Interstate 405 (usually pronounced four-oh-five), also known as I-405 or "the 405", is a major north–south Interstate Highway in Southern California.
Interstate 405 (I-405, also known as the Stadium Freeway No. 61) is a short Interstate Highway in Portland, Oregon.
Interstate 405 (abbreviated I-405, and colloquially referred to as 405 or four-oh-five) in Washington is a stretch of freeway that bypasses Seattle east of Lake Washington.
King's Highway 405, also known as Highway 405 and the General Brock Parkway, is a 400-Series Highway in the Canadian province of Ontario connecting the Queen Elizabeth Way (QEW) near St. Catharines with the Lewiston–Queenston Bridge in the village of Queenston.