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Huntington's disease

Index Huntington's disease

Huntington's disease (HD), also known as Huntington's chorea, is an inherited disorder that results in death of brain cells. [1]

296 relations: Abdomen, Abortion, Abstraction, Adenine, Age of majority, Age of onset, Aggression, Alcoholism, Allele, Allopatric speciation, Alzheimer's disease, Amantadine, Amino acid, Amniocentesis, Amyloid, Anita Harding, Anticipation (genetics), Antiparkinson medication, Antipsychotic, Anxiety, Apoptosis, Astrocyte, Astrogliosis, Ataxia, Atypical antipsychotic, Autosome, Basal ganglia, Behavioral addiction, Benign hereditary chorea, Benzodiazepine, Boston, Brain-derived neurotrophic factor, Breast cancer, California, Camillo Golgi, Cardiovascular disease, Caregiver, Caspase, Caudate nucleus, Cell (journal), Cell nucleus, Cell signaling, Cell-free fetal DNA, Cerebellum, Cerebral atrophy, Cerebral cortex, Cerebrospinal fluid, Chaperone (protein), Charles Davenport, CHDI Foundation, ..., Chorea, Chorea acanthocytosis, Chorionic villus sampling, Chromosome 4, Clinical trial, Coenzyme Q10, Cognition, Compulsive behavior, Compulsory sterilization, Creatine, CREB-binding protein, CT scan, Cytoplasm, Cytosine, Désiré-Magloire Bourneville, Dementia, Dentatorubral-pallidoluysian atrophy, DNA, DNA methylation, DNA replication, Dominance (genetics), Drosophila melanogaster, Drug development, Dynamic mutation, Dysarthria, Dysphagia, Dystonia, East Coast of the United States, Egocentrism, Electron transport chain, Embryo, Embryonic stem cell, England, Epileptic seizure, Episodic memory, Ethnic group, Ethyl eicosapentaenoic acid, Eugenics, European Huntington's Disease Network, Excitotoxicity, Executive functions, Exile, Family history (medicine), Fetus, Financial institution, Finland, Founder effect, Functional magnetic resonance imaging, Functional neuroimaging, Gait, Gambling, Gene, Gene expression, Gene silencing, Genealogy, Genetic code, Genetic counseling, Genetic disorder, Genetic linkage, Genetic testing, Genetically modified organism, Genetics, George Huntington, Gillick competence, Globus pallidus, Glutamine, Guanine, Haploinsufficiency, Haplotype, Heart, Heart failure, Hereditary Disease Foundation, Hippocampus, Histone deacetylase, Histone deacetylase inhibitor, Human Genome Project, Huntingtin, Huntington's Disease Association, Huntington's Disease Outreach Project for Education at Stanford, Huntington's Disease Society of America, Huntington's disease-like syndrome, Hypersexuality, Hypokinesia, Hypothalamus, Iceland, Icelanders, Immigration, Immunoassay, Impaired glucose tolerance, In vitro, In vitro fertilisation, Inclusion bodies, Injury, Institutionalisation, Interdisciplinarity, Interneuron, Ionis Pharmaceuticals, Joseph Jules Dejerine, Journal of Clinical Investigation, JPH3, Lake Maracaibo, Latrepirdine, Liver, Locus (genetics), Long-term memory, Los Angeles, Louis Théophile Joseph Landouzy, Lung, Magnetic resonance imaging, Major depressive disorder, Marjorie Guthrie, McLeod syndrome, Medical diagnosis, Medical imaging, Medical test, Medium spiny neuron, Memory, Mendelian inheritance, Mental disorder, Metabolism, Microglia, Micrometre, Middle Ages, Milton Wexler, Minocycline, Mirtazapine, Mitochondrion, Mobility aid, Model organism, Muscle atrophy, Mutation, Myoclonus, Nancy Wexler, Nematode, Neural pathway, Neurodegeneration, Neuroferritinopathy, Neurogenesis, Neurology, Neuron, Neuropsychiatry, Neurotoxicity, New England, New York (state), Nonprofit organization, Norway, Nucleobase, Occupational therapy, Oogenesis, Osteoporosis, Oxidative stress, Pantothenate kinase-associated neurodegeneration, Paraneoplastic syndrome, Parkinson's disease, Penetrance, Percutaneous endoscopic gastrostomy, Phenotype, Phosphodiesterase inhibitor, Physical examination, Physical medicine and rehabilitation, Physical therapy, Pneumonia, Polycystic kidney disease, Polyglutamine tract, Positron emission tomography, Predictive testing, Preimplantation genetic diagnosis, Prenatal testing, Prevalence, PRNP, Procedural memory, Programmed cell death, Protein, Protein aggregation, Protein folding, Proteostasis, Psychoanalysis, Psychological evaluation, Psychomotor retardation, Pulmonary aspiration, Purkinje cell, Putamen, Quality of life, Reactive oxygen species, Recombinant DNA, Reduced affect display, Reference range, Rehabilitation (neuropsychology), Remacemide, Riluzole, Robley Dunglison, Saccade, Scotland, Selective serotonin reuptake inhibitor, Setesdal, Sex linkage, Short-term memory, Shunning, Sleep disorder, Smith Ely Jelliffe, Sodium phenylbutyrate, Speech-language pathology, Spermatogenesis, Spinocerebellar ataxia, Stem cell, Stem-cell therapy, Striatum, Substantia nigra, Suicide, Support group, Survivor guilt, Sweden, Swedes, Sydenham's chorea, Synapse, Synapsis, Synaptic vesicle, Systemic lupus erythematosus, Tasmania, TATA-binding protein, Testicle, Testicular atrophy, Tetrabenazine, Thalamus, The Times of Israel, Therapy, Thickening agent, Thomas Jefferson University, Transcription (biology), Transcriptional regulation, Transgene, Trinucleotide repeat disorder, UCL Institute of Neurology, United States Senate, Valproate, Venezuela, Venipuncture, Wales, Weight loss, William Bateson, William Osler, Wilson's disease, Witchcraft, Woody Guthrie, Working memory, Zygosity. Expand index (246 more) »

Abdomen

The abdomen (less formally called the belly, stomach, tummy or midriff) constitutes the part of the body between the thorax (chest) and pelvis, in humans and in other vertebrates.

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Abortion

Abortion is the ending of pregnancy by removing an embryo or fetus before it can survive outside the uterus.

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Abstraction

Abstraction in its main sense is a conceptual process where general rules and concepts are derived from the usage and classification of specific examples, literal ("real" or "concrete") signifiers, first principles, or other methods.

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Adenine

Adenine (A, Ade) is a nucleobase (a purine derivative).

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Age of majority

The age of majority is the threshold of adulthood as recognized or declared in law.

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Age of onset

The age of onset is a medical term referring to the age at which an individual acquires, develops, or first experiences a condition or symptoms of a disease or disorder.

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Aggression

Aggression is overt, often harmful, social interaction with the intention of inflicting damage or other unpleasantness upon another individual.

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Alcoholism

Alcoholism, also known as alcohol use disorder (AUD), is a broad term for any drinking of alcohol that results in mental or physical health problems.

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Allele

An allele is a variant form of a given gene.

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Allopatric speciation

Allopatric speciation (from the ancient Greek allos, meaning "other", and patris, meaning "fatherland"), also referred to as geographic speciation, vicariant speciation, or its earlier name, the dumbbell model, is a mode of speciation that occurs when biological populations of the same species become isolated from each other to an extent that prevents or interferes with genetic interchange.

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Alzheimer's disease

Alzheimer's disease (AD), also referred to simply as Alzheimer's, is a chronic neurodegenerative disease that usually starts slowly and worsens over time.

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Amantadine

Amantadine (trade name Symmetrel, by Endo Pharmaceuticals) is a medication that has U.S. Food and Drug Administration approval for use both as an antiviral and an antiparkinsonian medication.

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Amino acid

Amino acids are organic compounds containing amine (-NH2) and carboxyl (-COOH) functional groups, along with a side chain (R group) specific to each amino acid.

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Amniocentesis

Amniocentesis (also referred to as amniotic fluid test or AFT) is a medical procedure used in prenatal diagnosis of chromosomal abnormalities and fetal infections, and also for sex determination, in which a small amount of amniotic fluid, which contains fetal tissues, is sampled from the amniotic sac surrounding a developing fetus, and then the fetal DNA is examined for genetic abnormalities.

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Amyloid

Amyloids are aggregates of proteins that become folded into a shape that allows many copies of that protein to stick together forming fibrils.

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Anita Harding

Anita Elizabeth Harding (17 September 1952 – 11 September 1995) was an Irish-British neurologist, and Professor of Clinical Neurology at the Institute of Neurology of the University of London.

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Anticipation (genetics)

In genetics, anticipation is a phenomenon whereby as a genetic disorder is passed on to the next generation, the symptoms of the genetic disorder become apparent at an earlier age with each generation.

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Antiparkinson medication

An antiparkinson medication is a type of drug which is intended to treat and relieve the symptoms of Parkinson's disease.

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Antipsychotic

Antipsychotics, also known as neuroleptics or major tranquilizers, are a class of medication primarily used to manage psychosis (including delusions, hallucinations, paranoia or disordered thought), principally in schizophrenia and bipolar disorder.

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Anxiety

Anxiety is an emotion characterized by an unpleasant state of inner turmoil, often accompanied by nervous behaviour such as pacing back and forth, somatic complaints, and rumination.

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Apoptosis

Apoptosis (from Ancient Greek ἀπόπτωσις "falling off") is a process of programmed cell death that occurs in multicellular organisms.

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Astrocyte

Astrocytes (Astro from Greek astron.

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Astrogliosis

Astrogliosis (also known as astrocytosis or referred to as reactive astrocytosis) is an abnormal increase in the number of astrocytes due to the destruction of nearby neurons from CNS trauma, infection, ischemia, stroke, autoimmune responses, and neurodegenerative disease.

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Ataxia

Ataxia is a neurological sign consisting of lack of voluntary coordination of muscle movements that includes gait abnormality.

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Atypical antipsychotic

The atypical antipsychotics (AAP; also known as second generation antipsychotics (SGAs)) are a group of antipsychotic drugs (antipsychotic drugs in general are also known as major tranquilizers and neuroleptics, although the latter is usually reserved for the typical antipsychotics) used to treat psychiatric conditions.

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Autosome

An autosome is a chromosome that is not an allosome (a sex chromosome).

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Basal ganglia

The basal ganglia (or basal nuclei) is a group of subcortical nuclei, of varied origin, in the brains of vertebrates including humans, which are situated at the base of the forebrain.

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Behavioral addiction

Behavioral addiction is a form of addiction that involves a compulsion to engage in a rewarding non-drug-related behavior – sometimes called a natural reward – despite any negative consequences to the person's physical, mental, social or financial well-being.

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Benign hereditary chorea

Benign hereditary chorea (BHC), also known as benign familial chorea, is a rare autosomal dominant neurogenetic syndrome.

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Benzodiazepine

Benzodiazepines (BZD, BZs), sometimes called "benzos", are a class of psychoactive drugs whose core chemical structure is the fusion of a benzene ring and a diazepine ring.

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Boston

Boston is the capital city and most populous municipality of the Commonwealth of Massachusetts in the United States.

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Brain-derived neurotrophic factor

Brain-derived neurotrophic factor, also known as BDNF, is a protein that, in humans, is encoded by the BDNF gene.

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Breast cancer

Breast cancer is cancer that develops from breast tissue.

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California

California is a state in the Pacific Region of the United States.

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Camillo Golgi

Camillo Golgi (7 July 1843 – 21 January 1926) was an Italian biologist and pathologist known for his works on the central nervous system.

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Cardiovascular disease

Cardiovascular disease (CVD) is a class of diseases that involve the heart or blood vessels.

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Caregiver

A caregiver or carer is an unpaid or paid member of a person's social network who helps them with activities of daily living.

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Caspase

Caspases (cysteine-aspartic proteases, cysteine aspartases or cysteine-dependent aspartate-directed proteases) are a family of protease enzymes playing essential roles in programmed cell death (including apoptosis, pyroptosis and necroptosis) and inflammation.

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Caudate nucleus

The caudate nucleus is one of the structures that make up the dorsal striatum, which is a component of the basal ganglia.

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Cell (journal)

Cell is a peer-reviewed scientific journal publishing research papers across a broad range of disciplines within the life sciences.

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Cell nucleus

In cell biology, the nucleus (pl. nuclei; from Latin nucleus or nuculeus, meaning kernel or seed) is a membrane-enclosed organelle found in eukaryotic cells.

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Cell signaling

Cell signaling (cell signalling in British English) is part of any communication process that governs basic activities of cells and coordinates all cell actions.

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Cell-free fetal DNA

Cell-free fetal DNA (cffDNA) is fetal DNA which circulates freely in the maternal blood.

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Cerebellum

The cerebellum (Latin for "little brain") is a major feature of the hindbrain of all vertebrates.

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Cerebral atrophy

Cerebral atrophy is a common feature of many of the diseases that affect the brain.

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Cerebral cortex

The cerebral cortex is the largest region of the cerebrum in the mammalian brain and plays a key role in memory, attention, perception, cognition, awareness, thought, language, and consciousness.

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Cerebrospinal fluid

Cerebrospinal fluid (CSF) is a clear, colorless body fluid found in the brain and spinal cord.

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Chaperone (protein)

In molecular biology, molecular chaperones are proteins that assist the covalent folding or unfolding and the assembly or disassembly of other macromolecular structures.

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Charles Davenport

Charles Benedict Davenport (June 1, 1866 – February 18, 1944) was a prominent American eugenicist and biologist.

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CHDI Foundation

The CHDI Foundation, Inc., is a United States-based non-profit biomedical foundation that aims to "rapidly discover and develop drugs that delay or slow the progression of Huntington's disease", a neurodegenerative genetic disorder that affects muscle coordination and leads to cognitive decline.

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Chorea

Chorea (or choreia, occasionally) is an abnormal involuntary movement disorder, one of a group of neurological disorders called dyskinesias.

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Chorea acanthocytosis

Chorea-acanthocytosis (ChAc, also called Choreoacanthocytosis), is a rare hereditary disease caused by a mutation of the gene that directs structural proteins in red blood cells.

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Chorionic villus sampling

Chorionic villus sampling (CVS), sometimes called "chorionic villous sampling" (as "villous" is the adjectival form of the word "villus"), is a form of prenatal diagnosis to determine chromosomal or genetic disorders in the fetus.

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Chromosome 4

Chromosome 4 is one of the 23 pairs of chromosomes in humans.

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Clinical trial

Clinical trials are experiments or observations done in clinical research.

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Coenzyme Q10

Coenzyme Q10, also known as ubiquinone, ubidecarenone, coenzyme Q, and abbreviated at times to CoQ10, CoQ, or Q10 is a coenzyme that is ubiquitous in animals and most bacteria (hence the name ubiquinone).

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Cognition

Cognition is "the mental action or process of acquiring knowledge and understanding through thought, experience, and the senses".

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Compulsive behavior

Compulsive behavior is defined as performing an act persistently and repetitively without it necessarily leading to an actual reward or pleasure.

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Compulsory sterilization

Compulsory sterilization, also known as forced or coerced sterilization, programs are government policies which force people to undergo surgical or other sterilization.

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Creatine

Creatine is a nitrogenous organic acid that occurs naturally in vertebrates.

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CREB-binding protein

CREB-binding protein, also known as CREBBP or CBP, is a protein that in humans is encoded by the CREBBP gene.

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CT scan

A CT scan, also known as computed tomography scan, makes use of computer-processed combinations of many X-ray measurements taken from different angles to produce cross-sectional (tomographic) images (virtual "slices") of specific areas of a scanned object, allowing the user to see inside the object without cutting.

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Cytoplasm

In cell biology, the cytoplasm is the material within a living cell, excluding the cell nucleus.

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Cytosine

Cytosine (C) is one of the four main bases found in DNA and RNA, along with adenine, guanine, and thymine (uracil in RNA).

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Désiré-Magloire Bourneville

Désiré-Magloire Bourneville (October 20, 1840 – May 28, 1909) was a French neurologist born in Garencières.

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Dementia

Dementia is a broad category of brain diseases that cause a long-term and often gradual decrease in the ability to think and remember that is great enough to affect a person's daily functioning.

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Dentatorubral-pallidoluysian atrophy

Dentatorubral-pallidoluysian atrophy (DRPLA) is an autosomal dominant spinocerebellar degeneration caused by an expansion of a CAG repeat encoding a polyglutamine tract in the atrophin-1 protein.

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DNA

Deoxyribonucleic acid (DNA) is a thread-like chain of nucleotides carrying the genetic instructions used in the growth, development, functioning and reproduction of all known living organisms and many viruses.

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DNA methylation

DNA methylation is a process by which methyl groups are added to the DNA molecule.

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DNA replication

In molecular biology, DNA replication is the biological process of producing two identical replicas of DNA from one original DNA molecule.

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Dominance (genetics)

Dominance in genetics is a relationship between alleles of one gene, in which the effect on phenotype of one allele masks the contribution of a second allele at the same locus.

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Drosophila melanogaster

Drosophila melanogaster is a species of fly (the taxonomic order Diptera) in the family Drosophilidae.

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Drug development

Drug development is the process of bringing a new pharmaceutical drug to the market once a lead compound has been identified through the process of drug discovery.

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Dynamic mutation

In genetics, a dynamic mutation is an unstable heritable element where the probability of expression of a mutant phenotype is a function of the number of copies of the mutation.

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Dysarthria

Dysarthria is a motor speech disorder resulting from neurological injury of the motor component of the motor-speech system and is characterized by poor articulation of phonemes.

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Dysphagia

Dysphagia is the medical term for the symptom of difficulty in swallowing.

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Dystonia

Dystonia is a neurological movement disorder syndrome in which sustained or repetitive muscle contractions result in twisting and repetitive movements or abnormal fixed postures.

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East Coast of the United States

The East Coast of the United States is the coastline along which the Eastern United States meets the North Atlantic Ocean.

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Egocentrism

Egocentrism is the inability to differentiate between self and other.

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Electron transport chain

An electron transport chain (ETC) is a series of complexes that transfer electrons from electron donors to electron acceptors via redox (both reduction and oxidation occurring simultaneously) reactions, and couples this electron transfer with the transfer of protons (H+ ions) across a membrane.

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Embryo

An embryo is an early stage of development of a multicellular diploid eukaryotic organism.

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Embryonic stem cell

Embryonic stem cells (ES cells or ESCs) are pluripotent stem cells derived from the inner cell mass of a blastocyst, an early-stage pre-implantation embryo.

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England

England is a country that is part of the United Kingdom.

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Epileptic seizure

An epileptic seizure is a brief episode of signs or symptoms due to abnormally excessive or synchronous neuronal activity in the brain.

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Episodic memory

Episodic memory is the memory of autobiographical events (times, places, associated emotions, and other contextual who, what, when, where, why knowledge) that can be explicitly stated or conjured.

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Ethnic group

An ethnic group, or an ethnicity, is a category of people who identify with each other based on similarities such as common ancestry, language, history, society, culture or nation.

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Ethyl eicosapentaenoic acid

Ethyl eicosapentaenoic acid (E-EPA, icosapent ethyl) is a derivative of the omega-3 fatty acid eicosapentaenoic acid (EPA) that is used in combination with changes in diet to lower triglyceride levels in adults with severe (≥ 500 mg/dL) hypertriglyceridemia.

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Eugenics

Eugenics (from Greek εὐγενής eugenes 'well-born' from εὖ eu, 'good, well' and γένος genos, 'race, stock, kin') is a set of beliefs and practices that aims at improving the genetic quality of a human population.

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European Huntington's Disease Network

The European Huntington's Disease Network (Euro-HD or EHDN) is a Europe-wide network of professionals and people affected by Huntington's disease, who collaborate to organise and perform research into the condition, and improve the care of HD-affected individuals.

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Excitotoxicity

Excitotoxicity is the pathological process by which nerve cells are damaged or killed by excessive stimulation by neurotransmitters such as glutamate and similar substances.

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Executive functions

Executive functions (collectively referred to as executive function and cognitive control) are a set of cognitive processes that are necessary for the cognitive control of behavior: selecting and successfully monitoring behaviors that facilitate the attainment of chosen goals.

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Exile

To be in exile means to be away from one's home (i.e. city, state, or country), while either being explicitly refused permission to return or being threatened with imprisonment or death upon return.

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Family history (medicine)

In medicine, a family history (FH or FHx) consists of information about disorders from which the direct blood relatives of the patient have suffered.

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Fetus

A fetus is a stage in the prenatal development of viviparous organisms.

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Financial institution

Financial institutions, otherwise known as banking institutions, are corporations which provide services as intermediaries of financial markets.

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Finland

Finland (Suomi; Finland), officially the Republic of Finland is a country in Northern Europe bordering the Baltic Sea, Gulf of Bothnia, and Gulf of Finland, between Norway to the north, Sweden to the northwest, and Russia to the east.

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Founder effect

In population genetics, the founder effect is the loss of genetic variation that occurs when a new population is established by a very small number of individuals from a larger population.

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Functional magnetic resonance imaging

Functional magnetic resonance imaging or functional MRI (fMRI) measures brain activity by detecting changes associated with blood flow.

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Functional neuroimaging

Functional neuroimaging is the use of neuroimaging technology to measure an aspect of brain function, often with a view to understanding the relationship between activity in certain brain areas and specific mental functions.

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Gait

Gait is the pattern of movement of the limbs of animals, including humans, during locomotion over a solid substrate.

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Gambling

Gambling is the wagering of money or something of value (referred to as "the stakes") on an event with an uncertain outcome with the primary intent of winning money or material goods.

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Gene

In biology, a gene is a sequence of DNA or RNA that codes for a molecule that has a function.

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Gene expression

Gene expression is the process by which information from a gene is used in the synthesis of a functional gene product.

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Gene silencing

Gene silencing is the regulation of gene expression in a cell to prevent the expression of a certain gene.

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Genealogy

Genealogy (from γενεαλογία from γενεά, "generation" and λόγος, "knowledge"), also known as family history, is the study of families and the tracing of their lineages and history.

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Genetic code

The genetic code is the set of rules used by living cells to translate information encoded within genetic material (DNA or mRNA sequences) into proteins.

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Genetic counseling

Genetic counseling is the process by which the patients or relatives at risk of an inherited disorder (or may be carrying a child at risk) are advised of the consequences and nature of the disorder, the probability of developing or transmitting it, and the options open to them in management and family planning.

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Genetic disorder

A genetic disorder is a genetic problem caused by one or more abnormalities in the genome.

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Genetic linkage

Genetic linkage is the tendency of DNA sequences that are close together on a chromosome to be inherited together during the meiosis phase of sexual reproduction.

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Genetic testing

Genetic testing, also known as DNA testing, allows the determination of bloodlines and the genetic diagnosis of vulnerabilities to inherited diseases.

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Genetically modified organism

A genetically modified organism (GMO) is any organism whose genetic material has been altered using genetic engineering techniques (i.e., a genetically engineered organism).

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Genetics

Genetics is the study of genes, genetic variation, and heredity in living organisms.

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George Huntington

George Huntington (April 9, 1850 – March 3, 1916) was an American physician who contributed a classic clinical description of the disease that bears his name – Huntington's disease.

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Gillick competence

Gillick competence is a term originating in England and is used in medical law to decide whether a child (under 16 years of age) is able to consent to his or her own medical treatment, without the need for parental permission or knowledge.

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Globus pallidus

The globus pallidus (Latin for "pale globe") also known as paleostriatum or dorsal pallidum, is a subcortical structure of the brain.

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Glutamine

Glutamine (symbol Gln or Q) is an α-amino acid that is used in the biosynthesis of proteins.

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Guanine

Guanine (or G, Gua) is one of the four main nucleobases found in the nucleic acids DNA and RNA, the others being adenine, cytosine, and thymine (uracil in RNA).

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Haploinsufficiency

Haploinsufficiency is a mechanism of action to explain a phenotype when a diploid organism has lost one copy of a gene and is left with a single functional copy of that gene.

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Haplotype

A haplotype (haploid genotype) is a group of alleles in an organism that are inherited together from a single parent.

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Heart

The heart is a muscular organ in most animals, which pumps blood through the blood vessels of the circulatory system.

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Heart failure

Heart failure (HF), often referred to as congestive heart failure (CHF), is when the heart is unable to pump sufficiently to maintain blood flow to meet the body's needs.

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Hereditary Disease Foundation

The Hereditary Disease Foundation (HDF) aims to cure genetic disorders, notably Huntington's disease, by supporting basic biomedical research.

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Hippocampus

The hippocampus (named after its resemblance to the seahorse, from the Greek ἱππόκαμπος, "seahorse" from ἵππος hippos, "horse" and κάμπος kampos, "sea monster") is a major component of the brains of humans and other vertebrates.

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Histone deacetylase

Histone deacetylases (HDAC) are a class of enzymes that remove acetyl groups (O.

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Histone deacetylase inhibitor

Histone deacetylase inhibitors (HDAC inhibitors, HDACi, HDIs) are chemical compounds that inhibit histone deacetylases.

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Human Genome Project

The Human Genome Project (HGP) was an international scientific research project with the goal of determining the sequence of nucleotide base pairs that make up human DNA, and of identifying and mapping all of the genes of the human genome from both a physical and a functional standpoint.

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Huntingtin

The huntingtin gene, also called the HTT or HD (Huntington disease) gene, is the IT15 ("interesting transcript 15") gene, which codes for a protein called the huntingtin protein.

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Huntington's Disease Association

The Huntington's Disease Association (HDA) is a charity that supports people in England and Wales affected by the genetic neurodegenerative brain condition Huntington's disease (HD).

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Huntington's Disease Outreach Project for Education at Stanford

The Huntington’s disease Outreach Project for Education at Stanford (HOPES) is a student-run project at Stanford University dedicated to making scientific information about Huntington's disease (HD) more readily accessible to patients and the public.

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Huntington's Disease Society of America

The Huntington's Disease Society of America is a US non-profit organization dedicated to improving the lives of those affected by Huntington's disease, an incurable, genetically transmitted degenerative disease of the nervous system that affects movement, thinking, and some aspects of personality.

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Huntington's disease-like syndrome

The Huntington's disease-like syndromes (often abbreviated as HD-like or HDL syndromes) are a family of inherited neurodegenerative diseases that closely resemble Huntington's disease (HD) in that they typically produce a combination of chorea, cognitive decline or dementia and behavioural or psychiatric problems.

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Hypersexuality

Hypersexuality is a clinical diagnosis used by mental healthcare professionals to describe extremely frequent or suddenly increased libido.

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Hypokinesia

Hypokinesia refers to decreased bodily movement.

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Hypothalamus

The hypothalamus(from Greek ὑπό, "under" and θάλαμος, thalamus) is a portion of the brain that contains a number of small nuclei with a variety of functions.

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Iceland

Iceland is a Nordic island country in the North Atlantic, with a population of and an area of, making it the most sparsely populated country in Europe.

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Icelanders

Icelanders (Íslendingar) are a Germanic ethnic group and nation, native to Iceland, mostly speaking the Germanic language Icelandic.

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Immigration

Immigration is the international movement of people into a destination country of which they are not natives or where they do not possess citizenship in order to settle or reside there, especially as permanent residents or naturalized citizens, or to take up employment as a migrant worker or temporarily as a foreign worker.

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Immunoassay

An immunoassay is a biochemical test that measures the presence or concentration of a macromolecule or a small molecule in a solution through the use of an antibody (usually) or an antigen (sometimes).

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Impaired glucose tolerance

Impaired glucose tolerance (IGT) is a pre-diabetic state of hyperglycemia that is associated with insulin resistance and increased risk of cardiovascular pathology.

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In vitro

In vitro (meaning: in the glass) studies are performed with microorganisms, cells, or biological molecules outside their normal biological context.

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In vitro fertilisation

In vitro fertilisation (IVF) is a process of fertilisation where an egg is combined with sperm outside the body, in vitro ("in glass").

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Inclusion bodies

Inclusion bodies, sometimes called elementary bodies, are nuclear or cytoplasmic aggregates of stable substances, usually proteins.

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Injury

Injury, also known as physical trauma, is damage to the body caused by external force.

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Institutionalisation

Institutionalisation (or institutionalization) refers to the process of embedding some conception (for example a belief, norm, social role, particular value or mode of behavior) within an organization, social system, or society as a whole.

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Interdisciplinarity

Interdisciplinarity or interdisciplinary studies involves the combining of two or more academic disciplines into one activity (e.g., a research project).

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Interneuron

An interneuron (also called internuncial neuron, relay neuron, association neuron, connector neuron, intermediate neuron or local circuit neuron) is a broad class of neurons found in the human body.

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Ionis Pharmaceuticals

Ionis Pharmaceuticals (known as Isis Pharmaceuticals until December 2015) is a publicly traded pharmaceutical company based in Carlsbad, California, United States.

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Joseph Jules Dejerine

Joseph Jules Dejerine (3 August 1849 – 26 February 1917), was a French neurologist.

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Journal of Clinical Investigation

The Journal of Clinical Investigation (JCI) is a peer-reviewed biomedical research journal published by the American Society for Clinical Investigation (ASCI).

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JPH3

Junctophilin-3 is a protein that in humans is encoded by the JPH3 gene.

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Lake Maracaibo

Lake Maracaibo (Lago de Maracaibo) is a large brackish tidal bay (or tidal estuary) in Venezuela and an "inlet of the Caribbean Sea." It is sometimes considered a lake rather than a bay or lagoon.

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Latrepirdine

Latrepirdine (INN, also known as dimebolin and sold as Dimebon), is an antihistamine drug which has been used clinically in Russia since 1983.

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Liver

The liver, an organ only found in vertebrates, detoxifies various metabolites, synthesizes proteins, and produces biochemicals necessary for digestion.

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Locus (genetics)

A locus (plural loci) in genetics is a fixed position on a chromosome, like the position of a gene or a marker (genetic marker).

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Long-term memory

Long-term memory (LTM) is the stage of the Atkinson–Shiffrin memory model where informative knowledge is held indefinitely.

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Los Angeles

Los Angeles (Spanish for "The Angels";; officially: the City of Los Angeles; colloquially: by its initials L.A.) is the second-most populous city in the United States, after New York City.

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Louis Théophile Joseph Landouzy

Louis Théophile Joseph Landouzy (27 March 1845 – 10 May 1917) was a French neurologist from Reims, and whose father and grandfather were also physicians.

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Lung

The lungs are the primary organs of the respiratory system in humans and many other animals including a few fish and some snails.

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Magnetic resonance imaging

Magnetic resonance imaging (MRI) is a medical imaging technique used in radiology to form pictures of the anatomy and the physiological processes of the body in both health and disease.

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Major depressive disorder

Major depressive disorder (MDD), also known simply as depression, is a mental disorder characterized by at least two weeks of low mood that is present across most situations.

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Marjorie Guthrie

Marjorie Mazia Guthrie (October 6, 1917 – March 13, 1983) was a dancer of the Martha Graham Company, a dance teacher, and, for a time, the wife of folk musician Woody Guthrie.

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McLeod syndrome

McLeod syndrome (or McLeod phenomenon) is an X-linked recessive genetic disorder that may affect the blood, brain, peripheral nerves, muscle, and heart.

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Medical diagnosis

Medical diagnosis (abbreviated Dx or DS) is the process of determining which disease or condition explains a person's symptoms and signs.

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Medical imaging

Medical imaging is the technique and process of creating visual representations of the interior of a body for clinical analysis and medical intervention, as well as visual representation of the function of some organs or tissues (physiology).

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Medical test

A medical test is a medical procedure performed to detect, diagnose, or monitor diseases, disease processes, susceptibility, and determine a course of treatment.

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Medium spiny neuron

Medium spiny neurons (MSNs), also known as spiny projection neurons, are a special type of GABAergic inhibitory cell representing 95% of neurons within the human striatum, a basal ganglia structure.

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Memory

Memory is the faculty of the mind by which information is encoded, stored, and retrieved.

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Mendelian inheritance

Mendelian inheritance is a type of biological inheritance that follows the laws originally proposed by Gregor Mendel in 1865 and 1866 and re-discovered in 1900.

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Mental disorder

A mental disorder, also called a mental illness or psychiatric disorder, is a behavioral or mental pattern that causes significant distress or impairment of personal functioning.

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Metabolism

Metabolism (from μεταβολή metabolē, "change") is the set of life-sustaining chemical transformations within the cells of organisms.

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Microglia

Microglia are a type of neuroglia (glial cell) located throughout the brain and spinal cord.

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Micrometre

The micrometre (International spelling as used by the International Bureau of Weights and Measures; SI symbol: μm) or micrometer (American spelling), also commonly known as a micron, is an SI derived unit of length equaling (SI standard prefix "micro-".

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Middle Ages

In the history of Europe, the Middle Ages (or Medieval Period) lasted from the 5th to the 15th century.

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Milton Wexler

Milton Wexler (August 24, 1908 – March 16, 2007) was a Los Angeles psychoanalyst who was responsible for the creation of the Hereditary Disease Foundation.

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Minocycline

Minocycline is a broad-spectrum tetracycline antibiotic, and has a broader spectrum than the other members of the group.

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Mirtazapine

Mirtazapine, sold under the brand name Remeron among others, is an atypical antidepressant which is used primarily in the treatment of depression.

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Mitochondrion

The mitochondrion (plural mitochondria) is a double-membrane-bound organelle found in most eukaryotic organisms.

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Mobility aid

A mobility aid is a device designed to assist walking or otherwise improve the mobility of people with a mobility impairment.

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Model organism

A model organism is a non-human species that is extensively studied to understand particular biological phenomena, with the expectation that discoveries made in the organism model will provide insight into the workings of other organisms.

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Muscle atrophy

Muscle atrophy is defined as a decrease in the mass of the muscle; it can be a partial or complete wasting away of muscle, and is most commonly experienced when persons suffer temporary disabling circumstances such as being restricted in movement and/or confined to bed as when hospitalized.

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Mutation

In biology, a mutation is the permanent alteration of the nucleotide sequence of the genome of an organism, virus, or extrachromosomal DNA or other genetic elements.

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Myoclonus

Myoclonus is a brief, involuntary twitching of a muscle or a group of muscles.

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Nancy Wexler

Nancy Wexler (born July 19, 1945) FRCP is an American geneticist and the Higgins Professor of Neuropsychology at Columbia University, best known for her involvement in the discovery of the location of the gene that causes Huntington's disease.

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Nematode

The nematodes or roundworms constitute the phylum Nematoda (also called Nemathelminthes).

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Neural pathway

A neural pathway is the connection formed by axons that project from neurons to make synapses onto neurons in another location, to enable a signal to be sent from one region of the nervous system to another.

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Neurodegeneration

Neurodegeneration is the progressive loss of structure or function of neurons, including death of neurons.

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Neuroferritinopathy

Neuroferritinopathy or adult-onset basal ganglia disease is a genetic neurodegenerative disorder characterized by the accumulation of iron in the basal ganglia, cerebellum, and motor cortex of the human brain.

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Neurogenesis

Neurogenesis is the process by which nervous system cells, known as neurons, are produced by neural stem cells (NSC)s, and it occurs in all species of animals except the porifera (sponges) and placozoans.

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Neurology

Neurology (from νεῦρον (neûron), "string, nerve" and the suffix -logia, "study of") is a branch of medicine dealing with disorders of the nervous system.

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Neuron

A neuron, also known as a neurone (British spelling) and nerve cell, is an electrically excitable cell that receives, processes, and transmits information through electrical and chemical signals.

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Neuropsychiatry

Neuropsychiatry is a branch of medicine that deals with mental disorders attributable to diseases of the nervous system.

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Neurotoxicity

Neurotoxicity is a form of toxicity in which a biological, chemical, or physical agent produces an adverse effect on the structure or function of the central and/or peripheral nervous system.

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New England

New England is a geographical region comprising six states of the northeastern United States: Maine, Vermont, New Hampshire, Massachusetts, Rhode Island and Connecticut.

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New York (state)

New York is a state in the northeastern United States.

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Nonprofit organization

A non-profit organization (NPO), also known as a non-business entity or non-profit institution, is dedicated to furthering a particular social cause or advocating for a shared point of view.

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Norway

Norway (Norwegian: (Bokmål) or (Nynorsk); Norga), officially the Kingdom of Norway, is a unitary sovereign state whose territory comprises the western portion of the Scandinavian Peninsula plus the remote island of Jan Mayen and the archipelago of Svalbard.

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Nucleobase

Nucleobases, also known as nitrogenous bases or often simply bases, are nitrogen-containing biological compounds that form nucleosides, which in turn are components of nucleotides, with all of these monomers constituting the basic building blocks of nucleic acids.

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Occupational therapy

Occupational therapy (OT) is the use of assessment and intervention to develop, recover, or maintain the meaningful activities, or occupations, of individuals, groups, or communities.

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Oogenesis

Oogenesis, ovogenesis, or oögenesis is the differentiation of the ovum (egg cell) into a cell competent to further development when fertilized.

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Osteoporosis

Osteoporosis is a disease where increased bone weakness increases the risk of a broken bone.

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Oxidative stress

Oxidative stress reflects an imbalance between the systemic manifestation of reactive oxygen species and a biological system's ability to readily detoxify the reactive intermediates or to repair the resulting damage.

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Pantothenate kinase-associated neurodegeneration

Pantothenate kinase-associated neurodegeneration (PKAN), also known as neurodegeneration with brain iron accumulation 1 (NBIA1), also called Hallervorden–Spatz syndrome, is a degenerative disease of the brain that can lead to parkinsonism, dystonia, dementia, and ultimately death.

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Paraneoplastic syndrome

A paraneoplastic syndrome is a syndrome (a set of signs and symptoms) that is the consequence of cancer in the body, but unlike mass effect, is not due to the local presence of cancer cells.

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Parkinson's disease

Parkinson's disease (PD) is a long-term degenerative disorder of the central nervous system that mainly affects the motor system.

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Penetrance

Penetrance in genetics is the proportion of individuals carrying a particular variant (or allele) of a gene (the genotype) that also express an associated trait (the phenotype).

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Percutaneous endoscopic gastrostomy

Percutaneous endoscopic gastrostomy (PEG) is an endoscopic medical procedure in which a tube (PEG tube) is passed into a patient's stomach through the abdominal wall, most commonly to provide a means of feeding when oral intake is not adequate (for example, because of dysphagia or sedation).

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Phenotype

A phenotype is the composite of an organism's observable characteristics or traits, such as its morphology, development, biochemical or physiological properties, behavior, and products of behavior (such as a bird's nest).

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Phosphodiesterase inhibitor

A phosphodiesterase inhibitor is a drug that blocks one or more of the five subtypes of the enzyme phosphodiesterase (PDE), thereby preventing the inactivation of the intracellular second messengers cyclic adenosine monophosphate (cAMP) and cyclic guanosine monophosphate (cGMP) by the respective PDE subtype(s).

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Physical examination

A physical examination, medical examination, or clinical examination (more popularly known as a check-up) is the process by which a medical professional investigates the body of a patient for signs of disease.

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Physical medicine and rehabilitation

Physical medicine and rehabilitation, also known as physiatry, is a branch of medicine that aims to enhance and restore functional ability and quality of life to those with physical impairments or disabilities.

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Physical therapy

Physical therapy (PT), also known as physiotherapy, is one of the allied health professions that, by using mechanical force and movements (bio-mechanics or kinesiology), manual therapy, exercise therapy, and electrotherapy, remediates impairments and promotes mobility and function.

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Pneumonia

Pneumonia is an inflammatory condition of the lung affecting primarily the small air sacs known as alveoli.

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Polycystic kidney disease

Polycystic kidney disease (PKD or PCKD, also known as polycystic kidney syndrome) is a genetic disorder in which the renal tubules become structurally abnormal, resulting in the development and growth of multiple cysts within the kidney.

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Polyglutamine tract

A polyglutamine tract or polyQ tract is a portion of a protein consisting of a sequence of several glutamine units.

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Positron emission tomography

Positron-emission tomography (PET) is a nuclear medicine functional imaging technique that is used to observe metabolic processes in the body as an aid to the diagnosis of disease.

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Predictive testing

Predictive testing is a form of genetic testing.

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Preimplantation genetic diagnosis

Pre-implantation genetic diagnosis (PGD or PIGD) is the genetic profiling of embryos prior to implantation (as a form of embryo profiling), and sometimes even of oocytes prior to fertilization.

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Prenatal testing

Prenatal testing consists of prenatal screening and prenatal diagnosis, which are aspects of prenatal care that focus on detecting problems with the pregnancy as early as possible.

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Prevalence

Prevalence in epidemiology is the proportion of a particular population found to be affected by a medical condition (typically a disease or a risk factor such as smoking or seat-belt use).

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PRNP

PRNP (PRioN Protein) is the human gene encoding for the major prion protein PrP (for prion protein), also known as CD230 (cluster of differentiation 230).

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Procedural memory

Procedural memory is a type of implicit memory (unconscious memory) and long-term memory which aids the performance of particular types of tasks without conscious awareness of these previous experiences.

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Programmed cell death

Programmed cell death (or PCD) is the death of a cell in any form, mediated by an intracellular program.

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Protein

Proteins are large biomolecules, or macromolecules, consisting of one or more long chains of amino acid residues.

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Protein aggregation

Protein aggregation is a biological phenomenon in which mis-folded proteins aggregate (i.e., accumulate and clump together) either intra- or extracellularly.

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Protein folding

Protein folding is the physical process by which a protein chain acquires its native 3-dimensional structure, a conformation that is usually biologically functional, in an expeditious and reproducible manner.

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Proteostasis

Proteostasis, a portmanteau of the words protein and homeostasis, is the concept that there are competing and integrated biological pathways within cells that control the biogenesis, folding, trafficking and degradation of proteins present within and outside the cell.

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Psychoanalysis

Psychoanalysis is a set of theories and therapeutic techniques related to the study of the unconscious mind, which together form a method of treatment for mental-health disorders.

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Psychological evaluation

Psychological evaluation is defined as a way of assessing an individual's behavior, personality, cognitive abilities, and several other domains.

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Psychomotor retardation

Psychomotor retardation (also known as "psychomotor impairment" or "motormental retardation" or "psychomotor slowing") involves a slowing-down of thought and a reduction of physical movements in an individual.

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Pulmonary aspiration

Pulmonary aspiration is the entry of material (such as pharyngeal secretions, food or drink, or stomach contents) from the oropharynx or gastrointestinal tract into the larynx (voice box) and lower respiratory tract (the portions of the respiratory system from the trachea—i.e., windpipe—to the lungs).

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Purkinje cell

Purkinje cells, or Purkinje neurons, are a class of GABAergic neurons located in the cerebellum.

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Putamen

The putamen is a round structure located at the base of the forebrain (telencephalon).

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Quality of life

Quality of life (QOL) is the general well-being of individuals and societies, outlining negative and positive features of life.

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Reactive oxygen species

Reactive oxygen species (ROS) are chemically reactive chemical species containing oxygen.

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Recombinant DNA

Recombinant DNA (rDNA) molecules are DNA molecules formed by laboratory methods of genetic recombination (such as molecular cloning) to bring together genetic material from multiple sources, creating sequences that would not otherwise be found in the genome.

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Reduced affect display

Reduced affect display, sometimes referred to as emotional blunting, is a condition of reduced emotional reactivity in an individual.

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Reference range

In health-related fields, a reference range or reference interval is the range of values for a physiologic measurement in healthy persons (for example, the amount of creatinine in the blood, or the partial pressure of oxygen).

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Rehabilitation (neuropsychology)

Rehabilitation of sensory and cognitive function typically involves methods for retraining neural pathways or training new neural pathways to regain or improve neurocognitive functioning that has been diminished by disease or trauma.

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Remacemide

Remacemide is a drug which acts as a low-affinity NMDA antagonist with sodium channel blocking properties.

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Riluzole

Riluzole (marketed as Rilutek and Teglutik) is a drug used to treat amyotrophic lateral sclerosis.

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Robley Dunglison

Robley Dunglison (4 January 1798 – 1 April 1869) was an English physician who moved to America to join the first faculty of the University of Virginia.

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Saccade

A saccade (French for jerk) is a quick, simultaneous movement of both eyes between two or more phases of fixation in the same direction.

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Scotland

Scotland (Alba) is a country that is part of the United Kingdom and covers the northern third of the island of Great Britain.

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Selective serotonin reuptake inhibitor

Selective serotonin reuptake inhibitors (SSRIs) are a class of drugs that are typically used as antidepressants in the treatment of major depressive disorder and anxiety disorders.

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Setesdal

Setesdal (older name: Sætersdal) is a valley and a traditional district in Aust-Agder County in southern Norway.

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Sex linkage

Sex linkage is the phenotypic expression of an allele related to the allosome (sex chromosome) of the individual.

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Short-term memory

Short-term memory (or "primary" or "active memory") is the capacity for holding, but not manipulating, a small amount of information in mind in an active, readily available state for a short period of time.

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Shunning

Shunning can be the act of social rejection, or emotional distance.

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Sleep disorder

A sleep disorder, or somnipathy, is a medical disorder of the sleep patterns of a person or animal.

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Smith Ely Jelliffe

Smith Ely Jelliffe (October 27, 1866 – September 25, 1945) was an American neurologist, psychiatrist, and psychoanalyst.

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Sodium phenylbutyrate

Sodium phenylbutyrate is a salt of an aromatic fatty acid, 4-phenylbutyrate (4-PBA) or 4-phenylbutyric acid.

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Speech-language pathology

Speech-language pathology is a field of expertise practiced by a clinician known as a speech-language pathologist (SLP), also sometimes referred to as a speech and language therapist or a speech therapist. SLP is considered a "related health profession" along with audiology, optometry, occupational therapy, clinical psychology, physical therapy, and others.

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Spermatogenesis

Spermatogenesis is the process by which haploid spermatozoa develop from germ cells in the seminiferous tubules of the testis.

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Spinocerebellar ataxia

Spinocerebellar ataxia (SCA), also known as spinocerebellar atrophy or spinocerebellar degeneration, is a progressive, degenerative, genetic disease with multiple types, each of which could be considered a disease in its own right.

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Stem cell

Stem cells are biological cells that can differentiate into other types of cells and can divide to produce more of the same type of stem cells.

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Stem-cell therapy

Stem-cell therapy is the use of stem cells to treat or prevent a disease or condition.

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Striatum

The striatum, or corpus striatum (also called the neostriatum and the striate nucleus) is a nucleus (a cluster of neurons) in the subcortical basal ganglia of the forebrain.

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Substantia nigra

The substantia nigra (SN) is a basal ganglia structure located in the midbrain that plays an important role in reward and movement.

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Suicide

Suicide is the act of intentionally causing one's own death.

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Support group

In a support group, members provide each other with various types of help, usually nonprofessional and nonmaterial, for a particular shared, usually burdensome, characteristic.

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Survivor guilt

Survivor guilt (or survivor's guilt; also called survivor syndrome or survivor's syndrome) is a mental condition that occurs when a person believes they have done something wrong by surviving a traumatic event when others did not.

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Sweden

Sweden (Sverige), officially the Kingdom of Sweden (Swedish), is a Scandinavian country in Northern Europe.

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Swedes

Swedes (svenskar) are a Germanic ethnic group native to Sweden.

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Sydenham's chorea

Sydenham's chorea (SC) or chorea minor (historically and traditionally referred to as St Vitus' dance) is a disorder characterized by rapid, uncoordinated jerking movements primarily affecting the face, hands and feet.

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Synapse

In the nervous system, a synapse is a structure that permits a neuron (or nerve cell) to pass an electrical or chemical signal to another neuron or to the target efferent cell.

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Synapsis

Synapsis (also called syndesis) is the pairing of two homologous chromosomes that occurs during meiosis.

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Synaptic vesicle

In a neuron, synaptic vesicles (or neurotransmitter vesicles) store various neurotransmitters that are released at the synapse.

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Systemic lupus erythematosus

Systemic lupus erythematosus (SLE), also known simply as lupus, is an autoimmune disease in which the body's immune system mistakenly attacks healthy tissue in many parts of the body.

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Tasmania

Tasmania (abbreviated as Tas and known colloquially as Tassie) is an island state of Australia.

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TATA-binding protein

The TATA-binding protein (TBP) is a general transcription factor that binds specifically to a DNA sequence called the TATA box.

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Testicle

The testicle or testis is the male reproductive gland in all animals, including humans.

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Testicular atrophy

Testicular atrophy is a medical condition in which the male reproductive organs (the testes, which in humans are located in the scrotum) diminish in size and may be accompanied by loss of function.

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Tetrabenazine

Tetrabenazine is a drug for the symptomatic treatment of hyperkinetic movement disorders.

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Thalamus

The thalamus (from Greek θάλαμος, "chamber") is the large mass of gray matter in the dorsal part of the diencephalon of the brain with several functions such as relaying of sensory signals, including motor signals, to the cerebral cortex, and the regulation of consciousness, sleep, and alertness.

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The Times of Israel

The Times of Israel is an Israeli-based online newspaper launched in 2012.

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Therapy

Therapy (often abbreviated tx, Tx, or Tx) is the attempted remediation of a health problem, usually following a diagnosis.

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Thickening agent

A thickening agent or thickener is a substance which can increase the viscosity of a liquid without substantially changing its other properties.

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Thomas Jefferson University

Thomas Jefferson University is a private university in Center City, Philadelphia, Pennsylvania, United States.

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Transcription (biology)

Transcription is the first step of gene expression, in which a particular segment of DNA is copied into RNA (especially mRNA) by the enzyme RNA polymerase.

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Transcriptional regulation

In molecular biology and genetics, transcriptional regulation is the means by which a cell regulates the conversion of DNA to RNA (transcription), thereby orchestrating gene activity.

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Transgene

A transgene is a gene or genetic material that has been transferred naturally, or by any of a number of genetic engineering techniques from one organism to another.

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Trinucleotide repeat disorder

Trinucleotide repeat disorders (also known as trinucleotide repeat expansion disorders, triplet repeat expansion disorders or codon reiteration disorders) are a set of genetic disorders caused by trinucleotide repeat expansion, a kind of mutation where trinucleotide repeats in certain genes or intronsDavid W. Sanders & Clifford P. Brangwynne (2017), Nature, 546, 215–216 (08 June 2017) exceed the normal, stable threshold, which differs per gene.

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UCL Institute of Neurology

The UCL Institute of Neurology is an institute within the Faculty of Brain Sciences of University College London (UCL) and is located in London, United Kingdom.

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United States Senate

The United States Senate is the upper chamber of the United States Congress, which along with the United States House of Representatives—the lower chamber—comprise the legislature of the United States.

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Valproate

Valproate (VPA), and its valproic acid, sodium valproate, and valproate semisodium forms, are medications primarily used to treat epilepsy and bipolar disorder and to prevent migraine headaches.

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Venezuela

Venezuela, officially denominated Bolivarian Republic of Venezuela (República Bolivariana de Venezuela),Previously, the official name was Estado de Venezuela (1830–1856), República de Venezuela (1856–1864), Estados Unidos de Venezuela (1864–1953), and again República de Venezuela (1953–1999).

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Venipuncture

In medicine, venipuncture or venepuncture is the process of obtaining intravenous access for the purpose of intravenous therapy or for blood sampling of venous blood.

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Wales

Wales (Cymru) is a country that is part of the United Kingdom and the island of Great Britain.

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Weight loss

Weight loss, in the context of medicine, health, or physical fitness, refers to a reduction of the total body mass, due to a mean loss of fluid, body fat or adipose tissue or lean mass, namely bone mineral deposits, muscle, tendon, and other connective tissue.

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William Bateson

William Bateson (8 August 1861 – 8 February 1926) was an English biologist who was the first person to use the term genetics to describe the study of heredity, and the chief populariser of the ideas of Gregor Mendel following their rediscovery in 1900 by Hugo de Vries and Carl Correns.

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William Osler

Sir William Osler, 1st Baronet, (July 12, 1849 – December 29, 1919) was a Canadian physician and one of the four founding professors of Johns Hopkins Hospital.

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Wilson's disease

Wilson's disease is a genetic disorder in which copper builds up in the body.

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Witchcraft

Witchcraft or witchery broadly means the practice of and belief in magical skills and abilities exercised by solitary practitioners and groups.

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Woody Guthrie

Woodrow Wilson Guthrie (July 14, 1912 – October 3, 1967) was an American singer-songwriter, one of the most significant figures in American folk music; his songs, including social justice songs, such as "This Land Is Your Land", have inspired several generations both politically and musically.

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Working memory

Working memory is a cognitive system with a limited capacity that is responsible for temporarily holding information available for processing.

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Zygosity

Zygosity is the degree of similarity of the alleles for a trait in an organism.

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Redirects here:

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References

[1] https://en.wikipedia.org/wiki/Huntington's_disease

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