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39 relations: Adenylyl cyclase, Alternative splicing, C1QTNF1, Cirrhosis, Collecting duct system, Demeclocycline, Desmopressin, Distal convoluted tubule, Factor VIII, Fetus, Food and Drug Administration, G protein, G protein–coupled receptor, Gs alpha subunit, Haemophilia A, Heart failure, Homeostasis, Hyponatremia, Kidney, Lithium carbonate, Lixivaptan, Lung, Lung cancer, Mozavaptan, Nephrogenic diabetes insipidus, Nephron, Protein, Protein–protein interaction, Satavaptan, Second messenger system, Syndrome of inappropriate antidiuretic hormone secretion, Tolvaptan, Urine, Vasopressin, Vasopressin receptor, Vasopressin receptor antagonist, Von Willebrand disease, Von Willebrand factor, Water.
Adenylyl cyclase
Adenylyl cyclase (also commonly known as adenyl cyclase and adenylate cyclase, abbreviated AC) is an enzyme with key regulatory roles in essentially all cells.
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Alternative splicing
Alternative splicing, or differential splicing, is a regulated process during gene expression that results in a single gene coding for multiple proteins.
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C1QTNF1
Complement C1q tumor necrosis factor-related protein 1 is a protein that in humans is encoded by the C1QTNF1 gene.
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Cirrhosis
Cirrhosis is a condition in which the liver does not function properly due to long-term damage.
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Collecting duct system
The collecting duct system of the kidney consists of a series of tubules and ducts that physically connect nephrons to a minor calyx or directly to the renal pelvis.
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Demeclocycline
Demeclocycline (INN, BAN, USAN) (brand names Declomycin, Declostatin, Ledermycin, Bioterciclin, Deganol, Deteclo), also known under the brand names Detravis, Meciclin, Mexocine, Clortetrin, is a semisynthetic tetracycline antibiotic which was derived from a strain of Streptomyces aureofaciens.
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Desmopressin
Desmopressin, sold under the trade name DDAVP among others, is a medication used to treat diabetes insipidus, bedwetting, hemophilia A, von Willebrand disease, and high blood urea levels.
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Distal convoluted tubule
The distal convoluted tubule (DCT) is a portion of kidney nephron between the loop of Henle and the collecting tubule.
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Factor VIII
Factor VIII (FVIII) is an essential blood-clotting protein, also known as anti-hemophilic factor (AHF).
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Fetus
A fetus is a stage in the prenatal development of viviparous organisms.
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Food and Drug Administration
The Food and Drug Administration (FDA or USFDA) is a federal agency of the United States Department of Health and Human Services, one of the United States federal executive departments.
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G protein
G proteins, also known as guanine nucleotide-binding proteins, are a family of proteins that act as molecular switches inside cells, and are involved in transmitting signals from a variety of stimuli outside a cell to its interior.
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G protein–coupled receptor
G protein–coupled receptors (GPCRs), also known as seven-(pass)-transmembrane domain receptors, 7TM receptors, heptahelical receptors, serpentine receptor, and G protein–linked receptors (GPLR), constitute a large protein family of receptors that detect molecules outside the cell and activate internal signal transduction pathways and, ultimately, cellular responses.
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Gs alpha subunit
The Gs alpha subunit (Gαs, Gsα, or Gs protein) is a heterotrimeric G protein subunit that activates the cAMP-dependent pathway by activating adenylyl cyclase.
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Haemophilia A
Haemophilia A (or hemophilia A) is a genetic deficiency in clotting factor VIII, which causes increased bleeding and usually affects males.
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Heart failure
Heart failure (HF), often referred to as congestive heart failure (CHF), is when the heart is unable to pump sufficiently to maintain blood flow to meet the body's needs.
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Homeostasis
Homeostasis is the tendency of organisms to auto-regulate and maintain their internal environment in a stable state.
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Hyponatremia
Hyponatremia is a low sodium level in the blood.
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Kidney
The kidneys are two bean-shaped organs present in left and right sides of the body in vertebrates.
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Lithium carbonate
No description.
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Lixivaptan
Lixivaptan (VPA-985) is a phase III pharmaceutical being developed by Cardiokine, Inc., a specialty pharmaceutical company based in Philadelphia, PA, focused on the development of pharmaceuticals for the treatment and prevention of cardiovascular diseases.
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Lung
The lungs are the primary organs of the respiratory system in humans and many other animals including a few fish and some snails.
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Lung cancer
Lung cancer, also known as lung carcinoma, is a malignant lung tumor characterized by uncontrolled cell growth in tissues of the lung.
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Mozavaptan
Mozavaptan (INN) is a vasopressin receptor antagonist marketed by Otsuka.
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Nephrogenic diabetes insipidus
Nephrogenic diabetes insipidus (also known as renal diabetes insipidus) is a form of diabetes insipidus primarily due to pathology of the kidney.
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Nephron
The nephron (from Greek νεφρός – nephros, meaning "kidney") is the microscopic structural and functional unit of the kidney.
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Protein
Proteins are large biomolecules, or macromolecules, consisting of one or more long chains of amino acid residues.
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Protein–protein interaction
Protein–protein interactions (PPIs) are the physical contacts of high specificity established between two or more protein molecules as a result of biochemical events steered by electrostatic forces including the hydrophobic effect.
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Satavaptan
Satavaptan (INN; developmental code name SR121463, former tentative brand name Aquilda) is a vasopressin-2 receptor antagonist which was investigation by Sanofi-Aventis and was under development for the treatment of hyponatremia.
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Second messenger system
Second messengers are intracellular signaling molecules released by the cell in response to exposure to extracellular signaling molecules—the first messengers.
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Syndrome of inappropriate antidiuretic hormone secretion
Syndrome of inappropriate antidiuretic hormone secretion (SIADH) is characterized by excessive unsuppressible release of antidiuretic hormone (ADH) either from the posterior pituitary gland, or an abnormal non-pituitary source.
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Tolvaptan
Tolvaptan (INN, trade names Samsca and Jinarc) is an aquaretic drug that functions as a selective, competitive vasopressin receptor 2 antagonist used to treat hyponatremia (low blood sodium levels) associated with congestive heart failure, cirrhosis, and the syndrome of inappropriate antidiuretic hormone (SIADH).
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Urine
Urine is a liquid by-product of metabolism in humans and in many animals.
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Vasopressin
Vasopressin, also named antidiuretic hormone (ADH), arginine vasopressin (AVP) or argipressin, is a hormone synthesized as a peptide prohormone in neurons in the hypothalamus, and is converted to AVP.
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Vasopressin receptor
The actions of vasopressin are mediated by stimulation of tissue-specific G protein-coupled receptors (GPCRs) called vasopressin receptors that are classified into the V1 (V1A), V2, and V3 (V1B) receptor subtypes.
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Vasopressin receptor antagonist
A vasopressin receptor antagonist (VRA) is an agent that interferes with action at the vasopressin receptors.
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Von Willebrand disease
Von Willebrand disease (vWD) is the most common hereditary blood-clotting disorder in humans.
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Von Willebrand factor
Von Willebrand factor (vWF) is a blood glycoprotein involved in hemostasis.
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Water
Water is a transparent, tasteless, odorless, and nearly colorless chemical substance that is the main constituent of Earth's streams, lakes, and oceans, and the fluids of most living organisms.
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Redirects here:
AVPR2, AVPR2 (gene), Arginine vasopressin receptor 2, V2 receptor, V2 vasopressin receptor, Vasopressin 2 receptor, Vasopressin V2 receptor.
References
[1] https://en.wikipedia.org/wiki/Vasopressin_receptor_2
