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Nucleophilic substitution

Index Nucleophilic substitution

In organic and inorganic chemistry, nucleophilic substitution is a fundamental class of reactions in which an electron rich nucleophile selectively bonds with or attacks the positive or partially positive charge of an atom or a group of atoms to replace a leaving group; the positive or partially positive atom is referred to as an electrophile. [1]

63 relations: Acyl chloride, Acyl group, Alcohol, Aliphatic compound, Alkane, Alkoxide, Alkyl, Allyl group, Allylic rearrangement, Amide, Aromaticity, Bromide, Carbocation, Carbonyl group, Carboxylic acid, Chemical kinetics, Chemical polarity, Christopher Kelk Ingold, Concerted reaction, Electrophile, Elimination reaction, Ester, Ether, Ferrier rearrangement, Finkelstein reaction, Haloalkane, Hydride, Hydrobromic acid, Hydrolysis, Hydroxy group, Inorganic chemistry, Journal of the Chemical Society, Kolbe nitrile synthesis, Leaving group, Lithium aluminium hydride, Michaelis–Arbuzov reaction, Nucleophile, Nucleophilic abstraction, Nucleophilic acyl substitution, Nucleophilic aromatic substitution, Organic chemistry, Organic redox reaction, Organometallic chemistry, Perkow reaction, Protic solvent, Racemization, Rate equation, Reaction rate, Rearrangement reaction, Saturation (chemistry), ..., SN1 reaction, Sn1CB mechanism, SN2 reaction, SNi, Sodium hydroxide, Sodium methoxide, Solvent, Stereochemistry, Steric effects, Substrate (chemistry), Thionyl chloride, Wenker synthesis, Williamson ether synthesis. Expand index (13 more) »

Acyl chloride

In organic chemistry, an acyl chloride (or acid chloride) is an organic compound with the functional group -COCl. Their formula is usually written RCOCl, where R is a side chain.

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Acyl group

An acyl group is a moiety derived by the removal of one or more hydroxyl groups from an oxoacid, including inorganic acids.

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Alcohol

In chemistry, an alcohol is any organic compound in which the hydroxyl functional group (–OH) is bound to a carbon.

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Aliphatic compound

In organic chemistry, hydrocarbons (compounds composed of carbon and hydrogen) are divided into two classes: aromatic compounds and aliphatic compounds (G. aleiphar, fat, oil) also known as non-aromatic compounds.

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Alkane

In organic chemistry, an alkane, or paraffin (a historical name that also has other meanings), is an acyclic saturated hydrocarbon.

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Alkoxide

An alkoxide is the conjugate base of an alcohol and therefore consists of an organic group bonded to a negatively charged oxygen atom.

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Alkyl

In organic chemistry, an alkyl substituent is an alkane missing one hydrogen.

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Allyl group

An allyl group is a substituent with the structural formula H2C.

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Allylic rearrangement

An allylic rearrangement or allylic shift is an organic reaction in which the double bond in an allyl chemical compound shifts to the next carbon atom.

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Amide

An amide (or or), also known as an acid amide, is a compound with the functional group RnE(O)xNR′2 (R and R′ refer to H or organic groups).

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Aromaticity

In organic chemistry, the term aromaticity is used to describe a cyclic (ring-shaped), planar (flat) molecule with a ring of resonance bonds that exhibits more stability than other geometric or connective arrangements with the same set of atoms.

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Bromide

A bromide is a chemical compound containing a bromide ion or ligand.

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Carbocation

A carbocation (/karbɔkətaɪː'jɔ̃/) is an ion with a positively charged carbon atom.

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Carbonyl group

In organic chemistry, a carbonyl group is a functional group composed of a carbon atom double-bonded to an oxygen atom: C.

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Carboxylic acid

A carboxylic acid is an organic compound that contains a carboxyl group (C(.

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Chemical kinetics

Chemical kinetics, also known as reaction kinetics, is the study of rates of chemical processes.

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Chemical polarity

In chemistry, polarity is a separation of electric charge leading to a molecule or its chemical groups having an electric dipole or multipole moment.

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Christopher Kelk Ingold

Sir Christopher Kelk Ingold (28 October 1893 – 8 December 1970) was a British chemist based in Leeds and London.

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Concerted reaction

A concerted reaction is a chemical reaction in which all bond breaking and bond making occurs in a single step.

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Electrophile

In organic chemistry, an electrophile is a reagent attracted to electrons.

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Elimination reaction

An elimination reaction is a type of organic reaction in which two substituents are removed from a molecule in either a one or two-step mechanism.

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Ester

In chemistry, an ester is a chemical compound derived from an acid (organic or inorganic) in which at least one –OH (hydroxyl) group is replaced by an –O–alkyl (alkoxy) group.

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Ether

Ethers are a class of organic compounds that contain an ether group—an oxygen atom connected to two alkyl or aryl groups.

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Ferrier rearrangement

The Ferrier rearrangement is an organic reaction that involves a nucleophilic substitution reaction combined with an allylic shift in a glycal (a 2,3-unsaturated glycoside).

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Finkelstein reaction

The Finkelstein reaction (often referred to as a halex reaction or halogen exchange) named after the German chemist Hans Finkelstein, is an SN2 reaction (Substitution Nucleophilic Bimolecular reaction) that involves the exchange of one halogen atom for another.

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Haloalkane

The haloalkanes (also known as halogenoalkanes or alkyl halides) are a group of chemical compounds derived from alkanes containing one or more halogens.

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Hydride

In chemistry, a hydride is the anion of hydrogen, H−, or, more commonly, it is a compound in which one or more hydrogen centres have nucleophilic, reducing, or basic properties.

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Hydrobromic acid

Hydrobromic acid is a strong acid formed by dissolving the diatomic molecule hydrogen bromide (HBr) in water.

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Hydrolysis

Hydrolysis is a term used for both an electro-chemical process and a biological one.

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Hydroxy group

A hydroxy or hydroxyl group is the entity with the formula OH.

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Inorganic chemistry

Inorganic chemistry deals with the synthesis and behavior of inorganic and organometallic compounds.

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Journal of the Chemical Society

The Journal of the Chemical Society was a scientific journal established by the Chemical Society in 1849 as the Quarterly Journal of the Chemical Society.

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Kolbe nitrile synthesis

The Kolbe nitrile synthesis is a method for the preparation of alkyl nitriles by reaction of the corresponding alkyl halide with a metal cyanide.

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Leaving group

In chemistry, a leaving group is a molecular fragment that departs with a pair of electrons in heterolytic bond cleavage.

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Lithium aluminium hydride

Lithium aluminium hydride, commonly abbreviated to LAH, is an inorganic compound with the chemical formula LiAlH4.

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Michaelis–Arbuzov reaction

The Michaelis–Arbuzov reaction (also called the Arbuzov reaction) is the chemical reaction of a trialkyl phosphite and an alkyl halide to form a phosphonate.

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Nucleophile

Nucleophile is a chemical species that donates an electron pair to an electrophile to form a chemical bond in relation to a reaction.

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Nucleophilic abstraction

Nucleophilic abstraction is a type of an organometallic reaction which can be defined as a nucleophilic attack on a ligand which causes part or all of the original ligand to be removed from the metal along with the nucleophile.

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Nucleophilic acyl substitution

Nucleophilic acyl substitution describe a class of substitution reactions involving nucleophiles and acyl compounds.

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Nucleophilic aromatic substitution

Aromatic nucleophilic substitution A nucleophilic aromatic substitution is a substitution reaction in organic chemistry in which the nucleophile displaces a good leaving group, such as a halide, on an aromatic ring.

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Organic chemistry

Organic chemistry is a chemistry subdiscipline involving the scientific study of the structure, properties, and reactions of organic compounds and organic materials, i.e., matter in its various forms that contain carbon atoms.

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Organic redox reaction

Organic reductions or organic oxidations or organic redox reactions are redox reactions that take place with organic compounds.

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Organometallic chemistry

Organometallic chemistry is the study of organometallic compounds, chemical compounds containing at least one chemical bond between a carbon atom of an organic molecule and a metal, including alkaline, alkaline earth, and transition metals, and sometimes broadened to include metalloids like boron, silicon, and tin, as well.

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Perkow reaction

The Perkow reaction is an organic reaction in which a trialkyl phosphite ester reacts with a haloketone to form a dialkyl vinyl phosphate and an alkyl halide.

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Protic solvent

In chemistry, a protic solvent is a solvent that has a hydrogen atom bound to an oxygen (as in a hydroxyl group) or a nitrogen (as in an amine group).

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Racemization

In chemistry, racemization is the conversion of an enantiomerically pure mixture (one where only one enantiomer is present) into a mixture where more than one of the enantiomers are present.

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Rate equation

The rate law or rate equation for a chemical reaction is an equation that links the reaction rate with the concentrations or pressures of the reactants and constant parameters (normally rate coefficients and partial reaction orders).

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Reaction rate

The reaction rate or rate of reaction is the speed at which reactants are converted into products.

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Rearrangement reaction

A rearrangement reaction is a broad class of organic reactions where the carbon skeleton of a molecule is rearranged to give a structural isomer of the original molecule.

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Saturation (chemistry)

In chemistry, saturation (from the Latin word saturare, meaning 'to fill') has diverse meanings, all based on the idea of reaching a maximum capacity.

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SN1 reaction

The SN1 reaction is a substitution reaction in organic chemistry.

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Sn1CB mechanism

The SN1cB (conjugate base) mechanism describes the pathway by which many metal amine complexes undergo substitution, that is ligand exchange.

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SN2 reaction

The SN2 reaction is a type of reaction mechanism that is common in organic chemistry.

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SNi

SNi or Substitution Nucleophilic internal stands for a specific but not often encountered nucleophilic aliphatic substitution reaction mechanism.

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Sodium hydroxide

Sodium hydroxide, also known as lye, is an inorganic compound with the formula NaOH. It is a white solid ionic compound consisting of sodium cations and hydroxide anions. Sodium hydroxide is a highly caustic base and alkali that decomposes proteins at ordinary ambient temperatures and may cause severe chemical burns. It is highly soluble in water, and readily absorbs moisture and carbon dioxide from the air. It forms a series of hydrates NaOH·n. The monohydrate NaOH· crystallizes from water solutions between 12.3 and 61.8 °C. The commercially available "sodium hydroxide" is often this monohydrate, and published data may refer to it instead of the anhydrous compound. As one of the simplest hydroxides, it is frequently utilized alongside neutral water and acidic hydrochloric acid to demonstrate the pH scale to chemistry students. Sodium hydroxide is used in many industries: in the manufacture of pulp and paper, textiles, drinking water, soaps and detergents, and as a drain cleaner. Worldwide production in 2004 was approximately 60 million tonnes, while demand was 51 million tonnes.

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Sodium methoxide

Sodium methoxide is a chemical compound with the formula CH3ONa.

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Solvent

A solvent (from the Latin solvō, "loosen, untie, solve") is a substance that dissolves a solute (a chemically distinct liquid, solid or gas), resulting in a solution.

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Stereochemistry

Stereochemistry, a subdiscipline of chemistry, involves the study of the relative spatial arrangement of atoms that form the structure of molecules and their manipulation.

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Steric effects

Steric effects are nonbonding interactions that influence the shape (conformation) and reactivity of ions and molecules.

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Substrate (chemistry)

In chemistry, a substrate is typically the chemical species being observed in a chemical reaction, which reacts with a reagent to generate a product.

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Thionyl chloride

Thionyl chloride is an inorganic compound with the chemical formula SOCl2.

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Wenker synthesis

The Wenker synthesis is an organic reaction converting a beta amino alcohol to an aziridine with the aid of sulfuric acid.

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Williamson ether synthesis

The Williamson ether synthesis is an organic reaction, forming an ether from an organohalide and a deprotonated alcohol (alkoxide).

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Intramolecular nucleophilic substitution, Nucleophilic Substitution, Nucleophilic aliphatic Substitution, Nucleophilic aliphatic substitution, Nucleophilic displacement, Nucleophilic substitution reaction, SN Reactions, SN reaction, Sn reactions.

References

[1] https://en.wikipedia.org/wiki/Nucleophilic_substitution

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