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Norepinephrine reuptake inhibitor

Index Norepinephrine reuptake inhibitor

A norepinephrine reuptake inhibitor (NRI, NERI) or adrenergic reuptake inhibitor (ARI), is a type of drug that acts as a reuptake inhibitor for the neurotransmitters norepinephrine (noradrenaline) and epinephrine (adrenaline) by blocking the action of the norepinephrine transporter (NET). [1]

54 relations: Adrenaline, Adrenergic, Amedalin, Anorectic, Antidepressant, Anxiety disorder, Atomoxetine, Attention deficit hyperactivity disorder, Bupropion, Ciclazindol, Cocaine, Concentration, CP-39,332, Daledalin, Desipramine, Dopamine reuptake inhibitor, Drug, Drug action, Edivoxetine, Esreboxetine, Extracellular, Lortalamine, Major depressive disorder, Manifaxine, Maprotiline, Methylphenidate, Monoamine reuptake inhibitor, Monoamine transporter, Narcolepsy, Neurotransmission, Neurotransmitter, Nisoxetine, Norepinephrine, Norepinephrine releasing agent, Norepinephrine transporter, Norepinephrine–dopamine reuptake inhibitor, Nortriptyline, Obesity, Panic disorder, Protriptyline, Radafaxine, Reboxetine, Reuptake inhibitor, Serotonin–norepinephrine reuptake inhibitor, Serotonin–norepinephrine–dopamine reuptake inhibitor, Stimulant, Substance abuse, Talopram, Talsupram, Tandamine, ..., Tapentadol, Teniloxazine, Tricyclic antidepressant, Viloxazine. Expand index (4 more) »

Adrenaline

Adrenaline, also known as adrenalin or epinephrine, is a hormone, neurotransmitter, and medication.

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Adrenergic

Adrenergic means "working on adrenaline (epinephrine) or noradrenaline (norepinephrine)".

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Amedalin

Amedalin (UK-3540-1) is an antidepressant which was synthesized in the early 1970s, but was never marketed.

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Anorectic

An anorectic or anorexic is a drug which reduces appetite, resulting in lower food consumption, leading to weight loss.

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Antidepressant

Antidepressants are drugs used for the treatment of major depressive disorder and other conditions, including dysthymia, anxiety disorders, obsessive–compulsive disorder, eating disorders, chronic pain, neuropathic pain and, in some cases, dysmenorrhoea, snoring, migraine, attention-deficit hyperactivity disorder (ADHD), addiction, dependence, and sleep disorders.

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Anxiety disorder

Anxiety disorders are a group of mental disorders characterized by significant feelings of anxiety and fear.

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Atomoxetine

Atomoxetine, sold under the brand name Strattera among others, is a norepinephrine (noradrenaline) reuptake inhibitor which is approved for the treatment of attention deficit hyperactivity disorder (ADHD).

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Attention deficit hyperactivity disorder

Attention-deficit hyperactivity disorder (ADHD) is a mental disorder of the neurodevelopmental type.

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Bupropion

Bupropion, sold under the brand names Wellbutrin and Zyban among others, is a medication primarily used as an antidepressant and smoking cessation aid.

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Ciclazindol

Ciclazindol (WY-23,409) is an antidepressant and anorectic drug of the tetracyclic chemical class that was developed in the mid to late 1970s, but was never marketed.

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Cocaine

Cocaine, also known as coke, is a strong stimulant mostly used as a recreational drug.

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Concentration

In chemistry, concentration is the abundance of a constituent divided by the total volume of a mixture.

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CP-39,332

CP-39,332 is a drug which acts as a serotonin-norepinephrine reuptake inhibitor.

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Daledalin

Daledalin (UK-3557-15) is an antidepressant which was synthesized and trialed for depression in the early 1970s, but was never marketed.

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Desipramine

Desipramine, sold under the brand name Norpramin and Pertofrane among others, is a tricyclic antidepressant (TCA) which is used in the treatment of depression.

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Dopamine reuptake inhibitor

A dopamine reuptake inhibitor (DRI) is a class of drug which acts as a reuptake inhibitor of the monoamine neurotransmitter dopamine by blocking the action of the dopamine transporter (DAT).

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Drug

A drug is any substance (other than food that provides nutritional support) that, when inhaled, injected, smoked, consumed, absorbed via a patch on the skin, or dissolved under the tongue causes a temporary physiological (and often psychological) change in the body.

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Drug action

The action of drugs on the human body is called pharmacodynamics, and what the body does with the drug is called pharmacokinetics.

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Edivoxetine

Edivoxetine (INN; code name LY-2216684) is a drug which acts as a selective norepinephrine reuptake inhibitor and was under development by Eli Lilly for attention-deficit disorder (ADD) and as an antidepressant treatment.

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Esreboxetine

Esreboxetine is a selective norepinephrine reuptake inhibitor which was under development by Pfizer for the treatment of neuropathic pain and fibromyalgia but failed to show significant benefit over currently available medications and was discontinued.

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Extracellular

In cell biology, molecular biology and related fields, the word extracellular (or sometimes extracellular space) means "outside the cell".

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Lortalamine

Lortalamine (LM-1404) is an antidepressant which was synthesized in the early 1980s.

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Major depressive disorder

Major depressive disorder (MDD), also known simply as depression, is a mental disorder characterized by at least two weeks of low mood that is present across most situations.

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Manifaxine

Manifaxine (GW-320,659) is a drug developed by GlaxoSmithKline through structural modification of radafaxine, one of the major active metabolites of bupropion.

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Maprotiline

Maprotiline, sold under the brand name Ludiomil among others, is a tetracyclic antidepressant (TeCA) that is used in the treatment of depression.

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Methylphenidate

Methylphenidate, sold under various trade names, Ritalin being one of the most commonly known, is a central nervous system (CNS) stimulant of the phenethylamine and piperidine classes that is used in the treatment of attention deficit hyperactivity disorder (ADHD) and narcolepsy.

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Monoamine reuptake inhibitor

A monoamine reuptake inhibitor (MRI) is a drug that acts as a reuptake inhibitor of one or more of the three major monoamine neurotransmitters serotonin, norepinephrine, and dopamine by blocking the action of one or more of the respective monoamine transporters (MATs), which include the serotonin transporter (SERT), norepinephrine transporter (NET), and dopamine transporter (DAT).

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Monoamine transporter

Monoamine transporters (MATs) are protein structures that function as integral plasma-membrane transporters to regulate concentrations of extracellular monoamine neurotransmitters.

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Narcolepsy

Narcolepsy is a long-term neurological disorder that involves a decreased ability to regulate sleep-wake cycles.

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Neurotransmission

Neurotransmission (Latin: transmissio "passage, crossing" from transmittere "send, let through"), also called synaptic transmission, is the process by which signaling molecules called neurotransmitters are released by the axon terminal of a neuron (the presynaptic neuron), and bind to and activate the receptors on the dendrites of another neuron (the postsynaptic neuron).

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Neurotransmitter

Neurotransmitters are endogenous chemicals that enable neurotransmission.

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Nisoxetine

Nisoxetine, originally synthesized in the Lilly research laboratories during the early 1970s, is a potent and selective inhibitor for the reuptake of norepinephrine (noradrenaline) into synapses.

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Norepinephrine

Norepinephrine (NE), also called noradrenaline (NA) or noradrenalin, is an organic chemical in the catecholamine family that functions in the brain and body as a hormone and neurotransmitter.

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Norepinephrine releasing agent

A norepinephrine releasing agent (NRA), also known as an adrenergic releasing agent, is a catecholaminergic type of drug which induces the release of norepinephrine (noradrenaline) and epinephrine (adrenaline) from the pre-synaptic neuron into the synapse.

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Norepinephrine transporter

The norepinephrine transporter (NET), also known as solute carrier family 6 member 2 (SLC6A2), is a protein that in humans is encoded by the SLC6A2 gene.

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Norepinephrine–dopamine reuptake inhibitor

A norepinephrine–dopamine reuptake inhibitor (NDRI) is a drug that acts as a reuptake inhibitor for the neurotransmitters norepinephrine and dopamine by blocking the action of the norepinephrine transporter (NET) and the dopamine transporter (DAT), respectively.

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Nortriptyline

Nortriptyline, sold under the brand names Allegron, Aventyl, Noritren, Nortrilen, and Pamelor among others, is a tricyclic antidepressant (TCA) used to treat clinical depression.

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Obesity

Obesity is a medical condition in which excess body fat has accumulated to the extent that it may have a negative effect on health.

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Panic disorder

Panic disorder is an anxiety disorder characterized by reoccurring unexpected panic attacks.

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Protriptyline

Protriptyline, sold under the brand name Vivactil among others, is a tricyclic antidepressant (TCA), specifically a secondary amine, indicated for the treatment of depression and attention-deficit hyperactivity disorder (ADHD).

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Radafaxine

Radafaxine is drug candidate designated GW-353,162 by GlaxoSmithKline, investigated for treatment of restless leg syndrome and as an NDRI antidepressant.

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Reboxetine

Reboxetine, sold under the brand name Edronax among others, is a drug of the norepinephrine reuptake inhibitor (NRI) class, marketed as an antidepressant by Pfizer for use in the treatment of major depression, although it has also been used off-label for panic disorder and attention deficit hyperactivity disorder (ADHD).

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Reuptake inhibitor

A reuptake inhibitor (RI) is a type of drug known as a reuptake modulator that inhibits the plasmalemmal transporter-mediated reuptake of a neurotransmitter from the synapse into the pre-synaptic neuron.

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Serotonin–norepinephrine reuptake inhibitor

Serotonin–norepinephrine reuptake inhibitors (SNRIs) are a class of antidepressant drugs that treat major depressive disorder (MDD) and can also treat anxiety disorders, obsessive-compulsive disorder (OCD), attention-deficit hyperactivity disorder (ADHD), chronic neuropathic pain, fibromyalgia syndrome (FMS), and menopausal symptoms.

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Serotonin–norepinephrine–dopamine reuptake inhibitor

A serotonin–norepinephrine–dopamine reuptake inhibitor (SNDRI), also known as a triple reuptake inhibitor (TRI), is a type of drug that acts as a combined reuptake inhibitor of the monoamine neurotransmitters serotonin, norepinephrine, and dopamine.

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Stimulant

Stimulants (also often referred to as psychostimulants or colloquially as uppers) is an overarching term that covers many drugs including those that increase activity of the central nervous system and the body, drugs that are pleasurable and invigorating, or drugs that have sympathomimetic effects.

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Substance abuse

Substance abuse, also known as drug abuse, is a patterned use of a drug in which the user consumes the substance in amounts or with methods which are harmful to themselves or others, and is a form of substance-related disorder.

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Talopram

Talopram (Lu 3-010), also known as phthalapromine, is a selective norepinephrine reuptake inhibitor (NRI) which was researched for the management of depression in the 1960s and 1970s but was never commercialized.

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Talsupram

Talsupram (Lu 5-005 or Lu 5-003) is a selective norepinephrine reuptake inhibitor (NRI) which was investigated as an antidepressant in the 1960s and 1970s but was never marketed.

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Tandamine

Tandamine is a selective norepinephrine reuptake inhibitor with a tricyclic structure.

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Tapentadol

Tapentadol (brand names: Nucynta, Palexia and Tapal) is a centrally acting opioid analgesic of the benzenoid class with a dual mode of action as an agonist of the μ-opioid receptor and as a norepinephrine reuptake inhibitor (NRI).

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Teniloxazine

Teniloxazine (Lucelan, Metatone), also known as sufoxazine and sulfoxazine, is a drug which is marketed in Japan.

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Tricyclic antidepressant

Tricyclic antidepressants (TCAs) are a class of medications that are used primarily as antidepressants.

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Viloxazine

Viloxazine (trade names Vivalan, Emovit, Vivarint and Vicilan) is a morpholine derivative and is a selective norepinephrine reuptake inhibitor (NRI).

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Redirects here:

Adrenergic reuptake inhibitor, Adrenergic uptake inhibitor, Adrenergic uptake inhibitors, Noradrenaline reuptake inhibitor, Noradrenergic reuptake inhibitors, Norepinephrine Reuptake Inhibitor, Norepinephrine reuptake inhibition, Norepinephrine reuptake inhibitors, Selective Norepinephrine Reuptake Inhibitor, Selective noradrenaline reuptake inhibitor, Selective norepinephrine reuptake inhibitor.

References

[1] https://en.wikipedia.org/wiki/Norepinephrine_reuptake_inhibitor

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