acid, Ketamine, Kynurenic acid, Major depressive disorder, Model organism, NMDA receptor, Prodrug, Receptor antagonist, Reuptake, Reuptake inhibitor, Synaptic vesicle, Vesicular glutamate transporter 1, Xanthurenic acid, 4-Chlorokynurenine, 5,7-Dichlorokynurenic acid.
Antidepressants are drugs used for the treatment of major depressive disorder and other conditions, including dysthymia, anxiety disorders, obsessive compulsive disorder, eating disorders, chronic pain, neuropathic pain and, in some cases, dysmenorrhoea, snoring, migraine, attention-deficit hyperactivity disorder (ADHD), addiction, dependence, and sleep disorders.
The blood–brain barrier (BBB) is a highly selective permeability barrier that separates the circulating blood from the brain extracellular fluid (BECF) in the central nervous system (CNS).
The central nervous system (CNS) is the part of the nervous system consisting of the brain and spinal cord.
A clinic (or outpatient clinic or ambulatory care clinic) is a health care facility that is primarily devoted to the care of outpatients.
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Clinical trials are experiments done in clinical research.
A competitive antagonist is a receptor antagonist that binds to a receptor but does not activate the receptor.
Depression is a state of low mood and aversion to activity that can affect a person's thoughts, behavior, feelings and sense of well-being.
A drug is, in the broadest of terms, a chemical substance that has known biological effects on humans or other animals.
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T-1824 or Evans Blue, often incorrectly rendered as Evan's Blue, is an azo dye which has a very high affinity for serum albumin.
An excitatory amino acid reuptake inhibitor (EAARI) is a type of drug which inhibits the reuptake of the excitatory neurotransmitters glutamate and aspartate by blocking one or more of the excitatory amino acid transporters (EAATs).
Glutamic acid (abbreviated as Glu or E) is one of the 20-23 proteinogenic amino acids, and its codons are GAA and GAG.
Ketamine (INN) is a medication used mainly for starting and maintaining anesthesia.
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Kynurenic acid (KYNA or KYN) is a product of the normal metabolism of amino acid L-tryptophan.
Major depressive disorder (MDD) (also known as clinical depression, major depression, unipolar depression, or unipolar disorder; or as recurrent depression in the case of repeated episodes) is a mental disorder characterized by a pervasive and persistent low mood that is accompanied by low self-esteem and by a loss of interest or pleasure in normally enjoyable activities.
A model organism is a non-human species that is extensively studied to understand particular biological phenomena, with the expectation that discoveries made in the organism model will provide insight into the workings of other organisms.
The N-methyl-D-aspartate receptor (also known as the NMDA receptor or NMDAR), is a glutamate receptor and ion channel protein found in nerve cells.
A prodrug is a medication or compound that, after administration, is metabolized (i.e., converted within the body) into a pharmacologically active drug.
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A receptor antagonist is a type of receptor ligand or drug that blocks or dampens agonist-mediated responses rather than provoking a biological response itself upon binding to a receptor.
Reuptake, or re-uptake, is the reabsorption of a neurotransmitter by a neurotransmitter transporter of a pre-synaptic neuron after it has performed its function of transmitting a neural impulse.
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A reuptake inhibitor (RI) is a type of reuptake modulator which inhibits the plasmalemmal transporter-mediated reuptake of a neurotransmitter from the synapse into the pre-synaptic neuron, leading to an increase in the extracellular concentrations of the neurotransmitter and therefore an increase in neurotransmission.
In a neuron, synaptic vesicles (or neurotransmitter vesicles) store various neurotransmitters that are released at the synapse.
Vesicular glutamate transporter 1 (VGLUT1) is a protein that in humans is encoded by the SLC17A7 gene.
Xanthurenic acid, or xanthurenate, is a chemical shown to induce gametogenesis of Plasmodium falciparum, the parasite that causes malaria.
L-4-Chlorokynurenine (4-Cl-KYN, developmental code name AV-101) is an orally active small molecule prodrug candidate that in vivo produces a glycine binding site NMDA receptor antagonist.
5,7-Dichlorokynurenic acid (DCKA) is a selective NMDA receptor antagonist acting at the glycine site of the NMDA receptor complex.