32 relations: African clawed frog, Bilateria, Bioinformatics, Blastocyst, CDH1 (gene), Cellular differentiation, Chordoma, Cnidaria, Dysplasia, Embryonic stem cell, Epithelial–mesenchymal transition, Fibrosis, Gastrulation, Gene, Gene regulatory network, GSC (gene), Hepatocellular carcinoma, Homeobox protein NANOG, Inner cell mass, Mesoderm, Metastasis, MIXL1, Notochord, Oct-4, Primitive streak, Protein, Protein kinase B, SOX2, T-box, Transcription factor, Xenbase, Zebrafish.
The African clawed frog (Xenopus laevis, also known as the xenopus, African clawed toad, African claw-toed frog or the platanna) is a species of African aquatic frog of the Pipidae family.
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The bilateria are the animals with bilateral symmetry, i.e., they have a front and a back end, as well as an upside and downside, and therefore a left and a right.
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Bioinformatics is an interdisciplinary field that develops methods and software tools for understanding biological data.
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The blastocyst is a structure formed in the early development of mammals.
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Cadherin-1 also known as CAM 120/80 or epithelial cadherin (E-cadherin) or uvomorulin is a protein that in humans is encoded by the CDH1 gene.
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In developmental biology, cellular differentiation is Most commonly this is a less specialized type becoming a more specialized type, such as during cell growth.
Chordoma is a rare slow-growing neoplasm thought to arise from cellular remnants of the notochord.
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Cnidaria is a phylum containing over 10,000 species of animals found exclusively in aquatic (freshwater and marine) environments: they are predominantly marine species.
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Dysplasia (from Ancient Greek δυσ- dys-, "bad" or "difficult" and πλάσις plasis, "formation") is an ambiguous term used in pathology to refer to an abnormality of development or an epithelial anomaly of growth and differentiation (epithelial dysplasia)). The terms hip dysplasia, fibrous dysplasia, renal dysplasia refer to an abnormal development, at macroscopic or microscopical level. Myelodysplastic syndromes, or dysplasia of blood-forming cells, show increased numbers of immature cells in the bone marrow, and a decrease in mature, functional cells in the blood.
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Embryonic stem cells (ES cells) are pluripotent stem cells derived from the inner cell mass of a blastocyst, an early-stage preimplantation embryo.
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The epithelial-mesenchymal transition (EMT) is a process by which epithelial cells lose their cell polarity and cell-cell adhesion, and gain migratory and invasive properties to become mesenchymal stem cells; these are multipotent stromal cells that can differentiate into a variety of cell types.
Fibrosis is the formation of excess fibrous connective tissue in an organ or tissue in a reparative or reactive process.
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Gastrulation is a phase early in the embryonic development of most animals, during which the single-layered blastula is reorganized into a trilaminar ("three-layered") structure known as the gastrula.
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A gene is a locus (or region) of DNA that encodes a functional RNA or protein product, and is the molecular unit of heredity.
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A gene regulatory network or genetic regulatory network (GRN) is a collection of regulators that interact with each other and with other substances in the cell to govern the gene expression levels of mRNA and proteins.
Homeobox protein goosecoid is a protein that in humans is encoded by the GSC gene.
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Hepatocellular carcinoma (HCC, also called malignant hepatoma) is the most common type of liver cancer.
NANOG (pron. nanOg) is a transcription factor critically involved with self-renewal of undifferentiated embryonic stem cells.
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In early embryogenesis of most eutherian mammals, the inner cell mass (abbreviated ICM and also known as the embryoblast or pluriblast, the latter term being applicable to all mammals) is the mass of cells inside the primordial embryo that will eventually give rise to the definitive structures of the fetus.
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In all bilaterian animals, the mesoderm is one of the three primary germ layers in the very early embryo.
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Metastasis, or metastatic disease, is the spread of a cancer or other disease from one organ or part to another not directly connected with it.
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Mixl1 is a paired-type homeobox transcription factor weighing 27 kDa with 232 amino acids.
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The notochord is a flexible rod-shaped body found in embryos of all chordates.
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Oct-4 (octamer-binding transcription factor 4) also known as POU5F1 (POU domain, class 5, transcription factor 1) is a protein that in humans is encoded by the POU5F1 gene.
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The primitive streak is a structure that forms in the blastula during the early stages of avian, reptilian and mammalian embryonic development.
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Proteins are large biomolecules, or macromolecules, consisting of one or more long chains of amino acid residues.
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Protein kinase B (PKB), also known as Akt, is a serine/threonine-specific protein kinase that plays a key role in multiple cellular processes such as glucose metabolism, apoptosis, cell proliferation, transcription and cell migration.
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SRY (sex determining region Y)-box 2, also known as SOX2, is a transcription factor that is essential for maintaining self-renewal, or pluripotency, of undifferentiated embryonic stem cells.
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T-box refers to a group of transcription factors involved in limb and heart development.
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In molecular biology and genetics, a transcription factor (sometimes called a sequence-specific DNA-binding factor) is a protein that binds to specific DNA sequences, thereby controlling the rate of transcription of genetic information from DNA to messenger RNA.
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Xenbase is a Model Organism Database (MOD), providing informatics resources, as well as genomic and biological data on Xenopus frogs.
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The zebrafish (Danio rerio) is a tropical freshwater fish belonging to the minnow family (Cyprinidae) of the order Cypriniformes.
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