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62 relations: Adenylyl cyclase, Agonist, Alkaloid, Amygdala, Analgesic, Arrestin, Arrestin beta 1, Arrestin beta 2, Barbiturate, Benzodiazepine, Beta-Endorphin, Biochemical Pharmacology (journal), Blood pressure, Bradycardia, Bradypnea, Cardiac output, Cerebral cortex, Chemical synapse, Circulatory collapse, Constipation, Cyclic adenosine monophosphate, Dynorphin, Enkephalin, Ethanol, Euphoria, Functional selectivity, G protein–coupled receptor, Gamma-Aminobutyric acid, Gastrin-releasing peptide receptor, Gi alpha subunit, Hypotension, Hypoxemia, Itch, Δ-opioid receptor, Κ-opioid receptor, Miosis, Morphine, Naloxone, Nausea, Nucleus (neuroanatomy), Nucleus accumbens, Olfactory bulb, Opioid peptide, Opioid receptor, Opium, Peptide, Periaqueductal gray, Posterior grey column, Potentiator, Receptor antagonist, ..., Regulator of G protein signaling, Reverse transcription polymerase chain reaction, RGS14, RGS17, RGS4, RGS9, Sedation, Spinal cord, Substantia gelatinosa of Rolando, Tachyphylaxis, TRIMU 5, Vasodilation. Expand index (12 more) »
Adenylyl cyclase
Adenylyl cyclase (also commonly known as adenyl cyclase and adenylate cyclase, abbreviated AC) is an enzyme with key regulatory roles in essentially all cells.
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Agonist
An agonist is a chemical that binds to a receptor and activates the receptor to produce a biological response.
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Alkaloid
Alkaloids are a class of naturally occurring chemical compounds that mostly contain basic nitrogen atoms.
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Amygdala
The amygdala (plural: amygdalae; also corpus amygdaloideum; Latin from Greek, ἀμυγδαλή, amygdalē, 'Almond', 'tonsil') is one of two almond-shaped groups of nuclei located deep and medially within the temporal lobes of the brain in complex vertebrates, including humans.
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Analgesic
An analgesic or painkiller is any member of the group of drugs used to achieve analgesia, relief from pain.
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Arrestin
Arrestins (abbreviated Arr) are a small family of proteins important for regulating signal transduction at G protein-coupled receptors.
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Arrestin beta 1
Arrestin, beta 1, also known as ARRB1, is a protein which in humans is encoded by the ARRB1 gene.
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Arrestin beta 2
Beta-arrestin-2, also known as arrestin beta-2, is an intracellular protein that in humans is encoded by the ARRB2 gene.
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Barbiturate
A barbiturate is a drug that acts as a central nervous system depressant, and can therefore produce a wide spectrum of effects, from mild sedation to death.
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Benzodiazepine
Benzodiazepines (BZD, BZs), sometimes called "benzos", are a class of psychoactive drugs whose core chemical structure is the fusion of a benzene ring and a diazepine ring.
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Beta-Endorphin
β-Endorphin is an endogenous opioid neuropeptide and peptide hormone that is produced in certain neurons within the central nervous system and peripheral nervous system.
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Biochemical Pharmacology (journal)
Biochemical Pharmacology is a peer-reviewed medical journal published by Elsevier.
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Blood pressure
Blood pressure (BP) is the pressure of circulating blood on the walls of blood vessels.
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Bradycardia
Bradycardia is a condition wherein an individual has a very slow heart rate, typically defined as a resting heart rate of under 60 beats per minute (BPM) in adults.
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Bradypnea
Bradypnea or bradypnoea is abnormally slow breathing.
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Cardiac output
Cardiac output (CO, also denoted by the symbols Q and \dot Q_), is a term used in cardiac physiology that describes the volume of blood being pumped by the heart, in particular by the left or right ventricle, per unit time.
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Cerebral cortex
The cerebral cortex is the largest region of the cerebrum in the mammalian brain and plays a key role in memory, attention, perception, cognition, awareness, thought, language, and consciousness.
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Chemical synapse
Chemical synapses are biological junctions through which neurons' signals can be exchanged to each other and to non-neuronal cells such as those in muscles or glands.
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Circulatory collapse
A circulatory collapse is defined as a general or specific failure of the circulation, either cardiac or peripheral in nature.
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Constipation
Constipation refers to bowel movements that are infrequent or hard to pass.
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Cyclic adenosine monophosphate
Cyclic adenosine monophosphate (cAMP, cyclic AMP, or 3',5'-cyclic adenosine monophosphate) is a second messenger important in many biological processes.
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Dynorphin
Dynorphins (Dyn) are a class of opioid peptides that arise from the precursor protein prodynorphin.
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Enkephalin
An enkephalin (occasionally spelled encephalin) is a pentapeptide involved in regulating nociception in the body.
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Ethanol
Ethanol, also called alcohol, ethyl alcohol, grain alcohol, and drinking alcohol, is a chemical compound, a simple alcohol with the chemical formula.
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Euphoria
Euphoria is an affective state in which a person experiences pleasure or excitement and intense feelings of well-being and happiness.
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Functional selectivity
Functional selectivity (or “agonist trafficking”, “biased agonism”, “biased signalling”, "ligand bias" and “differential engagement”) is the ligand-dependent selectivity for certain signal transduction pathways relative to a reference ligand (often the endogenous hormone or peptide) at the same receptor.
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G protein–coupled receptor
G protein–coupled receptors (GPCRs), also known as seven-(pass)-transmembrane domain receptors, 7TM receptors, heptahelical receptors, serpentine receptor, and G protein–linked receptors (GPLR), constitute a large protein family of receptors that detect molecules outside the cell and activate internal signal transduction pathways and, ultimately, cellular responses.
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Gamma-Aminobutyric acid
gamma-Aminobutyric acid, or γ-aminobutyric acid, or GABA, is the chief inhibitory neurotransmitter in the mammalian central nervous system.
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Gastrin-releasing peptide receptor
The gastrin-releasing peptide receptor (GRPR), now properly known as BB2 is a G protein-coupled receptor whose endogenous ligand is gastrin releasing peptide.
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Gi alpha subunit
Gi alpha subunit (Gαi, or Gi/G0 or Gi protein) is a heterotrimeric G protein subunit that inhibits the production of cAMP from ATP.
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Hypotension
Hypotension is low blood pressure, especially in the arteries of the systemic circulation.
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Hypoxemia
Hypoxemia (or hypoxaemia in British English) is an abnormally low level of oxygen in the blood.
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Itch
Itch (also known as pruritus) is a sensation that causes the desire or reflex to scratch.
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Δ-opioid receptor
The δ-opioid receptor, also known as delta opioid receptor or simply delta receptor, abbreviated DOR, is an inhibitory 7-transmembrane G-protein coupled receptor coupled to the G protein Gi/G0 and has enkephalins as its endogenous ligands.
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Κ-opioid receptor
The κ-opioid receptor (KOR) is a G protein-coupled receptor that in humans is encoded by the OPRK1 gene.
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Miosis
Miosis is excessive constriction of the pupil.
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Morphine
Morphine is a pain medication of the opiate variety which is found naturally in a number of plants and animals.
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Naloxone
Naloxone, sold under the brandname Narcan among others, is a medication used to block the effects of opioids, especially in overdose.
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Nausea
Nausea or queasiness is an unpleasant sense of unease, discomfort, and revulsion towards food.
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Nucleus (neuroanatomy)
In neuroanatomy, a nucleus (plural form: nuclei) is a cluster of neurons in the central nervous system, located deep within the cerebral hemispheres and brainstem.
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Nucleus accumbens
The nucleus accumbens (NAc or NAcc), also known as the accumbens nucleus, or formerly as the nucleus accumbens septi (Latin for nucleus adjacent to the septum) is a region in the basal forebrain rostral to the preoptic area of the hypothalamus.
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Olfactory bulb
The olfactory bulb (bulbus olfactorius) is a neural structure of the vertebrate forebrain involved in olfaction, the sense of smell.
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Opioid peptide
Opioid peptides are peptides that bind to opioid receptors in the brain; opiates and opioids mimic the effect of these peptides.
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Opioid receptor
Opioid receptors are a group of inhibitory G protein-coupled receptors with opioids as ligands.
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Opium
Opium (poppy tears, with the scientific name: Lachryma papaveris) is the dried latex obtained from the opium poppy (scientific name: Papaver somniferum).
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Peptide
Peptides (from Gr.: πεπτός, peptós "digested"; derived from πέσσειν, péssein "to digest") are short chains of amino acid monomers linked by peptide (amide) bonds.
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Periaqueductal gray
The periaqueductal gray (PAG, also known as the central gray) is the primary control center for descending pain modulation.
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Posterior grey column
The posterior grey column (posterior cornu, dorsal horn, spinal dorsal horn posterior horn) of the spinal cord is one of the three grey columns of the spinal cord.
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Potentiator
In clinical terms, a potentiator is a reagent that enhances sensitization of an antigen.
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Receptor antagonist
A receptor antagonist is a type of receptor ligand or drug that blocks or dampens a biological response by binding to and blocking a receptor rather than activating it like an agonist.
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Regulator of G protein signaling
Regulators of G protein signaling (or RGS) are protein structural domains that activate GTPases for heterotrimeric G-protein alpha-subunits.
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Reverse transcription polymerase chain reaction
Reverse transcription polymerase chain reaction (RT-PCR), a variant of polymerase chain reaction (PCR), is a technique commonly used in molecular biology to detect RNA expression.
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RGS14
Regulator of G-protein signaling 14 (RGS14) is a protein that in humans is encoded by the RGS14 gene.
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RGS17
Regulator of G-protein signaling 17 is a protein that in humans is encoded by the RGS17 gene.
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RGS4
Regulator of G protein signaling 4 also known as RGP4 is a protein that in humans is encoded by the RGS4 gene.
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RGS9
Regulator of G-protein signalling 9, also known as RGS9, is a human gene, which codes for a protein involved in regulation of signal transduction inside cells.
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Sedation
Sedation is the reduction of irritability or agitation by administration of sedative drugs, generally to facilitate a medical procedure or diagnostic procedure.
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Spinal cord
The spinal cord is a long, thin, tubular bundle of nervous tissue and support cells that extends from the medulla oblongata in the brainstem to the lumbar region of the vertebral column.
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Substantia gelatinosa of Rolando
The apex of the posterior grey column, one of the three grey columns of the spinal cord, is capped by a V-shaped or crescentic mass of translucent, gelatinous neuroglia, termed the substantia gelatinosa of Rolando (or SGR) (or gelatinous substance of posterior horn of spinal cord), which contains both neuroglia cells, and small nerve cells.
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Tachyphylaxis
Tachyphylaxis (Greek ταχύς, tachys, "rapid", and φύλαξις, phylaxis, "protection") is a medical term describing an acute, sudden decrease in response to a drug after its administration, i.e. a rapid and short-term onset of drug tolerance.
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TRIMU 5
TRIMU 5 is a selective agonist of the mu opioid receptor type 2.
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Vasodilation
Vasodilation is the widening of blood vessels.
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Redirects here:
M-opioid receptor, MOR1, Mu Opioid, Mu Opioid receptor, Mu opioid receptor, Mu receptor, Mu receptors, Mu-3 receptor, Mu-Opioid receptor, Mu-opioid receptor, OPRM, OPRM1, OPRM1 (gene).
References
[1] https://en.wikipedia.org/wiki/Μ-opioid_receptor
