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51 relations: Activated PI3K delta syndrome, Allergy, Antibody, Antigen, B cell, CD278, CD28, Chronic lymphocytic leukemia, Copanlisib, Cytokine, Dendritic cell, Enzyme, Follicular lymphoma, Food and Drug Administration, Gene, Gilead Sciences, Icos, Idelalisib, Interleukin 2, Lipid, Lipopolysaccharide, Mast cell, Neutrophil, P110α, PASLI disease, Peritoneum, Phosphatidylinositol, Phosphatidylinositol (3,4,5)-trisphosphate, Phosphatidylinositol 4,5-bisphosphate, Phosphoinositide 3-kinase, Phosphoinositide 3-kinase inhibitor, Phosphorylation, PIK3CB, PIK3CG, PIK3R1, PIK3R2, Placebo, Protein kinase B, Protein–protein interaction, Ras subfamily, Reactive oxygen species, Rituximab, SH2 domain, SH3 domain, Synapse, T cell, TEC (gene), Tumors of the hematopoietic and lymphoid tissues, Tyrosine, Tyrosine kinase, ..., White blood cell. Expand index (1 more) »
Activated PI3K delta syndrome
Activated PI3K delta syndrome is a primary immunodeficiency disease caused by activating gain of function mutations in the PIK3CD gene.
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Allergy
Allergies, also known as allergic diseases, are a number of conditions caused by hypersensitivity of the immune system to typically harmless substances in the environment.
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Antibody
An antibody (Ab), also known as an immunoglobulin (Ig), is a large, Y-shaped protein produced mainly by plasma cells that is used by the immune system to neutralize pathogens such as pathogenic bacteria and viruses.
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Antigen
In immunology, an antigen is a molecule capable of inducing an immune response (to produce an antibody) in the host organism.
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B cell
B cells, also known as B lymphocytes, are a type of white blood cell of the lymphocyte subtype.
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CD278
Inducible T-cell costimulator is an immune checkpoint protein that in humans is encoded by the ICOS gene.
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CD28
CD28 (Cluster of Differentiation 28) is one of the proteins expressed on T cells that provide co-stimulatory signals required for T cell activation and survival.
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Chronic lymphocytic leukemia
Chronic lymphocytic leukemia (CLL) is a type of cancer in which the bone marrow makes too many lymphocytes (a type of white blood cell).
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Copanlisib
Copanlisib (trade name Aliqopa; codenamed BAY 80-6946) is a drug which is approved by US FDA for the treatment of adult patients experiencing relapsed follicular lymphoma who have received at least two prior systemic therapies.
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Cytokine
Cytokines are a broad and loose category of small proteins (~5–20 kDa) that are important in cell signaling.
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Dendritic cell
Dendritic cells (DCs) are antigen-presenting cells (also known as accessory cells) of the mammalian immune system.
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Enzyme
Enzymes are macromolecular biological catalysts.
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Follicular lymphoma
Follicular lymphoma is a type of blood cancer.
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Food and Drug Administration
The Food and Drug Administration (FDA or USFDA) is a federal agency of the United States Department of Health and Human Services, one of the United States federal executive departments.
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Gene
In biology, a gene is a sequence of DNA or RNA that codes for a molecule that has a function.
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Gilead Sciences
Gilead Sciences, Inc., commonly known as Gilead Sciences or Gilead (also styled GILEAD), is an American biopharmaceutical company that researches, develops and commercializes drugs.
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Icos
Icos Corporation (trademark ICOS) was an American biotechnology company and the largest biotechnology company in the U.S. state of Washington, before it was sold to Eli Lilly and Company in 2007.
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Idelalisib
Idelalisib (trade name Zydelig, codenamed GS-1101 or CAL-101) is a drug used for the treatment of certain hematological malignancies.
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Interleukin 2
Interleukin-2 (IL-2) is an interleukin, a type of cytokine signaling molecule in the immune system.
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Lipid
In biology and biochemistry, a lipid is a biomolecule that is soluble in nonpolar solvents.
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Lipopolysaccharide
Lipopolysaccharides (LPS), also known as lipoglycans and endotoxins, are large molecules consisting of a lipid and a polysaccharide composed of O-antigen, outer core and inner core joined by a covalent bond; they are found in the outer membrane of Gram-negative bacteria.
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Mast cell
A mast cell (also known as a mastocyte or a labrocyte) is a type of white blood cell.
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Neutrophil
Neutrophils (also known as neutrocytes) are the most abundant type of granulocytes and the most abundant (40% to 70%) type of white blood cells in most mammals.
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P110α
The phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha (the HUGO-approved official symbol.
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PASLI disease
PASLI disease is a rare genetic disorder of the immune system.
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Peritoneum
The peritoneum is the serous membrane that forms the lining of the abdominal cavity or coelom in amniotes and some invertebrates, such as annelids.
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Phosphatidylinositol
Phosphatidylinositol consists of a family of lipids as illustrated on the right, a class of the phosphatidylglycerides.
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Phosphatidylinositol (3,4,5)-trisphosphate
Phosphatidylinositol (3,4,5)-trisphosphate (PtdIns(3,4,5)P3), abbreviated PIP3, is the product of the class I phosphoinositide 3-kinases (PI 3-kinases) phosphorylation of phosphatidylinositol (4,5)-bisphosphate (PIP2).
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Phosphatidylinositol 4,5-bisphosphate
Phosphatidylinositol 4,5-bisphosphate or PtdIns(4,5)P2, also known simply as PIP2 or PI(4,5)P2, is a minor phospholipid component of cell membranes.
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Phosphoinositide 3-kinase
Phosphatidylinositol-4,5-bisphosphate 3-kinase (also called phosphatidylinositide 3-kinases, phosphatidylinositol-3-kinases, PI 3-kinases, PI(3)Ks, PI-3Ks or by the HUGO official stem symbol for the gene family, PI3K(s)) are a family of enzymes involved in cellular functions such as cell growth, proliferation, differentiation, motility, survival and intracellular trafficking, which in turn are involved in cancer.
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Phosphoinositide 3-kinase inhibitor
A phosphoinositide 3-kinase inhibitor (PI3K inhibitor) is a class of medical drug that functions by inhibiting one or more of the phosphoinositide 3-kinase enzymes, which are part of the PI3K/AKT/mTOR pathway, an important signalling pathway for many cellular functions such as growth control, metabolism and translation initiation.
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Phosphorylation
In chemistry, phosphorylation of a molecule is the attachment of a phosphoryl group.
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PIK3CB
Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta isoform is an enzyme that in humans is encoded by the PIK3CB gene.
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PIK3CG
Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform is an enzyme that in humans is encoded by the PIK3CG gene.
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PIK3R1
Phosphatidylinositol 3-kinase regulatory subunit alpha is an enzyme that in humans is encoded by the PIK3R1 gene.
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PIK3R2
Phosphatidylinositol 3-kinase regulatory subunit beta is an enzyme that in humans is encoded by the PIK3R2 gene.
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Placebo
A placebo is a substance or treatment of no intended therapeutic value.
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Protein kinase B
Protein kinase B (PKB), also known as Akt, is a serine/threonine-specific protein kinase that plays a key role in multiple cellular processes such as glucose metabolism, apoptosis, cell proliferation, transcription and cell migration.
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Protein–protein interaction
Protein–protein interactions (PPIs) are the physical contacts of high specificity established between two or more protein molecules as a result of biochemical events steered by electrostatic forces including the hydrophobic effect.
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Ras subfamily
Ras is a family of related proteins which is expressed in all animal cell lineages and organs.
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Reactive oxygen species
Reactive oxygen species (ROS) are chemically reactive chemical species containing oxygen.
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Rituximab
Rituximab, sold under the brand name Rituxan among others, is a medication used to treat certain autoimmune diseases and types of cancer.
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SH2 domain
The SH2 (Src Homology 2) domain is a structurally conserved protein domain contained within the Src oncoprotein and in many other intracellular signal-transducing proteins.
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SH3 domain
The SRC Homology 3 Domain (or SH3 domain) is a small protein domain of about 60 amino acid residues.
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Synapse
In the nervous system, a synapse is a structure that permits a neuron (or nerve cell) to pass an electrical or chemical signal to another neuron or to the target efferent cell.
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T cell
A T cell, or T lymphocyte, is a type of lymphocyte (a subtype of white blood cell) that plays a central role in cell-mediated immunity.
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TEC (gene)
Tyrosine-protein kinase Tec is an enzyme that in humans is encoded by the TEC gene.
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Tumors of the hematopoietic and lymphoid tissues
Tumors of the hematopoietic and lymphoid tissues or haematopoietic and lymphoid malignancies are tumors that affect the blood, bone marrow, lymph, and lymphatic system.
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Tyrosine
Tyrosine (symbol Tyr or Y) or 4-hydroxyphenylalanine is one of the 20 standard amino acids that are used by cells to synthesize proteins.
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Tyrosine kinase
A tyrosine kinase is an enzyme that can transfer a phosphate group from ATP to a protein in a cell.
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White blood cell
White blood cells (WBCs), also called leukocytes or leucocytes, are the cells of the immune system that are involved in protecting the body against both infectious disease and foreign invaders.
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Redirects here:
P110d, P110delta, PIK3CD, PIK3CD (gene), Pik3cd.
References
[1] https://en.wikipedia.org/wiki/P110δ
