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41 relations: Action potential, Allosteric regulation, Baclofen, Barbiturate, Benzodiazepine, Bicuculline, Central nervous system, Chloride, Complementary DNA, Cys-loop receptor, Cysteine, Disulfide, Electrical resistance and conductance, G protein–coupled receptor, GABA receptor agonist, GABA receptor antagonist, GABAA receptor, GABAB receptor, Gamma-Aminobutyric acid, Glycine receptor, Inhibitory postsynaptic potential, International Union of Basic and Clinical Pharmacology, Ion, Ion channel, Ionotropic effect, Isoguvacine, Ligand-gated ion channel, Membrane potential, Metabotropic receptor, Neurotransmitter, Nicotinic acetylcholine receptor, Pharmacological Reviews, Picrotoxin, Receptor (biochemistry), Retina, Sedative, Shunting inhibition, Stereoselectivity, Vertebrate, Volt, 5-HT3 receptor.
Action potential
In physiology, an action potential occurs when the membrane potential of a specific axon location rapidly rises and falls: this depolarisation then causes adjacent locations to similarly depolarise.
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Allosteric regulation
In biochemistry, allosteric regulation (or allosteric control) is the regulation of an enzyme by binding an effector molecule at a site other than the enzyme's active site.
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Baclofen
Baclofen, sold under the brand name Lioresal among others, is a medication used to treat spasticity.
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Barbiturate
A barbiturate is a drug that acts as a central nervous system depressant, and can therefore produce a wide spectrum of effects, from mild sedation to death.
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Benzodiazepine
Benzodiazepines (BZD, BZs), sometimes called "benzos", are a class of psychoactive drugs whose core chemical structure is the fusion of a benzene ring and a diazepine ring.
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Bicuculline
Bicuculline is a phthalide-isoquinoline compound that is a light-sensitive competitive antagonist of GABAA receptors.
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Central nervous system
The central nervous system (CNS) is the part of the nervous system consisting of the brain and spinal cord.
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Chloride
The chloride ion is the anion (negatively charged ion) Cl−.
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Complementary DNA
In genetics, complementary DNA (cDNA) is DNA synthesized from a single stranded RNA (e.g., messenger RNA (mRNA) or microRNA) template in a reaction catalyzed by the enzyme reverse transcriptase.
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Cys-loop receptor
The Cys-loop ligand-gated ion channel superfamily is composed of nicotinic acetylcholine, GABAA, GABAA-ρ, glycine, 5-HT3 receptors, and zinc-activated ion channel that are composed of five protein subunits that form a pentameric arrangement around a central pore.
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Cysteine
Cysteine (symbol Cys or C) is a semi-essential proteinogenic amino acid with the formula HO2CCH(NH2)CH2SH.
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Disulfide
In chemistry, a disulfide refers to a functional group with the structure R−S−S−R′.
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Electrical resistance and conductance
The electrical resistance of an electrical conductor is a measure of the difficulty to pass an electric current through that conductor.
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G protein–coupled receptor
G protein–coupled receptors (GPCRs), also known as seven-(pass)-transmembrane domain receptors, 7TM receptors, heptahelical receptors, serpentine receptor, and G protein–linked receptors (GPLR), constitute a large protein family of receptors that detect molecules outside the cell and activate internal signal transduction pathways and, ultimately, cellular responses.
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GABA receptor agonist
A GABA receptor agonist is a drug that is an agonist for one or more of the GABA receptors, producing typically sedative effects, and may also cause other effects such as anxiolytic, anticonvulsant, and muscle relaxant effects.
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GABA receptor antagonist
GABA receptor antagonists are drugs that inhibit the action of GABA.
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GABAA receptor
The GABAA receptor (GABAAR) is an ionotropic receptor and ligand-gated ion channel.
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GABAB receptor
GABAB receptors (GABABR) are metabotropic transmembrane receptors for gamma-aminobutyric acid (GABA) that are linked via G-proteins to potassium channels.
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Gamma-Aminobutyric acid
gamma-Aminobutyric acid, or γ-aminobutyric acid, or GABA, is the chief inhibitory neurotransmitter in the mammalian central nervous system.
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Glycine receptor
The glycine receptor (abbreviated as GlyR or GLR) is the receptor of the amino acid neurotransmitter glycine.
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Inhibitory postsynaptic potential
An inhibitory postsynaptic potential (IPSP) is a kind of synaptic potential that makes a postsynaptic neuron less likely to generate an action potential.
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International Union of Basic and Clinical Pharmacology
The International Union of Basic and Clinical Pharmacology (IUPHAR) is a voluntary, non-profit association representing the interests of scientists in pharmacology-related fields to facilitate Better Medicines through Global Education and Research around the world.
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Ion
An ion is an atom or molecule that has a non-zero net electrical charge (its total number of electrons is not equal to its total number of protons).
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Ion channel
Ion channels are pore-forming membrane proteins that allow ions to pass through the channel pore.
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Ionotropic effect
An ionotropic effect can be applied to the effect of a transmitter substance or hormone on its target.
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Isoguvacine
Isoguvacine is a GABAA receptor agonist used in scientific research.
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Ligand-gated ion channel
Ligand-gated ion channels (LICs, LGIC), also commonly referred as ionotropic receptors, are a group of transmembrane ion-channel proteins which open to allow ions such as Na+, K+, Ca2+, and/or Cl− to pass through the membrane in response to the binding of a chemical messenger (i.e. a ligand), such as a neurotransmitter.
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Membrane potential
The term "membrane potential" may refer to one of three kinds of membrane potential.
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Metabotropic receptor
A metabotropic receptor is a type of membrane receptor of eukaryotic cells that acts through a second messenger.
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Neurotransmitter
Neurotransmitters are endogenous chemicals that enable neurotransmission.
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Nicotinic acetylcholine receptor
Nicotinic acetylcholine receptors, or nAChRs, are receptor proteins that respond to the neurotransmitter acetylcholine.
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Pharmacological Reviews
Pharmacological Reviews is a quarterly peer-reviewed scientific journal publishing review articles on all aspects of pharmacology and related topics.
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Picrotoxin
Picrotoxin, also known as cocculin, is a poisonous crystalline plant compound.
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Receptor (biochemistry)
In biochemistry and pharmacology, a receptor is a protein molecule that receives chemical signals from outside a cell.
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Retina
The retina is the innermost, light-sensitive "coat", or layer, of shell tissue of the eye of most vertebrates and some molluscs.
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Sedative
A sedative or tranquilliser is a substance that induces sedation by reducing irritability or excitement.
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Shunting inhibition
Shunting inhibition, also known as divisive inhibition, is a form of postsynaptic potential inhibition that can be represented mathematically as reducing the excitatory potential by division, rather than linear subtraction.
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Stereoselectivity
In chemistry, stereoselectivity is the property of a chemical reaction in which a single reactant forms an unequal mixture of stereoisomers during the non-stereospecific creation of a new stereocenter or during the non-stereospecific transformation of a pre-existing one.
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Vertebrate
Vertebrates comprise all species of animals within the subphylum Vertebrata (chordates with backbones).
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Volt
The volt (symbol: V) is the derived unit for electric potential, electric potential difference (voltage), and electromotive force.
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5-HT3 receptor
The 5-HT3 receptor belongs to the Cys-loop superfamily of ligand-gated ion channels (LGICs) and therefore differs structurally and functionally from all other 5-HT receptors (5-hydroxytryptamine, or serotonin) receptors which are G protein-coupled receptors.
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GABA receptors, GABA-A receptors, GABAR, Gaba receptor, Gaba receptors, Receptors, gaba.
References
[1] https://en.wikipedia.org/wiki/GABA_receptor
