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64 relations: Adenocarcinoma of the lung, Ann Marie Rogers, Apoptosis, Autophosphorylation, Beta-catenin, Biomarker (medicine), Biopsy, Breast cancer, CDKN1B, Cell membrane, Cetuximab, Chromosome 17, Cluster of differentiation, Coactivator (genetics), Corepressor, DLG4, ELISA, Endometrial cancer, Epidermal growth factor receptor, ErbB, ERBB3, ERBB4, Erbin (protein), Estradiol, Estrogen receptor, Fine-needle aspiration, Fluorescence in situ hybridization, Galena Biopharma, Gene, Gene duplication, Glioblastoma, Glycoprotein 130, GRB2, GRB7, Heat shock protein 90kDa alpha (cytosolic), member A1, Immunohistochemistry, Margetuximab, Mitogen-activated protein kinase, Monoclonal antibody, MUC1, NeuVax, Non-small-cell lung carcinoma, Nuclear receptor coactivator 3, Oncogene, PAX2, Pertuzumab, Phosphoinositide 3-kinase, Phospholipase C, PI3K/AKT/mTOR pathway, PICK1, ..., PIK3R2, PLCG1, Protein, Protein kinase C, Protein–protein interaction, Receptor tyrosine kinase, Sequence homology, SHC1, SKBR3, STAT protein, T cell, Tamoxifen, Trastuzumab, Vacuum-assisted breast biopsy. Expand index (14 more) »
Adenocarcinoma of the lung
Adenocarcinoma of the lung (also known as pulmonary adenocarcinoma) is the most common type of lung cancer, and is characterized by distinct cellular and molecular features including gland and/or duct formation and/or production of significant amounts of mucus.
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Ann Marie Rogers
Ann Marie Rogers (died 2 March 2009) was a British campaigner who fought a successful landmark court battle to receive the breast cancer drug Herceptin on the NHS.
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Apoptosis
Apoptosis (from Ancient Greek ἀπόπτωσις "falling off") is a process of programmed cell death that occurs in multicellular organisms.
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Autophosphorylation
Autophosphorylation is a type of post-translational modification of proteins.
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Beta-catenin
Catenin beta-1, also known as β-catenin, is a protein that in humans is encoded by the CTNNB1 gene.
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Biomarker (medicine)
In medicine, a biomarker is a measurable indicator of the severity or presence of some disease state.
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Biopsy
A biopsy is a medical test commonly performed by a surgeon, interventional radiologist, or an interventional cardiologist involving extraction of sample cells or tissues for examination to determine the presence or extent of a disease.
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Breast cancer
Breast cancer is cancer that develops from breast tissue.
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CDKN1B
Cyclin-dependent kinase inhibitor 1B (p27Kip1) is an enzyme inhibitor that in humans is encoded by the CDKN1B gene.
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Cell membrane
The cell membrane (also known as the plasma membrane or cytoplasmic membrane, and historically referred to as the plasmalemma) is a biological membrane that separates the interior of all cells from the outside environment (the extracellular space).
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Cetuximab
Cetuximab is an epidermal growth factor receptor (EGFR) inhibitor used for the treatment of metastatic colorectal cancer, metastatic non-small cell lung cancer and head and neck cancer.
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Chromosome 17
Chromosome 17 is one of the 23 pairs of chromosomes in humans.
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Cluster of differentiation
The cluster of differentiation (also known as cluster of designation or classification determinant and often abbreviated as CD) is a protocol used for the identification and investigation of cell surface molecules providing targets for immunophenotyping of cells.
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Coactivator (genetics)
A coactivator is a type of transcriptional coregulator that binds to an activator (a transcription factor) to increase the rate of transcription of a gene or set of genes.
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Corepressor
In the field of molecular biology, a corepressor is a substance that inhibits the expression of genes.
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DLG4
PSD-95 (postsynaptic density protein 95) also known as SAP-90 (synapse-associated protein 90) is a protein that in humans is encoded by the DLG4 (discs large homolog 4) gene.
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ELISA
The enzyme-linked immunosorbent assay (ELISA) is a test that uses antibodies and color change to identify a substance.
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Endometrial cancer
Endometrial cancer is a cancer that arises from the endometrium (the lining of the uterus or womb).
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Epidermal growth factor receptor
The epidermal growth factor receptor (EGFR; ErbB-1; HER1 in humans) is a transmembrane protein that is a receptor for members of the epidermal growth factor family (EGF family) of extracellular protein ligands.
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ErbB
The ErbB family of proteins contains four receptor tyrosine kinases, structurally related to the epidermal growth factor receptor (EGFR), its first discovered member.
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ERBB3
Receptor tyrosine-protein kinase erbB-3, also known as HER3 (human epidermal growth factor receptor 3), is a membrane bound protein that in humans is encoded by the ERBB3 gene.
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ERBB4
Receptor tyrosine-protein kinase erbB-4 is an enzyme that in humans is encoded by the ERBB4 gene.
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Erbin (protein)
Erbb2 interacting protein (ERBB2IP) also known as Erbin is a protein which in humans is encoded by the ERBB2IP gene.
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Estradiol
Estradiol (E2), also spelled oestradiol, is an estrogen steroid hormone and the major female sex hormone.
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Estrogen receptor
Estrogen receptors (ERs) are a group of proteins found inside cells.
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Fine-needle aspiration
Fine-needle aspiration (FNA) is a diagnostic procedure used to investigate lumps or masses.
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Fluorescence in situ hybridization
Fluorescent in situ hybridization (FISH) is a molecular cytogenetic technique that uses fluorescent probes that bind to only those parts of the chromosome with a high degree of sequence complementarity.
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Galena Biopharma
Galena Biopharma (originally RXi Pharmaceuticals) is a publicly traded pharmaceutical company based in San Ramon, California.
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Gene
In biology, a gene is a sequence of DNA or RNA that codes for a molecule that has a function.
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Gene duplication
Gene duplication (or chromosomal duplication or gene amplification) is a major mechanism through which new genetic material is generated during molecular evolution.
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Glioblastoma
Glioblastoma, also known as glioblastoma multiforme (GBM), is the most aggressive cancer that begins within the brain.
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Glycoprotein 130
Glycoprotein 130 (also known as gp130, IL6ST, IL6-beta or CD130) is a transmembrane protein which is the founding member of the class of all cytokine receptors.
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GRB2
Growth factor receptor-bound protein 2 also known as Grb2 is an adaptor protein involved in signal transduction/cell communication.
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GRB7
Growth factor receptor-bound protein 7, also known as GRB7, is a protein that in humans is encoded by the GRB7 gene.
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Heat shock protein 90kDa alpha (cytosolic), member A1
Heat shock protein HSP 90-alpha is a protein that in humans is encoded by the HSP90AA1 gene.
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Immunohistochemistry
Immunohistochemistry (IHC) involves the process of selectively imaging antigens (proteins) in cells of a tissue section by exploiting the principle of antibodies binding specifically to antigens in biological tissues.
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Margetuximab
Margetuximab is a chimeric IgG monoclonal antibody against HER2 designed for the treatment of cancer.
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Mitogen-activated protein kinase
A mitogen-activated protein kinase (MAPK or MAP kinase) is a type of protein kinase that is specific to the amino acids serine and threonine (i.e., a serine/threonine-specific protein kinase).
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Monoclonal antibody
Monoclonal antibodies (mAb or moAb) are antibodies that are made by identical immune cells that are all clones of a unique parent cell.
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MUC1
Mucin 1, cell surface associated (MUC1) or polymorphic epithelial mucin (PEM) is a mucin encoded by the MUC1 gene in humans.
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NeuVax
NeuVax is a peptide vaccine aimed at preventing or delaying the recurrence of breast cancer in cancer survivors who achieve remission after standard of care treatment (e.g., surgery, radiation, chemotherapy).
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Non-small-cell lung carcinoma
Non-small-cell lung carcinoma (NSCLC) is any type of epithelial lung cancer other than small cell lung carcinoma (SCLC).
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Nuclear receptor coactivator 3
The nuclear receptor coactivator 3 also known as NCOA3 is a protein that, in humans, is encoded by the NCOA3 gene.
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Oncogene
An oncogene is a gene that has the potential to cause cancer.
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PAX2
Paired box gene 2, also known as PAX2 is a protein which in humans is encoded by the PAX2 gene.
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Pertuzumab
Pertuzumab (also called 2C4, trade name Perjeta) is a monoclonal antibody used in combination with trastuzumab and docetaxel for the treatment of metastatic HER2-positive breast cancer; it also used in the same combination as a neoadjuvant in early HER2-positive breast cancer.
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Phosphoinositide 3-kinase
Phosphatidylinositol-4,5-bisphosphate 3-kinase (also called phosphatidylinositide 3-kinases, phosphatidylinositol-3-kinases, PI 3-kinases, PI(3)Ks, PI-3Ks or by the HUGO official stem symbol for the gene family, PI3K(s)) are a family of enzymes involved in cellular functions such as cell growth, proliferation, differentiation, motility, survival and intracellular trafficking, which in turn are involved in cancer.
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Phospholipase C
Phospholipase C (PLC) is a class of membrane-associated enzymes that cleave phospholipids just before the phosphate group (see figure).
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PI3K/AKT/mTOR pathway
The PI3K/AKT/mTOR pathway is an intracellular signaling pathway important in regulating the cell cycle.
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PICK1
Protein Interacting with C Kinase - 1 is a protein that in humans is encoded by the PICK1 gene.
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PIK3R2
Phosphatidylinositol 3-kinase regulatory subunit beta is an enzyme that in humans is encoded by the PIK3R2 gene.
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PLCG1
Phospholipase C, gamma 1, also known as PLCG1, is a protein that in humans is encoded by the PLCG1 gene.
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Protein
Proteins are large biomolecules, or macromolecules, consisting of one or more long chains of amino acid residues.
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Protein kinase C
Protein kinase C, commonly abbreviated to PKC (EC 2.7.11.13), is a family of protein kinase enzymes that are involved in controlling the function of other proteins through the phosphorylation of hydroxyl groups of serine and threonine amino acid residues on these proteins, or a member of this family.
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Protein–protein interaction
Protein–protein interactions (PPIs) are the physical contacts of high specificity established between two or more protein molecules as a result of biochemical events steered by electrostatic forces including the hydrophobic effect.
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Receptor tyrosine kinase
Receptor tyrosine kinases (RTKs) are the high-affinity cell surface receptors for many polypeptide growth factors, cytokines, and hormones.
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Sequence homology
Sequence homology is the biological homology between DNA, RNA, or protein sequences, defined in terms of shared ancestry in the evolutionary history of life.
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SHC1
SHC-transforming protein 1 is a protein that in humans is encoded by the SHC1 gene.
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SKBR3
SkBr3 (also known as SK-BR-3) is a breast cancer cell line isolated by the Memorial Sloan–Kettering Cancer Center in 1970 that is used in therapeutic research, especially in context of HER2 targeting.
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STAT protein
Members of the signal transducer and activator of transcription (STAT) protein family are intracellular transcription factors that mediate many aspects of cellular immunity, proliferation, apoptosis and differentiation.
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T cell
A T cell, or T lymphocyte, is a type of lymphocyte (a subtype of white blood cell) that plays a central role in cell-mediated immunity.
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Tamoxifen
Tamoxifen (TMX), sold under the brand name Nolvadex among others, is a medication that is used to prevent breast cancer in women and treat breast cancer in women and men.
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Trastuzumab
Trastuzumab, sold under the brand name Herceptin among others, is a monoclonal antibody used to treat breast cancer.
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Vacuum-assisted breast biopsy
Vacuum-assisted breast biopsy (VAB) is a minimally invasive procedure (Biopsy) to help in the diagnosis of breast cancer.
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C-erb b-2, C-erbB-2, CD340, ERBB2, ERBB2 (gene), Erb B2, Erb-B2, Erb2, ErbB 2, ErbB-2, ErbB-2 receptor, ErbB2, Erbb-2 receptor, Genes, erbb-2, HER-2, HER-2/Neu, HER2, HER2 positive, HER2 receptor, HER2 receptor positive, HER2-positive breast cancer, HER2/neu gene, Her-2 neu, Her2, Her2/neu, Her2neu, Human epidermal growth factor receptor 2, Receptor, erbb-2.
References
[1] https://en.wikipedia.org/wiki/HER2/neu
