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98 relations: Alanine transaminase, Alkaline phosphatase, American Society of Clinical Oncology, Amitriptyline, Anaphylaxis, Angioedema, Anhedonia, Annals of Internal Medicine, Anorgasmia, Anticonvulsant, Antidepressant discontinuation syndrome, Aspartate transaminase, Bilirubin, Biological half-life, BioMed Central, Blood pressure, Blood sugar level, Boxed warning, Central nervous system, Chronic pain, Citalopram, Clinical trial, Cochrane (organisation), Contraindication, CYP1A2, CYP2D6, Cytokine, Dizziness, Dopamine transporter, Dr. Reddy's Laboratories, Drug withdrawal, Dysphoria, Eli Lilly and Company, Enantiomer, Escitalopram, European Association of Urology, European Federation of Neurological Societies, Fibromyalgia, Fluoxetine, Food and Drug Administration, Generalized anxiety disorder, Glaucoma, Good manufacturing practice, Headache, Health Canada, Hepatotoxicity, Hives, Hypomania, Hyponatremia, Imipramine, ..., Insomnia, Jaundice, Major depressive disorder, Maudsley Prescribing Guidelines, Meta-analysis, Metabolism, Monoamine oxidase inhibitor, Musculoskeletal disorder, Mydriasis, Nausea, Neuropathic pain, New Drug Application, Norepinephrine transporter, Opioid, Orthostatic hypotension, Osteoarthritis, Paresthesia, Paroxetine, Patent application, Peripheral neuropathy, Placebo, Prescrire, Pseudobulbar affect, QT interval, Racemic mixture, Serotonin syndrome, Serotonin transporter, Serotonin–norepinephrine reuptake inhibitor, Sertraline, Sexual dysfunction, Side effect, Somnolence, Statistical significance, Stevens–Johnson syndrome, Stress incontinence, Suicidal ideation, Syncope (medicine), Therapeutic index, Thiophene, Thioridazine, Tinnitus, Tricyclic antidepressant, United Kingdom, Venlafaxine, Xerostomia, 5-HT2A receptor, 5-HT2C receptor, 5-HT6 receptor. Expand index (48 more) »
Alanine transaminase
Alanine transaminase (ALT) is a transaminase enzyme.
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Alkaline phosphatase
Alkaline phosphatase (ALP, ALKP, ALPase, Alk Phos) or basic phosphatase is a homodimeric protein enzyme of 86 kilodaltons.
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American Society of Clinical Oncology
The American Society of Clinical Oncology (ASCO) is a professional organization representing physicians of all oncology sub-specialties who care for people with cancer.
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Amitriptyline
Amitriptyline, sold under the brand name Elavil among others, is a medicine primarily used to treat a number of mental illnesses.
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Anaphylaxis
Anaphylaxis is a serious allergic reaction that is rapid in onset and may cause death.
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Angioedema
Angioedema is an area of swelling of the lower layer of skin and tissue just under the skin or mucous membranes.
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Anhedonia
Anhedonia refers to a diverse array of deficits in hedonic function, including reduced motivation or ability to experience pleasure.
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Annals of Internal Medicine
Annals of Internal Medicine is an academic medical journal published by the American College of Physicians (ACP).
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Anorgasmia
Anorgasmia, or Coughlan's syndrome, is a type of sexual dysfunction in which a person cannot achieve orgasm despite adequate stimulation.
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Anticonvulsant
Anticonvulsants (also commonly known as antiepileptic drugs or as antiseizure drugs) are a diverse group of pharmacological agents used in the treatment of epileptic seizures.
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Antidepressant discontinuation syndrome
Antidepressant discontinuation syndrome is a condition that can occur following the interruption, dose reduction, or discontinuation of antidepressant drugs, including selective serotonin re-uptake inhibitors (SSRIs) or serotonin–norepinephrine reuptake inhibitors (SNRIs).
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Aspartate transaminase
Aspartate transaminase (AST) or aspartate aminotransferase, also known as AspAT/ASAT/AAT or serum glutamic oxaloacetic transaminase (SGOT), is a pyridoxal phosphate (PLP)-dependent transaminase enzyme that was first described by Arthur Karmen and colleagues in 1954.
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Bilirubin
Bilirubin is a yellow compound that occurs in the normal catabolic pathway that breaks down heme in vertebrates.
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Biological half-life
The biological half-life of a biological substance is the time it takes for half to be removed by biological processes when the rate of removal is roughly exponential.
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BioMed Central
BioMed Central (BMC) is a United Kingdom-based, for-profit scientific open access publisher.
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Blood pressure
Blood pressure (BP) is the pressure of circulating blood on the walls of blood vessels.
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Blood sugar level
The blood sugar level, blood sugar concentration, or blood glucose level is the amount of glucose present in the blood of humans and other animals.
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Boxed warning
In the United States, a boxed warning (sometimes "black box warning", colloquially) is a type of warning that appears on the package insert for certain prescription drugs, so called because the U.S. Food and Drug Administration specifies that it is formatted with a 'box' or border around the text.
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Central nervous system
The central nervous system (CNS) is the part of the nervous system consisting of the brain and spinal cord.
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Chronic pain
Chronic pain is pain that lasts a long time.
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Citalopram
Citalopram (brand names: Celexa, Cipramil and others) is an antidepressant drug of the selective serotonin reuptake inhibitor (SSRI) class.
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Clinical trial
Clinical trials are experiments or observations done in clinical research.
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Cochrane (organisation)
Cochrane is a non-profit, non-governmental organization formed to organize medical research findings so as to facilitate evidence-based choices about health interventions faced by health professionals, patients, and policy makers.
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Contraindication
In medicine, a contraindication is a condition or factor that serves as a reason to withhold a certain medical treatment due to the harm that it would cause the patient.
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CYP1A2
Cytochrome P450 1A2 (abbreviated CYP1A2), a member of the cytochrome P450 mixed-function oxidase system, is involved in the metabolism of xenobiotics in the body.
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CYP2D6
Cytochrome P450 2D6 (CYP2D6) is an enzyme that in humans is encoded by the CYP2D6 gene.
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Cytokine
Cytokines are a broad and loose category of small proteins (~5–20 kDa) that are important in cell signaling.
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Dizziness
Dizziness is an impairment in spatial perception and stability.
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Dopamine transporter
The dopamine transporter (also dopamine active transporter, DAT, SLC6A3) is a membrane-spanning protein that pumps the neurotransmitter dopamine out of the synaptic cleft back into cytosol.
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Dr. Reddy's Laboratories
Dr.
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Drug withdrawal
Drug withdrawal is the group of symptoms that occur upon the abrupt discontinuation or decrease in intake of medications or recreational drugs.
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Dysphoria
Dysphoria (from δύσφορος (dysphoros), δυσ-, difficult, and φέρειν, to bear) is a profound state of unease or dissatisfaction.
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Eli Lilly and Company
Eli Lilly and Company is a global pharmaceutical company headquartered in Indianapolis, Indiana, with offices in 18 countries.
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Enantiomer
In chemistry, an enantiomer, also known as an optical isomer (and archaically termed antipode or optical antipode), is one of two stereoisomers that are mirror images of each other that are non-superposable (not identical), much as one's left and right hands are the same except for being reversed along one axis (the hands cannot be made to appear identical simply by reorientation).
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Escitalopram
Escitalopram, sold under the brand names Cipralex and Lexapro among others, is an antidepressant of the selective serotonin reuptake inhibitor (SSRI) class.
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European Association of Urology
The European Association of Urology (EAU) is a non-profit organisation committed to the representation of urology professionals worldwide.
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European Federation of Neurological Societies
The European Federation of Neurological Societies was an organisation that united and supported neurologists across the whole of Europe.
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Fibromyalgia
Fibromyalgia (FM) is a medical condition characterised by chronic widespread pain and a heightened pain response to pressure.
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Fluoxetine
Fluoxetine, also known by trade names Prozac and Sarafem, among others, is an antidepressant of the selective serotonin reuptake inhibitor (SSRI) class.
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Food and Drug Administration
The Food and Drug Administration (FDA or USFDA) is a federal agency of the United States Department of Health and Human Services, one of the United States federal executive departments.
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Generalized anxiety disorder
Generalized anxiety disorder (GAD) is an anxiety disorder characterized by excessive, uncontrollable and often irrational worry, that is, apprehensive expectation about events or activities.
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Glaucoma
Glaucoma is a group of eye diseases which result in damage to the optic nerve and vision loss.
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Good manufacturing practice
Good manufacturing practices (GMP) are the practices required in order to conform to the guidelines recommended by agencies that control the authorization and licensing of the manufacture and sale of food and beverages, cosmetics, pharmaceutical products, dietary supplements, and medical devices.
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Headache
Headache is the symptom of pain anywhere in the region of the head or neck.
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Health Canada
Health Canada (Santé Canada) is the department of the government of Canada with responsibility for national public health.
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Hepatotoxicity
Hepatotoxicity (from hepatic toxicity) implies chemical-driven liver damage.
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Hives
Hives, also known as urticaria, is a kind of skin rash with red, raised, itchy bumps.
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Hypomania
Hypomania (literally "under mania" or "less than mania") is a mood state characterized by persistent disinhibition and elevation (euphoria).
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Hyponatremia
Hyponatremia is a low sodium level in the blood.
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Imipramine
Imipramine, sold under the brand name Tofranil among others, is a tricyclic antidepressant (TCA) which is used mainly in the treatment of depression.
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Insomnia
Insomnia, also known as sleeplessness, is a sleep disorder where people have trouble sleeping.
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Jaundice
Jaundice, also known as icterus, is a yellowish or greenish pigmentation of the skin and whites of the eyes due to high bilirubin levels.
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Major depressive disorder
Major depressive disorder (MDD), also known simply as depression, is a mental disorder characterized by at least two weeks of low mood that is present across most situations.
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Maudsley Prescribing Guidelines
The Maudsley Prescribing Guidelines (also known by the abbreviation MPG) is a referenced prescribing guideline for psychotropic drugs.
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Meta-analysis
A meta-analysis is a statistical analysis that combines the results of multiple scientific studies.
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Metabolism
Metabolism (from μεταβολή metabolē, "change") is the set of life-sustaining chemical transformations within the cells of organisms.
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Monoamine oxidase inhibitor
Monoamine oxidase inhibitors (MAOIs) are a class of drugs that inhibit the activity of one or both monoamine oxidase enzymes: monoamine oxidase A (MAO-A) and monoamine oxidase B (MAO-B).
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Musculoskeletal disorder
Musculoskeletal disorders (MSDs) are injuries or pain in the human musculoskeletal system, including the joints, ligaments, muscles, nerves, tendons, and structures that support limbs, neck and back.
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Mydriasis
Mydriasis is the dilation of the pupil, usually having a non-physiological cause, or sometimes a physiological pupillary response.
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Nausea
Nausea or queasiness is an unpleasant sense of unease, discomfort, and revulsion towards food.
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Neuropathic pain
Neuropathic pain is pain caused by damage or disease affecting the somatosensory nervous system.
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New Drug Application
The Food and Drug Administration's New Drug Application (NDA) is the vehicle in the United States through which drug sponsors formally propose that the FDA approve a new pharmaceutical for sale and marketing.
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Norepinephrine transporter
The norepinephrine transporter (NET), also known as solute carrier family 6 member 2 (SLC6A2), is a protein that in humans is encoded by the SLC6A2 gene.
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Opioid
Opioids are substances that act on opioid receptors to produce morphine-like effects.
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Orthostatic hypotension
Orthostatic hypotension, also known as postural hypotension, occurs when a person's blood pressure falls when suddenly standing up from a lying or sitting position.
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Osteoarthritis
Osteoarthritis (OA) is a type of joint disease that results from breakdown of joint cartilage and underlying bone.
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Paresthesia
Paresthesia is an abnormal sensation such as tingling, tickling, pricking, numbness or burning of a person's skin with no apparent physical cause.
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Paroxetine
Paroxetine, also known by trade names including Paxil and Seroxat among others, is an antidepressant of the selective serotonin reuptake inhibitor (SSRI) class. It is used to treat major depressive disorder, obsessive-compulsive disorder, social anxiety disorder, panic disorder, posttraumatic stress disorder, generalized anxiety disorder and premenstrual dysphoric disorder. It has also been used in the treatment of hot flashes and night sweats associated with menopause. It has a similar tolerability profile to other SSRIs. The common side effects include drowsiness, dry mouth, loss of appetite, sweating, trouble sleeping and delayed ejaculation. It may also be associated with a slightly increased risk of birth defects. The rate of withdrawal symptoms in young people may be higher with paroxetine and venlafaxine than other SSRIs and SNRIs. Several studies have associated paroxetine with suicidal thinking and behavior in children and adolescents. Marketing of the drug began in 1992 by the pharmaceutical company SmithKline Beecham, known since 2000 as GlaxoSmithKline. Generic formulations have been available since 2003 when the patent expired. The United States Department of Justice fined GlaxoSmithKline $3 billion in 2012, including a sum for withholding data on paroxetine, unlawfully promoting it for under-18s and preparing an article, following one of its clinical trials, study 329, that misleadingly reported the drug was effective in treating adolescent depression.
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Patent application
A patent application is a request pending at a patent office for the grant of a patent for the invention described and claimed by that application.
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Peripheral neuropathy
Peripheral neuropathy (PN) is damage to or disease affecting nerves, which may impair sensation, movement, gland or organ function, or other aspects of health, depending on the type of nerve affected.
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Placebo
A placebo is a substance or treatment of no intended therapeutic value.
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Prescrire
Prescrire also known as La Revue Prescrire is a monthly medical journal in French which addresses developments in diseases, medications, and in medical techniques and technologies.
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Pseudobulbar affect
Pseudobulbar affect (PBA), or emotional incontinence, is a type of emotional disturbance characterized by uncontrollable episodes of crying and/or laughing, or other emotional displays.
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QT interval
In cardiology, the QT interval is a measure of the time between the start of the Q wave and the end of the T wave in the heart's electrical cycle.
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Racemic mixture
In chemistry, a racemic mixture, or racemate, is one that has equal amounts of left- and right-handed enantiomers of a chiral molecule.
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Serotonin syndrome
Serotonin syndrome (SS) is a group of symptoms that may occur following use of certain serotonergic medications or drugs.
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Serotonin transporter
The serotonin transporter (SERT or 5-HTT) also known as the sodium-dependent serotonin transporter and solute carrier family 6 member 4 is a protein that in humans is encoded by the SLC6A4 gene.
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Serotonin–norepinephrine reuptake inhibitor
Serotonin–norepinephrine reuptake inhibitors (SNRIs) are a class of antidepressant drugs that treat major depressive disorder (MDD) and can also treat anxiety disorders, obsessive-compulsive disorder (OCD), attention-deficit hyperactivity disorder (ADHD), chronic neuropathic pain, fibromyalgia syndrome (FMS), and menopausal symptoms.
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Sertraline
Sertraline, sold under the trade names Zoloft among others, is an antidepressant of the selective serotonin reuptake inhibitor (SSRI) class.
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Sexual dysfunction
Sexual dysfunction (or sexual malfunction or sexual disorder) is difficulty experienced by an individual or a couple during any stage of a normal sexual activity, including physical pleasure, desire, preference, arousal or orgasm.
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Side effect
In medicine, a side effect is an effect, whether therapeutic or adverse, that is secondary to the one intended; although the term is predominantly employed to describe adverse effects, it can also apply to beneficial, but unintended, consequences of the use of a drug.
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Somnolence
Somnolence (alternatively "sleepiness" or "drowsiness") is a state of strong desire for sleep, or sleeping for unusually long periods (compare hypersomnia).
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Statistical significance
In statistical hypothesis testing, a result has statistical significance when it is very unlikely to have occurred given the null hypothesis.
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Stevens–Johnson syndrome
Stevens–Johnson syndrome (SJS) is a type of severe skin reaction.
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Stress incontinence
Stress incontinence, also known as stress urinary incontinence (SUI) or effort incontinence is a form of urinary incontinence.
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Suicidal ideation
Suicidal ideation, also known as suicidal thoughts, is thinking about or having an unusual preoccupation with suicide.
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Syncope (medicine)
Syncope, also known as fainting, is a loss of consciousness and muscle strength characterized by a fast onset, short duration, and spontaneous recovery.
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Therapeutic index
The therapeutic index (TI; also referred to as therapeutic ratio) is a comparison of the amount of a therapeutic agent that causes the therapeutic effect to the amount that causes toxicity.
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Thiophene
Thiophene is a heterocyclic compound with the formula C4H4S.
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Thioridazine
Thioridazine (Mellaril or Melleril) is a piperidine typical antipsychotic drug belonging to the phenothiazine drug group and was previously widely used in the treatment of schizophrenia and psychosis.
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Tinnitus
Tinnitus is the hearing of sound when no external sound is present.
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Tricyclic antidepressant
Tricyclic antidepressants (TCAs) are a class of medications that are used primarily as antidepressants.
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United Kingdom
The United Kingdom of Great Britain and Northern Ireland, commonly known as the United Kingdom (UK) or Britain,Usage is mixed with some organisations, including the and preferring to use Britain as shorthand for Great Britain is a sovereign country in western Europe.
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Venlafaxine
Venlafaxine, sold under the brand name Effexor among others, is an antidepressant of the selective serotonin-norepinephrine reuptake inhibitor (SNRI) class.
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Xerostomia
Xerostomia, also known as dry mouth and dry mouth syndrome, is dryness in the mouth, which may be associated with a change in the composition of saliva, or reduced salivary flow, or have no identifiable cause.
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5-HT2A receptor
The mammalian 5-HT2A receptor is a subtype of the 5-HT2 receptor that belongs to the serotonin receptor family and is a G protein-coupled receptor (GPCR).
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5-HT2C receptor
The 5-HT2C receptor is a subtype of 5-HT receptor that binds the endogenous neurotransmitter serotonin (5-hydroxytryptamine, 5-HT).
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5-HT6 receptor
The 5HT6 receptor is a subtype of 5HT receptor that binds the endogenous neurotransmitter serotonin (5-hydroxytryptamine, 5HT).
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Redirects here:
ATC code N06AX21, ATCvet code QN06AX21, C18H19NOS, Cymbalta, Duloxetin, Duloxetine hydrochloride, LY 227,942, LY 227942, LY-227,942, LY-227942, LY227942, Sembalta, Simbalta, Symbalta, Yentreve, Zymbalta.
References
[1] https://en.wikipedia.org/wiki/Duloxetine
