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51 relations: Adenocarcinoma of the lung, Adenomatous polyposis coli, Allosteric regulation, C-Raf, C-terminus, Calmodulin, Cancer Research (journal), Cardiofaciocutaneous syndrome, Cell membrane, Cell signaling, Cetuximab, Colorectal cancer, Cytosol, Downregulation and upregulation, Ductal carcinoma, Epidermal growth factor receptor, Erlotinib, Exon, Gefitinib, Gene duplication, Germline, GLUT1, Growth factor, GTPase-activating protein, Guanine nucleotide exchange factor, Guanosine diphosphate, Guanosine triphosphate, HRAS, Isoprene, Leukemia, Lung cancer, MEK inhibitor, Monoclonal antibody, Neuroblastoma RAS viral oncogene homolog, Noonan syndrome, Oncogene, Pancreas, Pancreatic cancer, Panitumumab, Phosphoinositide 3-kinase, PIK3CG, Protein dynamics, Protein–protein interaction, RALGDS, RAS p21 protein activator 1, Ras subfamily, RASSF2, Signal transduction, Somatic (biology), SOS1, ..., Xenotransplantation. Expand index (1 more) »
Adenocarcinoma of the lung
Adenocarcinoma of the lung (also known as pulmonary adenocarcinoma) is the most common type of lung cancer, and is characterized by distinct cellular and molecular features including gland and/or duct formation and/or production of significant amounts of mucus.
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Adenomatous polyposis coli
Adenomatous polyposis coli (APC) also known as deleted in polyposis 2.5 (DP2.5) is a protein that in humans is encoded by the APC gene.
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Allosteric regulation
In biochemistry, allosteric regulation (or allosteric control) is the regulation of an enzyme by binding an effector molecule at a site other than the enzyme's active site.
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C-Raf
RAF proto-oncogene serine/threonine-protein kinase, also known as proto-oncogene c-RAF or simply c-Raf or even Raf-1, is an enzyme that in humans is encoded by the RAF1 gene.
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C-terminus
The C-terminus (also known as the carboxyl-terminus, carboxy-terminus, C-terminal tail, C-terminal end, or COOH-terminus) is the end of an amino acid chain (protein or polypeptide), terminated by a free carboxyl group (-COOH).
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Calmodulin
Calmodulin (CaM) (an abbreviation for calcium-modulated protein) is a multifunctional intermediate calcium-binding messenger protein expressed in all eukaryotic cells.
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Cancer Research (journal)
Cancer Research is a peer-reviewed scientific journal published by the American Association for Cancer Research.
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Cardiofaciocutaneous syndrome
Cardiofaciocutaneous (CFC) syndrome is an extremely rare and serious genetic disorder.
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Cell membrane
The cell membrane (also known as the plasma membrane or cytoplasmic membrane, and historically referred to as the plasmalemma) is a biological membrane that separates the interior of all cells from the outside environment (the extracellular space).
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Cell signaling
Cell signaling (cell signalling in British English) is part of any communication process that governs basic activities of cells and coordinates all cell actions.
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Cetuximab
Cetuximab is an epidermal growth factor receptor (EGFR) inhibitor used for the treatment of metastatic colorectal cancer, metastatic non-small cell lung cancer and head and neck cancer.
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Colorectal cancer
Colorectal cancer (CRC), also known as bowel cancer and colon cancer, is the development of cancer from the colon or rectum (parts of the large intestine).
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Cytosol
The cytosol, also known as intracellular fluid (ICF) or cytoplasmic matrix, is the liquid found inside cells.
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Downregulation and upregulation
In the biological context of organisms' production of gene products, downregulation is the process by which a cell decreases the quantity of a cellular component, such as RNA or protein, in response to an external stimulus.
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Ductal carcinoma
Ductal carcinoma is a type of tumor that primarily presents in the ducts of a gland.
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Epidermal growth factor receptor
The epidermal growth factor receptor (EGFR; ErbB-1; HER1 in humans) is a transmembrane protein that is a receptor for members of the epidermal growth factor family (EGF family) of extracellular protein ligands.
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Erlotinib
Erlotinib hydrochloride (trade name Tarceva) is a drug used to treat non-small cell lung cancer, pancreatic cancer and several other types of cancer.
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Exon
An exon is any part of a gene that will encode a part of the final mature RNA produced by that gene after introns have been removed by RNA splicing.
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Gefitinib
Gefitinib (ZD1839) (INN,, trade name Iressa) is a drug used for certain breast, lung and other cancers.
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Gene duplication
Gene duplication (or chromosomal duplication or gene amplification) is a major mechanism through which new genetic material is generated during molecular evolution.
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Germline
In biology and genetics, the germline in a multicellular organism is the population of its bodily cells that are so differentiated or segregated that in the usual processes of reproduction they may pass on their genetic material to the progeny.
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GLUT1
Glucose transporter 1 (or GLUT1), also known as solute carrier family 2, facilitated glucose transporter member 1 (SLC2A1), is a uniporter protein that in humans is encoded by the SLC2A1 gene.
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Growth factor
A growth factor is a naturally occurring substance capable of stimulating cellular growth, proliferation, healing, and cellular differentiation.
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GTPase-activating protein
GTPase-activating proteins or GTPase-accelerating proteins (GAPs) are a family of regulatory proteins whose members can bind to activated G proteins and stimulate their GTPase activity, with the result of terminating the signaling event.
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Guanine nucleotide exchange factor
Guanine nucleotide exchange factors (GEFs) are proteins or protein domains that activate monomeric GTPases by stimulating the release of guanosine diphosphate (GDP) to allow binding of guanosine triphosphate (GTP).
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Guanosine diphosphate
Guanosine diphosphate, abbreviated GDP, is a nucleoside diphosphate.
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Guanosine triphosphate
Guanosine-5'-triphosphate (GTP) is a purine nucleoside triphosphate.
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HRAS
GTPase HRas also known as transforming protein p21 is an enzyme that in humans is encoded by the HRAS gene.
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Isoprene
Isoprene, or 2-methyl-1,3-butadiene, is a common organic compound with the formula CH2.
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Leukemia
Leukemia, also spelled leukaemia, is a group of cancers that usually begin in the bone marrow and result in high numbers of abnormal white blood cells.
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Lung cancer
Lung cancer, also known as lung carcinoma, is a malignant lung tumor characterized by uncontrolled cell growth in tissues of the lung.
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MEK inhibitor
A MEK inhibitor is a chemical or drug that inhibits the mitogen-activated protein kinase kinase enzymes MEK1 and/or MEK2.
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Monoclonal antibody
Monoclonal antibodies (mAb or moAb) are antibodies that are made by identical immune cells that are all clones of a unique parent cell.
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Neuroblastoma RAS viral oncogene homolog
NRAS is an enzyme that in humans is encoded by the NRAS gene.
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Noonan syndrome
Noonan syndrome (NS) is a relatively common autosomal dominant congenital disorder and is named after Jacqueline Noonan, a pediatric cardiologist.
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Oncogene
An oncogene is a gene that has the potential to cause cancer.
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Pancreas
The pancreas is a glandular organ in the digestive system and endocrine system of vertebrates.
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Pancreatic cancer
Pancreatic cancer arises when cells in the pancreas, a glandular organ behind the stomach, begin to multiply out of control and form a mass.
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Panitumumab
Panitumumab (INN), formerly ABX-EGF, is a fully human monoclonal antibody specific to the epidermal growth factor receptor (also known as EGF receptor, EGFR, ErbB-1 and HER1 in humans).
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Phosphoinositide 3-kinase
Phosphatidylinositol-4,5-bisphosphate 3-kinase (also called phosphatidylinositide 3-kinases, phosphatidylinositol-3-kinases, PI 3-kinases, PI(3)Ks, PI-3Ks or by the HUGO official stem symbol for the gene family, PI3K(s)) are a family of enzymes involved in cellular functions such as cell growth, proliferation, differentiation, motility, survival and intracellular trafficking, which in turn are involved in cancer.
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PIK3CG
Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform is an enzyme that in humans is encoded by the PIK3CG gene.
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Protein dynamics
Proteins are generally thought to adopt unique structures determined by their amino acid sequences, as outlined by Anfinsen's dogma.
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Protein–protein interaction
Protein–protein interactions (PPIs) are the physical contacts of high specificity established between two or more protein molecules as a result of biochemical events steered by electrostatic forces including the hydrophobic effect.
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RALGDS
Ral guanine nucleotide dissociation stimulator is a protein that in humans is encoded by the RALGDS gene.
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RAS p21 protein activator 1
RAS p21 protein activator 1 or RasGAP (Ras GTPase activating protein), also known as RASA1, is a 120-kDa cytosolic human protein that provides two principal activities.
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Ras subfamily
Ras is a family of related proteins which is expressed in all animal cell lineages and organs.
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RASSF2
Ras association domain-containing protein 2 is a protein that in humans is encoded by the RASSF2 gene.
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Signal transduction
Signal transduction is the process by which a chemical or physical signal is transmitted through a cell as a series of molecular events, most commonly protein phosphorylation catalyzed by protein kinases, which ultimately results in a cellular response.
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Somatic (biology)
The term somatic is often used in biology to refer to the cells of the body in contrast to the germ line cells which usually give rise to the gametes (ovum or sperm).
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SOS1
Son of sevenless homolog 1 is a protein that in humans is encoded by the SOS1 gene.
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Xenotransplantation
Xenotransplantation (xenos- from the Greek meaning "foreign"), is the transplantation of living cells, tissues or organs from one species to another.
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Redirects here:
C-K-RAS, K-Ras, KRAS (gene), KRAS gene, KRAS2, KRas, RASK2, Rask2, V-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog.
References
[1] https://en.wikipedia.org/wiki/KRAS
