8-Carboxamidocyclazocine

8-Carboxamidocyclazocine (8-CAC) is an opioid analgesic drug related to cyclazocine, invented by medicinal chemist Mark P. Wentland and co-workers in Cogswell Laboratory at Rensselaer Polytechnic Institute. ^[1]

12 relations: Agonist, Analgesic, Carboxamide, Cocaine dependence, Cyclazocine, Hydroxy group, Κ-opioid receptor, Μ-opioid receptor, Opioid, Opioid receptor, Phenol, Samidorphan.

Agonist

An agonist is a chemical that binds to a receptor and activates the receptor to produce a biological response.

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Analgesic

An analgesic or painkiller is any member of the group of drugs used to achieve analgesia, relief from pain.

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Carboxamide

In organic chemistry carboxamides (or amino carbonyls) are functional groups with the general structure R-CO-NR'R′′ with R, R', and R′′ as organic substituents, or hydrogen.

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Cocaine dependence

Cocaine dependence is a psychological desire to use cocaine regularly.

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Cyclazocine

Cyclazocine is a mixed opioid agonist/antagonist related to dezocine, pentazocine and phenazocine.

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Hydroxy group

A hydroxy or hydroxyl group is the entity with the formula OH.

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Κ-opioid receptor

The κ-opioid receptor (KOR) is a G protein-coupled receptor that in humans is encoded by the OPRK1 gene.

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Μ-opioid receptor

The μ-opioid receptors (MOR) are a class of opioid receptors with a high affinity for enkephalins and beta-endorphin, but a low affinity for dynorphins.

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Opioid

Opioids are substances that act on opioid receptors to produce morphine-like effects.

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Opioid receptor

Opioid receptors are a group of inhibitory G protein-coupled receptors with opioids as ligands.

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Phenol

Phenol, also known as phenolic acid, is an aromatic organic compound with the molecular formula C6H5OH.

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Samidorphan

Samidorphan (INN, USAN) (developmental code names ALKS-33, RDC-0313), also known as 3-carboxamido-4-hydroxynaltrexone, is an opioid antagonist that preferentially acts as an antagonist of the μ-opioid receptor (MOR).

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8-CAC.

References

[1] https://en.wikipedia.org/wiki/8-Carboxamidocyclazocine

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