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Vinblastine

Index Vinblastine

Vinblastine is a chemotherapy medication, typically used with other medications, to treat a number of types of cancer. [1]

57 relations: ABVD, Accounts of Chemical Research, Anaphase, Bladder cancer, Blister agent, Bone marrow suppression, Brain tumor, Cancer, Cancer (journal), Catharanthine, Catharanthus roseus, Cell cycle, Charles Thomas Beer, Chemotherapy, Chemotherapy regimen, Constipation, CRC Press, Current Medicinal Chemistry, CYP3A4, Cytopenia, Demecolcine, Developing country, Extravasation, Gastrointestinal tract, Headache, Health system, Histiocytosis, Hodgkin's lymphoma, Intravenous therapy, John Wiley & Sons, Journal of Cell Science, Kidney, Kinetochore, Leukopenia, Liver, Lung cancer, Lymphoma, Melanoma, Microtubule, Mitotic inhibitor, Molecules (journal), Nocodazole, Pathogenic bacteria, Pregnancy, Robert Noble, Sharpless epoxidation, Shortness of breath, Southwestern Ontario, Spindle apparatus, Springer Science+Business Media, ..., Testicular cancer, Tubulin, Vinca alkaloid, Vincristine, Vindoline, White blood cell, WHO Model List of Essential Medicines. Expand index (7 more) »

ABVD

ABVD is a chemotherapy regimen used in the first-line treatment of Hodgkin lymphoma, supplanting the older MOPP protocol.

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Accounts of Chemical Research

Accounts of Chemical Research is a monthly peer-reviewed scientific journal published by the American Chemical Society containing overviews of basic research and applications in chemistry and biochemistry.

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Anaphase

Anaphase (from the Greek ἀνά, "up" and φάσις, "stage"), is the stage of mitosis after the metaphase when replicated chromosomes are split and the daughter chromatids are moved to opposite poles of the cell.

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Bladder cancer

Bladder cancer is any of several types of cancer arising from the tissues of the urinary bladder.

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Blister agent

A blister agent, or vesicant, is a chemical compound that causes severe skin, eye and mucosal pain and irritation.

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Bone marrow suppression

Bone marrow suppression also known as myelotoxicity or myelosuppression, is the decrease in production of cells responsible for providing immunity (leukocytes), carrying oxygen (erythrocytes), and/or those responsible for normal blood clotting (thrombocytes).

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Brain tumor

A brain tumor occurs when abnormal cells form within the brain.

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Cancer

Cancer is a group of diseases involving abnormal cell growth with the potential to invade or spread to other parts of the body.

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Cancer (journal)

Cancer is a biweekly peer-reviewed scientific journal covering oncology.

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Catharanthine

Catharanthine is a terpene indole alkaloid produced by the medicinal plant Catharanthus roseus.

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Catharanthus roseus

Catharanthus roseus, commonly known as the Madagascar periwinkle, rose periwinkle, or rosy periwinkle, is a species of flowering plant in the dogbane family Apocynaceae.

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Cell cycle

The cell cycle or cell-division cycle is the series of events that take place in a cell leading to its division and duplication of its DNA (DNA replication) to produce two daughter cells.

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Charles Thomas Beer

Charles Thomas Beer, (18 November 1915 – 15 June 2010) was a Canadian organic chemist who helped in the discovery of Vinblastine.

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Chemotherapy

Chemotherapy (often abbreviated to chemo and sometimes CTX or CTx) is a type of cancer treatment that uses one or more anti-cancer drugs (chemotherapeutic agents) as part of a standardized chemotherapy regimen.

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Chemotherapy regimen

A chemotherapy regimen is a regimen for chemotherapy, defining the drugs to be used, their dosage, the frequency and duration of treatments, and other considerations.

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Constipation

Constipation refers to bowel movements that are infrequent or hard to pass.

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CRC Press

The CRC Press, LLC is a publishing group based in the United States that specializes in producing technical books.

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Current Medicinal Chemistry

Current Medicinal Chemistry is a peer-reviewed medical journal published by Bentham Science Publishers.

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CYP3A4

Cytochrome P450 3A4 (abbreviated CYP3A4) is an important enzyme in the body, mainly found in the liver and in the intestine.

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Cytopenia

Cytopenia is a reduction in the number of mature blood cells.

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Demecolcine

Demecolcine (INN; also known as colcemid) is a drug used in chemotherapy.

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Developing country

A developing country (or a low and middle income country (LMIC), less developed country, less economically developed country (LEDC), underdeveloped country) is a country with a less developed industrial base and a low Human Development Index (HDI) relative to other countries.

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Extravasation

Extravasation is the leakage of a fluid out of its container.

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Gastrointestinal tract

The gastrointestinal tract (digestive tract, digestional tract, GI tract, GIT, gut, or alimentary canal) is an organ system within humans and other animals which takes in food, digests it to extract and absorb energy and nutrients, and expels the remaining waste as feces.

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Headache

Headache is the symptom of pain anywhere in the region of the head or neck.

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Health system

A health system, also sometimes referred to as health care system or as healthcare system, is the organization of people, institutions, and resources that deliver health care services to meet the health needs of target populations.

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Histiocytosis

In medicine, histiocytosis is an excessive number of histiocytes (tissue macrophages), and the term is also often used to refer to a group of rare diseases which share this sign as a characteristic.

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Hodgkin's lymphoma

Hodgkin's lymphoma (HL) is a type of lymphoma which is generally believed to result from white blood cells of the lymphocyte kind.

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Intravenous therapy

Intravenous therapy (IV) is a therapy that delivers liquid substances directly into a vein (intra- + ven- + -ous).

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John Wiley & Sons

John Wiley & Sons, Inc., also referred to as Wiley, is a global publishing company that specializes in academic publishing.

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Journal of Cell Science

The Journal of Cell Science (formerly the Quarterly Journal of Microscopical Science) is a peer-reviewed scientific journal in the field of cell biology.

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Kidney

The kidneys are two bean-shaped organs present in left and right sides of the body in vertebrates.

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Kinetochore

A kinetochore is a disc-shaped protein structure, found at the centromere of a chromatid, to which microtubules attach during cell division.

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Leukopenia

Leukopenia is a decrease in the number of white blood cells (leukocytes) found in the blood, which places individuals at increased risk of infection.

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Liver

The liver, an organ only found in vertebrates, detoxifies various metabolites, synthesizes proteins, and produces biochemicals necessary for digestion.

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Lung cancer

Lung cancer, also known as lung carcinoma, is a malignant lung tumor characterized by uncontrolled cell growth in tissues of the lung.

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Lymphoma

Lymphoma is a group of blood cancers that develop from lymphocytes (a type of white blood cell).

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Melanoma

Melanoma, also known as malignant melanoma, is a type of cancer that develops from the pigment-containing cells known as melanocytes.

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Microtubule

Microtubules are tubular polymers of tubulin that form part of the cytoskeleton that provides the cytoplasm of eukaryotic cells and some bacteria with structure and shape.

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Mitotic inhibitor

A mitotic inhibitor is a drug that inhibits mitosis, or cell division.

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Molecules (journal)

Molecules is a peer-reviewed open access scientific journal that focuses on all aspects of synthetic organic chemistry and natural product chemistry.

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Nocodazole

Nocodazole is an antineoplastic agent which exerts its effect in cells by interfering with the polymerization of microtubules.

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Pathogenic bacteria

Pathogenic bacteria are bacteria that can cause disease.

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Pregnancy

Pregnancy, also known as gestation, is the time during which one or more offspring develops inside a woman.

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Robert Noble

Robert Laing Noble, (February 3, 1910 – December 11, 1990) was a Canadian physician who was involved in the discovery of vinblastine.

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Sharpless epoxidation

The Sharpless epoxidation reaction is an enantioselective chemical reaction to prepare 2,3-epoxyalcohols from primary and secondary allylic alcohols.

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Shortness of breath

Shortness of breath, also known as dyspnea, is the feeling that one cannot breathe well enough.

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Southwestern Ontario

Southwestern Ontario is a secondary region of Southern Ontario in the Canadian province of Ontario.

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Spindle apparatus

In cell biology, the spindle apparatus (or mitotic spindle) refers to the cytoskeletal structure of eukaryotic cells that forms during cell division to separate sister chromatids between daughter cells.

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Springer Science+Business Media

Springer Science+Business Media or Springer, part of Springer Nature since 2015, is a global publishing company that publishes books, e-books and peer-reviewed journals in science, humanities, technical and medical (STM) publishing.

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Testicular cancer

Testicular cancer is cancer that develops in the testicles, a part of the male reproductive system.

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Tubulin

Tubulin in molecular biology can refer either to the tubulin protein superfamily of globular proteins, or one of the member proteins of that superfamily.

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Vinca alkaloid

Vinca alkaloids are a set of anti-mitotic and anti-microtubule alkaloid agents originally derived from the periwinkle plant Catharanthus roseus (basionym Vinca rosea) and other vinca plants.

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Vincristine

Vincristine, also known as leurocristine and marketed under the brandname Oncovin among others, is a chemotherapy medication used to treat a number of types of cancer. This includes acute lymphocytic leukemia, acute myeloid leukemia, Hodgkin's disease, neuroblastoma, and small cell lung cancer among others. It is given intravenously. Most people experience some side effects from vincristine treatment. Commonly it causes a change in sensation, hair loss, constipation, difficulty walking, and headaches. Serious side effects may include neuropathic pain, lung damage, or low blood white cells. It will likely cause harm to the baby if given during pregnancy. It works by stopping cells from dividing properly. Vincristine was first isolated in 1961. It is on the World Health Organization's List of Essential Medicines, the most effective and safe medicines needed in a health system. The wholesale cost in the developing world is between 1.80 and 42.60 USD per dose. It is a vinca alkaloid that can be obtained from the Madagascar periwinkle Catharanthus roseus.

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Vindoline

Vindoline is a chemical precursor to vinblastine.

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White blood cell

White blood cells (WBCs), also called leukocytes or leucocytes, are the cells of the immune system that are involved in protecting the body against both infectious disease and foreign invaders.

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WHO Model List of Essential Medicines

The WHO Model List of Essential Medicines (EML), published by the World Health Organization (WHO), contains the medications considered to be most effective and safe to meet the most important needs in a health system.

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Redirects here:

ATC code L01CA01, ATCvet code QL01CA01, C46H58N4O9, Nincaluicolflastine, Rozevin, Velban, Velbe, Vinblastin, Vinblastina, Vinblastine sulfate, Vinblastinum, Vincaleucoblastin, Vincaleucoblastine, Vincaleukoblastine, Vincoblastine.

References

[1] https://en.wikipedia.org/wiki/Vinblastine

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