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49 relations: Adrenal cortex, Adrenal gland, Alpha helix, Apolipoprotein, Atherosclerosis, Bronchus, Cardiovascular disease, Cell membrane, Cholesterol, Chromosome 19, Clathrin, Coronary artery disease, Cysteine, Cytosol, Disulfide, Endocytosis, Endoplasmic reticulum, Endosome, Epidermal growth factor, Epithelium, Exon, Extracellular matrix, Familial hypercholesterolemia, Gene, Golgi apparatus, Hepatitis C virus, Hyperthyroidism, Internalization, Joseph L. Goldstein, Ligand, Lipoprotein, Liver, Low-density lipoprotein, Low-density lipoprotein receptor gene family, Michael Stuart Brown, Mosaic protein, Mutation, N-terminus, Nobel Prize in Physiology or Medicine, Oligosaccharide, Phenotype, Protein domain, Protein isoform, Receptor-mediated endocytosis, Ribosome, Signal peptide, Single-nucleotide polymorphism, Statin, YWTD domain of low-density lipoprotein receptor.
Adrenal cortex
Situated along the perimeter of the adrenal gland, the adrenal cortex mediates the stress response through the production of mineralocorticoids and glucocorticoids, such as aldosterone and cortisol, respectively.
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Adrenal gland
The adrenal glands (also known as suprarenal glands) are endocrine glands that produce a variety of hormones including adrenaline and the steroids aldosterone and cortisol.
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Alpha helix
The alpha helix (α-helix) is a common motif in the secondary structure of proteins and is a righthand-spiral conformation (i.e. helix) in which every backbone N−H group donates a hydrogen bond to the backbone C.
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Apolipoprotein
Apolipoproteins are proteins that bind lipids (oil-soluble substances such as fat and cholesterol) to form lipoproteins.
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Atherosclerosis
Atherosclerosis is a disease in which the inside of an artery narrows due to the build up of plaque.
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Bronchus
A bronchus, is a passage of airway in the respiratory system that conducts air into the lungs.
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Cardiovascular disease
Cardiovascular disease (CVD) is a class of diseases that involve the heart or blood vessels.
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Cell membrane
The cell membrane (also known as the plasma membrane or cytoplasmic membrane, and historically referred to as the plasmalemma) is a biological membrane that separates the interior of all cells from the outside environment (the extracellular space).
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Cholesterol
Cholesterol (from the Ancient Greek chole- (bile) and stereos (solid), followed by the chemical suffix -ol for an alcohol) is an organic molecule.
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Chromosome 19
Chromosome 19 is one of the 23 pairs of chromosomes in humans.
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Clathrin
Clathrin is a protein that plays a major role in the formation of coated vesicles.
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Coronary artery disease
Coronary artery disease (CAD), also known as ischemic heart disease (IHD), refers to a group of diseases which includes stable angina, unstable angina, myocardial infarction, and sudden cardiac death.
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Cysteine
Cysteine (symbol Cys or C) is a semi-essential proteinogenic amino acid with the formula HO2CCH(NH2)CH2SH.
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Cytosol
The cytosol, also known as intracellular fluid (ICF) or cytoplasmic matrix, is the liquid found inside cells.
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Disulfide
In chemistry, a disulfide refers to a functional group with the structure R−S−S−R′.
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Endocytosis
Endocytosis is a form of bulk transport in which a cell transports molecules (such as proteins) into the cell (endo- + cytosis) by engulfing them in an energy-using process.
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Endoplasmic reticulum
The endoplasmic reticulum (ER) is a type of organelle found in eukaryotic cells that forms an interconnected network of flattened, membrane-enclosed sacs or tube-like structures known as cisternae.
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Endosome
In cell biology, an endosome is a membrane-bound compartment inside eukaryotic cells.
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Epidermal growth factor
Epidermal growth factor (EGF) stimulates cell growth and differentiation by binding to its receptor, EGFR.
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Epithelium
Epithelium is one of the four basic types of animal tissue, along with connective tissue, muscle tissue and nervous tissue.
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Exon
An exon is any part of a gene that will encode a part of the final mature RNA produced by that gene after introns have been removed by RNA splicing.
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Extracellular matrix
In biology, the extracellular matrix (ECM) is a collection of extracellular molecules secreted by support cells that provides structural and biochemical support to the surrounding cells.
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Familial hypercholesterolemia
Familial hypercholesterolemia (FH) is a genetic disorder characterized by high cholesterol levels, specifically very high levels of low-density lipoprotein (LDL, "bad cholesterol"), in the blood and early cardiovascular disease.
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Gene
In biology, a gene is a sequence of DNA or RNA that codes for a molecule that has a function.
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Golgi apparatus
The Golgi apparatus, also known as the Golgi complex, Golgi body, or simply the Golgi, is an organelle found in most eukaryotic cells.
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Hepatitis C virus
Hepatitis C virus (HCV) is a small (55–65 nm in size), enveloped, positive-sense single-stranded RNA virus of the family Flaviviridae.
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Hyperthyroidism
Hyperthyroidism is the condition that occurs due to excessive production of thyroid hormone by the thyroid gland.
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Internalization
Internalization (or internalisation) has different definitions depending on the field that the term is used in.
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Joseph L. Goldstein
Joseph Leonard Goldstein (born April 18, 1940) is an American biochemist.
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Ligand
In coordination chemistry, a ligand is an ion or molecule (functional group) that binds to a central metal atom to form a coordination complex.
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Lipoprotein
A lipoprotein is a biochemical assembly whose purpose is to transport hydrophobic lipid (a.k.a. fat) molecules in water, as in blood or extracellular fluid.
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Liver
The liver, an organ only found in vertebrates, detoxifies various metabolites, synthesizes proteins, and produces biochemicals necessary for digestion.
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Low-density lipoprotein
Low-density lipoprotein (LDL) is one of the five major groups of lipoprotein which transport all fat molecules around the body in the extracellular water.
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Low-density lipoprotein receptor gene family
The low-density lipoprotein receptor gene family codes for a class of structurally related cell surface receptors that fulfill diverse biological functions in different organs, tissues, and cell types.
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Michael Stuart Brown
Michael Stuart Brown (born April 13, 1941) is an American geneticist and Nobel laureate.
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Mosaic protein
Proteins are made up of amino acids which connect by peptide bonds and form into polypeptide chains.
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Mutation
In biology, a mutation is the permanent alteration of the nucleotide sequence of the genome of an organism, virus, or extrachromosomal DNA or other genetic elements.
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N-terminus
The N-terminus (also known as the amino-terminus, NH2-terminus, N-terminal end or amine-terminus) is the start of a protein or polypeptide referring to the free amine group (-NH2) located at the end of a polypeptide.
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Nobel Prize in Physiology or Medicine
The Nobel Prize in Physiology or Medicine (Nobelpriset i fysiologi eller medicin), administered by the Nobel Foundation, is awarded once a year for outstanding discoveries in the fields of life sciences and medicine.
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Oligosaccharide
An oligosaccharide (from the Greek ὀλίγος olígos, "a few", and σάκχαρ sácchar, "sugar") is a saccharide polymer containing a small number (typically three to ten) of monosaccharides (simple sugars).
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Phenotype
A phenotype is the composite of an organism's observable characteristics or traits, such as its morphology, development, biochemical or physiological properties, behavior, and products of behavior (such as a bird's nest).
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Protein domain
A protein domain is a conserved part of a given protein sequence and (tertiary) structure that can evolve, function, and exist independently of the rest of the protein chain.
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Protein isoform
A protein isoform, or "protein variant" is a member of a set of highly similar proteins that originate from a single gene or gene family and are the result of genetic differences.
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Receptor-mediated endocytosis
Receptor-mediated endocytosis (RME), also called clathrin-mediated endocytosis, is a process by which cells absorb metabolites, hormones, other proteins – and in some cases viruses – by the inward budding of plasma membrane vesicles containing proteins with receptor sites specific to the molecules being absorbed (endocytosis).
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Ribosome
The ribosome is a complex molecular machine, found within all living cells, that serves as the site of biological protein synthesis (translation).
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Signal peptide
A signal peptide (sometimes referred to as signal sequence, targeting signal, localization signal, localization sequence, transit peptide, leader sequence or leader peptide) is a short peptide (usually 16-30 amino acids long) present at the N-terminus of the majority of newly synthesized proteins that are destined towards the secretory pathway.
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Single-nucleotide polymorphism
A single-nucleotide polymorphism, often abbreviated to SNP (plural), is a variation in a single nucleotide that occurs at a specific position in the genome, where each variation is present to some appreciable degree within a population (e.g. > 1%).
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Statin
Statins, also known as HMG-CoA reductase inhibitors, are a class of lipid-lowering medications.
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YWTD domain of low-density lipoprotein receptor
The low-density lipoprotein receptor (LDLR) regulates cholesterol homeostasis in mammalian cells.
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LDL receptors, LDLR, LDLR (gene), Ldl receptor, Ldl-receptor related protein 2, Ldl-receptor related protein-associated protein, Low density lipoprotein receptor, Low-density lipoprotein receptor, Receptors, ldl.
References
[1] https://en.wikipedia.org/wiki/LDL_receptor
