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88 relations: ACTH receptor, Adrenal cortex, Adrenocorticotropic hormone, Alzheimer's disease, Anorexia nervosa, AP-1 transcription factor, Apoptosis, Atherosclerosis, Atypical antipsychotic, Autism, Basal forebrain, Bcl-2, Beta cell, Biomolecular structure, Bipolar disorder, Brain-derived neurotrophic factor, Bulimia nervosa, C-jun, C-Jun N-terminal kinases, Cardiovascular disease, Centenarian, Corneal ulcer, Cortisol, CREB, Dehydroepiandrosterone, Dementia, Diabetes mellitus, Endometriosis, Fulranumab, GAB1, GRB2, Growth factor, Hericium erinaceus, Homeostasis, Huperzine A, Hypothalamic–pituitary–adrenal axis, Immune system, Inflammation, Lithium, Low-affinity nerve growth factor receptor, Major depressive disorder, Mania, Mast cell, Medical University of South Carolina, Mental disorder, Mitogen-activated protein kinase, Multiple sclerosis, Nervous system, Neurodegeneration, Neuron, ..., Neuropeptide, Neurotrophic factor receptor, Neurotrophic factors, Neurotrophin, Neurotrophin-3, Neurotrophin-4, NF-κB, Nobel Prize, Obesity, Personalized medicine, Phosphoinositide 3-kinase, Phospholipase C, Polygala tenuifolia, Programmed cell death, Prostaglandin E2, Protein kinase B, Protein targeting, Protein–protein interaction, RAF kinase, Ras subfamily, Rett syndrome, Ribosomal s6 kinase, Rita Levi-Montalcini, Schizophrenia, Sensory neuron, Signal transducing adaptor protein, Stanley Cohen (biochemist), T helper cell, Tanezumab, TRAF6, Tropomyosin receptor kinase A, Typical antipsychotic, Ulcer (dermatology), Unified atomic mass unit, Vasopressin, VGF, Washington University in St. Louis, Zona fasciculata. Expand index (38 more) »
ACTH receptor
The adrenocorticotropic hormone receptor or ACTH receptor also known as the melanocortin receptor 2 or MC2 receptor is a type of melanocortin receptor (type 2) which is specific for ACTH.
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Adrenal cortex
Situated along the perimeter of the adrenal gland, the adrenal cortex mediates the stress response through the production of mineralocorticoids and glucocorticoids, such as aldosterone and cortisol, respectively.
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Adrenocorticotropic hormone
Adrenocorticotropic hormone (ACTH, also adrenocorticotropin, corticotropin) is a polypeptide tropic hormone produced by and secreted by the anterior pituitary gland.
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Alzheimer's disease
Alzheimer's disease (AD), also referred to simply as Alzheimer's, is a chronic neurodegenerative disease that usually starts slowly and worsens over time.
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Anorexia nervosa
Anorexia nervosa, often referred to simply as anorexia, is an eating disorder characterized by low weight, fear of gaining weight, and a strong desire to be thin, resulting in food restriction.
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AP-1 transcription factor
Activator protein 1 (AP-1) is a transcription factor that regulates gene expression in response to a variety of stimuli, including cytokines, growth factors, stress, and bacterial and viral infections.
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Apoptosis
Apoptosis (from Ancient Greek ἀπόπτωσις "falling off") is a process of programmed cell death that occurs in multicellular organisms.
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Atherosclerosis
Atherosclerosis is a disease in which the inside of an artery narrows due to the build up of plaque.
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Atypical antipsychotic
The atypical antipsychotics (AAP; also known as second generation antipsychotics (SGAs)) are a group of antipsychotic drugs (antipsychotic drugs in general are also known as major tranquilizers and neuroleptics, although the latter is usually reserved for the typical antipsychotics) used to treat psychiatric conditions.
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Autism
Autism is a developmental disorder characterized by troubles with social interaction and communication and by restricted and repetitive behavior.
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Basal forebrain
The basal forebrain structures are located in the forebrain to the front of and below the striatum.
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Bcl-2
Bcl-2 (B-cell lymphoma 2), encoded in humans by the BCL2 gene, is the founding member of the Bcl-2 family of regulator proteins that regulate cell death (apoptosis), by either inducing (pro-apoptotic) or inhibiting (anti-apoptotic) apoptosis.
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Beta cell
Beta cells (β cells) are a type of cell found in the pancreatic islets of the pancreas.
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Biomolecular structure
Biomolecular structure is the intricate folded, three-dimensional shape that is formed by a molecule of protein, DNA, or RNA, and that is important to its function.
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Bipolar disorder
Bipolar disorder, previously known as manic depression, is a mental disorder that causes periods of depression and periods of abnormally elevated mood.
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Brain-derived neurotrophic factor
Brain-derived neurotrophic factor, also known as BDNF, is a protein that, in humans, is encoded by the BDNF gene.
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Bulimia nervosa
Bulimia nervosa, also known as simply bulimia, is an eating disorder characterized by binge eating followed by purging.
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C-jun
c-Jun is a protein that in humans is encoded by the JUN gene.
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C-Jun N-terminal kinases
c-Jun N-terminal kinases (JNKs), were originally identified as kinases that bind and phosphorylate c-Jun on Ser-63 and Ser-73 within its transcriptional activation domain.
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Cardiovascular disease
Cardiovascular disease (CVD) is a class of diseases that involve the heart or blood vessels.
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Centenarian
A centenarian is a person who lives to or beyond the age of 100 years.
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Corneal ulcer
Corneal ulcer, or ulcerative keratitis, is an inflammatory or more seriously, infective condition of the cornea involving disruption of its epithelial layer with involvement of the corneal stroma.
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Cortisol
Cortisol is a steroid hormone, in the glucocorticoid class of hormones.
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CREB
CREB (cAMP response element-binding protein) is a cellular transcription factor.
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Dehydroepiandrosterone
Dehydroepiandrosterone (DHEA), also known as androstenolone, is an endogenous steroid hormone.
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Dementia
Dementia is a broad category of brain diseases that cause a long-term and often gradual decrease in the ability to think and remember that is great enough to affect a person's daily functioning.
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Diabetes mellitus
Diabetes mellitus (DM), commonly referred to as diabetes, is a group of metabolic disorders in which there are high blood sugar levels over a prolonged period.
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Endometriosis
Endometriosis is a condition in which the endometrium, the layer of tissue that normally covers the inside of the uterus, grows outside of it.
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Fulranumab
Fulranumab is a monoclonal antibody against nerve growth factor.
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GAB1
GRB2-associated-binding protein 1 is a protein that in humans is encoded by the GAB1 gene.
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GRB2
Growth factor receptor-bound protein 2 also known as Grb2 is an adaptor protein involved in signal transduction/cell communication.
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Growth factor
A growth factor is a naturally occurring substance capable of stimulating cellular growth, proliferation, healing, and cellular differentiation.
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Hericium erinaceus
Hericium erinaceus (also called lion's mane mushroom, monkey head, bearded tooth mushroom, satyr's beard, bearded hedgehog mushroom, pom pom mushroom, or bearded tooth fungus) is an edible and medicinal mushroom belonging to the tooth fungus group.
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Homeostasis
Homeostasis is the tendency of organisms to auto-regulate and maintain their internal environment in a stable state.
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Huperzine A
Huperzine A is a naturally occurring sesquiterpene alkaloid compound found in the firmoss Huperzia serrata and in varying quantities in other Huperzia species, including H. elmeri, H. carinat, and H. aqualupian.
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Hypothalamic–pituitary–adrenal axis
The hypothalamic–pituitary–adrenal axis (HPA axis or HTPA axis) is a complex set of direct influences and feedback interactions among three components: the hypothalamus, the pituitary gland (a pea-shaped structure located below the thalamus), and the adrenal (also called "suprarenal") glands (small, conical organs on top of the kidneys).
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Immune system
The immune system is a host defense system comprising many biological structures and processes within an organism that protects against disease.
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Inflammation
Inflammation (from inflammatio) is part of the complex biological response of body tissues to harmful stimuli, such as pathogens, damaged cells, or irritants, and is a protective response involving immune cells, blood vessels, and molecular mediators.
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Lithium
Lithium (from lit) is a chemical element with symbol Li and atomic number 3.
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Low-affinity nerve growth factor receptor
The low-affinity nerve growth factor receptor (nerve growth factor receptor (TNFR superfamily, member 16), also called the LNGFR or p75 neurotrophin receptor) is one of the two receptor types for the neurotrophins, a family of protein growth factors that stimulate neuronal cells to survive and differentiate.
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Major depressive disorder
Major depressive disorder (MDD), also known simply as depression, is a mental disorder characterized by at least two weeks of low mood that is present across most situations.
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Mania
Mania, also known as manic syndrome, is a state of abnormally elevated arousal, affect, and energy level, or "a state of heightened overall activation with enhanced affective expression together with lability of affect." Although mania is often conceived as a "mirror image" to depression, the heightened mood can be either euphoric or irritable; indeed, as the mania intensifies, irritability can be more pronounced and result in violence, or anxiety.
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Mast cell
A mast cell (also known as a mastocyte or a labrocyte) is a type of white blood cell.
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Medical University of South Carolina
The Medical University of South Carolina (MUSC) opened in Charleston, South Carolina in 1824 as a small private college for the training of physicians.
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Mental disorder
A mental disorder, also called a mental illness or psychiatric disorder, is a behavioral or mental pattern that causes significant distress or impairment of personal functioning.
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Mitogen-activated protein kinase
A mitogen-activated protein kinase (MAPK or MAP kinase) is a type of protein kinase that is specific to the amino acids serine and threonine (i.e., a serine/threonine-specific protein kinase).
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Multiple sclerosis
Multiple sclerosis (MS) is a demyelinating disease in which the insulating covers of nerve cells in the brain and spinal cord are damaged.
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Nervous system
The nervous system is the part of an animal that coordinates its actions by transmitting signals to and from different parts of its body.
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Neurodegeneration
Neurodegeneration is the progressive loss of structure or function of neurons, including death of neurons.
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Neuron
A neuron, also known as a neurone (British spelling) and nerve cell, is an electrically excitable cell that receives, processes, and transmits information through electrical and chemical signals.
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Neuropeptide
Neuropeptides are small protein-like molecules (peptides) used by neurons to communicate with each other.
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Neurotrophic factor receptor
Neurotrophic factor receptors or neurotrophin receptors are a group of growth factor receptors which specifically bind to neurotrophins (neurotrophic factors).
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Neurotrophic factors
Neurotrophic factors (NTFs) are a family of biomolecules – nearly all of which are peptides or small proteins – that support the growth, survival, and differentiation of both developing and mature neurons.
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Neurotrophin
Neurotrophins are a family of proteins that induce the survival, development, and function of neurons.
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Neurotrophin-3
Neurotrophin-3 is a protein that in humans is encoded by the NTF3 gene.
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Neurotrophin-4
Neurotrophin-4 (NT-4), also known as neurotrophin-5 (NT-5), is a protein that in humans is encoded by the NTF4 gene.
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NF-κB
NF-κB (nuclear factor kappa-light-chain-enhancer of activated B cells) is a protein complex that controls transcription of DNA, cytokine production and cell survival.
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Nobel Prize
The Nobel Prize (Swedish definite form, singular: Nobelpriset; Nobelprisen) is a set of six annual international awards bestowed in several categories by Swedish and Norwegian institutions in recognition of academic, cultural, or scientific advances.
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Obesity
Obesity is a medical condition in which excess body fat has accumulated to the extent that it may have a negative effect on health.
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Personalized medicine
Personalized medicine, also termed precision medicine, is a medical procedure that separates patients into different groups—with medical decisions, practices, interventions and/or products being tailored to the individual patient based on their predicted response or risk of disease.
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Phosphoinositide 3-kinase
Phosphatidylinositol-4,5-bisphosphate 3-kinase (also called phosphatidylinositide 3-kinases, phosphatidylinositol-3-kinases, PI 3-kinases, PI(3)Ks, PI-3Ks or by the HUGO official stem symbol for the gene family, PI3K(s)) are a family of enzymes involved in cellular functions such as cell growth, proliferation, differentiation, motility, survival and intracellular trafficking, which in turn are involved in cancer.
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Phospholipase C
Phospholipase C (PLC) is a class of membrane-associated enzymes that cleave phospholipids just before the phosphate group (see figure).
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Polygala tenuifolia
Polygala tenuifolia (yuan zhi) is an herb in the family Polygalaceae which is hardy to USDA Zone 6.
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Programmed cell death
Programmed cell death (or PCD) is the death of a cell in any form, mediated by an intracellular program.
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Prostaglandin E2
Prostaglandin E2 (PGE2), also known as dinoprostone, is a naturally occurring prostaglandin which is used as a medication.
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Protein kinase B
Protein kinase B (PKB), also known as Akt, is a serine/threonine-specific protein kinase that plays a key role in multiple cellular processes such as glucose metabolism, apoptosis, cell proliferation, transcription and cell migration.
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Protein targeting
Protein targeting or protein sorting is the biological mechanism by which proteins are transported to the appropriate destinations in the cell or outside it.
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Protein–protein interaction
Protein–protein interactions (PPIs) are the physical contacts of high specificity established between two or more protein molecules as a result of biochemical events steered by electrostatic forces including the hydrophobic effect.
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RAF kinase
RAF kinases are a family of three serine/threonine-specific protein kinases that are related to retroviral oncogenes.
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Ras subfamily
Ras is a family of related proteins which is expressed in all animal cell lineages and organs.
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Rett syndrome
Rett syndrome (RTT) is a genetic brain disorder which typically becomes apparent after 6 to 18 months of age in females.
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Ribosomal s6 kinase
In molecular biology, ribosomal s6 kinase (rsk) is a family of protein kinases involved in signal transduction.
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Rita Levi-Montalcini
Rita Levi-Montalcini, (22 April 1909 – 30 December 2012) was an Italian Nobel laureate, honored for her work in neurobiology.
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Schizophrenia
Schizophrenia is a mental disorder characterized by abnormal social behavior and failure to understand reality.
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Sensory neuron
Sensory neurons also known as afferent neurons are neurons that convert a specific type of stimulus, via their receptors, into action potentials or graded potentials.
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Signal transducing adaptor protein
Signal transducing adaptor proteins are proteins that are accessory to main proteins in a signal transduction pathway.
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Stanley Cohen (biochemist)
Stanley Cohen (born November 17, 1922) is an American biochemist who, along with Rita Levi-Montalcini, was awarded the Nobel Prize in Physiology or Medicine in 1986 for the isolation of nerve growth factor and the discovery of epidermal growth factor.
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T helper cell
The T helper cells (Th cells) are a type of T cell that play an important role in the immune system, particularly in the adaptive immune system.
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Tanezumab
Tanezumab (INN, codenamed RN624) is a monoclonal antibody against nerve growth factor.
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TRAF6
TRAF6 is a TRAF human protein.
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Tropomyosin receptor kinase A
Tropomyosin receptor kinase A (TrkA), also known as high affinity nerve growth factor receptor, neurotrophic tyrosine kinase receptor type 1, or TRK1-transforming tyrosine kinase protein is a protein that in humans is encoded by the NTRK1 gene.
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Typical antipsychotic
Typical antipsychotics are a class of antipsychotic drugs first developed in the 1950s and used to treat psychosis (in particular, schizophrenia).
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Ulcer (dermatology)
An ulcer is a sore on the skin or a mucous membrane, accompanied by the disintegration of tissue.
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Unified atomic mass unit
The unified atomic mass unit or dalton (symbol: u, or Da) is a standard unit of mass that quantifies mass on an atomic or molecular scale (atomic mass).
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Vasopressin
Vasopressin, also named antidiuretic hormone (ADH), arginine vasopressin (AVP) or argipressin, is a hormone synthesized as a peptide prohormone in neurons in the hypothalamus, and is converted to AVP.
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VGF
VGF or VGF nerve growth factor inducible is a secreted protein and neuropeptide precursor that may play a role in regulating energy homeostasis, metabolism and synaptic plasticity.
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Washington University in St. Louis
Washington University in St.
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Zona fasciculata
The zona fasciculata constitutes the middle and also the widest zone of the adrenal cortex, sitting directly beneath the zona glomerulosa.
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NGF (gene), NGFB, NGFß, Nerve Growth Factor, Nerve growth factor (beta polypeptide), Nerve growth factors, Neurogrowth factor, Receptor, nerve growth factor, Receptors, nerve growth factor, TNFSF16.
References
[1] https://en.wikipedia.org/wiki/Nerve_growth_factor
