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140 relations: Acid guanidinium thiocyanate-phenol-chloroform extraction, Affymetrix, Agilent Technologies, Allele, Alternative splicing, Aminoallyl nucleotide, Analysis of variance, Bayesian inference, Biochip, Bioinformatics, Capillary electrophoresis, Case-control study, Channel (digital image), Chemiluminescence, ChIP-on-chip, Chromatin immunoprecipitation, Citric acid, Cluster analysis, Comparative genomic hybridization, Complementarity (molecular biology), Complementary DNA, Cyanine, Cytoplasm, Dam methylase, Data analysis, Dextran, Disease, DNA, DNA adenine methyltransferase identification, DNA separation by silica adsorption, Electrochemistry, Epigenetics, Eppendorf (company), Excited state, Exon, Expressed sequence tag, FGED Society, Filtration, Fluorescence, Fluorophore, Food and Drug Administration, Forensic science, Fusion gene, Gene, Gene chip analysis, Gene expression, Gene expression profiling, Genetic linkage, Genetic predisposition, Genetically modified organism, ..., Genotyping, Germline, Glass, Glossary of gene expression terms, Grassroots, Hybridization probe, Hydrogen bond, Immunoprecipitation, InterMine, Interoperability, Lab-on-a-chip, Laser, Local regression, Loss of heterozygosity, MA plot, Mann–Whitney U test, Messenger RNA, Methylamine, Methylation specific oligonucleotide microarray, Microarray, Microarray analysis techniques, Microarray databases, Microfluidics, MicroRNA, Minimum information about a microarray experiment, Mole (unit), Multiple comparisons problem, Mycoplasma, N-Hydroxysuccinimide, Non-covalent interactions, Normalization (statistics), Nucleic acid, Nucleic acid hybridization, Nucleotide, Oligonucleotide, Oligonucleotide synthesis, Open reading frame, Open-source model, Pathogen, Pathogenomics, Phenotype microarray, Photolithography, Photomultiplier, Pico-, Plastic, Polyadenylation, Polycomb-group proteins, Polymerase chain reaction, Polyphosphate, Proceedings of the Royal Society, Protein, Protocol (science), Radioactivity in the life sciences, Replication (statistics), Reverse transcriptase, Ribosomal RNA, RNA, RNA polymerase II, RNA spike-in, RNA-Seq, Scientific journal, Sense (molecular biology), Serial analysis of gene expression, Significance analysis of microarrays, Silicon, Silverquant, Single-nucleotide polymorphism, SNP array, Sodium dodecyl sulfate, Somatic (biology), Spectrometer, Standard deviation, Standard score, Statistical significance, Statistics, Step detection, Student's t-test, Surface engineering, Systems biology, T-statistic, Tiling array, Transcription (biology), Transcriptomics technologies, Tris, Trithorax-group proteins, Trizol, Type I and type II errors, University of Delaware, Uridine, Whole genome sequencing. Expand index (90 more) »
Acid guanidinium thiocyanate-phenol-chloroform extraction
Acid guanidinium thiocyanate-phenol-chloroform extraction (abbreviated AGPC) is a liquid–liquid extraction technique in biochemistry.
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Affymetrix
Affymetrix, Inc. was an American company that manufactured DNA microarrays; it was based in Santa Clara, California, United States.
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Agilent Technologies
Agilent Technologies is an American public research, development and manufacturing company established in 1999 as a spin-off from Hewlett-Packard.
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Allele
An allele is a variant form of a given gene.
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Alternative splicing
Alternative splicing, or differential splicing, is a regulated process during gene expression that results in a single gene coding for multiple proteins.
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Aminoallyl nucleotide
Aminoallyl nucleotide is a nucleotide with a modified base containing an allylamine.
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Analysis of variance
Analysis of variance (ANOVA) is a collection of statistical models and their associated estimation procedures (such as the "variation" among and between groups) used to analyze the differences among group means in a sample.
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Bayesian inference
Bayesian inference is a method of statistical inference in which Bayes' theorem is used to update the probability for a hypothesis as more evidence or information becomes available.
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Biochip
In molecular biology, biochips are essentially miniaturized laboratories that can perform hundreds or thousands of simultaneous biochemical reactions.
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Bioinformatics
Bioinformatics is an interdisciplinary field that develops methods and software tools for understanding biological data.
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Capillary electrophoresis
Capillary electrophoresis (CE) is a family of electrokinetic separation methods performed in submillimeter diameter capillaries and in micro- and nanofluidic channels.
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Case-control study
A case-control study is a type of observational study in which two existing groups differing in outcome are identified and compared on the basis of some supposed causal attribute.
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Channel (digital image)
Color digital images are made of pixels, and pixels are made of combinations of primary colors represented by a series of code.
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Chemiluminescence
Chemiluminescence (also chemoluminescence) is the emission of light (luminescence), as the result of a chemical reaction.
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ChIP-on-chip
ChIP-on-chip (also known as ChIP-chip) is a technology that combines chromatin immunoprecipitation ('ChIP') with DNA microarray ("chip").
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Chromatin immunoprecipitation
Chromatin immunoprecipitation (ChIP) is a type of immunoprecipitation experimental technique used to investigate the interaction between proteins and DNA in the cell.
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Citric acid
Citric acid is a weak organic acid that has the chemical formula.
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Cluster analysis
Cluster analysis or clustering is the task of grouping a set of objects in such a way that objects in the same group (called a cluster) are more similar (in some sense) to each other than to those in other groups (clusters).
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Comparative genomic hybridization
Comparative genomic hybridization is a molecular cytogenetic method for analysing copy number variations (CNVs) relative to ploidy level in the DNA of a test sample compared to a reference sample, without the need for culturing cells.
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Complementarity (molecular biology)
In molecular biology, complementarity describes a relationship between two structures each following the lock-and-key principle.
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Complementary DNA
In genetics, complementary DNA (cDNA) is DNA synthesized from a single stranded RNA (e.g., messenger RNA (mRNA) or microRNA) template in a reaction catalyzed by the enzyme reverse transcriptase.
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Cyanine
Cyanine is the non-systematic name of a synthetic dye family belonging to polymethine group.
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Cytoplasm
In cell biology, the cytoplasm is the material within a living cell, excluding the cell nucleus.
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Dam methylase
DAM methylase, an abbreviation for Deoxyadenosine methylase, is an enzyme that adds a methyl group to the adenine of the sequence 5'-GATC-3' in newly synthesized DNA.
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Data analysis
Data analysis is a process of inspecting, cleansing, transforming, and modeling data with the goal of discovering useful information, informing conclusions, and supporting decision-making.
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Dextran
Dextran is a complex branched glucan (polysaccharide made of many glucose molecules) composed of chains of varying lengths (from 3 to 2000 kilodaltons).
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Disease
A disease is any condition which results in the disorder of a structure or function in an organism that is not due to any external injury.
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DNA
Deoxyribonucleic acid (DNA) is a thread-like chain of nucleotides carrying the genetic instructions used in the growth, development, functioning and reproduction of all known living organisms and many viruses.
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DNA adenine methyltransferase identification
DamID (DNA adenine methyltransferase identification) is a molecular biology protocol used to map the binding sites of DNA- and chromatin-binding proteins in eukaryotes.
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DNA separation by silica adsorption
DNA separation by silica adsorption is a method of DNA separation that is based on DNA molecules binding to silica surfaces in the presence of certain salts and under certain pH conditions.
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Electrochemistry
Electrochemistry is the branch of physical chemistry that studies the relationship between electricity, as a measurable and quantitative phenomenon, and identifiable chemical change, with either electricity considered an outcome of a particular chemical change or vice versa.
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Epigenetics
Epigenetics is the study of heritable changes in gene function that do not involve changes in the DNA sequence.
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Eppendorf (company)
Eppendorf, a company with its registered office in Germany, develops, produces and sells products and services for laboratories around the world.
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Excited state
In quantum mechanics, an excited state of a system (such as an atom, molecule or nucleus) is any quantum state of the system that has a higher energy than the ground state (that is, more energy than the absolute minimum).
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Exon
An exon is any part of a gene that will encode a part of the final mature RNA produced by that gene after introns have been removed by RNA splicing.
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Expressed sequence tag
In genetics, an expressed sequence tag (EST) is a short sub-sequence of a cDNA sequence.
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FGED Society
The Functional GEnomics Data Society (FGED) (formerly known as the MGED Society) is a non-profit, volunteer-run international organization of biologists, computer scientists, and data analysts that aims to facilitate biological and biomedical discovery through data integration.
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Filtration
Filtration is any of various mechanical, physical or biological operations that separate solids from fluids (liquids or gases) by adding a medium through which only the fluid can pass.
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Fluorescence
Fluorescence is the emission of light by a substance that has absorbed light or other electromagnetic radiation.
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Fluorophore
A fluorophore (or fluorochrome, similarly to a chromophore) is a fluorescent chemical compound that can re-emit light upon light excitation.
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Food and Drug Administration
The Food and Drug Administration (FDA or USFDA) is a federal agency of the United States Department of Health and Human Services, one of the United States federal executive departments.
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Forensic science
Forensic science is the application of science to criminal and civil laws, mainly—on the criminal side—during criminal investigation, as governed by the legal standards of admissible evidence and criminal procedure.
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Fusion gene
A fusion gene is a hybrid gene formed from two previously separate genes.
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Gene
In biology, a gene is a sequence of DNA or RNA that codes for a molecule that has a function.
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Gene chip analysis
Microarray technology is a powerful tool for genomic analysis.
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Gene expression
Gene expression is the process by which information from a gene is used in the synthesis of a functional gene product.
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Gene expression profiling
In the field of molecular biology, gene expression profiling is the measurement of the activity (the expression) of thousands of genes at once, to create a global picture of cellular function.
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Genetic linkage
Genetic linkage is the tendency of DNA sequences that are close together on a chromosome to be inherited together during the meiosis phase of sexual reproduction.
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Genetic predisposition
A genetic predisposition is a genetic characteristic which influences the possible phenotypic development of an individual organism within a species or population under the influence of environmental conditions.
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Genetically modified organism
A genetically modified organism (GMO) is any organism whose genetic material has been altered using genetic engineering techniques (i.e., a genetically engineered organism).
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Genotyping
Genotyping is the process of determining differences in the genetic make-up (genotype) of an individual by examining the individual's DNA sequence using biological assays and comparing it to another individual's sequence or a reference sequence.
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Germline
In biology and genetics, the germline in a multicellular organism is the population of its bodily cells that are so differentiated or segregated that in the usual processes of reproduction they may pass on their genetic material to the progeny.
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Glass
Glass is a non-crystalline amorphous solid that is often transparent and has widespread practical, technological, and decorative usage in, for example, window panes, tableware, and optoelectronics.
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Glossary of gene expression terms
No description.
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Grassroots
A grassroots movement (often referenced in the context of a left-wing political movement) is one which uses the people in a given district, region, or community as the basis for a political or economic movement.
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Hybridization probe
In molecular biology, a hybridization probe is a fragment of DNA or RNA of variable length (usually 100–1000 bases long) which can be radioactively labeled.
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Hydrogen bond
A hydrogen bond is a partially electrostatic attraction between a hydrogen (H) which is bound to a more electronegative atom such as nitrogen (N), oxygen (O), or fluorine (F), and another adjacent atom bearing a lone pair of electrons.
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Immunoprecipitation
Immunoprecipitation (IP) is the technique of precipitating a protein antigen out of solution using an antibody that specifically binds to that particular protein.
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InterMine
InterMine is an open source data warehouse system, licensed under the LGPL 2.1.
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Interoperability
Interoperability is a characteristic of a product or system, whose interfaces are completely understood, to work with other products or systems, at present or in the future, in either implementation or access, without any restrictions.
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Lab-on-a-chip
A lab-on-a-chip (LOC) is a device that integrates one or several laboratory functions on a single integrated circuit (commonly called a "chip") of only millimeters to a few square centimeters to achieve automation and high-throughput screening.
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Laser
A laser is a device that emits light through a process of optical amplification based on the stimulated emission of electromagnetic radiation.
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Local regression
LOESS and LOWESS (locally weighted scatterplot smoothing) are two strongly related non-parametric regression methods that combine multiple regression models in a ''k''-nearest-neighbor-based meta-model.
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Loss of heterozygosity
Loss of heterozygosity (LOH) is a cross chromosomal event that results in loss of the entire gene and the surrounding chromosomal region.
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MA plot
An MA plot is an application of a Bland–Altman plot for visual representation of genomic data.
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Mann–Whitney U test
In statistics, the Mann–Whitney U test (also called the Mann–Whitney–Wilcoxon (MWW), Wilcoxon rank-sum test, or Wilcoxon–Mann–Whitney test) is a nonparametric test of the null hypothesis that it is equally likely that a randomly selected value from one sample will be less than or greater than a randomly selected value from a second sample.
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Messenger RNA
Messenger RNA (mRNA) is a large family of RNA molecules that convey genetic information from DNA to the ribosome, where they specify the amino acid sequence of the protein products of gene expression.
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Methylamine
Methylamine is an organic compound with a formula of CH3NH2.
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Methylation specific oligonucleotide microarray
Methylation specific oligonucleotide microarray was developed as a technique to map methylation changes in DNA in cancer.
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Microarray
A microarray is a multiplex lab-on-a-chip.
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Microarray analysis techniques
Microarray analysis techniques are used in interpreting the data generated from experiments on DNA, RNA, and protein microarrays, which allow researchers to investigate the expression state of a large number of genes - in many cases, an organism's entire genome - in a single experiment.
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Microarray databases
A microarray database is a repository containing microarray gene expression data.
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Microfluidics
Microfluidics deals with the behaviour, precise control and manipulation of fluids that are geometrically constrained to a small, typically sub-millimeter, scale at which capillary penetration governs mass transport.
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MicroRNA
A microRNA (abbreviated miRNA) is a small non-coding RNA molecule (containing about 22 nucleotides) found in plants, animals and some viruses, that functions in RNA silencing and post-transcriptional regulation of gene expression.
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Minimum information about a microarray experiment
Minimum information about a microarray experiment (MIAME) is a standard created by the FGED Society for reporting microarray experiments.
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Mole (unit)
The mole, symbol mol, is the SI unit of amount of substance.
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Multiple comparisons problem
In statistics, the multiple comparisons, multiplicity or multiple testing problem occurs when one considers a set of statistical inferences simultaneously or infers a subset of parameters selected based on the observed values.
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Mycoplasma
Mycoplasma is a genus of bacteria that lack a cell wall around their cell membrane.
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N-Hydroxysuccinimide
N-Hydroxysuccinimide (NHS) is an organic compound with the formula C4H5NO3.
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Non-covalent interactions
A non-covalent interaction differs from a covalent bond in that it does not involve the sharing of electrons, but rather involves more dispersed variations of electromagnetic interactions between molecules or within a molecule.
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Normalization (statistics)
In statistics and applications of statistics, normalization can have a range of meanings.
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Nucleic acid
Nucleic acids are biopolymers, or small biomolecules, essential to all known forms of life.
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Nucleic acid hybridization
In molecular biology, hybridization (or hybridisation) is a phenomenon in which single-stranded deoxyribonucleic acid (DNA) or ribonucleic acid (RNA) molecules anneal to complementary DNA or RNA.
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Nucleotide
Nucleotides are organic molecules that serve as the monomer units for forming the nucleic acid polymers deoxyribonucleic acid (DNA) and ribonucleic acid (RNA), both of which are essential biomolecules within all life-forms on Earth.
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Oligonucleotide
Oligonucleotides are short DNA or RNA molecules, oligomers, that have a wide range of applications in genetic testing, research, and forensics.
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Oligonucleotide synthesis
Oligonucleotide synthesis is the chemical synthesis of relatively short fragments of nucleic acids with defined chemical structure (sequence).
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Open reading frame
In molecular genetics, an open reading frame (ORF) is the part of a reading frame that has the ability to be translated.
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Open-source model
The open-source model is a decentralized software-development model that encourages open collaboration.
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Pathogen
In biology, a pathogen (πάθος pathos "suffering, passion" and -γενής -genēs "producer of") or a '''germ''' in the oldest and broadest sense is anything that can produce disease; the term came into use in the 1880s.
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Pathogenomics
Pathogen infections are among the leading causes of infirmity and mortality among humans and other animals in the world.
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Phenotype microarray
The phenotype microarray approach is a technology for high-throughput phenotyping of cells.
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Photolithography
Photolithography, also termed optical lithography or UV lithography, is a process used in microfabrication to pattern parts of a thin film or the bulk of a substrate.
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Photomultiplier
Photomultiplier tubes (photomultipliers or PMTs for short), members of the class of vacuum tubes, and more specifically vacuum phototubes, are extremely sensitive detectors of light in the ultraviolet, visible, and near-infrared ranges of the electromagnetic spectrum.
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Pico-
Pico- (symbol p) is a unit prefix in the metric system denoting one trillionth, a factor of 10−12.
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Plastic
Plastic is material consisting of any of a wide range of synthetic or semi-synthetic organic compounds that are malleable and so can be molded into solid objects.
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Polyadenylation
Polyadenylation is the addition of a poly(A) tail to a messenger RNA.
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Polycomb-group proteins
Polycomb-group proteins are a family of proteins first discovered in fruit flies that can remodel chromatin such that epigenetic silencing of genes takes place.
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Polymerase chain reaction
Polymerase chain reaction (PCR) is a technique used in molecular biology to amplify a single copy or a few copies of a segment of DNA across several orders of magnitude, generating thousands to millions of copies of a particular DNA sequence.
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Polyphosphate
Polyphosphates are salts or esters of polymeric oxyanions formed from tetrahedral PO4 (phosphate) structural units linked together by sharing oxygen atoms.
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Proceedings of the Royal Society
Proceedings of the Royal Society is the parent title of two scientific journals published by the Royal Society.
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Protein
Proteins are large biomolecules, or macromolecules, consisting of one or more long chains of amino acid residues.
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Protocol (science)
In the natural sciences a protocol is a predefined written procedural method in the design and implementation of experiments.
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Radioactivity in the life sciences
Radioactivity is generally used in life sciences for highly sensitive and direct measurements of biological phenomena, and for visualizing the location of biomolecules radiolabelled with a radioisotope.
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Replication (statistics)
In engineering, science, and statistics, replication is the repetition of an experimental condition so that the variability associated with the phenomenon can be estimated.
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Reverse transcriptase
A reverse transcriptase (RT) is an enzyme used to generate complementary DNA (cDNA) from an RNA template, a process termed reverse transcription.
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Ribosomal RNA
Ribosomal ribonucleic acid (rRNA) is the RNA component of the ribosome, and is essential for protein synthesis in all living organisms.
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RNA
Ribonucleic acid (RNA) is a polymeric molecule essential in various biological roles in coding, decoding, regulation, and expression of genes.
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RNA polymerase II
RNA polymerase II (RNAP II and Pol II) is a multiprotein complex.
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RNA spike-in
An RNA spike-in is an RNA transcript of known sequence and quantity used to calibrate measurements in RNA hybridization assays, such as DNA microarray experiments, RT-qPCR, and RNA-Seq.
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RNA-Seq
RNA-Seq (RNA sequencing), also called whole transcriptome shotgun sequencing (WTSS), uses next-generation sequencing (NGS) to reveal the presence and quantity of RNA in a biological sample at a given moment.
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Scientific journal
In academic publishing, a scientific journal is a periodical publication intended to further the progress of science, usually by reporting new research.
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Sense (molecular biology)
In molecular biology and genetics, the sense of nucleic acid molecules (often DNA or RNA) is the nature of their roles and their complementary molecules' nucleic acid units' roles in specifying amino acids.
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Serial analysis of gene expression
Serial analysis of gene expression (SAGE) is a transcriptomic technique used by molecular biologists to produce a snapshot of the messenger RNA population in a sample of interest in the form of small tags that correspond to fragments of those transcripts.
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Significance analysis of microarrays
Significance analysis of microarrays (SAM) is a statistical technique, established in 2001 by Virginia Tusher, Robert Tibshirani and Gilbert Chu, for determining whether changes in gene expression are statistically significant.
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Silicon
Silicon is a chemical element with symbol Si and atomic number 14.
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Silverquant
Silverquant is a labeling and detection method for DNA microarrays or protein microarrays.
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Single-nucleotide polymorphism
A single-nucleotide polymorphism, often abbreviated to SNP (plural), is a variation in a single nucleotide that occurs at a specific position in the genome, where each variation is present to some appreciable degree within a population (e.g. > 1%).
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SNP array
In molecular biology, SNP array is a type of DNA microarray which is used to detect polymorphisms within a population.
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Sodium dodecyl sulfate
Sodium dodecyl sulfate (SDS), synonymously sodium lauryl sulfate (SLS), or sodium laurilsulfate, is a synthetic organic compound with the formula CH3(CH2)11SO4 Na.
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Somatic (biology)
The term somatic is often used in biology to refer to the cells of the body in contrast to the germ line cells which usually give rise to the gametes (ovum or sperm).
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Spectrometer
A spectrometer is a scientific instrument used to separate and measure spectral components of a physical phenomenon.
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Standard deviation
In statistics, the standard deviation (SD, also represented by the Greek letter sigma σ or the Latin letter s) is a measure that is used to quantify the amount of variation or dispersion of a set of data values.
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Standard score
In statistics, the standard score is the signed number of standard deviations by which the value of an observation or data point differs from the mean value of what is being observed or measured.
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Statistical significance
In statistical hypothesis testing, a result has statistical significance when it is very unlikely to have occurred given the null hypothesis.
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Statistics
Statistics is a branch of mathematics dealing with the collection, analysis, interpretation, presentation, and organization of data.
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Step detection
In statistics and signal processing, step detection (also known as step smoothing, step filtering, shift detection, jump detection or edge detection) is the process of finding abrupt changes (steps, jumps, shifts) in the mean level of a time series or signal.
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Student's t-test
The t-test is any statistical hypothesis test in which the test statistic follows a Student's ''t''-distribution under the null hypothesis.
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Surface engineering
Surface engineering is the sub-discipline of materials science which deals with the surface of solid matter.
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Systems biology
Systems biology is the computational and mathematical modeling of complex biological systems.
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T-statistic
In statistics, the t-statistic is the ratio of the departure of the estimated value of a parameter from its hypothesized value to its standard error.
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Tiling array
Tiling arrays are a subtype of microarray chips.
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Transcription (biology)
Transcription is the first step of gene expression, in which a particular segment of DNA is copied into RNA (especially mRNA) by the enzyme RNA polymerase.
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Transcriptomics technologies
Transcriptomics technologies are the techniques used to study an organism’s transcriptome, the sum of all of its RNA transcripts.
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Tris
Tris, or tris(hydroxymethyl)aminomethane, or known during medical use as tromethamine or THAM, is an organic compound with the formula (HOCH2)3CNH2.
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Trithorax-group proteins
Trithorax Group (TrxG) proteins are a heterogeneous collection of proteins whose main action is to maintain gene expression.
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Trizol
TRIzol is a chemical solution used in RNA/DNA/protein extraction, by the reference paper from Piotr Chomczyński and Sacchi, N. in 1987.
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Type I and type II errors
In statistical hypothesis testing, a type I error is the rejection of a true null hypothesis (also known as a "false positive" finding), while a type II error is failing to reject a false null hypothesis (also known as a "false negative" finding).
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University of Delaware
The University of Delaware (colloquially UD, UDel, or U of D) is a public research university located in Newark, Delaware.
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Uridine
Uridine is a glycosylated pyrimidine-analog containing uracil attached to a ribose ring (or more specifically, a ribofuranose) via a β-N1-glycosidic bond.
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Whole genome sequencing
Whole genome sequencing (also known as WGS, full genome sequencing, complete genome sequencing, or entire genome sequencing) is the process of determining the complete DNA sequence of an organism's genome at a single time.
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Redirects here:
CDNA microarray, DNA Chip, DNA Microarray, DNA array, DNA chip, DNA gene-expression microarray, DNA integrated analysis chip, DNA microarray experiment, DNA microarrays, Dna array, Dna microarray, Dna microarrays, Gene array, Gene chip, Gene chip technology, Gene microarray, Genome tiling arrays, Oligonucleotide array sequence analysis, Oligonucleotide microarray, PCR Microarrays, PCR microarrays.
References
[1] https://en.wikipedia.org/wiki/DNA_microarray
