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Lactate dehydrogenase

Index Lactate dehydrogenase

Lactate dehydrogenase (LDH or LD) is an enzyme found in nearly all living cells (animals, plants, and prokaryotes). [1]

79 relations: Allosteric regulation, Alpha helix, Amino acid, Antiparallel (biochemistry), Bacteria, Beta sheet, Brain, C-terminus, Cancer, Cancer cell, Cell membrane, Chromosome 11, Citric acid cycle, Cori cycle, Cytochrome c, D-lactate dehydrogenase (cytochrome), Dehydrogenase, Dysgerminoma, Empyema, Encephalitis, Enzyme, Exudate, Gene, Genetic code, Glycolysis, Heart, Hemolysis, Histoplasmosis, Hydride, Hydrostatics, Inflammation, International unit, Isozyme, Kidney, L-lactate dehydrogenase (cytochrome), Lactate dehydrogenase A, Lactic acid, Liver, Lung, Lymphoma, Medicine, Meningitis, Messenger RNA, Mononuclear phagocyte system, Morpheein, Myocardial infarction, Myoglobin, Myoglobinuria, N-terminus, Necrosis, ..., Nicotinamide adenine dinucleotide, Oncotic pressure, Oxidoreductase, Pancreas, Pericardial effusion, Peroxisomal targeting signal, Peroxisome, Placenta, Pleural effusion, Pneumocystis pneumonia, Prognosis, Prokaryote, Protein domain, Protein subunit, Pyruvic acid, Reactive oxygen species, Red blood cell, Rhabdomyolysis, Serum (blood), Skeletal muscle, Stop codon, Striated muscle tissue, Testicle, Translation, Transudate, Troponin, Tumor marker, Virus, 2-Hydroxybutyric acid. Expand index (29 more) »

Allosteric regulation

In biochemistry, allosteric regulation (or allosteric control) is the regulation of an enzyme by binding an effector molecule at a site other than the enzyme's active site.

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Alpha helix

The alpha helix (α-helix) is a common motif in the secondary structure of proteins and is a righthand-spiral conformation (i.e. helix) in which every backbone N−H group donates a hydrogen bond to the backbone C.

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Amino acid

Amino acids are organic compounds containing amine (-NH2) and carboxyl (-COOH) functional groups, along with a side chain (R group) specific to each amino acid.

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Antiparallel (biochemistry)

In biochemistry, two biopolymers are antiparallel if they run parallel to each other but with opposite alignments.

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Bacteria

Bacteria (common noun bacteria, singular bacterium) is a type of biological cell.

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Beta sheet

The β-sheet (also β-pleated sheet) is a common motif of regular secondary structure in proteins.

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Brain

The brain is an organ that serves as the center of the nervous system in all vertebrate and most invertebrate animals.

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C-terminus

The C-terminus (also known as the carboxyl-terminus, carboxy-terminus, C-terminal tail, C-terminal end, or COOH-terminus) is the end of an amino acid chain (protein or polypeptide), terminated by a free carboxyl group (-COOH).

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Cancer

Cancer is a group of diseases involving abnormal cell growth with the potential to invade or spread to other parts of the body.

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Cancer cell

Cancer cells are cells that divide relentlessly, forming solid tumors or flooding the blood with abnormal cells.

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Cell membrane

The cell membrane (also known as the plasma membrane or cytoplasmic membrane, and historically referred to as the plasmalemma) is a biological membrane that separates the interior of all cells from the outside environment (the extracellular space).

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Chromosome 11

Chromosome 11 is one of the 23 pairs of chromosomes in humans.

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Citric acid cycle

The citric acid cycle (CAC) – also known as the tricarboxylic acid (TCA) cycle or the Krebs cycle – is a series of chemical reactions used by all aerobic organisms to release stored energy through the oxidation of acetyl-CoA derived from carbohydrates, fats, and proteins into carbon dioxide and chemical energy in the form of adenosine triphosphate (ATP).

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Cori cycle

The Cori cycle (also known as the Lactic acid cycle), named after its discoverers, Carl Ferdinand Cori and Gerty Cori, refers to the metabolic pathway in which lactate produced by anaerobic glycolysis in the muscles moves to the liver and is converted to glucose, which then returns to the muscles and is metabolized back to lactate.

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Cytochrome c

The cytochrome complex, or cyt c is a small hemeprotein found loosely associated with the inner membrane of the mitochondrion.

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D-lactate dehydrogenase (cytochrome)

In enzymology, a D-lactate dehydrogenase (cytochrome) is an enzyme that catalyzes the chemical reaction Thus, the two substrates of this enzyme are (D)-lactate and ferricytochrome c, whereas its two products are pyruvate and ferrocytochrome c. This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with a cytochrome as acceptor.

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Dehydrogenase

A dehydrogenase (also called DH or DHase in the literature) is an enzyme belonging to the group of oxidoreductases that oxidizes a substrate by reducing an electron acceptor, usually NAD+/NADP+ or a flavin coenzyme such as FAD or FMN.

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Dysgerminoma

A dysgerminoma is a type of germ cell tumor; it usually is malignant and usually occurs in the ovary.

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Empyema

An empyema (from Greek ἐμπύημα, "abscess") is a collection or gathering of pus within a naturally existing anatomical cavity.

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Encephalitis

Encephalitis is inflammation of the brain.

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Enzyme

Enzymes are macromolecular biological catalysts.

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Exudate

An exudate is a fluid emitted by an organism through pores or a wound, a process known as exuding.

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Gene

In biology, a gene is a sequence of DNA or RNA that codes for a molecule that has a function.

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Genetic code

The genetic code is the set of rules used by living cells to translate information encoded within genetic material (DNA or mRNA sequences) into proteins.

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Glycolysis

Glycolysis (from glycose, an older term for glucose + -lysis degradation) is the metabolic pathway that converts glucose C6H12O6, into pyruvate, CH3COCOO− + H+.

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Heart

The heart is a muscular organ in most animals, which pumps blood through the blood vessels of the circulatory system.

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Hemolysis

Hemolysis or haemolysis, also known by several other names, is the rupturing (lysis) of red blood cells (erythrocytes) and the release of their contents (cytoplasm) into surrounding fluid (e.g. blood plasma).

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Histoplasmosis

Histoplasmosis (also known as "Cave disease", "Darling's disease", "Ohio valley disease", "reticuloendotheliosis", "spelunker's lung" and "caver's disease") is a disease caused by the fungus Histoplasma capsulatum.

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Hydride

In chemistry, a hydride is the anion of hydrogen, H−, or, more commonly, it is a compound in which one or more hydrogen centres have nucleophilic, reducing, or basic properties.

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Hydrostatics

Fluid statics or hydrostatics is the branch of fluid mechanics that studies fluids at rest.

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Inflammation

Inflammation (from inflammatio) is part of the complex biological response of body tissues to harmful stimuli, such as pathogens, damaged cells, or irritants, and is a protective response involving immune cells, blood vessels, and molecular mediators.

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International unit

In pharmacology, the international unit is a unit of measurement for the amount of a substance; the mass or volume that constitutes one international unit varies based on which substance is being measured, and the variance is based on the biological activity or effect, for the purpose of easier comparison across substances.

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Isozyme

Isozymes (also known as isoenzymes or more generally as multiple forms of enzymes) are enzymes that differ in amino acid sequence but catalyze the same chemical reaction.

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Kidney

The kidneys are two bean-shaped organs present in left and right sides of the body in vertebrates.

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L-lactate dehydrogenase (cytochrome)

In enzymology, an L-lactate dehydrogenase (cytochrome) (EC number 1.1.2.3) is an enzyme that catalyzes the chemical reaction Thus, the two substrates of this enzyme are (S)-lactate and ferricytochrome c, whereas its two products are pyruvate and ferrocytochrome c.

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Lactate dehydrogenase A

Lactate dehydrogenase A (LDHA) is an enzyme which in humans is encoded by the LDHA gene.

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Lactic acid

Lactic acid is an organic compound with the formula CH3CH(OH)COOH.

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Liver

The liver, an organ only found in vertebrates, detoxifies various metabolites, synthesizes proteins, and produces biochemicals necessary for digestion.

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Lung

The lungs are the primary organs of the respiratory system in humans and many other animals including a few fish and some snails.

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Lymphoma

Lymphoma is a group of blood cancers that develop from lymphocytes (a type of white blood cell).

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Medicine

Medicine is the science and practice of the diagnosis, treatment, and prevention of disease.

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Meningitis

Meningitis is an acute inflammation of the protective membranes covering the brain and spinal cord, known collectively as the meninges.

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Messenger RNA

Messenger RNA (mRNA) is a large family of RNA molecules that convey genetic information from DNA to the ribosome, where they specify the amino acid sequence of the protein products of gene expression.

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Mononuclear phagocyte system

In immunology, the mononuclear phagocyte system or mononuclear phagocytic system (MPS) (also known as the reticuloendothelial system or macrophage system) is a part of the immune system that consists of the phagocytic cells located in reticular connective tissue.

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Morpheein

Morpheeins are proteins that can form two or more different homo-oligomers (morpheein forms), but must come apart and change shape to convert between forms.

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Myocardial infarction

Myocardial infarction (MI), commonly known as a heart attack, occurs when blood flow decreases or stops to a part of the heart, causing damage to the heart muscle.

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Myoglobin

Myoglobin (symbol Mb or MB) is an iron- and oxygen-binding protein found in the muscle tissue of vertebrates in general and in almost all mammals.

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Myoglobinuria

Myoglobinuria is the presence of myoglobin in the urine, usually associated with rhabdomyolysis or muscle destruction.

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N-terminus

The N-terminus (also known as the amino-terminus, NH2-terminus, N-terminal end or amine-terminus) is the start of a protein or polypeptide referring to the free amine group (-NH2) located at the end of a polypeptide.

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Necrosis

Necrosis (from the Greek νέκρωσις "death, the stage of dying, the act of killing" from νεκρός "dead") is a form of cell injury which results in the premature death of cells in living tissue by autolysis.

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Nicotinamide adenine dinucleotide

Nicotinamide adenine dinucleotide (NAD) is a coenzyme found in all living cells.

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Oncotic pressure

Oncotic pressure, or colloid osmotic pressure, is a form of osmotic pressure exerted by proteins, notably albumin, in a blood vessel's plasma (blood/liquid) that usually tends to pull water into the circulatory system.

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Oxidoreductase

In biochemistry, an oxidoreductase is an enzyme that catalyzes the transfer of electrons from one molecule, the reductant, also called the electron donor, to another, the oxidant, also called the electron acceptor.

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Pancreas

The pancreas is a glandular organ in the digestive system and endocrine system of vertebrates.

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Pericardial effusion

Pericardial effusion ("fluid around the heart") is an abnormal accumulation of fluid in the pericardial cavity.

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Peroxisomal targeting signal

In biochemical protein targeting, a peroxisomal targeting signal (PTS) is a region of the peroxisomal protein that receptors recognize and bind to.

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Peroxisome

A peroxisome is a type of organelle known as a microbody, found in virtually all eukaryotic cells.

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Placenta

The placenta is an organ that connects the developing fetus to the uterine wall to allow nutrient uptake, thermo-regulation, waste elimination, and gas exchange via the mother's blood supply; to fight against internal infection; and to produce hormones which support pregnancy.

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Pleural effusion

A pleural effusion is excess fluid that accumulates in the pleural cavity, the fluid-filled space that surrounds the lungs.

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Pneumocystis pneumonia

Pneumocystis pneumonia (PCP) is a form of pneumonia that is caused by the yeast-like fungus Pneumocystis jirovecii.

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Prognosis

Prognosis (Greek: πρόγνωσις "fore-knowing, foreseeing") is a medical term for predicting the likely or expected development of a disease, including whether the signs and symptoms will improve or worsen (and how quickly) or remain stable over time; expectations of quality of life, such as the ability to carry out daily activities; the potential for complications and associated health issues; and the likelihood of survival (including life expectancy).

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Prokaryote

A prokaryote is a unicellular organism that lacks a membrane-bound nucleus, mitochondria, or any other membrane-bound organelle.

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Protein domain

A protein domain is a conserved part of a given protein sequence and (tertiary) structure that can evolve, function, and exist independently of the rest of the protein chain.

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Protein subunit

In structural biology, a protein subunit is a single protein molecule that assembles (or "coassembles") with other protein molecules to form a protein complex.

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Pyruvic acid

Pyruvic acid (CH3COCOOH) is the simplest of the alpha-keto acids, with a carboxylic acid and a ketone functional group.

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Reactive oxygen species

Reactive oxygen species (ROS) are chemically reactive chemical species containing oxygen.

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Red blood cell

Red blood cells-- also known as RBCs, red cells, red blood corpuscles, haematids, erythroid cells or erythrocytes (from Greek erythros for "red" and kytos for "hollow vessel", with -cyte translated as "cell" in modern usage), are the most common type of blood cell and the vertebrate's principal means of delivering oxygen (O2) to the body tissues—via blood flow through the circulatory system.

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Rhabdomyolysis

Rhabdomyolysis is a condition in which damaged skeletal muscle breaks down rapidly.

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Serum (blood)

In blood, the serum is the component that is neither a blood cell (serum does not contain white or red blood cells) nor a clotting factor; it is the blood plasma not including the fibrinogens.

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Skeletal muscle

Skeletal muscle is one of three major muscle types, the others being cardiac muscle and smooth muscle.

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Stop codon

In the genetic code, a stop codon (or termination codon) is a nucleotide triplet within messenger RNA that signals a termination of translation into proteins.

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Striated muscle tissue

Striated muscle tissue is a muscle tissue that features repeating functional units called sarcomeres, in contrast with smooth muscle tissue which does not.

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Testicle

The testicle or testis is the male reproductive gland in all animals, including humans.

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Translation

Translation is the communication of the meaning of a source-language text by means of an equivalent target-language text.

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Transudate

Transudate is extravascular fluid with low protein content and a low specific gravity (The University of Utah • Spencer S. Eccles Health Sciences Library; WebPath images Levels of lactate dehydrogenase (LDH) or a Rivalta test can be used to distinguish transudate from exudate. Their main role in nature is to protect elements of the skin and other subcutaneous substances against the contact effects of external climate and the environment and other substances – it also plays a role in integumental hygiene.

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Troponin

bibcode.

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Tumor marker

A tumor marker is a biomarker found in blood, urine, or body tissues that can be elevated by the presence of one or more types of cancer.

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Virus

A virus is a small infectious agent that replicates only inside the living cells of other organisms.

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2-Hydroxybutyric acid

2-Hydroxybutyric acid, also known as alpha-hydroxybutyrate and α-hydroxybutyrate, is a hydroxybutyric acid with the hydroxyl group on the carbon adjacent to the carboxyl.

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Redirects here:

(S)-lactate:NAD+ oxidoreductase, EC 1.1.1.27, L-lactate dehydrogenase, Lactate dehydrogenases, Lactic acid dehydrogenase, Lactic dehydrogenase.

References

[1] https://en.wikipedia.org/wiki/Lactate_dehydrogenase

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