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71 relations: Adenosine triphosphate, Allosteric regulation, Alzheimer's disease, Apoptosis, ATPase, Autophagy, Auxilin, BAG1, BAG2, BAG3, BAG4, Biomarker, Breast cancer, C-terminus, Cancer, CDC5L, Cell growth, Cell nucleus, Chaperone DnaJ, Chaperone-mediated autophagy, CITED1, Clathrin, Co-chaperone, Colorectal cancer, Cyclin D1, Cytoplasm, DNA, DNAJA3, Doxorubicin, Embryo, Embryology, Gene, GJA1, Heat shock protein, Hepatocellular carcinoma, Hop (protein), Hsp70, Hsp90, HSPBP1, Huntington's disease, Inflammation, Ischemia, Lumen (anatomy), Lung cancer, Lysosome, Malignancy, Mitosis, Myocardial infarction, N-terminus, Necrosis, ..., Neurodegeneration, P53 upregulated modulator of apoptosis, Parkin (ligase), Parkinson's disease, Pathology, Phagocyte, Physiology, Prognosis, Protein folding, Protein–protein interaction, Reperfusion injury, Senescence, Signal transduction, Spinocerebellar ataxia, Staurosporine, Stomach cancer, Stroke, STUB1, Synaptojanin, Ubiquitin, Vaccine. Expand index (21 more) »
Adenosine triphosphate
Adenosine triphosphate (ATP) is a complex organic chemical that participates in many processes.
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Allosteric regulation
In biochemistry, allosteric regulation (or allosteric control) is the regulation of an enzyme by binding an effector molecule at a site other than the enzyme's active site.
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Alzheimer's disease
Alzheimer's disease (AD), also referred to simply as Alzheimer's, is a chronic neurodegenerative disease that usually starts slowly and worsens over time.
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Apoptosis
Apoptosis (from Ancient Greek ἀπόπτωσις "falling off") is a process of programmed cell death that occurs in multicellular organisms.
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ATPase
ATPases (adenylpyrophosphatase, ATP monophosphatase, triphosphatase, SV40 T-antigen, adenosine 5'-triphosphatase, ATP hydrolase, complex V (mitochondrial electron transport), (Ca2+ + Mg2+)-ATPase, HCO3−-ATPase, adenosine triphosphatase) are a class of enzymes that catalyze the decomposition of ATP into ADP and a free phosphate ion.
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Autophagy
Autophagy (or autophagocytosis) (from the Ancient Greek αὐτόφαγος autóphagos, meaning "self-devouring" and κύτος kýtos, meaning "hollow") is the natural, regulated, destructive mechanism of the cell that disassembles unnecessary or dysfunctional components.
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Auxilin
Putative tyrosine-protein phosphatase auxilin is an enzyme that in humans is encoded by the DNAJC6 gene.
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BAG1
BAG family molecular chaperone regulator 1 is a protein that in humans is encoded by the BAG1 gene.
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BAG2
BAG family molecular chaperone regulator 2 is a protein that in humans is encoded by the BAG2 gene.
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BAG3
BAG family molecular chaperone regulator 3 is a protein that in humans is encoded by the BAG3 gene.
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BAG4
BAG family molecular chaperone regulator 4 is a protein that in humans is encoded by the BAG4 gene.
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Biomarker
A biomarker, or biological marker, generally refers to a measurable indicator of some biological state or condition.
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Breast cancer
Breast cancer is cancer that develops from breast tissue.
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C-terminus
The C-terminus (also known as the carboxyl-terminus, carboxy-terminus, C-terminal tail, C-terminal end, or COOH-terminus) is the end of an amino acid chain (protein or polypeptide), terminated by a free carboxyl group (-COOH).
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Cancer
Cancer is a group of diseases involving abnormal cell growth with the potential to invade or spread to other parts of the body.
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CDC5L
Cell division cycle 5-like protein is a protein that in humans is encoded by the CDC5L gene.
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Cell growth
The term cell growth is used in the contexts of biological cell development and cell division (reproduction).
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Cell nucleus
In cell biology, the nucleus (pl. nuclei; from Latin nucleus or nuculeus, meaning kernel or seed) is a membrane-enclosed organelle found in eukaryotic cells.
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Chaperone DnaJ
In molecular biology, chaperone DnaJ, also known as Hsp40 (heat shock protein 40 kD), is a molecular chaperone protein.
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Chaperone-mediated autophagy
Chaperone-mediated autophagy (CMA) refers to the chaperone-dependent selection of soluble cytosolic proteins that are then targeted to lysosomes and directly translocated across the lysosome membrane for degradation.
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CITED1
Cbp/p300-interacting transactivator 1 is a protein that in humans is encoded by the CITED1 gene.
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Clathrin
Clathrin is a protein that plays a major role in the formation of coated vesicles.
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Co-chaperone
Co-chaperones are proteins that assist chaperones in protein folding and other functions.
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Colorectal cancer
Colorectal cancer (CRC), also known as bowel cancer and colon cancer, is the development of cancer from the colon or rectum (parts of the large intestine).
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Cyclin D1
Cyclin D1 is a protein that in humans is encoded by the CCND1 gene.
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Cytoplasm
In cell biology, the cytoplasm is the material within a living cell, excluding the cell nucleus.
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DNA
Deoxyribonucleic acid (DNA) is a thread-like chain of nucleotides carrying the genetic instructions used in the growth, development, functioning and reproduction of all known living organisms and many viruses.
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DNAJA3
DnaJ homolog subfamily A member 3, mitochondrial, also known as Tumorous imaginal disc 1 (TID1), is a protein that in humans is encoded by the DNAJA3 gene on chromosome 16.
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Doxorubicin
Doxorubicin, sold under the trade names Adriamycin among others, is a chemotherapy medication used to treat cancer.
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Embryo
An embryo is an early stage of development of a multicellular diploid eukaryotic organism.
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Embryology
Embryology (from Greek ἔμβρυον, embryon, "the unborn, embryo"; and -λογία, -logia) is the branch of biology that studies the prenatal development of gametes (sex cells), fertilization, and development of embryos and fetuses.
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Gene
In biology, a gene is a sequence of DNA or RNA that codes for a molecule that has a function.
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GJA1
Gap junction alpha-1 protein (GJA1), also known as connexin 43 (Cx43), is a protein that in humans is encoded by the GJA1 gene on chromosome 6.
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Heat shock protein
Heat shock proteins (HSP) are a family of proteins that are produced by cells in response to exposure to stressful conditions.
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Hepatocellular carcinoma
Hepatocellular carcinoma (HCC) is the most common type of primary liver cancer in adults, and is the most common cause of death in people with cirrhosis.
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Hop (protein)
Hop, occasionally written HOP, is an abbreviation for Hsp70-Hsp90 Organizing Protein.
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Hsp70
The 70 kilodalton heat shock proteins (Hsp70s or DnaK) are a family of conserved ubiquitously expressed heat shock proteins.
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Hsp90
Hsp90 (heat shock protein 90) is a chaperone protein that assists other proteins to fold properly, stabilizes proteins against heat stress, and aids in protein degradation.
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HSPBP1
Hsp70-binding protein 1 is a protein that in humans is encoded by the HSPBP1 gene.
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Huntington's disease
Huntington's disease (HD), also known as Huntington's chorea, is an inherited disorder that results in death of brain cells.
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Inflammation
Inflammation (from inflammatio) is part of the complex biological response of body tissues to harmful stimuli, such as pathogens, damaged cells, or irritants, and is a protective response involving immune cells, blood vessels, and molecular mediators.
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Ischemia
Ischemia or ischaemia is a restriction in blood supply to tissues, causing a shortage of oxygen that is needed for cellular metabolism (to keep tissue alive).
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Lumen (anatomy)
In biology, a lumen (plural lumina) is the inside space of a tubular structure, such as an artery or intestine.
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Lung cancer
Lung cancer, also known as lung carcinoma, is a malignant lung tumor characterized by uncontrolled cell growth in tissues of the lung.
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Lysosome
A lysosome is a membrane-bound organelle found in nearly all animal cells.
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Malignancy
Malignancy is the tendency of a medical condition to become progressively worse.
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Mitosis
In cell biology, mitosis is a part of the cell cycle when replicated chromosomes are separated into two new nuclei.
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Myocardial infarction
Myocardial infarction (MI), commonly known as a heart attack, occurs when blood flow decreases or stops to a part of the heart, causing damage to the heart muscle.
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N-terminus
The N-terminus (also known as the amino-terminus, NH2-terminus, N-terminal end or amine-terminus) is the start of a protein or polypeptide referring to the free amine group (-NH2) located at the end of a polypeptide.
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Necrosis
Necrosis (from the Greek νέκρωσις "death, the stage of dying, the act of killing" from νεκρός "dead") is a form of cell injury which results in the premature death of cells in living tissue by autolysis.
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Neurodegeneration
Neurodegeneration is the progressive loss of structure or function of neurons, including death of neurons.
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P53 upregulated modulator of apoptosis
The p53 upregulated modulator of apoptosis (PUMA) also known as Bcl-2-binding component 3 (BBC3), is a pro-apoptotic protein, member of the Bcl-2 protein family.
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Parkin (ligase)
Parkin is a 465-residue E3 ubiquitin ligase that plays a critical role in ubiquitination- the process whereby molecules are covalently labelled with ubiquitin (Ub) and directed towards degradation in proteasomes or lysosomes.
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Parkinson's disease
Parkinson's disease (PD) is a long-term degenerative disorder of the central nervous system that mainly affects the motor system.
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Pathology
Pathology (from the Ancient Greek roots of pathos (πάθος), meaning "experience" or "suffering" and -logia (-λογία), "study of") is a significant field in modern medical diagnosis and medical research, concerned mainly with the causal study of disease, whether caused by pathogens or non-infectious physiological disorder.
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Phagocyte
Phagocytes are cells that protect the body by ingesting harmful foreign particles, bacteria, and dead or dying cells.
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Physiology
Physiology is the scientific study of normal mechanisms, and their interactions, which work within a living system.
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Prognosis
Prognosis (Greek: πρόγνωσις "fore-knowing, foreseeing") is a medical term for predicting the likely or expected development of a disease, including whether the signs and symptoms will improve or worsen (and how quickly) or remain stable over time; expectations of quality of life, such as the ability to carry out daily activities; the potential for complications and associated health issues; and the likelihood of survival (including life expectancy).
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Protein folding
Protein folding is the physical process by which a protein chain acquires its native 3-dimensional structure, a conformation that is usually biologically functional, in an expeditious and reproducible manner.
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Protein–protein interaction
Protein–protein interactions (PPIs) are the physical contacts of high specificity established between two or more protein molecules as a result of biochemical events steered by electrostatic forces including the hydrophobic effect.
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Reperfusion injury
Reperfusion injury or reperfusion insult, sometimes called ischemia-reperfusion injury (IRI) or reoxygenation injury, is the tissue damage caused when blood supply returns to tissue (re- + perfusion) after a period of ischemia or lack of oxygen (anoxia or hypoxia).
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Senescence
Senescence or biological ageing is the gradual deterioration of function characteristic of most complex lifeforms, arguably found in all biological kingdoms, that on the level of the organism increases mortality after maturation.
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Signal transduction
Signal transduction is the process by which a chemical or physical signal is transmitted through a cell as a series of molecular events, most commonly protein phosphorylation catalyzed by protein kinases, which ultimately results in a cellular response.
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Spinocerebellar ataxia
Spinocerebellar ataxia (SCA), also known as spinocerebellar atrophy or spinocerebellar degeneration, is a progressive, degenerative, genetic disease with multiple types, each of which could be considered a disease in its own right.
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Staurosporine
Staurosporine (antibiotic AM-2282 or STS) is a natural product originally isolated in 1977 from the bacterium Streptomyces staurosporeus.
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Stomach cancer
Stomach cancer, also known as gastric cancer, is cancer developing from the lining of the stomach.
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Stroke
A stroke is a medical condition in which poor blood flow to the brain results in cell death.
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STUB1
STUB1 (STIP1 homology and U-Box containing protein 1), also known as CHIP (C terminus of HSC70-Interacting Protein), is a human gene.
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Synaptojanin
Synaptojanin is a protein involved in vesicle uncoating in neurons.
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Ubiquitin
Ubiquitin is a small (8.5 kDa) regulatory protein found in most tissues of eukaryotic organisms, i.e. it occurs ''ubiquitously''.
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Vaccine
A vaccine is a biological preparation that provides active acquired immunity to a particular disease.
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Redirects here:
HSPA8 (gene), Hsc70, Hsc70 heat-shock proteins.
References
[1] https://en.wikipedia.org/wiki/HSPA8
