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18 relations: Amino acid, Atherosclerosis, Coronary artery disease, Darapladib, Enzyme, Gene, High-density lipoprotein, Low-density lipoprotein, Macrophage, Meta-analysis, PAF acetylhydrolase, Phospholipase A2, Phospholipid, Platelet-activating factor, Protein, Stroke, Tunica intima, White blood cell.
Amino acid
Amino acids are organic compounds containing amine (-NH2) and carboxyl (-COOH) functional groups, along with a side chain (R group) specific to each amino acid.
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Atherosclerosis
Atherosclerosis is a disease in which the inside of an artery narrows due to the build up of plaque.
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Coronary artery disease
Coronary artery disease (CAD), also known as ischemic heart disease (IHD), refers to a group of diseases which includes stable angina, unstable angina, myocardial infarction, and sudden cardiac death.
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Darapladib
Darapladib is an inhibitor lipoprotein-associated phospholipase A2 (Lp-PLA2) that is in development as a drug for treatment of atherosclerosis.
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Enzyme
Enzymes are macromolecular biological catalysts.
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Gene
In biology, a gene is a sequence of DNA or RNA that codes for a molecule that has a function.
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High-density lipoprotein
High-density lipoproteins (HDL) are one of the five major groups of lipoproteins.
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Low-density lipoprotein
Low-density lipoprotein (LDL) is one of the five major groups of lipoprotein which transport all fat molecules around the body in the extracellular water.
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Macrophage
Macrophages (big eaters, from Greek μακρός (makrós).
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Meta-analysis
A meta-analysis is a statistical analysis that combines the results of multiple scientific studies.
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PAF acetylhydrolase
PAF acetylhydrolase is an enzyme that catabolizes platelet-activating factor.
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Phospholipase A2
Phospholipases A2 (PLA2s) are enzymes that release fatty acids from the second carbon group of glycerol.
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Phospholipid
Phospholipids are a class of lipids that are a major component of all cell membranes.
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Platelet-activating factor
Platelet-activating factor, also known as PAF, PAF-acether or AGEPC (acetyl-glyceryl-ether-phosphorylcholine), is a potent phospholipid activator and mediator of many leukocyte functions, platelet aggregation and degranulation, inflammation, and anaphylaxis.
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Protein
Proteins are large biomolecules, or macromolecules, consisting of one or more long chains of amino acid residues.
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Stroke
A stroke is a medical condition in which poor blood flow to the brain results in cell death.
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Tunica intima
The tunica intima (New Latin "inner coat"), or intima for short, is the innermost tunica (layer) of an artery or vein.
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White blood cell
White blood cells (WBCs), also called leukocytes or leucocytes, are the cells of the immune system that are involved in protecting the body against both infectious disease and foreign invaders.
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Lp-PLA2, PAF-AH, PLA2G7, PLA2G7 (gene).
References
[1] https://en.wikipedia.org/wiki/Lipoprotein-associated_phospholipase_A2
