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114 relations: Addiction, Adrafinil, Adrenaline, Altropane, Amfonelic acid, Amineptine, Amphetamine, Anorectic, Antidepressant, Armodafinil, Attention deficit hyperactivity disorder, Benocyclidine, Benzatropine, Binge eating disorder, Biosynthesis, Brain, Bupropion, Catecholamine, Cathinone, Chaenomeles speciosa, Chemical synapse, Cocaine, Concentration, Conformational change, Controlled substance, DBL-583, Dexmethylphenidate, Difemetorex, Difluoropine, Diphenylpyraline, Dopamine, Dopamine agonist, Dopamine releasing agent, Dopamine transporter, Dopaminergic, Dopaminergic pathways, Drug, Enthalpy, Entropy, Ethylphenidate, Etybenzatropine, Eugeroic, Extracellular, Fencamfamin, Fluorenol, GBR-12783, GBR-12935, GBR-13069, GBR-13098, GYKI-52895, ..., Hydrophobe, Ketamine, Lefetamine, Levophacetoperane, Mazindol, MDMA, Medifoxamine, Mephedrone, Mesocarb, Metaphit, Methadone, Methamphetamine, Methcathinone, Methylenedioxypyrovalerone, Methylone, Methylphenidate, Modafinil, Molar concentration, Monoamine neurotransmitter, Monoamine reuptake inhibitor, Monoamine transporter, Mood disorder, Naphyrone, Narcolepsy, Nefazodone, Nefopam, Neuron, Neurotransmission, Nicotine replacement therapy, Nomifensine, Norepinephrine, Norepinephrine transporter, Norepinephrine–dopamine reuptake inhibitor, Obesity, Oocyte, Oroxylin A, Oroxylum indicum, Pethidine, Phencyclidine, Pipradrol, Prolintane, Pyrovalerone, Reuptake inhibitor, Reward system, Rimcazole, RTI-229, RTI-55, Scutellaria baicalensis, Serotonin transporter, Serotonin–norepinephrine–dopamine reuptake inhibitor, Sertraline, Shift work sleep disorder, Sibutramine, Stimulant, Structural analog, Substance abuse, Substituted amphetamine, Synapse, Tripelennamine, Vanoxerine, Venlafaxine, Yerkes–Dodson law, 1-(3-Chlorophenyl)-4-(2-phenylethyl)piperazine, 4-Hydroxy-1-methyl-4-(4-methylphenyl)-3-piperidyl 4-methylphenyl ketone. Expand index (64 more) »
Addiction
Addiction is a brain disorder characterized by compulsive engagement in rewarding stimuli despite adverse consequences.
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Adrafinil
Adrafinil (INN; brand name Olmifon) is a eugeroic that was formerly used in France to promote alertness, attention, wakefulness, mood, and other parameters, particularly in the elderly.
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Adrenaline
Adrenaline, also known as adrenalin or epinephrine, is a hormone, neurotransmitter, and medication.
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Altropane
Altropane, (O-587, IACFT, 2β-carbomethoxy-3β-(4-fluorophenyl)-N-((E)-3-iodo-prop-2-enyl)tropane) is a phenyltropane derivative which acts as a potent dopamine reuptake inhibitor and long-acting stimulant drug.
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Amfonelic acid
Amfonelic acid (AFA; WIN 25,978) is a research chemical and dopaminergic stimulant with antibiotic properties.
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Amineptine
Amineptine, sold under the brand name Survector among others, is an atypical antidepressant of the tricyclic antidepressant (TCA) family.
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Amphetamine
Amphetamine (contracted from) is a potent central nervous system (CNS) stimulant that is used in the treatment of attention deficit hyperactivity disorder (ADHD), narcolepsy, and obesity.
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Anorectic
An anorectic or anorexic is a drug which reduces appetite, resulting in lower food consumption, leading to weight loss.
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Antidepressant
Antidepressants are drugs used for the treatment of major depressive disorder and other conditions, including dysthymia, anxiety disorders, obsessive–compulsive disorder, eating disorders, chronic pain, neuropathic pain and, in some cases, dysmenorrhoea, snoring, migraine, attention-deficit hyperactivity disorder (ADHD), addiction, dependence, and sleep disorders.
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Armodafinil
Armodafinil (trade name Nuvigil) is the enantiopure compound of the eugeroic modafinil (Provigil).
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Attention deficit hyperactivity disorder
Attention-deficit hyperactivity disorder (ADHD) is a mental disorder of the neurodevelopmental type.
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Benocyclidine
Benocyclidine, also known as benzothiophenylcyclohexylpiperidine (BTCP), is a psychoactive recreational drug of the arylcyclohexylamine class which is related to phencyclidine (PCP).
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Benzatropine
Benzatropine, also known as benztropine, is an anticholinergic marketed under the trade name Cogentin which is used in the treatment of Parkinson's disease, Parkinsonism, and dystonia.
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Binge eating disorder
Binge eating disorder (BED) is an eating disorder characterized by frequent and recurrent binge eating episodes with associated negative psychological and social problems, but without subsequent purging episodes (e.g. vomiting).
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Biosynthesis
Biosynthesis (also called anabolism) is a multi-step, enzyme-catalyzed process where substrates are converted into more complex products in living organisms.
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Brain
The brain is an organ that serves as the center of the nervous system in all vertebrate and most invertebrate animals.
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Bupropion
Bupropion, sold under the brand names Wellbutrin and Zyban among others, is a medication primarily used as an antidepressant and smoking cessation aid.
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Catecholamine
A catecholamine (CA) is a monoamine, an organic compound that has a catechol (benzene with two hydroxyl side groups at carbons 1 and 2) and a side-chain amine.
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Cathinone
Cathinone (also known as benzoylethanamine, or β-keto-amphetamine) is a monoamine alkaloid found in the shrub Catha edulis (khat) and is chemically similar to ephedrine, cathine, methcathinone and other amphetamines.
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Chaenomeles speciosa
Chaenomeles speciosa (commonly known as flowering quince, Chinese quince, or Japanese quince;Bailey, L.H.; Bailey, E.Z.; the staff of the Liberty Hyde Bailey Hortorium. 1976. Hortus third: A concise dictionary of plants cultivated in the United States and Canada. Macmillan, New York. in the context of in traditional Chinese medicine known as zhou pi mugua) is a thorny deciduous or semi-evergreen shrub native to eastern Asia.
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Chemical synapse
Chemical synapses are biological junctions through which neurons' signals can be exchanged to each other and to non-neuronal cells such as those in muscles or glands.
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Cocaine
Cocaine, also known as coke, is a strong stimulant mostly used as a recreational drug.
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Concentration
In chemistry, concentration is the abundance of a constituent divided by the total volume of a mixture.
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Conformational change
In biochemistry, a conformational change is a change in the shape of a macromolecule, often induced by environmental factors.
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Controlled substance
A controlled substance is generally a drug or chemical whose manufacture, possession, or use is regulated by a government, such as illicitly used drugs or prescription medications that are designated a Controlled Drug in the United Kingdom.
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DBL-583
DBL-583 is a selective dopamine reuptake inhibitor of the piperazine chemical class.
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Dexmethylphenidate
Dexmethylphenidate, sold under the trade names Focalin among others, is a central nervous system (CNS) stimulant used in the treatment of attention deficit hyperactivity disorder (ADHD) and narcolepsy.
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Difemetorex
Difemetorex (INN; sold as Cleofil), also known as diphemethoxidine, is a stimulant drug of the piperidine class which was used as an appetite suppressant, but produced intolerable side effects such as insomnia which limited its clinical use.
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Difluoropine
Difluoropine (O-620) is a stimulant drug synthesised from tropinone, which acts as a potent and selective dopamine reuptake inhibitor.
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Diphenylpyraline
Diphenylpyraline (DPP; sold as Allergen, Arbid, Belfene, Diafen, Hispril, Histyn, Lergobine, Lyssipol, Mepiben, Neargal) is a first-generation antihistamine with anticholinergic effects of the diphenylpiperidine class.
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Dopamine
Dopamine (DA, a contraction of 3,4-dihydroxyphenethylamine) is an organic chemical of the catecholamine and phenethylamine families that plays several important roles in the brain and body.
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Dopamine agonist
A dopamine receptor agonist is a compound that activates dopamine receptors.
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Dopamine releasing agent
A dopamine releasing agent (DRA) is a type of drug which induces the release of dopamine in the body and/or brain.
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Dopamine transporter
The dopamine transporter (also dopamine active transporter, DAT, SLC6A3) is a membrane-spanning protein that pumps the neurotransmitter dopamine out of the synaptic cleft back into cytosol.
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Dopaminergic
Dopaminergic means "related to dopamine" (literally, "working on dopamine"), dopamine being a common neurotransmitter.
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Dopaminergic pathways
Dopaminergic pathways, sometimes called dopaminergic projections, are the sets of projection neurons in the brain that synthesize and release the neurotransmitter dopamine.
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Drug
A drug is any substance (other than food that provides nutritional support) that, when inhaled, injected, smoked, consumed, absorbed via a patch on the skin, or dissolved under the tongue causes a temporary physiological (and often psychological) change in the body.
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Enthalpy
Enthalpy is a property of a thermodynamic system.
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Entropy
In statistical mechanics, entropy is an extensive property of a thermodynamic system.
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Ethylphenidate
Ethylphenidate (EPH) is a psychostimulant and a close analog of methylphenidate.
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Etybenzatropine
Etybenzatropine (INN), also known as ethybenztropine (USAN, BAN) and tropethydrylin, is an anticholinergic/antihistamine marketed under the trade names Panolid, Ponalid, and Ponalide, which is used as an antiparkinsonian agent.
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Eugeroic
Eugeroics (originally, "eugrégorique" or "eugregoric"), also known as wakefulness-promoting agents and wakefulness-promoting drugs, are a class of drugs that promote wakefulness and alertness.
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Extracellular
In cell biology, molecular biology and related fields, the word extracellular (or sometimes extracellular space) means "outside the cell".
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Fencamfamin
Fencamfamin (INN), also known as fencamfamine or by the brand names Glucoenergan and Reactivan, is a stimulant which was developed by Merck in the 1960s.
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Fluorenol
Fluorenol is an alcohol derivative of fluorene.
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GBR-12783
GBR-12783 is a psychostimulant which acts as a selective dopamine reuptake inhibitor.
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GBR-12935
GBR-12935 is a piperazine derivative which is a potent and selective dopamine reuptake inhibitor.
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GBR-13069
GBR-13069 is a psychostimulant and selective dopamine reuptake inhibitor.
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GBR-13098
GBR-13098 is a psychostimulant and selective dopamine uptake inhibitor.
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GYKI-52895
GYKI-52895 is a drug which is a 2,3-benzodiazepine derivative.
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Hydrophobe
In chemistry, hydrophobicity is the physical property of a molecule (known as a hydrophobe) that is seemingly repelled from a mass of water.
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Ketamine
Ketamine, sold under the brand name Ketalar among others, is a medication mainly used for starting and maintaining anesthesia.
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Lefetamine
Lefetamine (Santenol) is a drug which is a stimulant and also an analgesic with effects comparable to codeine.
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Levophacetoperane
Levophacetoperane (Lidépran, Phacétoperane) is a psychostimulant developed by Rhône-Poulenc in the 1950s.
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Mazindol
Mazindol (brand names Mazanor, Sanorex) is a stimulant drug which is used as an appetite suppressant.
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MDMA
3,4-Methylenedioxymethamphetamine (MDMA), commonly known as ecstasy (E), is a psychoactive drug used primarily as a recreational drug.
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Medifoxamine
Medifoxamine, previously sold under the brand names Clédial and Gerdaxyl, is an atypical antidepressant with additional anxiolytic properties acting via dopaminergic and serotonergic mechanisms which was formerly marketed in France and Spain, as well as Morocco.
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Mephedrone
Mephedrone, also known as 4-methyl methcathinone (4-MMC) or 4-methyl ephedrone, is a synthetic stimulant drug of the amphetamine and cathinone classes.
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Mesocarb
Mesocarb (brand names Sidnocarb, Sydnocarb) is a stimulant drug which was developed in the USSR in the 1970s.
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Metaphit
Metaphit (1-cyclohexylpiperidine) is a research chemical that acts as an acylator of NMDARAn, sigma and DAT binding sites in the CNS.
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Methadone
Methadone, sold under the brand name Dolophine among others, is an opioid used to treat pain and as maintenance therapy or to help with tapering in people with opioid dependence.
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Methamphetamine
Methamphetamine (contracted from) is a potent central nervous system (CNS) stimulant that is mainly used as a recreational drug and less commonly as a second-line treatment for attention deficit hyperactivity disorder and obesity.
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Methcathinone
Methcathinone (α-methylamino-propiophenone or ephedrone) (sometimes called "cat" or "jeff" or "catnip" or "intash") is a monoamine alkaloid and psychoactive stimulant, a substituted cathinone.
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Methylenedioxypyrovalerone
Methylenedioxypyrovalerone (MDPV) is a stimulant of the cathinone class which acts as a norepinephrine-dopamine reuptake inhibitor (NDRI).
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Methylone
Methylone (also known as "3,4-methylenedioxy-N-methylcathinone", "MDMC", "βk-MDMA" and by the slang term "M1") is an empathogen and stimulant psychoactive drug.
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Methylphenidate
Methylphenidate, sold under various trade names, Ritalin being one of the most commonly known, is a central nervous system (CNS) stimulant of the phenethylamine and piperidine classes that is used in the treatment of attention deficit hyperactivity disorder (ADHD) and narcolepsy.
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Modafinil
Modafinil, sold under the brand name Provigil among others, is a medication to treat sleepiness due to narcolepsy, shift work sleep disorder, or obstructive sleep apnea (OSA). In OSA continuous positive airway pressure is the preferred treatment. While it has seen off-label use as a purported cognitive enhancer, evidence for any benefit is lacking. It is taken by mouth. Common side effects include headache, anxiety, trouble sleeping, and nausea. Serious side effects may include allergic reactions such as anaphylaxis, Stevens–Johnson syndrome, abuse, or hallucinations. It is unclear if use during pregnancy is safe. The amount of medication used may need to be adjusted in those with kidney or liver problems. It is not recommended in those with an arrhythmia, significant hypertension, or left ventricular hypertrophy. How it works is not entirely clear. One possibility is that it may affect the areas of the brain involved with the sleep cycle. Modafinil was approved for medical use in the United States in 1998. In the United States it is classified as a schedule IV controlled substance due to concerns about addiction. In the United Kingdom it is a prescription only medication. It is avaliable as a generic medication. In the United Kingdom it costs the NHS about £105.21 a month as of 2018. In the United States the wholesale cost per month is about 34.20 USD as of 2018.
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Molar concentration
Molar concentration (also called molarity, amount concentration or substance concentration) is a measure of the concentration of a chemical species, in particular of a solute in a solution, in terms of amount of substance per unit volume of solution.
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Monoamine neurotransmitter
Monoamine neurotransmitters are neurotransmitters and neuromodulators that contain one amino group that is connected to an aromatic ring by a two-carbon chain (such as -CH2-CH2-). All monoamines are derived from aromatic amino acids like phenylalanine, tyrosine, tryptophan, and the thyroid hormones by the action of aromatic amino acid decarboxylase enzymes.
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Monoamine reuptake inhibitor
A monoamine reuptake inhibitor (MRI) is a drug that acts as a reuptake inhibitor of one or more of the three major monoamine neurotransmitters serotonin, norepinephrine, and dopamine by blocking the action of one or more of the respective monoamine transporters (MATs), which include the serotonin transporter (SERT), norepinephrine transporter (NET), and dopamine transporter (DAT).
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Monoamine transporter
Monoamine transporters (MATs) are protein structures that function as integral plasma-membrane transporters to regulate concentrations of extracellular monoamine neurotransmitters.
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Mood disorder
Mood disorder, also known as mood (affective) disorders, is a group of conditions where a disturbance in the person's mood is the main underlying feature.
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Naphyrone
Naphyrone, also known as O-2482 and naphthylpyrovalerone, is a drug derived from pyrovalerone that acts as a triple reuptake inhibitor, producing stimulant effects and has been reported as a novel designer drug.
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Narcolepsy
Narcolepsy is a long-term neurological disorder that involves a decreased ability to regulate sleep-wake cycles.
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Nefazodone
Nefazodone, sold formerly under the brand names Serzone, Dutonin, and Nefadar among others, is an atypical antidepressant which was first marketed by Bristol-Myers Squibb in 1994 but has since largely been discontinued.
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Nefopam
Nefopam, sold under the brand names Acupan among others, is a painkilling medication.
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Neuron
A neuron, also known as a neurone (British spelling) and nerve cell, is an electrically excitable cell that receives, processes, and transmits information through electrical and chemical signals.
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Neurotransmission
Neurotransmission (Latin: transmissio "passage, crossing" from transmittere "send, let through"), also called synaptic transmission, is the process by which signaling molecules called neurotransmitters are released by the axon terminal of a neuron (the presynaptic neuron), and bind to and activate the receptors on the dendrites of another neuron (the postsynaptic neuron).
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Nicotine replacement therapy
Nicotine replacement therapy (NRT) is a medically-approved way to take nicotine by means other than tobacco.
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Nomifensine
Nomifensine (Merital, Alival) is a norepinephrine-dopamine reuptake inhibitor, i.e. a drug that increases the amount of synaptic norepinephrine and dopamine available to receptors by blocking the dopamine and norepinephrine reuptake transporters.
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Norepinephrine
Norepinephrine (NE), also called noradrenaline (NA) or noradrenalin, is an organic chemical in the catecholamine family that functions in the brain and body as a hormone and neurotransmitter.
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Norepinephrine transporter
The norepinephrine transporter (NET), also known as solute carrier family 6 member 2 (SLC6A2), is a protein that in humans is encoded by the SLC6A2 gene.
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Norepinephrine–dopamine reuptake inhibitor
A norepinephrine–dopamine reuptake inhibitor (NDRI) is a drug that acts as a reuptake inhibitor for the neurotransmitters norepinephrine and dopamine by blocking the action of the norepinephrine transporter (NET) and the dopamine transporter (DAT), respectively.
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Obesity
Obesity is a medical condition in which excess body fat has accumulated to the extent that it may have a negative effect on health.
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Oocyte
An oocyte, oöcyte, ovocyte, or rarely ocyte, is a female gametocyte or germ cell involved in reproduction.
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Oroxylin A
Oroxylin A is an O-methylated flavone, a chemical compound that can be found in the medicinal plant Scutellaria baicalensis and the Oroxylum indicum tree.
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Oroxylum indicum
Oroxylum indicum is a species of flowering plant belonging to the monotypic genus Oroxylum and the family Bignoniaceae, are commonly called midnight horror, oroxylum, Indian trumpet flower, broken bones, Indian caper, or tree of Damocles.
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Pethidine
Pethidine, also known as meperidine and sold under the brand name Demerol among others, is a synthetic opioid pain medication of the phenylpiperidine class.
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Phencyclidine
Phencyclidine (PCP), also known as angel dust among other names, is a drug used for its mind altering effects.
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Pipradrol
Pipradrol (Meratran) is a mild central nervous system stimulant (norepinephrine-dopamine reuptake inhibitor) that is no longer widely used in most countries due to concerns about its abuse potential.
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Prolintane
Prolintane (Catovit, Katovit, Promotil, Villescon) is a stimulant and norepinephrine-dopamine reuptake inhibitor developed in the 1950s.
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Pyrovalerone
Pyrovalerone (Centroton, 4-Methyl-β-keto-prolintane, Thymergix, O-2371) is a psychoactive drug with stimulant effects via acting as a norepinephrine-dopamine reuptake inhibitor (NDRI), and is used for the clinical treatment of chronic fatigue or lethargy and as an anorectic or appetite suppressant for weight loss purposes.
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Reuptake inhibitor
A reuptake inhibitor (RI) is a type of drug known as a reuptake modulator that inhibits the plasmalemmal transporter-mediated reuptake of a neurotransmitter from the synapse into the pre-synaptic neuron.
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Reward system
The reward system is a group of neural structures responsible for incentive salience (i.e., motivation and "wanting", desire, or craving for a reward), associative learning (primarily positive reinforcement and classical conditioning), and positive emotions, particularly ones which involve pleasure as a core component (e.g., joy, euphoria and ecstasy).
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Rimcazole
Rimcazole is an antagonist of the sigma receptor as well as a dopamine reuptake inhibitor.
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RTI-229
(–)-3β-(4-iodophenyl)tropane-2β-pyrrolidine carboxamide (RTI-4229-229) is a potent and long-lasting stimulant drug which was developed in the 1990s as part of a large group of related analogues from the phenyltropane family.
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RTI-55
RTI(-4229)-55, also called RTI-55 or iometopane, is a phenyltropane-based psychostimulant used in scientific research and in some medical applications.
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Scutellaria baicalensis
Scutellaria baicalensis, with the common name Baikal skullcap, is a species of flowering plant in the Lamiaceae family.
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Serotonin transporter
The serotonin transporter (SERT or 5-HTT) also known as the sodium-dependent serotonin transporter and solute carrier family 6 member 4 is a protein that in humans is encoded by the SLC6A4 gene.
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Serotonin–norepinephrine–dopamine reuptake inhibitor
A serotonin–norepinephrine–dopamine reuptake inhibitor (SNDRI), also known as a triple reuptake inhibitor (TRI), is a type of drug that acts as a combined reuptake inhibitor of the monoamine neurotransmitters serotonin, norepinephrine, and dopamine.
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Sertraline
Sertraline, sold under the trade names Zoloft among others, is an antidepressant of the selective serotonin reuptake inhibitor (SSRI) class.
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Shift work sleep disorder
Shift work sleep disorder (SWSD) is a circadian rhythm sleep disorder characterized by insomnia and excessive sleepiness affecting people whose work hours overlap with the typical sleep period.
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Sibutramine
Sibutramine, formerly sold under the brand name Meridia among others, is an appetite suppressant which has been discontinued in many countries.
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Stimulant
Stimulants (also often referred to as psychostimulants or colloquially as uppers) is an overarching term that covers many drugs including those that increase activity of the central nervous system and the body, drugs that are pleasurable and invigorating, or drugs that have sympathomimetic effects.
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Structural analog
A structural analog, also known as a chemical analog or simply an analog, is a compound having a structure similar to that of another compound, but differing from it in respect to a certain component.
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Substance abuse
Substance abuse, also known as drug abuse, is a patterned use of a drug in which the user consumes the substance in amounts or with methods which are harmful to themselves or others, and is a form of substance-related disorder.
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Substituted amphetamine
Substituted amphetamines are a class of compounds based upon the amphetamine structure; it includes all derivative compounds which are formed by replacing, or substituting, one or more hydrogen atoms in the amphetamine core structure with substituents.
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Synapse
In the nervous system, a synapse is a structure that permits a neuron (or nerve cell) to pass an electrical or chemical signal to another neuron or to the target efferent cell.
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Tripelennamine
Tripelennamine, sold under the brand name Pyribenzamine by Novartis, is a drug that is used as an antipruritic and first-generation antihistamine.
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Vanoxerine
Vanoxerine (GBR-12909) is a piperazine derivative which is a potent and selective dopamine reuptake inhibitor (DRI).
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Venlafaxine
Venlafaxine, sold under the brand name Effexor among others, is an antidepressant of the selective serotonin-norepinephrine reuptake inhibitor (SNRI) class.
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Yerkes–Dodson law
The Yerkes–Dodson law is an empirical relationship between arousal and performance, originally developed by psychologists Robert M. Yerkes and John Dillingham Dodson in 1908.
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1-(3-Chlorophenyl)-4-(2-phenylethyl)piperazine
1-(3-Chlorophenyl)-4-(2-phenylethyl)piperazine (3C-PEP) is a research chemical of the piperazine class of chemical substances with psychoactive properties.
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4-Hydroxy-1-methyl-4-(4-methylphenyl)-3-piperidyl 4-methylphenyl ketone
4-Hydroxy-1-methyl-4-(4-methylphenyl)-3-piperidyl 4-Methylphenyl Ketone is a dopamine transporter reuptake inhibitor used as a lead compound to find a DRI transporter site antagonist (i.e. a compound that fills the ligand binding site without inhibiting the flow of neurotransmitters to the degree that another ligand at its site would).
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Redirects here:
DARI, Dopamine reuptake inhibition, Dopamine reuptake inhibitors, Dopamine uptake inhibitor, Dopamine uptake inhibitors.
References
[1] https://en.wikipedia.org/wiki/Dopamine_reuptake_inhibitor
