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J-113,397

J-113,397 is an opioid drug which was the first compound found to be a highly selective antagonist for the nociceptin receptor, also known as the ORL-1 receptor. [1]

14 relations: Cocaine, Dopamine, Drug, Hyperalgesia, JTC-801, LY-2940094, Morphine, Nociceptin, Nociceptin receptor, Opioid, Parkinson's disease, SB-612,111, Striatum, Tachyphylaxis.

Cocaine

Cocaine, also known as benzoylmethylecgonine or coke, is a strong stimulant mostly used as a recreational drug.

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Dopamine

Dopamine is an organic chemical of the catecholamine and phenethylamine families that plays a number of important roles in the human brain and body, as well as elsewhere in biology.

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Drug

A drug is, in the broadest of terms, a chemical substance that has known biological effects on humans or other animals.

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Hyperalgesia

Hyperalgesia (or; 'hyper' from Greek ὑπέρ (huper, “over”), '-algesia' from Greek algos, ἄλγος (pain)) is an increased sensitivity to pain, which may be caused by damage to nociceptors or peripheral nerves.

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JTC-801

JTC-801 is an opioid analgesic drug used in scientific research.

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LY-2940094

LY-2940094 is a potent and selective nociceptin receptor antagonist which is under investigation by Eli Lilly for the treatment of major depressive disorder and alcohol dependence.

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Morphine

Morphine, sold under many trade names, is a pain medication of the opiate type.

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Nociceptin

Nociceptin/orphanin FQ (N/OFQ), a 17-amino acid neuropeptide, is the endogenous ligand for the nociceptin receptor (NOP, ORL-1).

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Nociceptin receptor

The nociceptin receptor or NOP also known as the orphanin FQ receptor or kappa-type 3 opioid receptor is a protein that in humans is encoded by the OPRL1 (opioid receptor-like 1) gene.

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Opioid

An "opioid" is any synthetic narcotic not derived from opium.

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Parkinson's disease

Parkinson's disease (PD, also known as idiopathic or primary parkinsonism, hypokinetic rigid syndrome (HRS), or paralysis agitans) is a degenerative disorder of the central nervous system mainly affecting the motor system.

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SB-612,111

SB-612,111 is an opioid receptor ligand which is a potent and selective antagonist for the nociceptin receptor (ORL-1), several times more potent than the older drug J-113,397.

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Striatum

The striatum, also known as the neostriatum or striate nucleus, is a subcortical part of the forebrain and a critical component of the reward system.

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Tachyphylaxis

Tachyphylaxis (Greek ταχύς, tachys, "rapid", and φύλαξις, phylaxis, "protection") is a medical term describing an acute (sudden) decrease in the response to a drug after its administration.

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Redirects here:

C24H37N3O2, J 113397, J-113397, J113397.

References

[1] https://en.wikipedia.org/wiki/J-113,397

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