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74 relations: ABCC8, ABCC9, Action potential, Adenosine triphosphate, AKAP5, Alpha helix, Andersen–Tawil syndrome, Atherosclerosis, ATP-sensitive potassium channel, Barium, Bartter syndrome, Bertil Hille, Beta cell, Burkholderia pseudomallei, Cardiac action potential, Cardiac muscle cell, Congenital hyperinsulinism, Depolarization, DLG1, DLG2, DLG4, Dysmorphic feature, Endothelium, G protein, G protein-coupled inwardly-rectifying potassium channel, Heart, Heart arrhythmia, HERG, Hypoglycemia, Hypokalemia, KCNJ10, KCNJ12, KCNJ13, KCNJ14, KCNJ15, KCNJ16, KCNJ3, KCNJ4, KCNJ5, KCNJ6, KCNJ8, KCNJ9, Kidney, Kir2.1, Kir6.2, Ligand-gated ion channel, LIN7A, LIN7C, Macrophage, Magnesium, ..., Meglumine, Neuron, Neurotransmitter, Nitric oxide synthase, Periodic paralysis, Phosphatidylinositol 4,5-bisphosphate, Polyamine, Potassium, Potassium channel, Resting potential, Reversal potential, ROMK, Sodium-hydrogen exchange regulatory cofactor 2, Spermine, Sulfonylurea, Sulfonylurea receptor, Thyrotoxic periodic paralysis, Transmembrane domain, Transporter Classification Database, Two-pore-domain potassium channel, Voltage clamp, Voltage-gated ion channel, Voltage-gated potassium channel, White blood cell. Expand index (24 more) »
ABCC8
ATP-binding cassette transporter sub-family C member 8 is a protein that in humans is encoded by the ABCC8 gene.
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ABCC9
ATP-binding cassette, sub-family C member 9 (ABCC9) also known as sulfonylurea receptor 2 (SUR2) is an ATP-binding cassette transporter that in humans is encoded by the ABCC9 gene.
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Action potential
In physiology, an action potential occurs when the membrane potential of a specific axon location rapidly rises and falls: this depolarisation then causes adjacent locations to similarly depolarise.
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Adenosine triphosphate
Adenosine triphosphate (ATP) is a complex organic chemical that participates in many processes.
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AKAP5
A-kinase anchor protein 5 is a protein that in humans is encoded by the AKAP5 gene.
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Alpha helix
The alpha helix (α-helix) is a common motif in the secondary structure of proteins and is a righthand-spiral conformation (i.e. helix) in which every backbone N−H group donates a hydrogen bond to the backbone C.
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Andersen–Tawil syndrome
Andersen–Tawil syndrome, also called Andersen syndrome and Long QT syndrome 7, is a form of long QT syndrome.
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Atherosclerosis
Atherosclerosis is a disease in which the inside of an artery narrows due to the build up of plaque.
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ATP-sensitive potassium channel
An ATP-sensitive potassium channel (or KATP channel) is a type of potassium channel that is gated by intracellular nucleotides, ATP and ADP.
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Barium
Barium is a chemical element with symbol Ba and atomic number 56.
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Bartter syndrome
Bartter syndrome is a rare inherited defect in the thick ascending limb of the loop of Henle.
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Bertil Hille
Bertil Hille (born October 10, 1940) is a professor in the Department of Physiology and Biophysics at the University of Washington.
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Beta cell
Beta cells (β cells) are a type of cell found in the pancreatic islets of the pancreas.
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Burkholderia pseudomallei
Burkholderia pseudomallei (also known as Pseudomonas pseudomallei) is a Gram-negative, bipolar, aerobic, motile rod-shaped bacterium.
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Cardiac action potential
The cardiac action potential is a brief change in voltage (membrane potential) across the cell membrane of heart cells.
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Cardiac muscle cell
Cardiac muscle cells or cardiomyocytes (also known as myocardiocytes or cardiac myocytes) are the muscle cells (myocytes) that make up the cardiac muscle (heart muscle).
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Congenital hyperinsulinism
Congenital hyperinsulinism,CHI, is a medical term referring to a variety of congenital disorders in which hypoglycemia is caused by excessive insulin secretion.
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Depolarization
In biology, depolarization is a change within a cell, during which the cell undergoes a shift in electric charge distribution, resulting in less negative charge inside the cell.
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DLG1
Discs large homolog 1 (DLG1), also known as synapse-associated protein 97 or SAP97, is a scaffold protein that in humans is encoded by the SAP97 gene.
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DLG2
Disks large homolog 2 (DLG2) also known as channel-associated protein of synapse-110 (chapsyn-110) or postsynaptic density protein 93 (PSD-93) is a protein that in humans is encoded by the DLG2 gene.
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DLG4
PSD-95 (postsynaptic density protein 95) also known as SAP-90 (synapse-associated protein 90) is a protein that in humans is encoded by the DLG4 (discs large homolog 4) gene.
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Dysmorphic feature
A dysmorphic feature is a difference of body structure.
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Endothelium
Endothelium refers to cells that line the interior surface of blood vessels and lymphatic vessels, forming an interface between circulating blood or lymph in the lumen and the rest of the vessel wall.
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G protein
G proteins, also known as guanine nucleotide-binding proteins, are a family of proteins that act as molecular switches inside cells, and are involved in transmitting signals from a variety of stimuli outside a cell to its interior.
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G protein-coupled inwardly-rectifying potassium channel
The G protein-coupled inwardly-rectifying potassium channels (GIRKs) are a family of inward-rectifier potassium ion channels which are activated (opened) via a signal transduction cascade starting with ligand-stimulated G protein-coupled receptors (GPCRs).
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Heart
The heart is a muscular organ in most animals, which pumps blood through the blood vessels of the circulatory system.
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Heart arrhythmia
Heart arrhythmia (also known as arrhythmia, dysrhythmia, or irregular heartbeat) is a group of conditions in which the heartbeat is irregular, too fast, or too slow.
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HERG
hERG (the human Ether-à-go-go-Related Gene) is a gene that codes for a protein known as Kv11.1, the alpha subunit of a potassium ion channel.
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Hypoglycemia
Hypoglycemia, also known as low blood sugar, is when blood sugar decreases to below normal levels.
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Hypokalemia
Hypokalemia, also spelled hypokalaemia, is a low level of potassium (K+) in the blood serum.
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KCNJ10
ATP-sensitive inward rectifier potassium channel 10 is a protein that in humans is encoded by the KCNJ10 gene.
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KCNJ12
ATP-sensitive inward rectifier potassium channel 12 is a protein that in humans is encoded by the KCNJ12 gene.
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KCNJ13
Potassium inwardly-rectifying channel, subfamily J, member 13 (KCNJ13) is a human gene encoding the Kir7.1 protein.
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KCNJ14
Potassium inwardly-rectifying channel, subfamily J, member 14 (KCNJ14), also known as Kir2.4, is a human gene.
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KCNJ15
Potassium inwardly-rectifying channel, subfamily J, member 15, also known as KCNJ15 is a human gene, which encodes the Kir4.2 protein.
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KCNJ16
Potassium inwardly-rectifying channel, subfamily J, member 16 (KCNJ16) is a human gene encoding the Kir5.1 protein.
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KCNJ3
Potassium inwardly-rectifying channel, subfamily J, member 3, also known as KCNJ3 or Kir3.1, is a human gene.
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KCNJ4
Potassium inwardly-rectifying channel, subfamily J, member 4, also known as KCNJ4 or Kir2.3, is a human gene.
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KCNJ5
G protein-activated inward rectifier potassium channel 4 is a protein that in humans is encoded by the KCNJ5 gene and is a type of G protein-gated ion channel.
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KCNJ6
G protein-activated inward rectifier potassium channel 2 is a protein that in humans is encoded by the KCNJ6 gene.
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KCNJ8
Potassium inwardly-rectifying channel, subfamily J, member 8, also known as KCNJ8, is a human gene encoding the Kir6.1 protein.
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KCNJ9
G protein-activated inward rectifier potassium channel 3 is a protein that in humans is encoded by the KCNJ9 gene.
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Kidney
The kidneys are two bean-shaped organs present in left and right sides of the body in vertebrates.
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Kir2.1
The Kir2.1 inward-rectifier potassium ion channel is encoded by the gene.
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Kir6.2
Kir6.2 is a major subunit of the ATP-sensitive K+ channel, an inward-rectifier potassium ion channel.
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Ligand-gated ion channel
Ligand-gated ion channels (LICs, LGIC), also commonly referred as ionotropic receptors, are a group of transmembrane ion-channel proteins which open to allow ions such as Na+, K+, Ca2+, and/or Cl− to pass through the membrane in response to the binding of a chemical messenger (i.e. a ligand), such as a neurotransmitter.
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LIN7A
Lin-7 homolog A is a protein that in humans is encoded by the LIN7A gene.
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LIN7C
Lin-7 homolog C is a protein that in humans is encoded by the LIN7C gene.
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Macrophage
Macrophages (big eaters, from Greek μακρός (makrós).
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Magnesium
Magnesium is a chemical element with symbol Mg and atomic number 12.
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Meglumine
Meglumine is an amino sugar derived from glucose.
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Neuron
A neuron, also known as a neurone (British spelling) and nerve cell, is an electrically excitable cell that receives, processes, and transmits information through electrical and chemical signals.
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Neurotransmitter
Neurotransmitters are endogenous chemicals that enable neurotransmission.
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Nitric oxide synthase
Nitric oxide synthases (NOSs) are a family of enzymes catalyzing the production of nitric oxide (NO) from L-arginine.
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Periodic paralysis
Periodic paralysis (also known as myoplegia paroxysmalis familiaris) is a group of rare genetic diseases that lead to weakness or paralysis from common triggers such as cold, heat, high carbohydrate meals, not eating, stress or excitement and physical activity of any kind.
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Phosphatidylinositol 4,5-bisphosphate
Phosphatidylinositol 4,5-bisphosphate or PtdIns(4,5)P2, also known simply as PIP2 or PI(4,5)P2, is a minor phospholipid component of cell membranes.
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Polyamine
A polyamine is an organic compound having more than two amino groups.
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Potassium
Potassium is a chemical element with symbol K (from Neo-Latin kalium) and atomic number 19.
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Potassium channel
Potassium channels are the most widely distributed type of ion channel and are found in virtually all living organisms.
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Resting potential
The relatively static membrane potential of quiescent cells is called the resting membrane potential (or resting voltage), as opposed to the specific dynamic electrochemical phenomena called action potential and graded membrane potential.
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Reversal potential
In a biological membrane, the reversal potential (also known as the Nernst potential) of an ion is the membrane potential at which there is no net (overall) flow of that particular ion from one side of the membrane to the other.
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ROMK
The renal outer medullary potassium channel (ROMK) is an ATP-dependent potassium channel (Kir1.1) that transports potassium out of cells.
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Sodium-hydrogen exchange regulatory cofactor 2
Sodium-hydrogen exchange regulatory cofactor NHE-RF2 (NHERF-2) also known as tyrosine kinase activator protein 1 (TKA-1) or SRY-interacting protein 1 (SIP-1) is a protein that in humans is encoded by the SLC9A3R2 (solute carrier family 9 isoform A3 regulatory factor 2) gene.
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Spermine
Spermine is a polyamine involved in cellular metabolism found in all eukaryotic cells.
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Sulfonylurea
Sulfonylureas (UK: sulphonylurea) are a class of organic compounds used in medicine and agriculture.
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Sulfonylurea receptor
In the field of molecular biology, the sulfonylurea receptors (SUR) are membrane proteins which are the molecular targets of the sulfonylurea class of antidiabetic drugs whose mechanism of action is to promote insulin release from pancreatic beta cells.
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Thyrotoxic periodic paralysis
Thyrotoxic periodic paralysis (TPP) is a condition featuring attacks of muscle weakness in the presence of hyperthyroidism (overactivity of the thyroid gland).
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Transmembrane domain
Transmembrane domain usually denotes a transmembrane segment of single alpha helix of a transmembrane protein.
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Transporter Classification Database
The Transporter Classification Database (or TCDB) is an International Union of Biochemistry and Molecular Biology (IUBMB)-approved classification system for membrane transport proteins, including ion channels.
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Two-pore-domain potassium channel
The two-pore-domain potassium channel is a family of 15 members that form what is known as "leak channels" which possess Goldman-Hodgkin-Katz (open) rectification.
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Voltage clamp
The voltage clamp is an experimental method used by electrophysiologists to measure the ion currents through the membranes of excitable cells, such as neurons, while holding the membrane voltage at a set level.
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Voltage-gated ion channel
Voltage-gated ion channels are a class of transmembrane proteins that form ion channels that are activated by changes in the electrical membrane potential near the channel.
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Voltage-gated potassium channel
Voltage-gated potassium channels (VGKCs) are transmembrane channels specific for potassium and sensitive to voltage changes in the cell's membrane potential.
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White blood cell
White blood cells (WBCs), also called leukocytes or leucocytes, are the cells of the immune system that are involved in protecting the body against both infectious disease and foreign invaders.
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References
[1] https://en.wikipedia.org/wiki/Inward-rectifier_potassium_channel
