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S100A1

Index S100A1

S100A1, also known as S100 calcium-binding protein A1 is a protein which in humans is encoded by the S100A1 gene. [1]

78 relations: Actin, alpha 1, Adenoviridae, Adrenergic receptor, Alpha helix, Amlexanox, Angiogenesis, Apoptosis, ATP2A2, Atrium (heart), Beta sheet, Brain, C-terminus, Calcium, Calcium-induced calcium release, Cardiac marker, Cardiac muscle, Cardiac muscle cell, Cardiomyopathy, Cardiopulmonary bypass, Cell cycle, Cell nucleus, Cellular differentiation, Contractility, Coronary artery disease, Creatine kinase, Cromoglicic acid, Cyanotic heart defect, Cysteine, Cytoplasm, Diabetes mellitus type 1, Dissociation constant, EF hand, Emergency position-indicating radiobeacon station, Endothelium, Gene, Gene therapy, Heart failure, Hydrophobe, L-type calcium channel, Melanocytic nevus, Microphthalmia-associated transcription factor, Microtubule, Muscle contraction, MYH7, Myocardial infarction, Myofibril, N-terminus, Nuclear magnetic resonance spectroscopy of proteins, Olopatadine, Pentamidine, ..., PGM1, Phosphorylation, Propranolol, Protein, Protein dimer, Protein kinase A, Protein kinase C, Protein–protein interaction, Pulmonary hypertension, Ryanodine receptor 2, RYR1, S-Nitrosylation, S100 protein, S100A4, S100B, Sarcolemma, Sarcomere, Sarcoplasmic reticulum, Skeletal muscle, Sodium, Structural motif, Systole, Titin, TNNI3, TRPM3, Ventricle (heart), Ventricular assist device, Ventricular hypertrophy. Expand index (28 more) »

Actin, alpha 1

Actin, alpha skeletal muscle is a protein that in humans is encoded by the ACTA1 gene.

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Adenoviridae

Adenoviruses (members of the family Adenoviridae) are medium-sized (90–100 nm), nonenveloped (without an outer lipid bilayer) viruses with an icosahedral nucleocapsid containing a double stranded DNA genome.

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Adrenergic receptor

The adrenergic receptors (or adrenoceptors) are a class of G protein-coupled receptors that are targets of the catecholamines, especially norepinephrine (noradrenaline) and epinephrine (adrenaline).

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Alpha helix

The alpha helix (α-helix) is a common motif in the secondary structure of proteins and is a righthand-spiral conformation (i.e. helix) in which every backbone N−H group donates a hydrogen bond to the backbone C.

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Amlexanox

Amlexanox (trade name Aphthasol) is an anti-inflammatory antiallergic immunomodulator used to treat recurrent aphthous ulcers (canker sores), and (in Japan) several inflammatory conditions.

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Angiogenesis

Angiogenesis is the physiological process through which new blood vessels form from pre-existing vessels.

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Apoptosis

Apoptosis (from Ancient Greek ἀπόπτωσις "falling off") is a process of programmed cell death that occurs in multicellular organisms.

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ATP2A2

ATP2A2 is an ATPase associated with Darier's disease and Acrokeratosis verruciformis.

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Atrium (heart)

The atrium is the upper chamber in which blood enters the heart.

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Beta sheet

The β-sheet (also β-pleated sheet) is a common motif of regular secondary structure in proteins.

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Brain

The brain is an organ that serves as the center of the nervous system in all vertebrate and most invertebrate animals.

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C-terminus

The C-terminus (also known as the carboxyl-terminus, carboxy-terminus, C-terminal tail, C-terminal end, or COOH-terminus) is the end of an amino acid chain (protein or polypeptide), terminated by a free carboxyl group (-COOH).

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Calcium

Calcium is a chemical element with symbol Ca and atomic number 20.

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Calcium-induced calcium release

Calcium-induced calcium release (CICR) describes a biological process whereby calcium is able to activate calcium release from intracellular Ca2+ stores (e.g., endoplasmic reticulum or sarcoplasmic reticulum).

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Cardiac marker

Cardiac markers are biomarkers measured to evaluate heart function.

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Cardiac muscle

Cardiac muscle (heart muscle) is one of the three major types of muscle, the others being skeletal and smooth muscle.

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Cardiac muscle cell

Cardiac muscle cells or cardiomyocytes (also known as myocardiocytes or cardiac myocytes) are the muscle cells (myocytes) that make up the cardiac muscle (heart muscle).

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Cardiomyopathy

Cardiomyopathy is a group of diseases that affect the heart muscle.

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Cardiopulmonary bypass

Cardiopulmonary bypass (CPB) is a technique that temporarily takes over the function of the heart and lungs during surgery, maintaining the circulation of blood and the oxygen content of the patient's body.

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Cell cycle

The cell cycle or cell-division cycle is the series of events that take place in a cell leading to its division and duplication of its DNA (DNA replication) to produce two daughter cells.

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Cell nucleus

In cell biology, the nucleus (pl. nuclei; from Latin nucleus or nuculeus, meaning kernel or seed) is a membrane-enclosed organelle found in eukaryotic cells.

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Cellular differentiation

In developmental biology, cellular differentiation is the process where a cell changes from one cell type to another.

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Contractility

Contractility refers to the ability for self-contraction, especially of the muscles, or similar active biological tissue.

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Coronary artery disease

Coronary artery disease (CAD), also known as ischemic heart disease (IHD), refers to a group of diseases which includes stable angina, unstable angina, myocardial infarction, and sudden cardiac death.

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Creatine kinase

Creatine kinase (CK), also known as creatine phosphokinase (CPK) or phosphocreatine kinase, is an enzyme expressed by various tissues and cell types.

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Cromoglicic acid

Cromoglicic acid (INN) (also referred to as cromolyn (USAN), cromoglycate (former BAN), or cromoglicate) is traditionally described as a mast cell stabilizer, and is commonly marketed as the sodium salt sodium cromoglicate or cromolyn sodium.

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Cyanotic heart defect

Cyanotic heart defect is a group-type of congenital heart defect (CHD) that occurs due to deoxygenated blood bypassing the lungs and entering the systemic circulation or a mixture of oxygenated and unoxygenated blood entering the systemic circulation.

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Cysteine

Cysteine (symbol Cys or C) is a semi-essential proteinogenic amino acid with the formula HO2CCH(NH2)CH2SH.

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Cytoplasm

In cell biology, the cytoplasm is the material within a living cell, excluding the cell nucleus.

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Diabetes mellitus type 1

Diabetes mellitus type 1, also known as type 1 diabetes, is a form of diabetes mellitus in which not enough insulin is produced.

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Dissociation constant

In chemistry, biochemistry, and pharmacology, a dissociation constant (K_d) is a specific type of equilibrium constant that measures the propensity of a larger object to separate (dissociate) reversibly into smaller components, as when a complex falls apart into its component molecules, or when a salt splits up into its component ions.

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EF hand

The EF hand is a helix-loop-helix structural domain or motif found in a large family of calcium-binding proteins.

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Emergency position-indicating radiobeacon station

An emergency position-indicating radiobeacon station is a distress radiobeacon, a tracking transmitter that is triggered during an accident.

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Endothelium

Endothelium refers to cells that line the interior surface of blood vessels and lymphatic vessels, forming an interface between circulating blood or lymph in the lumen and the rest of the vessel wall.

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Gene

In biology, a gene is a sequence of DNA or RNA that codes for a molecule that has a function.

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Gene therapy

In the medicine field, gene therapy (also called human gene transfer) is the therapeutic delivery of nucleic acid into a patient's cells as a drug to treat disease.

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Heart failure

Heart failure (HF), often referred to as congestive heart failure (CHF), is when the heart is unable to pump sufficiently to maintain blood flow to meet the body's needs.

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Hydrophobe

In chemistry, hydrophobicity is the physical property of a molecule (known as a hydrophobe) that is seemingly repelled from a mass of water.

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L-type calcium channel

The L-type calcium channel (also known as the dihydropyridine channel, or DHP channel) is part of the high-voltage activated family of voltage-dependent calcium channel.

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Melanocytic nevus

A melanocytic nevus (also known as nevocytic nevus, nevus-cell nevus and commonly as a mole) is a type of melanocytic tumor that contains nevus cells.

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Microphthalmia-associated transcription factor

Microphthalmia-associated transcription factor also known as class E basic helix-loop-helix protein 32 or bHLHe32 is a protein that in humans is encoded by the MITF gene.

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Microtubule

Microtubules are tubular polymers of tubulin that form part of the cytoskeleton that provides the cytoplasm of eukaryotic cells and some bacteria with structure and shape.

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Muscle contraction

Muscle contraction is the activation of tension-generating sites within muscle fibers.

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MYH7

MYH7 is a gene encoding a myosin heavy chain beta (MHC-β) isoform (slow twitch) expressed primarily in the heart, but also in skeletal muscles (type I fibers).

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Myocardial infarction

Myocardial infarction (MI), commonly known as a heart attack, occurs when blood flow decreases or stops to a part of the heart, causing damage to the heart muscle.

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Myofibril

A myofibril (also known as a muscle fibril) is a basic rod-like unit of a muscle cell.

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N-terminus

The N-terminus (also known as the amino-terminus, NH2-terminus, N-terminal end or amine-terminus) is the start of a protein or polypeptide referring to the free amine group (-NH2) located at the end of a polypeptide.

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Nuclear magnetic resonance spectroscopy of proteins

Nuclear magnetic resonance spectroscopy of proteins (usually abbreviated protein NMR) is a field of structural biology in which NMR spectroscopy is used to obtain information about the structure and dynamics of proteins, and also nucleic acids, and their complexes.

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Olopatadine

Olopatadine is an antihistamine (as well as anticholinergic and mast cell stabilizer), sold as a prescription eye drop manufactured by Alcon in one of three strengths: 0.7% solution or Pazeo in the United States, 0.2% solution or Pataday (also called Patanol S in some countries), and 0.1% or Patanol (also called Opatanol in some countries; Olopat in India).

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Pentamidine

Pentamidine is an antimicrobial medication used to treat African trypanosomiasis, leishmaniasis, babesiosis, and to prevent and treat pneumocystis pneumonia (PCP) in people with poor immune function.

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PGM1

Phosphoglucomutase-1 is an enzyme that in humans is encoded by the PGM1 gene.

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Phosphorylation

In chemistry, phosphorylation of a molecule is the attachment of a phosphoryl group.

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Propranolol

Propranolol, sold under the brand name Inderal among others, is a medication of the beta blocker type. It is used to treat high blood pressure, a number of types of irregular heart rate, thyrotoxicosis, capillary hemangiomas, performance anxiety, and essential tremors. It is used to prevent migraine headaches, and to prevent further heart problems in those with angina or previous heart attacks. It can be taken by mouth or by injection into a vein. The formulation that is taken by mouth comes in short-acting and long-acting versions. Propranolol appears in the blood after 30 minutes and has a maximum effect between 60 and 90 minutes when taken by mouth. Common side effects include nausea, abdominal pain, and constipation. It should not be used in those with an already slow heart rate and most of those with heart failure. Quickly stopping the medication in those with coronary artery disease may worsen symptoms. It may worsen the symptoms of asthma. Caution is recommended in those with liver or kidney problems. Propranolol may cause harmful effects in the baby if taken during pregnancy. Its use during breastfeeding is probably safe, but the baby should be monitored for side effects. It is a non-selective beta blocker which works by blocking β-adrenergic receptors. Propranolol was discovered in 1964. It is on the World Health Organization's List of Essential Medicines, the most effective and safe medicines needed in a health system. Propranolol is available as a generic medication. The wholesale cost in the developing world is between 0.24 and 2.16 per month as of 2014. In the United States it costs about $15 per month at a typical dose.

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Protein

Proteins are large biomolecules, or macromolecules, consisting of one or more long chains of amino acid residues.

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Protein dimer

In biochemistry, a protein dimer is a macromolecular complex formed by two protein monomers, or single proteins, which are usually non-covalently bound.

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Protein kinase A

In cell biology, protein kinase A (PKANot to be confused with pKa, the symbol for the acid dissociation constant.) is a family of enzymes whose activity is dependent on cellular levels of cyclic AMP (cAMP).

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Protein kinase C

Protein kinase C, commonly abbreviated to PKC (EC 2.7.11.13), is a family of protein kinase enzymes that are involved in controlling the function of other proteins through the phosphorylation of hydroxyl groups of serine and threonine amino acid residues on these proteins, or a member of this family.

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Protein–protein interaction

Protein–protein interactions (PPIs) are the physical contacts of high specificity established between two or more protein molecules as a result of biochemical events steered by electrostatic forces including the hydrophobic effect.

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Pulmonary hypertension

Pulmonary hypertension (PH or PHTN) is a condition of increased blood pressure within the arteries of the lungs.

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Ryanodine receptor 2

Ryanodine receptor 2 (RYR2) is a protein found primarily in cardiac muscle.

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RYR1

Ryanodine receptor 1 (RYR-1) also known as skeletal muscle calcium release channel or skeletal muscle-type ryanodine receptor is a protein found primarily in skeletal muscle.

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S-Nitrosylation

S-Nitrosylation, the covalent attachment of NO to a cysteine residue to form an ''S''-nitrosothiol (SNO), is a post-translational protein modification of broad purview across phylogeny and cell types.

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S100 protein

The S100 proteins are a family of low-molecular-weight proteins found in vertebrates and characterized by two calcium-binding sites that have helix-loop-helix ("EF-hand type") conformation.

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S100A4

S100 calcium-binding protein A4 (S100A4) is a protein that in humans is encoded by the S100A4 gene.

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S100B

S100 calcium-binding protein B (S100B) is a protein of the S-100 protein family.

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Sarcolemma

The sarcolemma (sarco (from sarx) from Greek; flesh, and lemma from Greek; sheath) also called the myolemma, is the cell membrane of a striated muscle fiber cell.

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Sarcomere

A sarcomere (Greek sarx "flesh", meros "part") is the basic unit of striated muscle tissue.

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Sarcoplasmic reticulum

The sarcoplasmic reticulum (SR) is a membrane-bound structure found within muscle cells that is similar to the endoplasmic reticulum in other cells.

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Skeletal muscle

Skeletal muscle is one of three major muscle types, the others being cardiac muscle and smooth muscle.

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Sodium

Sodium is a chemical element with symbol Na (from Latin natrium) and atomic number 11.

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Structural motif

In a chain-like biological molecule, such as a protein or nucleic acid, a structural motif is a supersecondary structure, which also appears in a variety of other molecules.

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Systole

The systole is that part of the cardiac cycle during which some chambers of the heart muscle contract after refilling with blood.

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Titin

Titin, also known as connectin, is a protein that, in humans, is encoded by the TTN gene.

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TNNI3

Troponin I, cardiac muscle is a protein that in humans is encoded by the TNNI3 gene.

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TRPM3

Transient receptor potential cation channel subfamily M member 3 is a protein that in humans is encoded by the TRPM3 gene.

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Ventricle (heart)

A ventricle is one of two large chambers in the heart that collect and expel blood received from an atrium towards the peripheral beds within the body and lungs.

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Ventricular assist device

A ventricular assist device (VAD) is an electromechanical device for assisting cardiac circulation, which is used either to partially or to completely replace the function of a failing heart.

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Ventricular hypertrophy

Ventricular hypertrophy (VH) is thickening of the walls of a ventricle (lower chamber) of the heart.

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S100 calcium binding protein A1, S100 calcium-binding protein A1, S100A1 (gene).

References

[1] https://en.wikipedia.org/wiki/S100A1

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