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62 relations: Alzheimer's disease, Aminoglycoside, Amnesia, Amyotrophic lateral sclerosis, Animal model of schizophrenia, Animal models of depression, Animal testing, Anticonvulsant, Astrocyte, Benzodiazepine, Brain, Calcium, Cell culture, Clinical trial, Conditioned place preference, Depolarization, Dextromethorphan, Dissociative, Dopamine transporter, Drug overdose, Epileptic seizure, Ethanol, Excitotoxicity, Glutamate receptor, Glutamic acid, Hallucination, Heat shock protein, Huntington's disease, Hypokinesia, International nonproprietary name, Intramuscular injection, Ion, Ion channel, Ketamine, L-DOPA, Long-term potentiation, Merck & Co., Microglia, Neurodegeneration, Neuroglia, Neuron, Neurotransmitter, Nicotinic acetylcholine receptor, Nicotinic antagonist, NMDA receptor, NMDA receptor antagonist, Olney's lesions, Oral administration, Parkinsonism, Pharmacodynamics, ..., Phencyclidine, Posterior cingulate cortex, Prepulse inhibition, Psychosis, Psychotomimetic, Rabies, Receptor (biochemistry), Reuptake inhibitor, Schizophrenia, Serotonin transporter, Stroke, Traumatic brain injury. Expand index (12 more) »
Alzheimer's disease
Alzheimer's disease (AD), also referred to simply as Alzheimer's, is a chronic neurodegenerative disease that usually starts slowly and worsens over time.
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Aminoglycoside
Aminoglycoside is a medicinal and bacteriologic category of traditional Gram-negative antibacterial therapeutic agents that inhibit protein synthesis and contain as a portion of the molecule an amino-modified glycoside (sugar); the term can also refer more generally to any organic molecule that contains aminosugar substructures.
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Amnesia
Amnesia is a deficit in memory caused by brain damage, disease, or psychological trauma.
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Amyotrophic lateral sclerosis
Amyotrophic lateral sclerosis (ALS), also known as motor neurone disease (MND), and Lou Gehrig's disease, is a specific disease which causes the death of neurons controlling voluntary muscles.
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Animal model of schizophrenia
Research into the psychotic disorder of schizophrenia, involves multiple animal models as a tool, including in the pre-clinical development of drugs.
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Animal models of depression
Animal models of depression are research tools used to investigate depression and action of antidepressants as a simulation to investigate the symptomatology and pathophysiology of depressive illness or used to screen novel antidepressants.
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Animal testing
Animal testing, also known as animal experimentation, animal research and in vivo testing, is the use of non-human animals in experiments that seek to control the variables that affect the behavior or biological system under study.
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Anticonvulsant
Anticonvulsants (also commonly known as antiepileptic drugs or as antiseizure drugs) are a diverse group of pharmacological agents used in the treatment of epileptic seizures.
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Astrocyte
Astrocytes (Astro from Greek astron.
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Benzodiazepine
Benzodiazepines (BZD, BZs), sometimes called "benzos", are a class of psychoactive drugs whose core chemical structure is the fusion of a benzene ring and a diazepine ring.
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Brain
The brain is an organ that serves as the center of the nervous system in all vertebrate and most invertebrate animals.
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Calcium
Calcium is a chemical element with symbol Ca and atomic number 20.
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Cell culture
Cell culture is the process by which cells are grown under controlled conditions, generally outside their natural environment.
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Clinical trial
Clinical trials are experiments or observations done in clinical research.
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Conditioned place preference
Conditioned place preference (CPP) is a form of Pavlovian conditioning used to measure the motivational effects of objects or experiences.
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Depolarization
In biology, depolarization is a change within a cell, during which the cell undergoes a shift in electric charge distribution, resulting in less negative charge inside the cell.
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Dextromethorphan
Dextromethorphan (DXM or DM) is a drug of the morphinan class with sedative, dissociative, and stimulant properties (at higher doses).
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Dissociative
Dissociatives are a class of hallucinogen, which distort perceptions of sight and sound and produce feelings of detachment – dissociation – from the environment and self.
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Dopamine transporter
The dopamine transporter (also dopamine active transporter, DAT, SLC6A3) is a membrane-spanning protein that pumps the neurotransmitter dopamine out of the synaptic cleft back into cytosol.
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Drug overdose
The term drug overdose (or simply overdose or OD) describes the ingestion or application of a drug or other substance in quantities greater than are recommended or generally practiced.
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Epileptic seizure
An epileptic seizure is a brief episode of signs or symptoms due to abnormally excessive or synchronous neuronal activity in the brain.
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Ethanol
Ethanol, also called alcohol, ethyl alcohol, grain alcohol, and drinking alcohol, is a chemical compound, a simple alcohol with the chemical formula.
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Excitotoxicity
Excitotoxicity is the pathological process by which nerve cells are damaged or killed by excessive stimulation by neurotransmitters such as glutamate and similar substances.
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Glutamate receptor
Glutamate receptors are synaptic and non synaptic receptors located primarily on the membranes of neuronal and glial cells.
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Glutamic acid
Glutamic acid (symbol Glu or E) is an α-amino acid with formula.
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Hallucination
A hallucination is a perception in the absence of external stimulus that has qualities of real perception.
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Heat shock protein
Heat shock proteins (HSP) are a family of proteins that are produced by cells in response to exposure to stressful conditions.
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Huntington's disease
Huntington's disease (HD), also known as Huntington's chorea, is an inherited disorder that results in death of brain cells.
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Hypokinesia
Hypokinesia refers to decreased bodily movement.
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International nonproprietary name
The International Nonproprietary Name (INN) is an official generic and non-proprietary name given to a pharmaceutical drug or an active ingredient.
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Intramuscular injection
Intramuscular (also IM or im) injection is the injection of a substance directly into muscle.
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Ion
An ion is an atom or molecule that has a non-zero net electrical charge (its total number of electrons is not equal to its total number of protons).
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Ion channel
Ion channels are pore-forming membrane proteins that allow ions to pass through the channel pore.
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Ketamine
Ketamine, sold under the brand name Ketalar among others, is a medication mainly used for starting and maintaining anesthesia.
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L-DOPA
L-DOPA, also known as levodopa or L-3,4-dihydroxyphenylalanine is an amino acid that is made and used as part of the normal biology of humans, as well as some animals and plants.
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Long-term potentiation
In neuroscience, long-term potentiation (LTP) is a persistent strengthening of synapses based on recent patterns of activity.
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Merck & Co.
Merck & Company, Inc., d.b.a. Merck Sharp & Dohme (MSD) outside the United States and Canada, is an American pharmaceutical company and one of the largest pharmaceutical companies in the world.
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Microglia
Microglia are a type of neuroglia (glial cell) located throughout the brain and spinal cord.
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Neurodegeneration
Neurodegeneration is the progressive loss of structure or function of neurons, including death of neurons.
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Neuroglia
Neuroglia, also called glial cells or simply glia, are non-neuronal cells in the central nervous system (brain and spinal cord) and the peripheral nervous system.
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Neuron
A neuron, also known as a neurone (British spelling) and nerve cell, is an electrically excitable cell that receives, processes, and transmits information through electrical and chemical signals.
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Neurotransmitter
Neurotransmitters are endogenous chemicals that enable neurotransmission.
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Nicotinic acetylcholine receptor
Nicotinic acetylcholine receptors, or nAChRs, are receptor proteins that respond to the neurotransmitter acetylcholine.
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Nicotinic antagonist
A nicotinic antagonist is a type of anticholinergic drug that inhibits the action of acetylcholine (ACh) at nicotinic acetylcholine receptors.
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NMDA receptor
The N-methyl-D-aspartate receptor (also known as the NMDA receptor or NMDAR), is a glutamate receptor and ion channel protein found in nerve cells.
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NMDA receptor antagonist
NMDA receptor antagonists are a class of anesthetics that work to antagonize, or inhibit the action of, the ''N''-Methyl-D-aspartate receptor (NMDAR).
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Olney's lesions
Olney's lesions, also known as NMDA receptor antagonist neurotoxicity (NAN), are a potential form of brain damage due to drugs that have been studied experimentally and have produced neuronal damage, yet are administered by doctors to humans in the settings of pharmacotherapy and of anesthesia.
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Oral administration
| name.
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Parkinsonism
Parkinsonism is a clinical syndrome characterized by tremor, bradykinesia, rigidity, and postural instability.
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Pharmacodynamics
Pharmacodynamics is the study of the biochemical and physiologic effects of drugs (especially pharmaceutical drugs).
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Phencyclidine
Phencyclidine (PCP), also known as angel dust among other names, is a drug used for its mind altering effects.
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Posterior cingulate cortex
The posterior cingulate cortex (PCC) is the caudal part of the cingulate cortex, located posterior to the anterior cingulate cortex.
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Prepulse inhibition
Prepulse inhibition (PPI) is a neurological phenomenon in which a weaker prestimulus (prepulse) inhibits the reaction of an organism to a subsequent strong startling stimulus (pulse).
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Psychosis
Psychosis is an abnormal condition of the mind that results in difficulties telling what is real and what is not.
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Psychotomimetic
A drug with psychotomimetic (also known as psychotogenic) actions mimics the symptoms of psychosis, including delusions and/or delirium, as opposed to just hallucinations.
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Rabies
Rabies is a viral disease that causes inflammation of the brain in humans and other mammals.
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Receptor (biochemistry)
In biochemistry and pharmacology, a receptor is a protein molecule that receives chemical signals from outside a cell.
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Reuptake inhibitor
A reuptake inhibitor (RI) is a type of drug known as a reuptake modulator that inhibits the plasmalemmal transporter-mediated reuptake of a neurotransmitter from the synapse into the pre-synaptic neuron.
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Schizophrenia
Schizophrenia is a mental disorder characterized by abnormal social behavior and failure to understand reality.
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Serotonin transporter
The serotonin transporter (SERT or 5-HTT) also known as the sodium-dependent serotonin transporter and solute carrier family 6 member 4 is a protein that in humans is encoded by the SLC6A4 gene.
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Stroke
A stroke is a medical condition in which poor blood flow to the brain results in cell death.
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Traumatic brain injury
Traumatic brain injury (TBI), also known as intracranial injury, occurs when an external force injures the brain.
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Redirects here:
C16H15N, Dizocilpine maleate, MK 801, MK-801, MK801.
References
[1] https://en.wikipedia.org/wiki/Dizocilpine
