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40 relations: Acute myeloid leukemia, Antibody, AXL receptor tyrosine kinase, B cell, Bone marrow, CD135, Cellular and Molecular Life Sciences, Cellular Signalling, Cluster of differentiation, Cytokine, Cytokine receptor, FMS-like tyrosine kinase 3 ligand, Gene, Glycosylation, Growth Factors (journal), Haematopoiesis, Hematopoietic stem cell, Immunoglobulin domain, Lestaurtinib, Leukemia, Leukemia & Lymphoma, Lymphocyte, Lymphopoiesis, Midostaurin, Mutation, Myeloid tissue, Oncogene, Orphan drug, Progenitor cell, Prognosis, Protein, Quizartinib, Receptor tyrosine kinase, Sorafenib, Sunitinib, T cell, The International Journal of Biochemistry & Cell Biology, Transforming growth factor beta, Tumor necrosis factor alpha, Tyrosine kinase.
Acute myeloid leukemia
Acute myeloid leukemia (AML) is a cancer of the myeloid line of blood cells, characterized by the rapid growth of abnormal cells that build up in the bone marrow and blood and interfere with normal blood cells.
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Antibody
An antibody (Ab), also known as an immunoglobulin (Ig), is a large, Y-shaped protein produced mainly by plasma cells that is used by the immune system to neutralize pathogens such as pathogenic bacteria and viruses.
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AXL receptor tyrosine kinase
Tyrosine-protein kinase receptor UFO is an enzyme that in humans is encoded by the AXL gene.
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B cell
B cells, also known as B lymphocytes, are a type of white blood cell of the lymphocyte subtype.
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Bone marrow
Bone marrow is a semi-solid tissue which may be found within the spongy or cancellous portions of bones.
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CD135
Cluster of differentiation antigen 135 (CD135) also known as fms like tyrosine kinase 3 (FLT-3), receptor-type tyrosine-protein kinase FLT3, or fetal liver kinase-2 (Flk2) is a protein that in humans is encoded by the FLT3 gene.
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Cellular and Molecular Life Sciences
Cellular and Molecular Life Sciences is a peer-reviewed scientific journal covering cellular and molecular life sciences.
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Cellular Signalling
Cellular Signalling is a peer-reviewed scientific journal focusing on various aspects of cell signalling.
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Cluster of differentiation
The cluster of differentiation (also known as cluster of designation or classification determinant and often abbreviated as CD) is a protocol used for the identification and investigation of cell surface molecules providing targets for immunophenotyping of cells.
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Cytokine
Cytokines are a broad and loose category of small proteins (~5–20 kDa) that are important in cell signaling.
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Cytokine receptor
Cytokine receptors are receptors that bind cytokines.
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FMS-like tyrosine kinase 3 ligand
FMS-like tyrosine kinase 3 ligand (FLT3L) is an endogenous small molecule that functions as a cytokine and growth factor that increases the number of immune cells (lymphocytes (B cells and T cells)) by activating the hematopoietic progenitors.
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Gene
In biology, a gene is a sequence of DNA or RNA that codes for a molecule that has a function.
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Glycosylation
Glycosylation (see also chemical glycosylation) is the reaction in which a carbohydrate, i.e. a glycosyl donor, is attached to a hydroxyl or other functional group of another molecule (a glycosyl acceptor).
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Growth Factors (journal)
Growth Factors is a bimonthly peer-reviewed scientific journal that covers research on the control of cell production and differentiation and survival.
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Haematopoiesis
Haematopoiesis (from Greek αἷμα, "blood" and ποιεῖν "to make"; also hematopoiesis in American English; sometimes also haemopoiesis or hemopoiesis) is the formation of blood cellular components.
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Hematopoietic stem cell
Hematopoietic stem cells (HSCs) are the stem cells that give rise to other blood cells.
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Immunoglobulin domain
The immunoglobulin domain is a type of protein domain that consists of a 2-layer sandwich of 7-9 antiparallel β-strands arranged in two β-sheets with a Greek key topology, consisting of about 125 amino acids.
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Lestaurtinib
Lestaurtinib (rINN, codenamed CEP-701) is a tyrosine kinase inhibitor structurally related to staurosporine.
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Leukemia
Leukemia, also spelled leukaemia, is a group of cancers that usually begin in the bone marrow and result in high numbers of abnormal white blood cells.
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Leukemia & Lymphoma
Leukemia & Lymphoma is a peer-reviewed medical journal published by Informa Healthcare.
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Lymphocyte
A lymphocyte is one of the subtypes of white blood cell in a vertebrate's immune system.
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Lymphopoiesis
Lymphopoiesis (lĭm'fō-poi-ē'sĭs) (or lymphocytopoiesis) is the generation of lymphocytes, one of the five types of white blood cell (WBC).
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Midostaurin
Midostaurin (sold under the name Rydapt) is a multi-targeted protein kinase inhibitor that has been investigated for the treatment of acute myeloid leukemia (AML), myelodysplastic syndrome (MDS) and advanced systemic mastocytosis.
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Mutation
In biology, a mutation is the permanent alteration of the nucleotide sequence of the genome of an organism, virus, or extrachromosomal DNA or other genetic elements.
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Myeloid tissue
Myeloid tissue, in the bone marrow sense of the word myeloid (myelo- + -oid), is tissue of bone marrow, of bone marrow cell lineage, or resembling bone marrow, and myelogenous tissue (myelo- + -genous) is any tissue of, or arising from, bone marrow; in these senses the terms are usually used synonymously, as for example with chronic myeloid/myelogenous leukemia.
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Oncogene
An oncogene is a gene that has the potential to cause cancer.
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Orphan drug
An orphan drug is a pharmaceutical agent that has been developed specifically to treat a rare medical condition, the condition itself being referred to as an orphan disease.
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Progenitor cell
A progenitor cell is a biological cell that, like a stem cell, has a tendency to differentiate into a specific type of cell, but is already more specific than a stem cell and is pushed to differentiate into its "target" cell.
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Prognosis
Prognosis (Greek: πρόγνωσις "fore-knowing, foreseeing") is a medical term for predicting the likely or expected development of a disease, including whether the signs and symptoms will improve or worsen (and how quickly) or remain stable over time; expectations of quality of life, such as the ability to carry out daily activities; the potential for complications and associated health issues; and the likelihood of survival (including life expectancy).
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Protein
Proteins are large biomolecules, or macromolecules, consisting of one or more long chains of amino acid residues.
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Quizartinib
Quizartinib (AC220) is a small molecule receptor tyrosine kinase inhibitor that is currently under development by Ambit Biosciences for the treatment of acute myeloid leukaemia.
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Receptor tyrosine kinase
Receptor tyrosine kinases (RTKs) are the high-affinity cell surface receptors for many polypeptide growth factors, cytokines, and hormones.
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Sorafenib
Sorafenib (co-developed and co-marketed by Bayer and Onyx Pharmaceuticals as Nexavar), is a kinase inhibitor drug approved for the treatment of primary kidney cancer (advanced renal cell carcinoma), advanced primary liver cancer (hepatocellular carcinoma), and radioactive iodine resistant advanced thyroid carcinoma.
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Sunitinib
Sunitinib (marketed as Sutent by Pfizer, and previously known as SU11248) is an oral, small-molecule, multi-targeted receptor tyrosine kinase (RTK) inhibitor that was approved by the FDA for the treatment of renal cell carcinoma (RCC) and imatinib-resistant gastrointestinal stromal tumor (GIST) on January 26, 2006.
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T cell
A T cell, or T lymphocyte, is a type of lymphocyte (a subtype of white blood cell) that plays a central role in cell-mediated immunity.
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The International Journal of Biochemistry & Cell Biology
The International Journal of Biochemistry & Cell Biology is a monthly peer-reviewed scientific journal published by Elsevier, covering research in all areas of biochemistry and cell biology.
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Transforming growth factor beta
Transforming growth factor beta (TGF-β) is a multifunctional cytokine belonging to the transforming growth factor superfamily that includes four different isoforms (TGF-β 1 to 4, HGNC symbols TGFB1, TGFB2, TGFB3, TGFB4) and many other signaling proteins produced by all white blood cell lineages.
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Tumor necrosis factor alpha
Tumor necrosis factor (TNF, tumor necrosis factor alpha, TNFα, cachexin, or cachectin) is a cell signaling protein (cytokine) involved in systemic inflammation and is one of the cytokines that make up the acute phase reaction.
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Tyrosine kinase
A tyrosine kinase is an enzyme that can transfer a phosphate group from ATP to a protein in a cell.
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Cd135, FLK2, FLT3, FLT3 (gene), FLT3 inhibitor, Flk2, Fms-like tyrosine kinase 3, Fms-related tyrosine kinase 3.
References
[1] https://en.wikipedia.org/wiki/CD135
