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45 relations: ABL (gene), Amitriptyline, Apoptosis, Autophosphorylation, Brain-derived neurotrophic factor, Cancer, Cellular differentiation, Congenital insensitivity to pain with anhidrosis, DNA sequencing, Entrectinib, Enzyme-linked receptor, Fluorescence in situ hybridization, FRS2, Gambogic acid, Gene, GRB2, Intellectual disability, Keratoconus, Low-affinity nerve growth factor receptor, MAPK/ERK pathway, Megakaryocyte-associated tyrosine kinase, Nature (journal), Nerve growth factor, Neuron, Neurotrophin, Oncogene, PLCG1, Proceedings of the National Academy of Sciences of the United States of America, Proteasome, Protein, Protein–protein interaction, RICS (gene), Science (journal), Self-harm, Sequestosome 1, SH2B1, SH2B2, SHC1, Sp3 transcription factor, Trk receptor, Tropomyosin receptor kinase B, Tropomyosin receptor kinase C, Tyrosine-kinase inhibitor, Ubiquitin, Ubiquitin ligase.
ABL (gene)
Abelson murine leukemia viral oncogene homolog 1 also known as ABL1 is a protein that, in humans, is encoded by the ABL1 gene (previous symbol ABL) located on chromosome 9.
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Amitriptyline
Amitriptyline, sold under the brand name Elavil among others, is a medicine primarily used to treat a number of mental illnesses.
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Apoptosis
Apoptosis (from Ancient Greek ἀπόπτωσις "falling off") is a process of programmed cell death that occurs in multicellular organisms.
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Autophosphorylation
Autophosphorylation is a type of post-translational modification of proteins.
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Brain-derived neurotrophic factor
Brain-derived neurotrophic factor, also known as BDNF, is a protein that, in humans, is encoded by the BDNF gene.
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Cancer
Cancer is a group of diseases involving abnormal cell growth with the potential to invade or spread to other parts of the body.
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Cellular differentiation
In developmental biology, cellular differentiation is the process where a cell changes from one cell type to another.
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Congenital insensitivity to pain with anhidrosis
Congenital insensitivity to pain with anhidrosis (CIPA), also called hereditary sensory and autonomic neuropathy type IV, is an extremely rare inherited disorder of the nervous system which prevents the sensation of pain, heat, cold, or any real nerve-related sensations (including feeling the need to urinate); however, patients can still feel pressure.
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DNA sequencing
DNA sequencing is the process of determining the precise order of nucleotides within a DNA molecule.
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Entrectinib
Entrectinib (INN, previously known as RXDX-101 and NMS-E628) is an investigational drug with preliminary antitumor activity.
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Enzyme-linked receptor
An enzyme-linked receptor, also known as a catalytic receptor, is a transmembrane receptor, where the binding of an extracellular ligand causes enzymatic activity on the intracellular side.
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Fluorescence in situ hybridization
Fluorescent in situ hybridization (FISH) is a molecular cytogenetic technique that uses fluorescent probes that bind to only those parts of the chromosome with a high degree of sequence complementarity.
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FRS2
Fibroblast growth factor receptor substrate 2 is a protein that in humans is encoded by the FRS2 gene.
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Gambogic acid
Gambogic acid is a xanthonoid that is derived from the brownish or orange resin from Garcinia hanburyi.
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Gene
In biology, a gene is a sequence of DNA or RNA that codes for a molecule that has a function.
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GRB2
Growth factor receptor-bound protein 2 also known as Grb2 is an adaptor protein involved in signal transduction/cell communication.
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Intellectual disability
Intellectual disability (ID), also known as general learning disability, and mental retardation (MR), is a generalized neurodevelopmental disorder characterized by significantly impaired intellectual and adaptive functioning.
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Keratoconus
Keratoconus (KC) is a disorder of the eye which results in progressive thinning of the cornea.
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Low-affinity nerve growth factor receptor
The low-affinity nerve growth factor receptor (nerve growth factor receptor (TNFR superfamily, member 16), also called the LNGFR or p75 neurotrophin receptor) is one of the two receptor types for the neurotrophins, a family of protein growth factors that stimulate neuronal cells to survive and differentiate.
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MAPK/ERK pathway
The MAPK/ERK pathway (also known as the Ras-Raf-MEK-ERK pathway) is a chain of proteins in the cell that communicates a signal from a receptor on the surface of the cell to the DNA in the nucleus of the cell.
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Megakaryocyte-associated tyrosine kinase
Megakaryocyte-associated tyrosine-protein kinase is an enzyme that in humans is encoded by the MATK gene.
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Nature (journal)
Nature is a British multidisciplinary scientific journal, first published on 4 November 1869.
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Nerve growth factor
Nerve growth factor (NGF) is a neurotrophic factor and neuropeptide primarily involved in the regulation of growth, maintenance, proliferation, and survival of certain target neurons.
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Neuron
A neuron, also known as a neurone (British spelling) and nerve cell, is an electrically excitable cell that receives, processes, and transmits information through electrical and chemical signals.
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Neurotrophin
Neurotrophins are a family of proteins that induce the survival, development, and function of neurons.
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Oncogene
An oncogene is a gene that has the potential to cause cancer.
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PLCG1
Phospholipase C, gamma 1, also known as PLCG1, is a protein that in humans is encoded by the PLCG1 gene.
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Proceedings of the National Academy of Sciences of the United States of America
Proceedings of the National Academy of Sciences of the United States of America (PNAS) is the official scientific journal of the National Academy of Sciences, published since 1915.
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Proteasome
Proteasomes are protein complexes which degrade unneeded or damaged proteins by proteolysis, a chemical reaction that breaks peptide bonds.
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Protein
Proteins are large biomolecules, or macromolecules, consisting of one or more long chains of amino acid residues.
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Protein–protein interaction
Protein–protein interactions (PPIs) are the physical contacts of high specificity established between two or more protein molecules as a result of biochemical events steered by electrostatic forces including the hydrophobic effect.
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RICS (gene)
Rho GTPase-activating protein 32 is a protein that in humans is encoded by the RICS gene.
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Science (journal)
Science, also widely referred to as Science Magazine, is the peer-reviewed academic journal of the American Association for the Advancement of Science (AAAS) and one of the world's top academic journals.
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Self-harm
Self-harm, also known as self-injury, is defined as the intentional, direct injuring of body tissue, done without suicidal intentions.
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Sequestosome 1
Sequestosome-1 is a protein that in humans is encoded by the SQSTM1 gene.
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SH2B1
SH2B adapter protein 1 is a protein that in humans is encoded by the SH2B1 gene.
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SH2B2
SH2B adapter protein 2 is a protein that in humans is encoded by the SH2B2 gene.
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SHC1
SHC-transforming protein 1 is a protein that in humans is encoded by the SHC1 gene.
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Sp3 transcription factor
Sp3 transcription factor, also known as SP3, refers to both a protein and the gene it is encoded by.
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Trk receptor
Trk receptors are a family of tyrosine kinases that regulates synaptic strength and plasticity in the mammalian nervous system.
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Tropomyosin receptor kinase B
Tropomyosin receptor kinase B (TrkB), also known as tyrosine receptor kinase B, or BDNF/NT-3 growth factors receptor or neurotrophic tyrosine kinase, receptor, type 2 is a protein that in humans is encoded by the NTRK2 gene.
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Tropomyosin receptor kinase C
Tropomyosin receptor kinase C (TrkC), also known as NT-3 growth factor receptor, neurotrophic tyrosine kinase receptor type 3, or TrkC tyrosine kinase is a protein that in humans is encoded by the NTRK3 gene.
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Tyrosine-kinase inhibitor
A tyrosine kinase inhibitor (TKI) is a pharmaceutical drug that inhibits tyrosine kinases.
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Ubiquitin
Ubiquitin is a small (8.5 kDa) regulatory protein found in most tissues of eukaryotic organisms, i.e. it occurs ''ubiquitously''.
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Ubiquitin ligase
A ubiquitin ligase (also called an E3 ubiquitin ligase) is a protein that recruits an E2 ubiquitin-conjugating enzyme that has been loaded with ubiquitin, recognizes a protein substrate, and assists or directly catalyzes the transfer of ubiquitin from the E2 to the protein substrate.
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Redirects here:
NTRK1, NTRK1 (gene), NTRK1 gene, Ntrk1, Receptor, trka, Trk A, Trk-A, TrkA, TrkA receptor, Trka, Tropomyosin-Related Kinase A.
References
[1] https://en.wikipedia.org/wiki/Tropomyosin_receptor_kinase_A
