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62 relations: Acenocoumarol, Amyloidosis, Anticoagulant, Antithrombin, Apixaban, Arginine, Betrixaban, Bio Products Laboratory, Biosynthesis, Blood plasma, Calcium, Chromosome, Coagulation, Cofactor (biochemistry), Coumarin, CSL Behring, Darexaban, Direct Xa inhibitor, Edoxaban, Enzyme, Eponym, Factor IX, Factor V, Factor VII, Factor VIII, Factor X, Factor XI, Fibrin, Fondaparinux, Fresh frozen plasma, Gene, Hemarthrosis, Heparin, Isoleucine, Liver, Low molecular weight heparin, MEROPS, Nosebleed, PA clan, Phenprocoumon, Phospholipid, Platelet, Polymerization, Protein Z, Protein Z-related protease inhibitor, Protein–protein interaction, Prothrombinase, Rivaroxaban, Serine protease, Serpin, ..., Tenase, The Wall Street Journal, Threonine, Thrombin, Thrombosis, Thrombus, Tissue factor, Tissue factor pathway inhibitor, Transmembrane protein, Vitamin K, Warfarin, World Federation of Hemophilia. Expand index (12 more) »
Acenocoumarol
Acenocoumarol is an anticoagulant that functions as a vitamin K antagonist (like warfarin).
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Amyloidosis
Amyloidosis is a group of diseases in which abnormal protein, known as amyloid fibrils, builds up in tissue.
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Anticoagulant
Anticoagulants, commonly referred to as blood thinners, are chemical substances that prevent or reduce coagulation of blood, prolonging the clotting time.
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Antithrombin
Antithrombin (AT) is a small protein molecule that inactivates several enzymes of the coagulation system.
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Apixaban
Apixaban, sold under the tradename Eliquis, is an anticoagulant for the treatment of venous thromboembolic events.
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Arginine
Arginine (symbol Arg or R) is an α-amino acid that is used in the biosynthesis of proteins.
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Betrixaban
Betrixaban (INN; trade name Bevyxxa; development code PRT-054,021) is an anticoagulant drug which acts as a direct factor Xa inhibitor.
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Bio Products Laboratory
The Bio Products Laboratory (BPL) is a company involved in the manufacture of human blood plasma products, located in Elstree in the United Kingdom.
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Biosynthesis
Biosynthesis (also called anabolism) is a multi-step, enzyme-catalyzed process where substrates are converted into more complex products in living organisms.
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Blood plasma
Blood plasma is a yellowish coloured liquid component of blood that normally holds the blood cells in whole blood in suspension; this makes plasma the extracellular matrix of blood cells.
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Calcium
Calcium is a chemical element with symbol Ca and atomic number 20.
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Chromosome
A chromosome (from Ancient Greek: χρωμόσωμα, chromosoma, chroma means colour, soma means body) is a DNA molecule with part or all of the genetic material (genome) of an organism.
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Coagulation
Coagulation (also known as clotting) is the process by which blood changes from a liquid to a gel, forming a blood clot.
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Cofactor (biochemistry)
A cofactor is a non-protein chemical compound or metallic ion that is required for an enzyme's activity.
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Coumarin
Coumarin (2H-chromen-2-one) is a fragrant organic chemical compound in the benzopyrone chemical class, although it may also be seen as a subclass of lactones.
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CSL Behring
CSL Behring is a biopharmaceutical company, manufacturing plasma-derived and recombinant therapeutic products.
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Darexaban
Darexaban (YM150) is a direct inhibitor of factor Xa created by Astellas Pharma.
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Direct Xa inhibitor
Direct factor Xa inhibitors ('xabans') are a class of anticoagulant drugs which act directly upon Factor X in the coagulation cascade, without using antithrombin as a mediator.
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Edoxaban
Edoxaban (DU-176b, trade names Savaysa, Lixiana) is an oral anticoagulant drug which acts as a direct factor Xa inhibitor.
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Enzyme
Enzymes are macromolecular biological catalysts.
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Eponym
An eponym is a person, place, or thing after whom or after which something is named, or believed to be named.
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Factor IX
Factor IX (or Christmas factor) is one of the serine proteases of the coagulation system; it belongs to peptidase family S1.
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Factor V
Factor V (pronounced factor five) is a protein of the coagulation system, rarely referred to as proaccelerin or labile factor.
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Factor VII
Factor VII (blood-coagulation factor VIIa, activated blood coagulation factor VII, formerly known as proconvertin) is one of the proteins that causes blood to clot in the coagulation cascade.
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Factor VIII
Factor VIII (FVIII) is an essential blood-clotting protein, also known as anti-hemophilic factor (AHF).
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Factor X
Factor X, also known by the eponym Stuart–Prower factor, is an enzyme of the coagulation cascade.
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Factor XI
Factor XI or plasma thromboplastin antecedent is the zymogen form of factor XIa, one of the enzymes of the coagulation cascade.
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Fibrin
Fibrin (also called Factor Ia) is a fibrous, non-globular protein involved in the clotting of blood.
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Fondaparinux
Fondaparinux (trade name Arixtra) is an anticoagulant medication chemically related to low molecular weight heparins.
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Fresh frozen plasma
Fresh frozen plasma (FFP) is a blood product made from the liquid portion of whole blood.
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Gene
In biology, a gene is a sequence of DNA or RNA that codes for a molecule that has a function.
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Hemarthrosis
Hemarthrosis (or haemarthrosis) is a bleeding into joint spaces.
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Heparin
Heparin, also known as unfractionated heparin (UFH), is medication which is used as an anticoagulant (blood thinner).
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Isoleucine
Isoleucine (symbol Ile or I) is an α-amino acid that is used in the biosynthesis of proteins.
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Liver
The liver, an organ only found in vertebrates, detoxifies various metabolites, synthesizes proteins, and produces biochemicals necessary for digestion.
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Low molecular weight heparin
Low-molecular-weight heparin (LMWH) is a class of anticoagulant medications.
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MEROPS
MEROPS is an on-line database for peptidases (also known as proteases, proteinases and proteolytic enzymes) and their inhibitors.
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Nosebleed
A nosebleed, also known as epistaxis, is the common occurrence of bleeding from the nose.
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PA clan
The PA clan ('''P'''roteases of mixed nucleophile, superfamily A) is the largest group of proteases with common ancestry as identified by structural homology.
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Phenprocoumon
Phenprocoumon (marketed under the brand names Marcoumar, Marcumar and Falithrom) is a long-acting oral anticoagulant drug, a derivative of coumarin.
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Phospholipid
Phospholipids are a class of lipids that are a major component of all cell membranes.
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Platelet
Platelets, also called thrombocytes (from Greek θρόμβος, "clot" and κύτος, "cell"), are a component of blood whose function (along with the coagulation factors) is to react to bleeding from blood vessel injury by clumping, thereby initiating a blood clot.
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Polymerization
In polymer chemistry, polymerization is a process of reacting monomer molecules together in a chemical reaction to form polymer chains or three-dimensional networks.
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Protein Z
Protein Z (PZ or PROZ) is a protein which in humans is encoded by the PROZ gene.
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Protein Z-related protease inhibitor
Protein Z-dependent protease inhibitor is a protein circulating in the blood which inhibits factors Xa and XIa of the coagulation cascade.
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Protein–protein interaction
Protein–protein interactions (PPIs) are the physical contacts of high specificity established between two or more protein molecules as a result of biochemical events steered by electrostatic forces including the hydrophobic effect.
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Prothrombinase
The prothrombinase complex consists of the serine protein, Factor Xa, and the protein cofactor, Factor Va.
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Rivaroxaban
Rivaroxaban, sold under the brand name Xarelto, among others, is an oral anticoagulant medication (blood thinner).
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Serine protease
Serine proteases (or serine endopeptidases) are enzymes that cleave peptide bonds in proteins, in which serine serves as the nucleophilic amino acid at the (enzyme's) active site.
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Serpin
Serpins are a superfamily of proteins with similar structures that were first identified for their protease inhibition activity and are found in all kingdoms of life.
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Tenase
In coagulation, the procoagulant protein factor X can be activated into factor Xa two ways; extrinsically or intrinsically.
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The Wall Street Journal
The Wall Street Journal is a U.S. business-focused, English-language international daily newspaper based in New York City.
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Threonine
Threonine (symbol Thr or T) is an amino acid that is used in the biosynthesis of proteins.
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Thrombin
Thrombin (fibrinogenase, thrombase, thrombofort, topical, thrombin-C, tropostasin, activated blood-coagulation factor II, blood-coagulation factor IIa, factor IIa, E thrombin, beta-thrombin, gamma-thrombin) is a serine protease, an enzyme that, in humans, is encoded by the F2 gene.
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Thrombosis
Thrombosis (from Ancient Greek θρόμβωσις thrómbōsis "clotting”) is the formation of a blood clot inside a blood vessel, obstructing the flow of blood through the circulatory system.
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Thrombus
A thrombus, colloquially called a blood clot, is the final product of the blood coagulation step in hemostasis.
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Tissue factor
Tissue factor, also called platelet tissue factor, factor III, or CD142 is a protein encoded by the F3 gene, present in subendothelial tissue and leukocytes.
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Tissue factor pathway inhibitor
Tissue factor pathway inhibitor (or TFPI) is a single-chain polypeptide which can reversibly inhibit Factor Xa (Xa).
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Transmembrane protein
A transmembrane protein (TP) is a type of integral membrane protein that spans the entirety of the biological membrane to which it is permanently attached.
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Vitamin K
Vitamin K is a group of structurally similar, fat-soluble vitamins that the human body requires for complete synthesis of certain proteins that are prerequisites for blood coagulation (K from Koagulation, Danish for "coagulation") and which the body also needs for controlling binding of calcium in bones and other tissues.
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Warfarin
Warfarin, sold under the brand name Coumadin among others, is a medication that is used as an anticoagulant (blood thinner).
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World Federation of Hemophilia
The World Federation of Hemophilia (WFH) is an international non-profit organization dedicated to improving the lives of people with hemophilia (also spelled haemophilia) and other genetic bleeding disorders.
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Redirects here:
Coagulation factor X, Coagulation factor Xa, EC 3.4.21.6, F10 (gene), FXA, Factor Xa, Factor x, Factor x deficiency, Factor xa, Fxa, Stuart factor, Stuart-Prower factor, Thrombokinase.
References
[1] https://en.wikipedia.org/wiki/Factor_X
