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Beta-lactamase

Index Beta-lactamase

Beta-lactamases are enzymes produced by bacteria that provide multi-resistance to β-lactam antibiotics such as penicillins, cephalosporins, cephamycins, and carbapenems (ertapenem), although carbapenems are relatively resistant to beta-lactamase. [1]

86 relations: Acinetobacter, Amide, Amino acid, Aminoglycoside, Amoxicillin, Amoxicillin/clavulanic acid, Ampicillin, Ampicillin/sulbactam, Antibiotic, Antimicrobial resistance, Aztreonam, Beta, Bya, Carbapenem, Cefalotin, Cefepime, Cefotaxime, Cefotetan, Cefoxitin, Ceftazidime, Ceftizoxime, Ceftriaxone, Cephalosporin, Cephamycin, Chloramphenicol, Ciprofloxacin, Citrobacter, Citrobacter freundii, Clavulanic acid, Cloxacillin, Decarboxylation, Diastase, Enterobacter, Enterobacter cloacae, Enterobacteriaceae, Enzyme, Ertapenem, Escherichia coli, Fosfomycin, Gentamicin, Gram-negative bacteria, Gram-positive bacteria, Greek language, Haemophilus influenzae, Hydrolysis, Imipenem, Klebsiella, Klebsiella oxytoca, Klebsiella pneumoniae, Kluyvera, ..., Lactic acid, Latin, Mecillinam, Meropenem, Methicillin, Multiple drug resistance, Neisseria gonorrhoeae, New Delhi, Nitrocefin, Nitrofurantoin, Nitrogen, North Carolina, Oxacillin, Penicillin, Piperacillin/tazobactam, Plasmid, Portmanteau, Proteus mirabilis, Pseudomonas, Pseudomonas aeruginosa, Quinolone antibiotic, Salmonella, Salmonella enterica, Serratia, Serratia marcescens, Streptomyces, Streptomyces albus, Sulbactam, Sulfamethoxazole, Sulfonamide (medicine), Tazobactam, Temocillin, Ticarcillin, Ticarcillin/clavulanic acid, Trimethoprim, Urinary tract infection. Expand index (36 more) »

Acinetobacter

Acinetobacter is a genus of Gram-negative bacteria belonging to the wider class of Gammaproteobacteria.

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Amide

An amide (or or), also known as an acid amide, is a compound with the functional group RnE(O)xNR′2 (R and R′ refer to H or organic groups).

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Amino acid

Amino acids are organic compounds containing amine (-NH2) and carboxyl (-COOH) functional groups, along with a side chain (R group) specific to each amino acid.

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Aminoglycoside

Aminoglycoside is a medicinal and bacteriologic category of traditional Gram-negative antibacterial therapeutic agents that inhibit protein synthesis and contain as a portion of the molecule an amino-modified glycoside (sugar); the term can also refer more generally to any organic molecule that contains aminosugar substructures.

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Amoxicillin

Amoxicillin, also spelled amoxycillin, is an antibiotic useful for the treatment of a number of bacterial infections.

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Amoxicillin/clavulanic acid

Amoxicillin/clavulanic acid, also known as co-amoxiclav, is an antibiotic useful for the treatment of a number of bacterial infections.

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Ampicillin

Ampicillin is an antibiotic used to prevent and treat a number of bacterial infections, such as respiratory tract infections, urinary tract infections, meningitis, salmonellosis, and endocarditis.

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Ampicillin/sulbactam

Ampicillin/sulbactam is a combination of the common penicillin-derived antibiotic ampicillin and sulbactam, an inhibitor of bacterial beta-lactamase.

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Antibiotic

An antibiotic (from ancient Greek αντιβιοτικά, antibiotiká), also called an antibacterial, is a type of antimicrobial drug used in the treatment and prevention of bacterial infections.

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Antimicrobial resistance

Antimicrobial resistance (AMR or AR) is the ability of a microbe to resist the effects of medication that once could successfully treat the microbe.

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Aztreonam

Aztreonam, sold under the brand name Azactam among others, is an antibiotic used primarily to treat infections caused by gram-negative bacteria such as Pseudomonas aeruginosa.

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Beta

Beta (uppercase, lowercase, or cursive; bē̂ta or βήτα) is the second letter of the Greek alphabet.

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Bya

bya or b.y.a. is an abbreviation for "billion years ago".

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Carbapenem

Carbapenems are a class of highly effective antibiotic agents commonly used for the treatment of severe or high-risk bacterial infections.

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Cefalotin

Cefalotin (INN) or cephalothin (USAN) is a first-generation cephalosporin antibiotic.

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Cefepime

Cefepime is a fourth-generation cephalosporin antibiotic.

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Cefotaxime

Cefotaxime is an antibiotic used to treat a number of bacterial infections.

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Cefotetan

Cefotetan is an injectable antibiotic of the cephamycin type for prophylaxis and treatment of bacterial infections.

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Cefoxitin

Cefoxitin is a second-generation cephamycin antibiotic developed by Merck & Co., Inc.

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Ceftazidime

Ceftazidime, sold under the brand names Fortaz among others, is an antibiotic useful for the treatment of a number of bacterial infections.

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Ceftizoxime

Ceftizoxime is a third-generation cephalosporin available for parenteral administration.

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Ceftriaxone

Ceftriaxone, sold under the trade name Rocephin, is an antibiotic useful for the treatment of a number of bacterial infections.

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Cephalosporin

The cephalosporins (sg.) are a class of β-lactam antibiotics originally derived from the fungus Acremonium, which was previously known as "Cephalosporium".

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Cephamycin

Cephamycins are a group of beta-lactam antibiotics.

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Chloramphenicol

Chloramphenicol is an antibiotic useful for the treatment of a number of bacterial infections.

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Ciprofloxacin

Ciprofloxacin is an antibiotic used to treat a number of bacterial infections.

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Citrobacter

Citrobacter is a genus of Gram-negative coliform bacteria in the Enterobacteriaceae family.

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Citrobacter freundii

Citrobacter freundii is a species of facultative anaerobic gram-negative bacteria of the family Enterobacteriaceae.

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Clavulanic acid

Clavulanic acid is a β-lactam drug that functions as a mechanism-based β-lactamase inhibitor.

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Cloxacillin

Cloxacillin is an antibiotic useful for the treatment of a number of bacterial infections.

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Decarboxylation

Decarboxylation is a chemical reaction that removes a carboxyl group and releases carbon dioxide (CO2).

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Diastase

A diastase (from Greek διάστασις, "separation") is any one of a group of enzymes that catalyses the breakdown of starch into maltose.

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Enterobacter

Enterobacter is a genus of common Gram-negative, facultatively anaerobic, rod-shaped, non-spore-forming bacteria of the family Enterobacteriaceae.

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Enterobacter cloacae

Enterobacter cloacae is a clinically significant Gram-negative, facultatively-anaerobic, rod-shaped bacterium.

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Enterobacteriaceae

The Enterobacteriaceae are a large family of Gram-negative bacteria.

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Enzyme

Enzymes are macromolecular biological catalysts.

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Ertapenem

Ertapenem is a carbapenem antibiotic marketed by Merck as Invanz.

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Escherichia coli

Escherichia coli (also known as E. coli) is a Gram-negative, facultatively anaerobic, rod-shaped, coliform bacterium of the genus Escherichia that is commonly found in the lower intestine of warm-blooded organisms (endotherms).

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Fosfomycin

Fosfomycin (also known as phosphomycin or phosphonomycin and the trade names Monurol and Monuril) is a broad-spectrum antibiotic produced by certain Streptomyces species, although it can now be made by chemical synthesis.

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Gentamicin

Gentamicin, sold under brand names Garamycin among others, is an antibiotic used to treat several types of bacterial infections.

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Gram-negative bacteria

Gram-negative bacteria are bacteria that do not retain the crystal violet stain used in the gram-staining method of bacterial differentiation.

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Gram-positive bacteria

Gram-positive bacteria are bacteria that give a positive result in the Gram stain test, which is traditionally used to quickly classify bacteria into two broad categories according to their cell wall.

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Greek language

Greek (Modern Greek: ελληνικά, elliniká, "Greek", ελληνική γλώσσα, ellinikí glóssa, "Greek language") is an independent branch of the Indo-European family of languages, native to Greece and other parts of the Eastern Mediterranean and the Black Sea.

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Haemophilus influenzae

Haemophilus influenzae (formerly called Pfeiffer's bacillus or Bacillus influenzae) is a Gram-negative, coccobacillary, facultatively anaerobic pathogenic bacterium belonging to the Pasteurellaceae family.

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Hydrolysis

Hydrolysis is a term used for both an electro-chemical process and a biological one.

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Imipenem

Imipenem (Primaxin) is an intravenous β-lactam antibiotic discovered by Merck scientists Burton Christensen, William Leanza, and Kenneth Wildonger in the mid-1970s.

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Klebsiella

Klebsiella is a genus of nonmotile, Gram-negative, oxidase-negative, rod-shaped bacteria with a prominent polysaccharide-based capsule.

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Klebsiella oxytoca

Klebsiella oxytoca is a Gram-negative, rod-shaped bacterium that is closely related to K. pneumoniae, from which it is distinguished by being indole-positive; it also has slightly different growth characteristics in that it is able to grow on melezitose, but not 3-hydroxybutyrate.

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Klebsiella pneumoniae

Klebsiella pneumoniae is a Gram-negative, non-motile, encapsulated, lactose-fermenting, facultative anaerobic, rod-shaped bacterium.

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Kluyvera

Kluyvera is a Gram negative, facultatively anaerobic bacterial and motile genus from the family of Enterobacteriaceae with have a peritrichous flagella.

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Lactic acid

Lactic acid is an organic compound with the formula CH3CH(OH)COOH.

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Latin

Latin (Latin: lingua latīna) is a classical language belonging to the Italic branch of the Indo-European languages.

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Mecillinam

Mecillinam (INN) or amdinocillin (USAN) is an extended-spectrum penicillin antibiotic of the amidinopenicillin class that binds specifically to penicillin binding protein 2 (PBP2), and is only considered to be active against Gram-negative bacteria.

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Meropenem

Meropenem, sold under the brandname Merrem among others, is a broad-spectrum antibiotic used to treat a variety of bacterial infections.

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Methicillin

Methicillin, also known as meticillin, is a narrow-spectrum β-lactam antibiotic of the penicillin class.

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Multiple drug resistance

Multiple drug resistance (MDR), multidrug resistance or multiresistance is antimicrobial resistance shown by a species of microorganism to multiple antimicrobial drugs.

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Neisseria gonorrhoeae

Neisseria gonorrhoeae, also known as gonococcus (singular), or gonococci (plural) is a species of gram-negative diplococci bacteria isolated by Albert Neisser in 1879.

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New Delhi

New Delhi is an urban district of Delhi which serves as the capital of India and seat of all three branches of Government of India.

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Nitrocefin

Nitrocefin is a chromogenic cephalosporin substrate routinely used to detect the presence of beta-lactamase enzymes produced by various microbes.

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Nitrofurantoin

Nitrofurantoin, sold under the trade name Macrobid among others, is an antibiotic used to treat bladder infections.

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Nitrogen

Nitrogen is a chemical element with symbol N and atomic number 7.

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North Carolina

North Carolina is a U.S. state in the southeastern region of the United States.

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Oxacillin

Oxacillin sodium (trade name Bactocill) is a narrow-spectrum beta-lactam antibiotic of the penicillin class developed by Beecham.

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Penicillin

Penicillin (PCN or pen) is a group of antibiotics which include penicillin G (intravenous use), penicillin V (use by mouth), procaine penicillin, and benzathine penicillin (intramuscular use).

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Piperacillin/tazobactam

Piperacillin/tazobactam, sold under the brand name Tazocin among others, is a combination medication containing the antibiotic piperacillin and the β-lactamase inhibitor tazobactam.

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Plasmid

A plasmid is a small DNA molecule within a cell that is physically separated from a chromosomal DNA and can replicate independently.

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Portmanteau

A portmanteau or portmanteau word is a linguistic blend of words,, p. 644 in which parts of multiple words or their phones (sounds) are combined into a new word, as in smog, coined by blending smoke and fog, or motel, from motor and hotel.

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Proteus mirabilis

Proteus mirabilis is a Gram-negative, facultatively anaerobic, rod-shaped bacterium.

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Pseudomonas

Pseudomonas is a genus of Gram-negative, Gammaproteobacteria, belonging to the family Pseudomonadaceae and containing 191 validly described species.

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Pseudomonas aeruginosa

Pseudomonas aeruginosa is a common Gram-negative, rod-shaped bacterium that can cause disease in plants and animals, including humans.

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Quinolone antibiotic

A quinolone antibiotic is any member of a large group of broad-spectrum bactericides that share a bicyclic core structure related to the compound 4-quinolone.

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Salmonella

Salmonella is a genus of rod-shaped (bacillus) Gram-negative bacteria of the family Enterobacteriaceae.

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Salmonella enterica

Salmonella enterica (formerly Salmonella choleraesuis) is a rod-shaped, flagellate, facultative anaerobic, gram-negative bacterium and a species of the genus Salmonella.

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Serratia

Serratia is a genus of Gram-negative, facultatively anaerobic, rod-shaped bacteria of the Enterobacteriaceae family.

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Serratia marcescens

Serratia marcescens is a species of rod-shaped gram-negative bacteria in the family Enterobacteriaceae.

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Streptomyces

Streptomyces is the largest genus of Actinobacteria and the type genus of the family Streptomycetaceae.

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Streptomyces albus

Streptomyces albus is a bacterial species from which the pseudodisaccharide aminoglycoside salbostatin was isolated.

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Sulbactam

Sulbactam is a β-lactamase inhibitor.

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Sulfamethoxazole

Sulfamethoxazole (SMZ or SMX) is an antibiotic.

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Sulfonamide (medicine)

Sulfonamide (also called sulphonamide, sulfa drugs or sulpha drugs) is the basis of several groups of drugs.

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Tazobactam

Tazobactam is a pharmaceutical drug that inhibits the action of bacterial β-lactamases, especially those belonging to the SHV-1 and TEM groups.

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Temocillin

Temocillin is a β-lactamase-resistant penicillin introduced by Beecham, marketed by Eumedica Pharmaceuticals as Negaban.

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Ticarcillin

Ticarcillin is a carboxypenicillin.

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Ticarcillin/clavulanic acid

Ticarcillin/clavulanic acid, or co-ticarclav, is a combination antibiotic consisting of ticarcillin, a β-lactam antibiotic, and clavulanic acid, a β-lactamase inhibitor.

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Trimethoprim

Trimethoprim (TMP) is an antibiotic used mainly in the treatment of bladder infections.

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Urinary tract infection

A urinary tract infection (UTI) is an infection that affects part of the urinary tract.

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AmpC cephalosporinase, AmpR gene, B lactamase, B-lactamase, Beta lactamase, Beta-lactam hydrolase, Beta-lactamases, Betalactamase, Carbapenemase, EC 3.5.2.6, ESBL, Esbl, Extended spectrum beta-lactamase, Extended-spectrum beta-lactamase, Lactamase, Penicillinase, Ss lactamase, TEM beta-lactamase, TEM-1, ß lactamase, Β lactamase, Β-Lactamase, Β-lactamase.

References

[1] https://en.wikipedia.org/wiki/Beta-lactamase

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