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44 relations: Acid catalysis, Alglucerase, Alternative splicing, Chicago Tribune, Chromosome 1, Covalent bond, Crystal structure, Endoplasmic reticulum, Enzyme, Enzyme inhibitor, Epoxide, Gaucher's disease, GBA2, GBA3, Gene, Glucocerebroside, Glucose, Glucosylceramidase, Glutamic acid, Glycolipid, Glycoside, Glycoside hydrolase, Glycoside hydrolase family 30, Glycosidic bond, Hydrolysis, Imiglucerase, Immunoglobulin domain, Lysosomal storage disease, Lysosome, Mannose 6-phosphate receptor, Mutation, Nucleophile, Parkinson's disease, Placentalia, Pseudogene, Recombinant DNA, Reuters, Saposin protein domain, Sphingosine, Taliglucerase alfa, TIM barrel, Tissue (biology), Unified atomic mass unit, Velaglucerase alfa.
Acid catalysis
In acid catalysis and base catalysis a chemical reaction is catalyzed by an acid or a base.
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Alglucerase
Alglucerase was a biopharmaceutical drug for the treatment of Gaucher's disease.
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Alternative splicing
Alternative splicing, or differential splicing, is a regulated process during gene expression that results in a single gene coding for multiple proteins.
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Chicago Tribune
The Chicago Tribune is a daily newspaper based in Chicago, Illinois, United States, owned by Tronc, Inc., formerly Tribune Publishing.
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Chromosome 1
Chromosome 1 is the designation for the largest human chromosome.
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Covalent bond
A covalent bond, also called a molecular bond, is a chemical bond that involves the sharing of electron pairs between atoms.
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Crystal structure
In crystallography, crystal structure is a description of the ordered arrangement of atoms, ions or molecules in a crystalline material.
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Endoplasmic reticulum
The endoplasmic reticulum (ER) is a type of organelle found in eukaryotic cells that forms an interconnected network of flattened, membrane-enclosed sacs or tube-like structures known as cisternae.
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Enzyme
Enzymes are macromolecular biological catalysts.
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Enzyme inhibitor
4QI9) An enzyme inhibitor is a molecule that binds to an enzyme and decreases its activity.
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Epoxide
An epoxide is a cyclic ether with a three-atom ring.
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Gaucher's disease
Gaucher's disease or Gaucher disease (GD) is a genetic disorder in which glucocerebroside (a sphingolipid, also known as glucosylceramide) accumulates in cells and certain organs.
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GBA2
GBA2 is the gene that encodes the enzyme non-lysosomal glucosylceramidase in humans.
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GBA3
Cytosolic beta-glucosidase, also known as cytosolic beta-glucosidase-like protein 1, is a beta-glucosidase enzyme that in humans is encoded by the GBA3 gene.
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Gene
In biology, a gene is a sequence of DNA or RNA that codes for a molecule that has a function.
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Glucocerebroside
Glucocerebroside (also called glucosylceramide) is any of the cerebrosides in which the monosaccharide head group is glucose.
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Glucose
Glucose is a simple sugar with the molecular formula C6H12O6.
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Glucosylceramidase
In enzymology, a glucosylceramidase is an enzyme that catalyzes the chemical reaction Thus, the two substrates of this enzyme are D-glucosyl-N-acylsphingosine and H2O, whereas its two products are D-glucose and N-acylsphingosine.
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Glutamic acid
Glutamic acid (symbol Glu or E) is an α-amino acid with formula.
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Glycolipid
Glycolipids are lipids with a carbohydrate attached by a glycosidic bond or covalently bonded.
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Glycoside
In chemistry, a glycoside is a molecule in which a sugar is bound to another functional group via a glycosidic bond.
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Glycoside hydrolase
Glycoside hydrolases (also called glycosidases or glycosyl hydrolases) catalyze the hydrolysis of glycosidic bonds in complex sugars.
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Glycoside hydrolase family 30
In molecular biology, glycoside hydrolase family 30 is a family of glycoside hydrolases.
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Glycosidic bond
In chemistry, a glycosidic bond or glycosidic linkage is a type of covalent bond that joins a carbohydrate (sugar) molecule to another group, which may or may not be another carbohydrate.
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Hydrolysis
Hydrolysis is a term used for both an electro-chemical process and a biological one.
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Imiglucerase
Imiglucerase is a medication used in the treatment of Gaucher's disease.
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Immunoglobulin domain
The immunoglobulin domain is a type of protein domain that consists of a 2-layer sandwich of 7-9 antiparallel β-strands arranged in two β-sheets with a Greek key topology, consisting of about 125 amino acids.
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Lysosomal storage disease
Lysosomal storage diseases (LSDs) are a group of about 50 rare inherited metabolic disorders that result from defects in lysosomal function.
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Lysosome
A lysosome is a membrane-bound organelle found in nearly all animal cells.
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Mannose 6-phosphate receptor
The mannose 6-phosphate receptors (MPRs) are transmembrane glycoproteins that target enzymes to lysosomes in vertebrates.
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Mutation
In biology, a mutation is the permanent alteration of the nucleotide sequence of the genome of an organism, virus, or extrachromosomal DNA or other genetic elements.
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Nucleophile
Nucleophile is a chemical species that donates an electron pair to an electrophile to form a chemical bond in relation to a reaction.
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Parkinson's disease
Parkinson's disease (PD) is a long-term degenerative disorder of the central nervous system that mainly affects the motor system.
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Placentalia
Placentalia ("Placentals") is one of the three extant subdivisions of the class of animals Mammalia; the other two are Monotremata and Marsupialia.
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Pseudogene
Pseudogenes are segments of DNA that are related to real genes.
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Recombinant DNA
Recombinant DNA (rDNA) molecules are DNA molecules formed by laboratory methods of genetic recombination (such as molecular cloning) to bring together genetic material from multiple sources, creating sequences that would not otherwise be found in the genome.
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Reuters
Reuters is an international news agency headquartered in London, United Kingdom.
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Saposin protein domain
In molecular biology a saposin protein domain is a region of the saposin protein that has a certain conserved sequence or structure that defines a domain.
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Sphingosine
Sphingosine (2-amino-4-octadecene-1,3-diol) is an 18-carbon amino alcohol with an unsaturated hydrocarbon chain, which forms a primary part of sphingolipids, a class of cell membrane lipids that include sphingomyelin, an important phospholipid.
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Taliglucerase alfa
Taliglucerase alfa, commercially known as Elelyso, is a biopharmaceutical drug developed by Protalix and Pfizer.
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TIM barrel
In biochemistry and molecular biology, the TIM barrel is a conserved protein fold consisting of eight α-helices and eight parallel β-strands that alternate along the peptide backbone.
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Tissue (biology)
In biology, tissue is a cellular organizational level between cells and a complete organ.
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Unified atomic mass unit
The unified atomic mass unit or dalton (symbol: u, or Da) is a standard unit of mass that quantifies mass on an atomic or molecular scale (atomic mass).
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Velaglucerase alfa
Velaglucerase alfa (trade name VPRIV), manufactured by Shire plc is a hydrolytic lysosomal glucocerebroside-specific enzyme, which is a recombinant form of glucocerebrosidase indicated as a long-term enzyme replacement therapy for those suffering of Gaucher disease Type 1.
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Redirects here:
EC 3.2.1.45, GBA (gene), GBA1, GLUC, Gba1, Gluc, Β-Glucocerebrosidase.
References
[1] https://en.wikipedia.org/wiki/Glucocerebrosidase
