17 relations: Adverse effect, Agonist, Allodynia, Analgesic, Benzothiophene, Binding selectivity, Drug tolerance, Eptapirone, F-15,599, Flesinoxan, Laboratoires Pierre Fabre, Levodopa-induced dyskinesia, Neurolixis, Opioid, Parkinson's disease, Potency (pharmacology), 5-HT1A receptor.
In medicine, an adverse effect is an undesired harmful effect resulting from a medication or other intervention such as surgery.
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An agonist is a chemical that binds to a receptor and activates the receptor to produce a biological response.
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Allodynia (Ancient Greek άλλος állos "other" and οδύνη odúnē "pain") refers to central pain sensitization (increased response of neurons) following painful, often repetitive, stimulation.
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An analgesic or painkiller is any member of the group of drugs used to achieve analgesia, relief from pain.
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Benzothiophene is an aromatic organic compound with a molecular formula C8H6S and an odor similar to naphthalene (mothballs).
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Binding selectivity is defined with respect to the binding of ligands to a substrate forming a complex.
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Drug tolerance is a pharmacology concept where a subject's reaction to a specific drug and concentration of the drug is reduced followed repeated use, requiring an increase in concentration to achieve the desired effect.
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Eptapirone (F-11,440) is a very potent and highly selective 5-HT1A receptor full agonist of the azapirone family.
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F-15,599, also known as NLX-101, is a very potent and highly selective 5-HT1A receptor full agonist.
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Flesinoxan (DU-29,373) is a potent and selective 5-HT1A receptor partial/near-full agonist of the phenylpiperazine class.
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Laboratoires Pierre Fabre is a French multinational pharmaceutical and cosmetics company.
Levodopa-induced dyskinesia is a form of dyskinesia associated with levodopa used to treat Parkinson's disease.
Neurolixis is a biopharmaceutical company focused on novel drugs for the treatment of human central nervous system diseases.
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An "opioid" is any synthetic narcotic not derived from opium.
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Parkinson's disease (PD, also known as idiopathic or primary parkinsonism, hypokinetic rigid syndrome (HRS), or paralysis agitans) is a degenerative disorder of the central nervous system mainly affecting the motor system.
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In the field of pharmacology, potency is a measure of drug activity expressed in terms of the amount required to produce an effect of given intensity.
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The 5-HT1A receptor is a subtype of 5-HT receptor that binds the endogenous neurotransmitter serotonin (5-hydroxytryptamine, 5-HT).
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