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82 relations: Acid catalysis, AlkD, Amino acid, AP endonuclease, AP site, Aspartic acid, Bacillus cereus, Base excision repair, Base pair, Biomolecular structure, BRCA1, BRCA2, Cancer, Cancer epigenetics, Carcinogenesis, Catalysis, Cell nucleus, Cis-regulatory element, Colorectal cancer, Conserved sequence, Crystallography, Cytosine, Deamination, DNA, DNA base flipping, DNA oxidation, DNA repair, DNA replication, DNA-3-methyladenine glycosylase, Enzyme, Enzyme Commission number, Epigenetics, Escherichia coli, Eukaryote, Gene silencing, Glycosidic bond, Guanine, Herpesviridae, Homo sapiens, Hydantoin, Intron, Lyase, MBD4, Messenger RNA, Mitochondrion, MLH1, Mutation, MUTYH, NEIL1, NEIL2, ..., NEIL3, Non-small-cell lung carcinoma, O-6-methylguanine-DNA methyltransferase, Oxoguanine glycosylase, P53, Peptide, Phosphodiester bond, Polymerase, Polyp (medicine), Poxviridae, Promoter (genetics), Protein, Pyrimidine, Residue (chemistry), Saccharomyces cerevisiae, Schiff base, Sequence (biology), Single-nucleotide polymorphism, SMUG1, Thermophile, Thymine, Thymine glycol, Thymine-DNA glycosylase, Transition (genetics), Uracil, Uracil-DNA glycosylase, X-ray, Zinc-dependent phospholipase C, 5-Formyluracil, 5-Methylcytosine, 8-Oxo-2'-deoxyguanosine, 8-Oxoguanine. Expand index (32 more) »
Acid catalysis
In acid catalysis and base catalysis a chemical reaction is catalyzed by an acid or a base.
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AlkD
AlkD (Alkylpurine glycosylase D) is an enzyme belonging to a family of DNA glycosylases that are involved in DNA repair.
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Amino acid
Amino acids are organic compounds containing amine (-NH2) and carboxyl (-COOH) functional groups, along with a side chain (R group) specific to each amino acid.
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AP endonuclease
Apurinic/apyrimidinic (AP) endonuclease is an enzyme that is involved in the DNA base excision repair pathway (BER).
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AP site
In biochemistry and molecular genetics, an AP site (apurinic/apyrimidinic site), also known as an abasic site, is a location in DNA (also in RNA but much less likely) that has neither a purine nor a pyrimidine base, either spontaneously or due to DNA damage.
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Aspartic acid
Aspartic acid (symbol Asp or D; salts known as aspartates), is an α-amino acid that is used in the biosynthesis of proteins.
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Bacillus cereus
Bacillus cereus is a Gram-positive, rod-shaped, aerobic, facultatively anaerobic, motile, beta hemolytic bacterium commonly found in soil and food.
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Base excision repair
In biochemistry and genetics, base excision repair (BER) is a cellular mechanism that repairs damaged DNA throughout the cell cycle.
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Base pair
A base pair (bp) is a unit consisting of two nucleobases bound to each other by hydrogen bonds.
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Biomolecular structure
Biomolecular structure is the intricate folded, three-dimensional shape that is formed by a molecule of protein, DNA, or RNA, and that is important to its function.
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BRCA1
BRCA1 and BRCA1 are a human gene and its protein product, respectively.
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BRCA2
BRCA2 and BRCA2 are a human gene and its protein product, respectively.
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Cancer
Cancer is a group of diseases involving abnormal cell growth with the potential to invade or spread to other parts of the body.
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Cancer epigenetics
Cancer epigenetics is the study of epigenetic modifications to the DNA of cancer cells that do not involve a change in the nucleotide sequence.
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Carcinogenesis
Carcinogenesis, also called oncogenesis or tumorigenesis, is the formation of a cancer, whereby normal cells are transformed into cancer cells.
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Catalysis
Catalysis is the increase in the rate of a chemical reaction due to the participation of an additional substance called a catalysthttp://goldbook.iupac.org/C00876.html, which is not consumed in the catalyzed reaction and can continue to act repeatedly.
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Cell nucleus
In cell biology, the nucleus (pl. nuclei; from Latin nucleus or nuculeus, meaning kernel or seed) is a membrane-enclosed organelle found in eukaryotic cells.
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Cis-regulatory element
Cis-regulatory elements (CREs) are regions of non-coding DNA which regulate the transcription of neighboring genes.
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Colorectal cancer
Colorectal cancer (CRC), also known as bowel cancer and colon cancer, is the development of cancer from the colon or rectum (parts of the large intestine).
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Conserved sequence
In evolutionary biology, conserved sequences are similar or identical sequences in nucleic acids (DNA and RNA) or proteins across species (orthologous sequences) or within a genome (paralogous sequences).
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Crystallography
Crystallography is the experimental science of determining the arrangement of atoms in crystalline solids (see crystal structure).
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Cytosine
Cytosine (C) is one of the four main bases found in DNA and RNA, along with adenine, guanine, and thymine (uracil in RNA).
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Deamination
Deamination is the removal of an amine group from a protein molecule.
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DNA
Deoxyribonucleic acid (DNA) is a thread-like chain of nucleotides carrying the genetic instructions used in the growth, development, functioning and reproduction of all known living organisms and many viruses.
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DNA base flipping
DNA base flipping, or nucleotide flipping, is a mechanism in which a single nucleotide base, or nucleobase, is rotated outside the nucleic acid double helix.
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DNA oxidation
DNA oxidation is the process of oxidative damage of deoxyribonucleic acid.
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DNA repair
DNA repair is a collection of processes by which a cell identifies and corrects damage to the DNA molecules that encode its genome.
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DNA replication
In molecular biology, DNA replication is the biological process of producing two identical replicas of DNA from one original DNA molecule.
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DNA-3-methyladenine glycosylase
DNA-3-methyladenine glycosylase also known as 3-alkyladenine DNA glycosylase (AAG) or N-methylpurine DNA glycosylase (MPG) is an enzyme that in humans is encoded by the MPG gene.
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Enzyme
Enzymes are macromolecular biological catalysts.
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Enzyme Commission number
The Enzyme Commission number (EC number) is a numerical classification scheme for enzymes, based on the chemical reactions they catalyze.
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Epigenetics
Epigenetics is the study of heritable changes in gene function that do not involve changes in the DNA sequence.
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Escherichia coli
Escherichia coli (also known as E. coli) is a Gram-negative, facultatively anaerobic, rod-shaped, coliform bacterium of the genus Escherichia that is commonly found in the lower intestine of warm-blooded organisms (endotherms).
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Eukaryote
Eukaryotes are organisms whose cells have a nucleus enclosed within membranes, unlike Prokaryotes (Bacteria and other Archaea).
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Gene silencing
Gene silencing is the regulation of gene expression in a cell to prevent the expression of a certain gene.
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Glycosidic bond
In chemistry, a glycosidic bond or glycosidic linkage is a type of covalent bond that joins a carbohydrate (sugar) molecule to another group, which may or may not be another carbohydrate.
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Guanine
Guanine (or G, Gua) is one of the four main nucleobases found in the nucleic acids DNA and RNA, the others being adenine, cytosine, and thymine (uracil in RNA).
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Herpesviridae
Herpesviridae is a large family of DNA viruses that cause diseases in animals, including humans.
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Homo sapiens
Homo sapiens is the systematic name used in taxonomy (also known as binomial nomenclature) for the only extant human species.
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Hydantoin
Hydantoin, or glycolylurea, is a heterocyclic organic compound with the formula CH2C(O)NHC(O)NH.
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Intron
An intron is any nucleotide sequence within a gene that is removed by RNA splicing during maturation of the final RNA product.
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Lyase
In biochemistry, a lyase is an enzyme that catalyzes the breaking (an "elimination" reaction) of various chemical bonds by means other than hydrolysis (a "substitution" reaction) and oxidation, often forming a new double bond or a new ring structure.
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MBD4
Methyl-CpG-binding domain protein 4 is a protein that in humans is encoded by the MBD4 gene.
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Messenger RNA
Messenger RNA (mRNA) is a large family of RNA molecules that convey genetic information from DNA to the ribosome, where they specify the amino acid sequence of the protein products of gene expression.
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Mitochondrion
The mitochondrion (plural mitochondria) is a double-membrane-bound organelle found in most eukaryotic organisms.
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MLH1
MutL homolog 1, colon cancer, nonpolyposis type 2 (E. coli) is a protein that in humans is encoded by the MLH1 gene located on Chromosome 3.
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Mutation
In biology, a mutation is the permanent alteration of the nucleotide sequence of the genome of an organism, virus, or extrachromosomal DNA or other genetic elements.
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MUTYH
MUTYH (mutY Homolog (E. coli)) is a human gene that encodes a DNA glycosylase, MUTYH glycosylase.
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NEIL1
Endonuclease VIII-like 1 is an enzyme that in humans is encoded by the NEIL1 gene.
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NEIL2
Endonuclease VIII-like 2 is an enzyme that in humans is encoded by the NEIL2 gene.
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NEIL3
Nei endonuclease VIII-like 3 (E. coli) is a protein in humans that is encoded by the NEIL3 gene.
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Non-small-cell lung carcinoma
Non-small-cell lung carcinoma (NSCLC) is any type of epithelial lung cancer other than small cell lung carcinoma (SCLC).
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O-6-methylguanine-DNA methyltransferase
O6-alkylguanine DNA alkyltransferase (also known as AGT, MGMT or AGAT) is a protein that in humans is encoded by the O6-methylguanine DNA methyltransferase (MGMT) gene.
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Oxoguanine glycosylase
8-Oxoguanine glycosylase also known as OGG1 is a DNA glycosylase enzyme that, in humans, is encoded by the OGG1 gene.
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P53
Tumor protein p53, also known as p53, cellular tumor antigen p53 (UniProt name), phosphoprotein p53, tumor suppressor p53, antigen NY-CO-13, or transformation-related protein 53 (TRP53), is any isoform of a protein encoded by homologous genes in various organisms, such as TP53 (humans) and Trp53 (mice).
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Peptide
Peptides (from Gr.: πεπτός, peptós "digested"; derived from πέσσειν, péssein "to digest") are short chains of amino acid monomers linked by peptide (amide) bonds.
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Phosphodiester bond
A phosphodiester bond occurs when exactly two of the hydroxyl groups in phosphoric acid react with hydroxyl groups on other molecules to form two ester bonds.
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Polymerase
A polymerase is an enzyme (EC 2.7.7.6/7/19/48/49) that synthesizes long chains of polymers or nucleic acids.
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Polyp (medicine)
A polyp is an abnormal growth of tissue projecting from a mucous membrane.
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Poxviridae
Poxviridae is a family of viruses.
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Promoter (genetics)
In genetics, a promoter is a region of DNA that initiates transcription of a particular gene.
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Protein
Proteins are large biomolecules, or macromolecules, consisting of one or more long chains of amino acid residues.
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Pyrimidine
Pyrimidine is an aromatic heterocyclic organic compound similar to pyridine.
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Residue (chemistry)
In chemistry residue is whatever remains or acts as a contaminant after a given class of events.
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Saccharomyces cerevisiae
Saccharomyces cerevisiae is a species of yeast.
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Schiff base
A Schiff base (named after Hugo Schiff) is a compound with the general structure R2C.
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Sequence (biology)
A sequence in biology is the one-dimensional ordering of monomers, covalently linked within a biopolymer; it is also referred to as the primary structure of the biological macromolecule.
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Single-nucleotide polymorphism
A single-nucleotide polymorphism, often abbreviated to SNP (plural), is a variation in a single nucleotide that occurs at a specific position in the genome, where each variation is present to some appreciable degree within a population (e.g. > 1%).
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SMUG1
Single-strand selective monofunctional uracil DNA glycosylase is an enzyme that in humans is encoded by the SMUG1 gene.
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Thermophile
A thermophile is an organism—a type of extremophile—that thrives at relatively high temperatures, between.
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Thymine
---> Thymine (T, Thy) is one of the four nucleobases in the nucleic acid of DNA that are represented by the letters G–C–A–T.
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Thymine glycol
Thymine glycol (5,6-dihydroxy-5,6-dihydrothymine) is one of the principal DNA lesions that can be induced by oxidation and ionizing radiation.
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Thymine-DNA glycosylase
G/T mismatch-specific thymine DNA glycosylase is an enzyme that in humans is encoded by the TDG gene.
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Transition (genetics)
In genetics, a transition is a point mutation that changes a purine nucleotide to another purine (A ↔ G) or a pyrimidine nucleotide to another pyrimidine (C ↔ T).
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Uracil
Uracil (U) is one of the four nucleobases in the nucleic acid of RNA that are represented by the letters A, G, C and U. The others are adenine (A), cytosine (C), and guanine (G).
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Uracil-DNA glycosylase
Uracil-DNA glycosylase, also known as UNG or UDG, is an enzyme.
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X-ray
X-rays make up X-radiation, a form of electromagnetic radiation.
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Zinc-dependent phospholipase C
In molecular biology, zinc-dependent phospholipases C is a family of bacterial phospholipases C enzymes, some of which are also known as alpha toxins.
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5-Formyluracil
5-Formyluracil is produced from the oxidation of the methyl group of thymine.
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5-Methylcytosine
5-Methylcytosine is a methylated form of the DNA base cytosine that may be involved in the regulation of gene transcription.
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8-Oxo-2'-deoxyguanosine
8-Oxo-2'-deoxyguanosine (8-oxo-dG) is an oxidized derivative of deoxyguanosine.
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8-Oxoguanine
8-Oxoguanine (8-hydroxyguanine, 8-oxo-Gua, or OH8Gua) is one of the most common DNA lesions resulting from reactive oxygen species and can result in a mismatched pairing with adenine resulting in G to T and C to A substitutions in the genome.
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Redirects here:
DNA glycosylases, Dna Glycosylase, Dna glycosylase, Dna glycosylases, GO system.
References
[1] https://en.wikipedia.org/wiki/DNA_glycosylase
