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Gut-specific homing

Index Gut-specific homing

Gut-specific homing is the mechanism by which activated T cells and antibody-secreting cells (ASCs) are targeted to both inflamed and non-inflamed regions of the gut in order to provide an effective immune response. [1]

53 relations: Addressin, Alcohol dehydrogenase, Antibody, Antigen, Antigen-presenting cell, Attenuated vaccine, Blood, CCL25, CCR9, Cell (biology), Cell adhesion molecule, Chemokine, Chemokine receptor, Citral, Conformational change, Dendritic cell, E-selectin, Endothelium, Gastrointestinal tract, Gut-associated lymphoid tissue, High endothelial venules, Immune system, Immunity (journal), Immunoblast, Inflammation, Integrin, Intercellular adhesion molecule, ITGAE, L-selectin, Lamina propria, Leukocyte extravasation, Lymph node, Lymphatic system, Lymphatic vessel, Lymphocyte, Lymphocyte function-associated antigen 1, Lymphocyte homing receptor, Mesenteric lymph nodes, Mucous membrane, Nature (journal), P-selectin glycoprotein ligand-1, Pathogen, Peyer's patch, Phenotype, Retinal dehydrogenase, Retinoic acid, Selectin, T cell, The FEBS Journal, Thymus, ..., Tissue (biology), Tropism, Vitamin A. Expand index (3 more) »

Addressin

Addressin also known as mucosal vascular addressin cell adhesion molecule 1 (MAdCAM-1) is a protein that in humans is encoded by the MADCAM1 gene.

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Alcohol dehydrogenase

Alcohol dehydrogenases (ADH) are a group of dehydrogenase enzymes that occur in many organisms and facilitate the interconversion between alcohols and aldehydes or ketones with the reduction of nicotinamide adenine dinucleotide (NAD+ to NADH).

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Antibody

An antibody (Ab), also known as an immunoglobulin (Ig), is a large, Y-shaped protein produced mainly by plasma cells that is used by the immune system to neutralize pathogens such as pathogenic bacteria and viruses.

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Antigen

In immunology, an antigen is a molecule capable of inducing an immune response (to produce an antibody) in the host organism.

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Antigen-presenting cell

An antigen-presenting cell (APC) or accessory cell is a cell that displays antigen complexed with major histocompatibility complexes (MHCs) on their surfaces; this process is known as antigen presentation.

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Attenuated vaccine

An attenuated vaccine is a vaccine created by reducing the virulence of a pathogen, but still keeping it viable (or "live").

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Blood

Blood is a body fluid in humans and other animals that delivers necessary substances such as nutrients and oxygen to the cells and transports metabolic waste products away from those same cells.

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CCL25

Chemokine (C-C motif) ligand 25 (CCL25) is a small cytokine belonging to the CC chemokine family that is also known as TECK (Thymus-Expressed Chemokine).

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CCR9

C-C chemokine receptor type 9 is a protein that in humans is encoded by the CCR9 gene.

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Cell (biology)

The cell (from Latin cella, meaning "small room") is the basic structural, functional, and biological unit of all known living organisms.

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Cell adhesion molecule

Cell adhesion molecules (CAMs) are proteins located on the cell surface involved in binding with other cells or with the extracellular matrix (ECM) in the process called cell adhesion.

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Chemokine

Chemokines (Greek -kinos, movement) are a family of small cytokines, or signaling proteins secreted by cells.

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Chemokine receptor

Chemokine receptors are cytokine receptors found on the surface of certain cells that interact with a type of cytokine called a chemokine.

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Citral

Citral, or 3,7-dimethyl-2,6-octadienal or lemonal, is either a pair, or a mixture of terpenoids with the molecular formula C10H16O.

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Conformational change

In biochemistry, a conformational change is a change in the shape of a macromolecule, often induced by environmental factors.

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Dendritic cell

Dendritic cells (DCs) are antigen-presenting cells (also known as accessory cells) of the mammalian immune system.

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E-selectin

E-selectin, also known as CD62 antigen-like family member E (CD62E), endothelial-leukocyte adhesion molecule 1 (ELAM-1), or leukocyte-endothelial cell adhesion molecule 2 (LECAM2), is a cell adhesion molecule expressed only on endothelial cells activated by cytokines.

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Endothelium

Endothelium refers to cells that line the interior surface of blood vessels and lymphatic vessels, forming an interface between circulating blood or lymph in the lumen and the rest of the vessel wall.

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Gastrointestinal tract

The gastrointestinal tract (digestive tract, digestional tract, GI tract, GIT, gut, or alimentary canal) is an organ system within humans and other animals which takes in food, digests it to extract and absorb energy and nutrients, and expels the remaining waste as feces.

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Gut-associated lymphoid tissue

Gut-associated lymphoid tissue (GALT) is a component of the mucosa-associated lymphoid tissue (MALT) which works in the immune system to protect the body from invasion in the gut.

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High endothelial venules

High endothelial venules (HEV) are specialized post-capillary venous swellings characterized by plump endothelial cells as opposed to the usual thinner endothelial cells found in regular venules.

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Immune system

The immune system is a host defense system comprising many biological structures and processes within an organism that protects against disease.

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Immunity (journal)

Immunity is a monthly peer-reviewed medical journal of immunology published by Cell Press.

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Immunoblast

An immunoblast is a lymphocyte that has been activated by an antigen, which will further undergo clonal expansion to increase the number of lymphocytes capable of binding to that antigen.

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Inflammation

Inflammation (from inflammatio) is part of the complex biological response of body tissues to harmful stimuli, such as pathogens, damaged cells, or irritants, and is a protective response involving immune cells, blood vessels, and molecular mediators.

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Integrin

Integrins are transmembrane receptors that facilitate cell-extracellular matrix (ECM) adhesion.

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Intercellular adhesion molecule

In molecular biology, intercellular adhesion molecules (ICAMs) and vascular cell adhesion molecule-1 (VCAM-1) are part of the immunoglobulin superfamily.

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ITGAE

Integrin, alpha E (ITGAE) also known as CD103 (cluster of differentiation 103) is an integrin protein that in human is encoded by the ITGAE gene.

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L-selectin

L-selectin, also known as CD62L, is a cell adhesion molecule found on lymphocytes and the preimplantation embryo.

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Lamina propria

The lamina propria is a thin layer of connective tissue that forms part of the moist linings known as mucous membranes or mucosa, which line various tubes in the body, such as the respiratory tract, the gastrointestinal tract, and the urogenital tract.

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Leukocyte extravasation

Leukocyte extravasation, less commonly called diapedesis, is the movement of leukocytes out of the circulatory system and towards the site of tissue damage or infection.

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Lymph node

A lymph node or lymph gland is an ovoid or kidney-shaped organ of the lymphatic system, and of the adaptive immune system, that is widely present throughout the body.

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Lymphatic system

The lymphatic system is part of the vascular system and an important part of the immune system, comprising a network of lymphatic vessels that carry a clear fluid called lymph (from Latin, lympha meaning "water") directionally towards the heart.

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Lymphatic vessel

The lymphatic vessels (or lymph vessels or lymphatics) are thin-walled vessels structured like blood vessels, that carry lymph.

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Lymphocyte

A lymphocyte is one of the subtypes of white blood cell in a vertebrate's immune system.

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Lymphocyte function-associated antigen 1

Lymphocyte function-associated antigen 1 (LFA-1) is a cellular adhesion molecule found on lymphocytes.

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Lymphocyte homing receptor

Lymphocyte homing receptors are cell adhesion molecules expressed on lymphocyte cell membranes that recognize addressins on target tissues.

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Mesenteric lymph nodes

The mesenteric lymph nodes are one of the three principal groups of superior mesenteric lymph nodes and lie between the layers of the mesentery.

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Mucous membrane

A mucous membrane or mucosa is a membrane that lines various cavities in the body and covers the surface of internal organs.

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Nature (journal)

Nature is a British multidisciplinary scientific journal, first published on 4 November 1869.

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P-selectin glycoprotein ligand-1

Selectin P ligand, also known as SELPLG or CD162 (cluster of differentiation 162), is a human gene.

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Pathogen

In biology, a pathogen (πάθος pathos "suffering, passion" and -γενής -genēs "producer of") or a '''germ''' in the oldest and broadest sense is anything that can produce disease; the term came into use in the 1880s.

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Peyer's patch

Peyer's patches (or aggregated lymphoid nodules, or occasionally PP for brevity) are organized lymphoid follicles, named after the 17th-century Swiss anatomist Johann Conrad Peyer.

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Phenotype

A phenotype is the composite of an organism's observable characteristics or traits, such as its morphology, development, biochemical or physiological properties, behavior, and products of behavior (such as a bird's nest).

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Retinal dehydrogenase

In enzymology, a retinal dehydrogenase is an enzyme that catalyzes the chemical reaction The 3 substrates of this enzyme are retinal, NAD+, and H2O, whereas its 3 products are retinoic acid, NADH, and H+.

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Retinoic acid

Retinoic acid is a metabolite of vitamin A (retinol) that mediates the functions of vitamin A required for growth and development.

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Selectin

The selectins (cluster of differentiation 62 or CD62) are a family of cell adhesion molecules (or CAMs).

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T cell

A T cell, or T lymphocyte, is a type of lymphocyte (a subtype of white blood cell) that plays a central role in cell-mediated immunity.

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The FEBS Journal

The FEBS Journal is a biweekly peer-reviewed scientific journal published by John Wiley & Sons on behalf of the Federation of European Biochemical Societies.

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Thymus

The thymus is a specialized primary lymphoid organ of the immune system.

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Tissue (biology)

In biology, tissue is a cellular organizational level between cells and a complete organ.

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Tropism

A tropism (from Greek τρόπος, tropos, "a turning") is a biological phenomenon, indicating growth or turning movement of a biological organism, usually a plant, in response to an environmental stimulus.

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Vitamin A

Vitamin A is a group of unsaturated nutritional organic compounds that includes retinol, retinal, retinoic acid, and several provitamin A carotenoids (most notably beta-carotene).

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References

[1] https://en.wikipedia.org/wiki/Gut-specific_homing

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