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Bcl-2-associated X protein

Index Bcl-2-associated X protein

Apoptosis regulator BAX, also known as bcl-2-like protein 4, is a protein that in humans is encoded by the BAX gene. [1]

37 relations: Apoptosis, Apoptosome, Bcl-2, Bcl-2 family, Bcl-2 homologous antagonist killer, BCL2-like 1 (gene), BCL2-related protein A1, BH3 interacting-domain death agonist, Cardiolipin, Caspase, Cell signaling, Cholesterol, Cytochrome c, Cytosol, Domain (biology), Gene, Homology (biology), Mammal, MFN2, Mitochondrial apoptosis-induced channel, Mitochondrion, Ovarian cancer, P53, P53 upregulated modulator of apoptosis, Paclitaxel, Phorbol-12-myristate-13-acetate-induced protein 1, Protein, Protein family, Protein–protein interaction, SH3GLB1, SLC25A4, Transcription factor, Translationally-controlled tumor protein, Tumor suppressor, VDAC1, Voltage-dependent anion channel, YWHAQ.

Apoptosis

Apoptosis (from Ancient Greek ἀπόπτωσις "falling off") is a process of programmed cell death that occurs in multicellular organisms.

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Apoptosome

The apoptosome is a large quaternary protein structure formed in the process of apoptosis.

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Bcl-2

Bcl-2 (B-cell lymphoma 2), encoded in humans by the BCL2 gene, is the founding member of the Bcl-2 family of regulator proteins that regulate cell death (apoptosis), by either inducing (pro-apoptotic) or inhibiting (anti-apoptotic) apoptosis.

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Bcl-2 family

The Bcl-2 Family consists of a number of evolutionarily-conserved proteins that share Bcl-2 homology (BH) domains.

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Bcl-2 homologous antagonist killer

Bcl-2 homologous antagonist/killer is a protein that in humans is encoded by the BAK1 gene on chromosome 6.

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BCL2-like 1 (gene)

Bcl-2-like 1 or BCL2L1 is a human gene.

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BCL2-related protein A1

Bcl-2-related protein A1 is a protein that in humans is encoded by the BCL2A1 gene.

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BH3 interacting-domain death agonist

The BH3 interacting-domain death agonist, or BID, gene is a pro-apoptotic member of the Bcl-2 protein family.

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Cardiolipin

Cardiolipin (IUPAC name "1,3-bis(sn-3’-phosphatidyl)-sn-glycerol") is an important component of the inner mitochondrial membrane, where it constitutes about 20% of the total lipid composition.

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Caspase

Caspases (cysteine-aspartic proteases, cysteine aspartases or cysteine-dependent aspartate-directed proteases) are a family of protease enzymes playing essential roles in programmed cell death (including apoptosis, pyroptosis and necroptosis) and inflammation.

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Cell signaling

Cell signaling (cell signalling in British English) is part of any communication process that governs basic activities of cells and coordinates all cell actions.

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Cholesterol

Cholesterol (from the Ancient Greek chole- (bile) and stereos (solid), followed by the chemical suffix -ol for an alcohol) is an organic molecule.

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Cytochrome c

The cytochrome complex, or cyt c is a small hemeprotein found loosely associated with the inner membrane of the mitochondrion.

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Cytosol

The cytosol, also known as intracellular fluid (ICF) or cytoplasmic matrix, is the liquid found inside cells.

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Domain (biology)

In biological taxonomy, a domain (Latin: regio), also superkingdom or empire, is the highest taxonomic rank of organisms in the three-domain system of taxonomy designed by Carl Woese, an American microbiologist and biophysicist.

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Gene

In biology, a gene is a sequence of DNA or RNA that codes for a molecule that has a function.

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Homology (biology)

In biology, homology is the existence of shared ancestry between a pair of structures, or genes, in different taxa.

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Mammal

Mammals are the vertebrates within the class Mammalia (from Latin mamma "breast"), a clade of endothermic amniotes distinguished from reptiles (including birds) by the possession of a neocortex (a region of the brain), hair, three middle ear bones, and mammary glands.

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MFN2

Mitofusin-2 is a protein that in humans is encoded by the MFN2 gene.

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Mitochondrial apoptosis-induced channel

The mitochondrial apoptosis-induced channel (or MAC), is an early marker of the onset of apoptosis.

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Mitochondrion

The mitochondrion (plural mitochondria) is a double-membrane-bound organelle found in most eukaryotic organisms.

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Ovarian cancer

Ovarian cancer is a cancer that forms in or on an ovary.

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P53

Tumor protein p53, also known as p53, cellular tumor antigen p53 (UniProt name), phosphoprotein p53, tumor suppressor p53, antigen NY-CO-13, or transformation-related protein 53 (TRP53), is any isoform of a protein encoded by homologous genes in various organisms, such as TP53 (humans) and Trp53 (mice).

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P53 upregulated modulator of apoptosis

The p53 upregulated modulator of apoptosis (PUMA) also known as Bcl-2-binding component 3 (BBC3), is a pro-apoptotic protein, member of the Bcl-2 protein family.

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Paclitaxel

Paclitaxel (PTX), sold under the brand name Taxol among others, is a chemotherapy medication used to treat a number of types of cancer.

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Phorbol-12-myristate-13-acetate-induced protein 1

Phorbol-12-myristate-13-acetate-induced protein 1 is a protein that in humans is encoded by the PMAIP1 gene, and is also known as Noxa.

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Protein

Proteins are large biomolecules, or macromolecules, consisting of one or more long chains of amino acid residues.

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Protein family

A protein family is a group of evolutionarily-related proteins.

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Protein–protein interaction

Protein–protein interactions (PPIs) are the physical contacts of high specificity established between two or more protein molecules as a result of biochemical events steered by electrostatic forces including the hydrophobic effect.

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SH3GLB1

Endophilin-B1 is a protein that in humans is encoded by the SH3GLB1 gene.

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SLC25A4

ADP/ATP translocase 1 is an enzyme that in humans is encoded by the SLC25A4 gene or adenine nucleotide translocator, ANT.

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Transcription factor

In molecular biology, a transcription factor (TF) (or sequence-specific DNA-binding factor) is a protein that controls the rate of transcription of genetic information from DNA to messenger RNA, by binding to a specific DNA sequence.

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Translationally-controlled tumor protein

Translationally Controlled Tumor Protein (TCTP) is a protein that in humans is encoded by the TPT1 gene.

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Tumor suppressor

A tumor suppressor gene, or antioncogene, is a gene that protects a cell from one step on the path to cancer.

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VDAC1

Voltage-dependent anion-selective channel 1 (VDAC-1) is a beta barrel protein that in humans is encoded by the VDAC1 gene located on chromosome 5.

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Voltage-dependent anion channel

Voltage-dependent anion channels are a class of porin ion channel located on the outer mitochondrial membrane.

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YWHAQ

14-3-3 protein theta is a protein that in humans is encoded by the YWHAQ gene.

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Redirects here:

BAX (gene), BAX (protein), BAX protein, BCL2-associated X protein, Bax (biochemistry), Bcl-2-associated death protein, Bcl-2-associated x protein, Bcl-2–associated death protein.

References

[1] https://en.wikipedia.org/wiki/Bcl-2-associated_X_protein

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