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43 relations: Aromatic amino acid, Aromatic L-amino acid decarboxylase inhibitor, Autism, Bipolar disorder, Blood–brain barrier, Carbidopa, Chromosome 7, Cofactor (biochemistry), Decarboxylation, Dopamine, Dopamine agonist, Dysthymia, Enzyme, Exon, Gene, Histamine, Histidine, Histidine decarboxylase, International Working Group on Neurotransmitter Related Disorders, L-DOPA, Lyase, Major depressive disorder, Mental disorder, Monoamine oxidase inhibitor, Neuromodulation, Neurotransmitter, Oculogyric crisis, Parkinson's disease, Phenethylamine, Phenylalanine, Protein dimer, Pyridoxal phosphate, Pyridoxine, Rate-determining step, Serotonin, Single-nucleotide polymorphism, Trace amine, Tryptamine, Tryptophan, Tyramine, Tyrosine, Vitamin B6, 5-Hydroxytryptophan.
Aromatic amino acid
An aromatic amino acid (AAA) is an amino acid that includes an aromatic ring.
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Aromatic L-amino acid decarboxylase inhibitor
An aromatic L-amino acid decarboxylase inhibitor (synonyms: DOPA decarboxylase inhibitor, DDCI and AAADI) is a drug which inhibits the synthesis of dopamine by the enzyme aromatic L-amino acid decarboxylase (AADC, AAAD, or DOPA decarboxylase).
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Autism
Autism is a developmental disorder characterized by troubles with social interaction and communication and by restricted and repetitive behavior.
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Bipolar disorder
Bipolar disorder, previously known as manic depression, is a mental disorder that causes periods of depression and periods of abnormally elevated mood.
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Blood–brain barrier
The blood–brain barrier (BBB) is a highly selective semipermeable membrane barrier that separates the circulating blood from the brain and extracellular fluid in the central nervous system (CNS).
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Carbidopa
Carbidopa (Lodosyn) is a drug given to people with Parkinson's disease in order to inhibit peripheral metabolism of levodopa.
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Chromosome 7
Chromosome 7 is one of the 23 pairs of chromosomes in humans.
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Cofactor (biochemistry)
A cofactor is a non-protein chemical compound or metallic ion that is required for an enzyme's activity.
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Decarboxylation
Decarboxylation is a chemical reaction that removes a carboxyl group and releases carbon dioxide (CO2).
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Dopamine
Dopamine (DA, a contraction of 3,4-dihydroxyphenethylamine) is an organic chemical of the catecholamine and phenethylamine families that plays several important roles in the brain and body.
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Dopamine agonist
A dopamine receptor agonist is a compound that activates dopamine receptors.
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Dysthymia
Dysthymia, now known as persistent depressive disorder (PDD), is a mood disorder consisting of the same cognitive and physical problems as depression, with less severe but longer-lasting symptoms.
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Enzyme
Enzymes are macromolecular biological catalysts.
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Exon
An exon is any part of a gene that will encode a part of the final mature RNA produced by that gene after introns have been removed by RNA splicing.
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Gene
In biology, a gene is a sequence of DNA or RNA that codes for a molecule that has a function.
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Histamine
Histamine is an organic nitrogenous compound involved in local immune responses, as well as regulating physiological function in the gut and acting as a neurotransmitter for the brain, spinal cord, and uterus.
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Histidine
Histidine (symbol His or H) is an α-amino acid that is used in the biosynthesis of proteins.
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Histidine decarboxylase
Histidine decarboxylase (HDC) is an enzyme responsible for catalyzing the decarboxylation of histidine to form histamine.
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International Working Group on Neurotransmitter Related Disorders
The International Working Group on Neurotransmitter Related Disorders is an international collaboration of researchers studying neurotransmitter disorders.
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L-DOPA
L-DOPA, also known as levodopa or L-3,4-dihydroxyphenylalanine is an amino acid that is made and used as part of the normal biology of humans, as well as some animals and plants.
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Lyase
In biochemistry, a lyase is an enzyme that catalyzes the breaking (an "elimination" reaction) of various chemical bonds by means other than hydrolysis (a "substitution" reaction) and oxidation, often forming a new double bond or a new ring structure.
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Major depressive disorder
Major depressive disorder (MDD), also known simply as depression, is a mental disorder characterized by at least two weeks of low mood that is present across most situations.
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Mental disorder
A mental disorder, also called a mental illness or psychiatric disorder, is a behavioral or mental pattern that causes significant distress or impairment of personal functioning.
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Monoamine oxidase inhibitor
Monoamine oxidase inhibitors (MAOIs) are a class of drugs that inhibit the activity of one or both monoamine oxidase enzymes: monoamine oxidase A (MAO-A) and monoamine oxidase B (MAO-B).
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Neuromodulation
Neuromodulation is the physiological process by which a given neuron uses one or more chemicals to regulate diverse populations of neurons.
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Neurotransmitter
Neurotransmitters are endogenous chemicals that enable neurotransmission.
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Oculogyric crisis
Oculogyric crisis (OGC) is the name of a dystonic reaction to certain drugs or medical conditions characterized by a prolonged involuntary upward deviation of the eyes.
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Parkinson's disease
Parkinson's disease (PD) is a long-term degenerative disorder of the central nervous system that mainly affects the motor system.
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Phenethylamine
Phenethylamine (PEA) is an organic compound, natural monoamine alkaloid, and trace amine which acts as a central nervous system stimulant in humans.
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Phenylalanine
Phenylalanine (symbol Phe or F) is an α-amino acid with the formula.
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Protein dimer
In biochemistry, a protein dimer is a macromolecular complex formed by two protein monomers, or single proteins, which are usually non-covalently bound.
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Pyridoxal phosphate
Pyridoxal phosphate (PLP, pyridoxal 5'-phosphate, P5P), the active form of vitamin B6, is a coenzyme in a variety of enzymatic reactions.
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Pyridoxine
Pyridoxine, also known as vitamin B6, is a form of vitamin B6 found commonly in food and used as dietary supplement.
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Rate-determining step
In chemical kinetics, the overall rate of a reaction is often approximately determined by the slowest step, known as the rate-determining step (RDS) or rate-limiting step.
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Serotonin
Serotonin or 5-hydroxytryptamine (5-HT) is a monoamine neurotransmitter.
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Single-nucleotide polymorphism
A single-nucleotide polymorphism, often abbreviated to SNP (plural), is a variation in a single nucleotide that occurs at a specific position in the genome, where each variation is present to some appreciable degree within a population (e.g. > 1%).
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Trace amine
Trace amines are an endogenous group of trace amine-associated receptor 1 (TAAR1) agonists – and hence, monoaminergic neuromodulators – that are structurally and metabolically related to classical monoamine neurotransmitters.
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Tryptamine
Tryptamine is a monoamine alkaloid.
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Tryptophan
Tryptophan (symbol Trp or W) is an α-amino acid that is used in the biosynthesis of proteins.
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Tyramine
Tyramine (also spelled tyramin), also known by several other names is a naturally occurring trace amine derived from the amino acid tyrosine.
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Tyrosine
Tyrosine (symbol Tyr or Y) or 4-hydroxyphenylalanine is one of the 20 standard amino acids that are used by cells to synthesize proteins.
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Vitamin B6
Vitamin B6 refers to a group of chemically similar compounds which can be interconverted in biological systems.
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5-Hydroxytryptophan
5-Hydroxytryptophan (5-HTP), also known as oxitriptan, is a naturally occurring amino acid and chemical precursor as well as a metabolic intermediate in the biosynthesis of the neurotransmitter serotonin.
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Redirects here:
5 hydroxytryptophan decarboxylase, 5-hydroxytryptophan decarboxylase, Amino acid decarboxylase, Aromatic amino acid decarboxylase, Aromatic-L-amino-acid carboxy-lyase, Aromatic-L-amino-acid decarboxylase, DOPA decarboxylase, Dopa decarboxylase, EC 4.1.1.26, EC 4.1.1.27, EC 4.1.1.28.
References
[1] https://en.wikipedia.org/wiki/Aromatic_L-amino_acid_decarboxylase
