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27 relations: Accelerated approval (FDA), Acute myeloid leukemia, Antibody-drug conjugate, Biological agent, Blood cell, Bone marrow, Bone marrow suppression, Calicheamicin, CD33, Celltech, Fever, Hematopoietic stem cell transplantation, Hepatic veno-occlusive disease, Inotuzumab ozogamicin, Intravenous therapy, Monoclonal antibody, Nausea, Pfizer, Respiratory system, Response rate (medicine), Shivering, Stem cell, Surrogate endpoint, Tumor lysis syndrome, Type III hypersensitivity, UCB (company), Wyeth.
Accelerated approval (FDA)
The United States Food and Drug Administration (FDA) initiated the FDA Accelerated Approval Program in 1992 to allow faster approval of drugs for serious conditions that fill an unmet medical need.
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Acute myeloid leukemia
Acute myeloid leukemia (AML) is a cancer of the myeloid line of blood cells, characterized by the rapid growth of abnormal cells that build up in the bone marrow and blood and interfere with normal blood cells.
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Antibody-drug conjugate
Antibody-drug conjugates or ADCs are an important class of highly potent biopharmaceutical drugs designed as a targeted therapy for the treatment of people with cancer.
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Biological agent
A biological agent—also called bio-agent, biological threat agent, biological warfare agent, biological weapon, or bioweapon—is a bacterium, virus, protozoan, parasite, or fungus that can be used purposefully as a weapon in bioterrorism or biological warfare (BW).
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Blood cell
A blood cell, also called a haematopoietic cell, hemocyte, or hematocyte, is a cell produced through hematopoiesis and found mainly in the blood.
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Bone marrow
Bone marrow is a semi-solid tissue which may be found within the spongy or cancellous portions of bones.
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Bone marrow suppression
Bone marrow suppression also known as myelotoxicity or myelosuppression, is the decrease in production of cells responsible for providing immunity (leukocytes), carrying oxygen (erythrocytes), and/or those responsible for normal blood clotting (thrombocytes).
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Calicheamicin
The calicheamicins are a class of enediyne antitumor antibiotics derived from the bacterium Micromonospora echinospora, with calicheamicin γ1 being the most notable.
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CD33
CD33 or Siglec-3 (sialic acid binding Ig-like lectin 3, SIGLEC3, SIGLEC-3, gp67, p67) is a transmembrane receptor expressed on cells of myeloid lineage.
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Celltech
Celltech Group plc was a leading British-based biotechnology business based in Slough.
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Fever
Fever, also known as pyrexia and febrile response, is defined as having a temperature above the normal range due to an increase in the body's temperature set-point.
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Hematopoietic stem cell transplantation
Hematopoietic stem cell transplantation (HSCT) is the transplantation of multipotent hematopoietic stem cells, usually derived from bone marrow, peripheral blood, or umbilical cord blood.
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Hepatic veno-occlusive disease
Hepatic veno-occlusive disease or veno-occlusive disease with immunodeficiency (VODI) is a condition in which some of the small veins in the liver are obstructed.
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Inotuzumab ozogamicin
Inotuzumab ozogamicin (trade name Besponsa) is an antibody-drug conjugate used to treat relapsed or refractory B-cell precursor acute lymphoblastic leukemia.
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Intravenous therapy
Intravenous therapy (IV) is a therapy that delivers liquid substances directly into a vein (intra- + ven- + -ous).
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Monoclonal antibody
Monoclonal antibodies (mAb or moAb) are antibodies that are made by identical immune cells that are all clones of a unique parent cell.
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Nausea
Nausea or queasiness is an unpleasant sense of unease, discomfort, and revulsion towards food.
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Pfizer
Pfizer Inc. is an American pharmaceutical conglomerate headquartered in New York City, with its research headquarters in Groton, Connecticut.
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Respiratory system
The respiratory system (also respiratory apparatus, ventilatory system) is a biological system consisting of specific organs and structures used for gas exchange in animals and plants.
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Response rate (medicine)
In medicine, a response rate is the percentage of patients whose cancer shrinks or disappears after treatment.
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Shivering
Shivering (also called shuddering) is a bodily function in response to cold in warm-blooded animals.
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Stem cell
Stem cells are biological cells that can differentiate into other types of cells and can divide to produce more of the same type of stem cells.
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Surrogate endpoint
In clinical trials, a surrogate endpoint (or marker) is a measure of effect of a specific treatment that may correlate with a real clinical endpoint but does not necessarily have a guaranteed relationship.
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Tumor lysis syndrome
Tumor lysis syndrome (TLS) is a group of metabolic abnormalities that can occur as a complication during the treatment of cancer, where large amounts of tumor cells are killed off (lysed) at the same time by the treatment, releasing their contents into the bloodstream.
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Type III hypersensitivity
Type III hypersensitivity occurs when there is accumulation of immune complexes (antigen-antibody complexes) that have not been adequately cleared by innate immune cells, giving rise to an inflammatory response and attraction of leukocytes.
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UCB (company)
UCB (Union Chimique Belge) is a multinational biopharmaceutical company headquartered in Brussels, Belgium.
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Wyeth
Wyeth was a pharmaceutical company purchased by Pfizer in 2009.
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Redirects here:
ATC code L01XC05, ATCvet code QL01XC05, Gemtuzumab, Mylotarg, Ozogamicin, gemtuzumab.
References
[1] https://en.wikipedia.org/wiki/Gemtuzumab_ozogamicin
