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Endoglin

Index Endoglin

Endoglin (ENG) is a type I membrane glycoprotein located on cell surfaces and is part of the TGF beta receptor complex. [1]

31 relations: Activin and inhibin, Angiogenesis, Angiogenesis inhibitor, Antibody, Bone morphogenetic protein 2, Bone morphogenetic protein 7, Cell (biology), Cluster of differentiation, Disulfide, Dominance (genetics), Endothelium, Extracellular matrix, Fibroblast, GDF2, Glycoprotein, Hereditary hemorrhagic telangiectasia, International Immunology, Macrophage, Pre-eclampsia, Protein dimer, Protein–protein interaction, Smooth muscle tissue, Soft-tissue sarcoma, TGF beta 1, TGF beta receptor 1, TGF beta receptor 2, TGF beta signaling pathway, TGFBR3, Transforming growth factor beta, Transforming growth factor, beta 3, Zona pellucida-like domain.

Activin and inhibin

Activin and inhibin are two closely related protein complexes that have almost directly opposite biological effects.

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Angiogenesis

Angiogenesis is the physiological process through which new blood vessels form from pre-existing vessels.

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Angiogenesis inhibitor

An angiogenesis inhibitor is a substance that inhibits the growth of new blood vessels (angiogenesis).

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Antibody

An antibody (Ab), also known as an immunoglobulin (Ig), is a large, Y-shaped protein produced mainly by plasma cells that is used by the immune system to neutralize pathogens such as pathogenic bacteria and viruses.

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Bone morphogenetic protein 2

Bone morphogenetic protein 2 or BMP-2 belongs to the TGF-β superfamily of proteins.

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Bone morphogenetic protein 7

Bone morphogenetic protein 7 or BMP7 (also known as osteogenic protein-1 or OP-1) is a protein that in humans is encoded by the BMP7 gene.

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Cell (biology)

The cell (from Latin cella, meaning "small room") is the basic structural, functional, and biological unit of all known living organisms.

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Cluster of differentiation

The cluster of differentiation (also known as cluster of designation or classification determinant and often abbreviated as CD) is a protocol used for the identification and investigation of cell surface molecules providing targets for immunophenotyping of cells.

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Disulfide

In chemistry, a disulfide refers to a functional group with the structure R−S−S−R′.

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Dominance (genetics)

Dominance in genetics is a relationship between alleles of one gene, in which the effect on phenotype of one allele masks the contribution of a second allele at the same locus.

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Endothelium

Endothelium refers to cells that line the interior surface of blood vessels and lymphatic vessels, forming an interface between circulating blood or lymph in the lumen and the rest of the vessel wall.

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Extracellular matrix

In biology, the extracellular matrix (ECM) is a collection of extracellular molecules secreted by support cells that provides structural and biochemical support to the surrounding cells.

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Fibroblast

A fibroblast is a type of biological cell that synthesizes the extracellular matrix and collagen, the structural framework (stroma) for animal tissues, and plays a critical role in wound healing.

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GDF2

Growth differentiation factor 2 (GDF2) also known as bone morphogenetic protein (BMP)-9 is a protein that in humans is encoded by the GDF2 gene.

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Glycoprotein

Glycoproteins are proteins that contain oligosaccharide chains (glycans) covalently attached to amino acid side-chains.

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Hereditary hemorrhagic telangiectasia

Hereditary hemorrhagic telangiectasia (HHT), also known as Osler–Weber–Rendu disease and Osler–Weber–Rendu syndrome, is a rare autosomal dominant genetic disorder that leads to abnormal blood vessel formation in the skin, mucous membranes, and often in organs such as the lungs, liver, and brain.

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International Immunology

International Immunology is a peer-reviewed medical journal published by Oxford University Press on behalf of the Japanese Society for Immunology, addressing studies in allergology and immunology.

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Macrophage

Macrophages (big eaters, from Greek μακρός (makrós).

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Pre-eclampsia

Pre-eclampsia (PE) is a disorder of pregnancy characterized by the onset of high blood pressure and often a significant amount of protein in the urine.

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Protein dimer

In biochemistry, a protein dimer is a macromolecular complex formed by two protein monomers, or single proteins, which are usually non-covalently bound.

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Protein–protein interaction

Protein–protein interactions (PPIs) are the physical contacts of high specificity established between two or more protein molecules as a result of biochemical events steered by electrostatic forces including the hydrophobic effect.

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Smooth muscle tissue

Smooth muscle is an involuntary non-striated muscle.

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Soft-tissue sarcoma

A soft-tissue sarcoma is a form of sarcoma that develops in connective tissue, though the term is sometimes applied to elements of the soft tissue that are not currently considered connective tissue.

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TGF beta 1

Transforming growth factor beta 1 or TGF-β1 is a polypeptide member of the transforming growth factor beta superfamily of cytokines.

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TGF beta receptor 1

Transforming growth factor beta receptor I (activin A receptor type II-like kinase, 53kDa) is a membrane-bound receptor protein for the TGF beta superfamily of signaling ligands.

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TGF beta receptor 2

Transforming growth factor, beta receptor II (70/80kDa) is a TGF beta receptor.

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TGF beta signaling pathway

The transforming growth factor beta (TGFB) signaling pathway is involved in many cellular processes in both the adult organism and the developing embryo including cell growth, cell differentiation, apoptosis, cellular homeostasis and other cellular functions.

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TGFBR3

Betaglycan also known as Transforming growth factor beta receptor III (TGFBR3), is a cell-surface chondroitin sulfate / heparan sulfate proteoglycan >300 kDa in molecular weight.

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Transforming growth factor beta

Transforming growth factor beta (TGF-β) is a multifunctional cytokine belonging to the transforming growth factor superfamily that includes four different isoforms (TGF-β 1 to 4, HGNC symbols TGFB1, TGFB2, TGFB3, TGFB4) and many other signaling proteins produced by all white blood cell lineages.

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Transforming growth factor, beta 3

Transforming growth factor beta-3 is a protein that in humans is encoded by the TGFB3 gene.

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Zona pellucida-like domain

The Zona pellucida-like domain (ZP domain / ZP-like domain / ZP module) defines a family of evolutionarily related proteins.

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Redirects here:

CD105, Cd105, ENG (gene), HHT1, Hht1, ORW, Orw, TRC105.

References

[1] https://en.wikipedia.org/wiki/Endoglin

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