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Glibenclamide

Index Glibenclamide

Glibenclamide, also known as glyburide, is an antidiabetic drug in a class of medications known as sulfonylureas, closely related to sulfonamide antibiotics. [1]

31 relations: Anti-diabetic medication, Antibiotic, ATP-sensitive potassium channel, Beta cell, Blood–brain barrier, Calcium, Combination drug, CYP2C9, Depolarization, Diabetes mellitus type 2, Generic drug, Gestational diabetes, Glipizide, Hoechst AG, Hoffmann-La Roche, Hydroxylation, Hypoglycemia, Insulin, Jaundice, Kidney, Liver, Metformin, Pancreas, Roche Diagnostics, Sanofi, Structural analog, Sulfonamide (medicine), Sulfonylurea, Sulfonylurea receptor, Tolbutamide, Voltage-gated calcium channel.

Anti-diabetic medication

Drugs used in diabetes treat diabetes mellitus by lowering glucose levels in the blood.

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Antibiotic

An antibiotic (from ancient Greek αντιβιοτικά, antibiotiká), also called an antibacterial, is a type of antimicrobial drug used in the treatment and prevention of bacterial infections.

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ATP-sensitive potassium channel

An ATP-sensitive potassium channel (or KATP channel) is a type of potassium channel that is gated by intracellular nucleotides, ATP and ADP.

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Beta cell

Beta cells (β cells) are a type of cell found in the pancreatic islets of the pancreas.

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Blood–brain barrier

The blood–brain barrier (BBB) is a highly selective semipermeable membrane barrier that separates the circulating blood from the brain and extracellular fluid in the central nervous system (CNS).

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Calcium

Calcium is a chemical element with symbol Ca and atomic number 20.

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Combination drug

A combination drug is a fixed-dose combination (FDC) that includes two or more active pharmaceutical ingredients (APIs) combined in a single dosage form, which is manufactured and distributed in fixed doses.

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CYP2C9

Cytochrome P450 2C9 (abbreviated CYP2C9) is an enzyme that in humans is encoded by the CYP2C9 gene.

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Depolarization

In biology, depolarization is a change within a cell, during which the cell undergoes a shift in electric charge distribution, resulting in less negative charge inside the cell.

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Diabetes mellitus type 2

Diabetes mellitus type 2 (also known as type 2 diabetes) is a long-term metabolic disorder that is characterized by high blood sugar, insulin resistance, and relative lack of insulin.

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Generic drug

A generic drug is a pharmaceutical drug that is equivalent to a brand-name product in dosage, strength, route of administration, quality, performance, and intended use, but does not carry the brand name.

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Gestational diabetes

Gestational diabetes is a condition in which a woman without diabetes develops high blood sugar levels during pregnancy.

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Glipizide

Glipizide is an oral rapid- and short-acting anti-diabetic medication from the sulfonylurea class.

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Hoechst AG

Hoechst AG was a German chemicals then life-sciences company that became Aventis Deutschland after its merger with France's Rhône-Poulenc S.A. in 1999.

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Hoffmann-La Roche

F.

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Hydroxylation

Hydroxylation is a chemical process that introduces a hydroxyl group (-OH) into an organic compound.

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Hypoglycemia

Hypoglycemia, also known as low blood sugar, is when blood sugar decreases to below normal levels.

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Insulin

Insulin (from Latin insula, island) is a peptide hormone produced by beta cells of the pancreatic islets; it is considered to be the main anabolic hormone of the body.

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Jaundice

Jaundice, also known as icterus, is a yellowish or greenish pigmentation of the skin and whites of the eyes due to high bilirubin levels.

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Kidney

The kidneys are two bean-shaped organs present in left and right sides of the body in vertebrates.

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Liver

The liver, an organ only found in vertebrates, detoxifies various metabolites, synthesizes proteins, and produces biochemicals necessary for digestion.

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Metformin

Metformin, marketed under the trade name Glucophage among others, is the first-line medication for the treatment of type 2 diabetes, particularly in people who are overweight.

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Pancreas

The pancreas is a glandular organ in the digestive system and endocrine system of vertebrates.

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Roche Diagnostics

Roche Diagnostics is a diagnostic division of Hoffmann-La Roche which manufactures equipment and reagents for research and medical diagnostic applications.

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Sanofi

Sanofi S.A. is a French multinational pharmaceutical company headquartered in Gentilly, France, as of 2013 the world's fifth-largest by prescription sales.

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Structural analog

A structural analog, also known as a chemical analog or simply an analog, is a compound having a structure similar to that of another compound, but differing from it in respect to a certain component.

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Sulfonamide (medicine)

Sulfonamide (also called sulphonamide, sulfa drugs or sulpha drugs) is the basis of several groups of drugs.

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Sulfonylurea

Sulfonylureas (UK: sulphonylurea) are a class of organic compounds used in medicine and agriculture.

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Sulfonylurea receptor

In the field of molecular biology, the sulfonylurea receptors (SUR) are membrane proteins which are the molecular targets of the sulfonylurea class of antidiabetic drugs whose mechanism of action is to promote insulin release from pancreatic beta cells.

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Tolbutamide

Tolbutamide is a first-generation potassium channel blocker, sulfonylurea oral hypoglycemic medication.

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Voltage-gated calcium channel

Voltage-gated calcium channels (VGCCs), also known as voltage-dependent calcium channels (VDCCs), are a group of voltage-gated ion channels found in the membrane of excitable cells (e.g., muscle, glial cells, neurons, etc.) with a permeability to the calcium ion Ca2+.

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Redirects here:

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References

[1] https://en.wikipedia.org/wiki/Glibenclamide

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