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58 relations: Blood cell, Clonal hypereosinophilia, DNAJA3, Epidermal growth factor receptor, Erythropoietin, Erythropoietin receptor, Essential thrombocythemia, FYN, Glycoprotein 130, Granulocyte-macrophage colony-stimulating factor, Granulocyte-macrophage colony-stimulating factor receptor, GRB2, Growth hormone receptor, Homology (biology), Interferon, Interleukin 12 receptor, beta 2 subunit, Interleukin 5 receptor alpha subunit, Interleukin-3 receptor, Interleukin-5 receptor, Interleukin-6 receptor, IRS1, Janus kinase, Janus kinase inhibitor, Leukemia, Mammal, Myelofibrosis, Myeloproliferative neoplasm, Non-receptor tyrosine kinase, Phenylalanine, PIK3R1, Polycythemia vera, PPP2R4, Prolactin, Prolactin receptor, Protein arginine methyltransferase 5, Protein–protein interaction, PTK2, PTPN11, PTPN6, SH2 domain, SH2B1, SH3 domain, SHC1, Signal transducing adaptor molecule, SOCS3, STAT5, STAT5A, STAT5B, Suppressor of cytokine signaling 1, TEC (gene), ..., TEL-JAK2, Thrombopoietin, Thrombopoietin receptor, Tumor necrosis factor receptor 1, Type II cytokine receptor, Valine, VAV1, YES1. Expand index (8 more) »
Blood cell
A blood cell, also called a haematopoietic cell, hemocyte, or hematocyte, is a cell produced through hematopoiesis and found mainly in the blood.
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Clonal hypereosinophilia
Clonal hypereosinophilia, also termed primary hypereosinophilia or clonal eosinophilia, is a grouping of hematological disorders all of which are characterized by the development and growth of a pre-malignant or malignant population of eosinophils, a type of white blood cell that occupies the bone marrow, blood, and other tissues.
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DNAJA3
DnaJ homolog subfamily A member 3, mitochondrial, also known as Tumorous imaginal disc 1 (TID1), is a protein that in humans is encoded by the DNAJA3 gene on chromosome 16.
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Epidermal growth factor receptor
The epidermal growth factor receptor (EGFR; ErbB-1; HER1 in humans) is a transmembrane protein that is a receptor for members of the epidermal growth factor family (EGF family) of extracellular protein ligands.
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Erythropoietin
Erythropoietin (EPO), also known as hematopoietin or hemopoietin, is a glycoprotein cytokine secreted by the kidney in response to cellular hypoxia; it stimulates red blood cell production (erythropoiesis) in the bone marrow.
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Erythropoietin receptor
The erythropoietin receptor (EpoR) is a protein that in humans is encoded by the EPOR gene.
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Essential thrombocythemia
Essential thrombocythemia (ET) is a rare chronic blood condition characterised by the overproduction of platelets (thrombocytes) by megakaryocytes in the bone marrow.
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FYN
Proto-oncogene tyrosine-protein kinase Fyn (p59-FYN, Slk, Syn, MGC45350, Gene ID 2534) is an enzyme that in humans is encoded by the FYN gene.
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Glycoprotein 130
Glycoprotein 130 (also known as gp130, IL6ST, IL6-beta or CD130) is a transmembrane protein which is the founding member of the class of all cytokine receptors.
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Granulocyte-macrophage colony-stimulating factor
Granulocyte-macrophage colony-stimulating factor (GM-CSF), also known as colony-stimulating factor 2 (CSF2), is a monomeric glycoprotein secreted by macrophages, T cells, mast cells, natural killer cells, endothelial cells and fibroblasts that functions as a cytokine.
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Granulocyte-macrophage colony-stimulating factor receptor
The granulocyte-macrophage colony-stimulating factor receptor also known as CD116 (Cluster of Differentiation 116), is a receptor for granulocyte-macrophage colony-stimulating factor, which stimulates the production of white blood cells.
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GRB2
Growth factor receptor-bound protein 2 also known as Grb2 is an adaptor protein involved in signal transduction/cell communication.
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Growth hormone receptor
Growth hormone receptor is a protein that in humans is encoded by the GHR gene.
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Homology (biology)
In biology, homology is the existence of shared ancestry between a pair of structures, or genes, in different taxa.
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Interferon
Interferons (IFNs) are a group of signaling proteins made and released by host cells in response to the presence of several pathogens, such as viruses, bacteria, parasites, and also tumor cells.
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Interleukin 12 receptor, beta 2 subunit
Interleukin 12 receptor, beta 2 subunit is a subunit of the interleukin 12 receptor.
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Interleukin 5 receptor alpha subunit
Interleukin 5 receptor, alpha (IL5RA) also known as CD125 (Cluster of Differentiation 125) is a subunit of the Interleukin-5 receptor.
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Interleukin-3 receptor
The interleukin-3 receptor (also known as CD123 antigen) is a molecule found on cells which helps transmit the signal of interleukin-3, a soluble cytokine important in the immune system.
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Interleukin-5 receptor
The interleukin-5 receptor is a type I cytokine receptor.
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Interleukin-6 receptor
Interleukin 6 receptor (IL6R) also known as CD126 (Cluster of Differentiation 126) is a type I cytokine receptor.
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IRS1
Insulin receptor substrate 1 (IRS-1) is a signaling adapter protein that in humans is encoded by the IRS-1 gene.
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Janus kinase
Janus kinase (JAK) is a family of intracellular, nonreceptor tyrosine kinases that transduce cytokine-mediated signals via the JAK-STAT pathway.
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Janus kinase inhibitor
Janus kinase inhibitors, also known as JAK inhibitors or jakinibs, are a type of medication that functions by inhibiting the activity of one or more of the Janus kinase family of enzymes (JAK1, JAK2, JAK3, TYK2), thereby interfering with the JAK-STAT signaling pathway.
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Leukemia
Leukemia, also spelled leukaemia, is a group of cancers that usually begin in the bone marrow and result in high numbers of abnormal white blood cells.
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Mammal
Mammals are the vertebrates within the class Mammalia (from Latin mamma "breast"), a clade of endothermic amniotes distinguished from reptiles (including birds) by the possession of a neocortex (a region of the brain), hair, three middle ear bones, and mammary glands.
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Myelofibrosis
Myelofibrosis, also known as osteomyelofibrosis, is a relatively rare bone marrow cancer.
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Myeloproliferative neoplasm
The myeloproliferative neoplasms (MPNs), previously myeloproliferative diseases (MPDs), are a group of diseases of the bone marrow in which excess cells are produced.
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Non-receptor tyrosine kinase
Non-receptor tyrosine kinases (nRTKs) are cytosolic enzymes that are responsible for catalysing the transfer of a phosphate group from a nucleoside triphosphate donor, such as ATP, to tyrosine residues in proteins.
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Phenylalanine
Phenylalanine (symbol Phe or F) is an α-amino acid with the formula.
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PIK3R1
Phosphatidylinositol 3-kinase regulatory subunit alpha is an enzyme that in humans is encoded by the PIK3R1 gene.
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Polycythemia vera
Polycythemia vera is an uncommon neoplasm in which the bone marrow makes too many red blood cells.
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PPP2R4
Serine/threonine-protein phosphatase 2A regulatory subunit B' is an enzyme that in humans is encoded by the PPP2R4 gene.
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Prolactin
Prolactin (PRL), also known as luteotropic hormone or luteotropin, is a protein that is best known for its role in enabling mammals, usually females, to produce milk.
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Prolactin receptor
The prolactin receptor (PRLR)—encoded by a gene on chromosome 5p13-14—interacts with prolactin as a transmembrane receptor.
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Protein arginine methyltransferase 5
Protein arginine N-methyltransferase 5 is an enzyme that in humans is encoded by the PRMT5 gene.
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Protein–protein interaction
Protein–protein interactions (PPIs) are the physical contacts of high specificity established between two or more protein molecules as a result of biochemical events steered by electrostatic forces including the hydrophobic effect.
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PTK2
PTK2 protein tyrosine kinase 2 (PTK2), also known as focal adhesion kinase (FAK), is a protein that, in humans, is encoded by the PTK2 gene.
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PTPN11
Tyrosine-protein phosphatase non-receptor type 11 (PTPN11) also known as protein-tyrosine phosphatase 1D (PTP-1D), SHP-2, or protein-tyrosine phosphatase 2C (PTP-2C) is an enzyme that in humans is encoded by the PTPN11 gene.
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PTPN6
Tyrosine-protein phosphatase non-receptor type 6, also known as Src homology region 2 domain-containing phosphatase-1 (SHP-1), is an enzyme that in humans is encoded by the PTPN6 gene.
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SH2 domain
The SH2 (Src Homology 2) domain is a structurally conserved protein domain contained within the Src oncoprotein and in many other intracellular signal-transducing proteins.
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SH2B1
SH2B adapter protein 1 is a protein that in humans is encoded by the SH2B1 gene.
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SH3 domain
The SRC Homology 3 Domain (or SH3 domain) is a small protein domain of about 60 amino acid residues.
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SHC1
SHC-transforming protein 1 is a protein that in humans is encoded by the SHC1 gene.
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Signal transducing adaptor molecule
Signal transducing adapter molecule 1 is a protein that in humans is encoded by the STAM gene.
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SOCS3
Suppressor of cytokine signaling 3 (SOCS3 or SOCS-3) is a protein that in humans is encoded by the SOCS3 gene.
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STAT5
Signal transducer and activator of transcription 5 (STAT5) refers to two highly related proteins, STAT5A and STAT5B, which are part of the seven-membered STAT family of proteins.
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STAT5A
Signal transducer and activator of transcription 5A is a protein that in humans is encoded by the STAT5A gene.
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STAT5B
Signal transducer and activator of transcription 5B is a protein that in humans is encoded by the STAT5B gene.
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Suppressor of cytokine signaling 1
Suppressor of cytokine signaling 1 is a protein that in humans is encoded by the SOCS1 gene.
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TEC (gene)
Tyrosine-protein kinase Tec is an enzyme that in humans is encoded by the TEC gene.
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TEL-JAK2
TEL-JAK2 is a gene fusion resulting from a chromosomal translocation between chromosomes 9 and 12 observed in human leukemia.
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Thrombopoietin
Thrombopoietin (THPO) also known as megakaryocyte growth and development factor (MGDF) is a protein that in humans is encoded by the THPO gene.
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Thrombopoietin receptor
The thrombopoietin receptor also known as the myeloproliferative leukemia protein or CD110 (Cluster of Differentiation 110) is a protein that in humans is encoded by the MPL (myeloproliferative leukemia virus) oncogene.
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Tumor necrosis factor receptor 1
Tumor necrosis factor receptor 1 (TNFR1), also known as tumor necrosis factor receptor superfamily member 1A (TNFRSF1A) and CD120a, is a ubiquitous membrane receptor that binds tumor necrosis factor-alpha (TNFα).
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Type II cytokine receptor
Type II cytokine receptors are transmembrane proteins that are expressed on the surface of certain cells, which bind and respond to a select group of cytokines.
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Valine
Valine (symbol Val or V) is an α-amino acid that is used in the biosynthesis of proteins.
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VAV1
Proto-oncogene vav is a protein that in humans is encoded by the VAV1 gene.
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YES1
Proto-oncogene tyrosine-protein kinase Yes is an enzyme that in humans is encoded by the YES1 gene.
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Redirects here:
JAK2, JAK2 (gene), Jak2.
References
[1] https://en.wikipedia.org/wiki/Janus_kinase_2
