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Anagrelide

Index Anagrelide

Anagrelide (Agrylin/Xagrid, Shire and Thromboreductin, AOP Orphan Pharmaceuticals AG) is a drug used for the treatment of essential thrombocytosis (ET; essential thrombocythemia), or overproduction of blood platelets. It also has been used in the treatment of chronic myeloid leukemia. Anagrelide controlled release (GALE-401) is in phase III clinical trials by Galena Biopharma for the treatment of ET. [1]

22 relations: Adverse drug reaction, Artery, Aspirin, Bleeding, Bristol-Myers Squibb, Chronic myelogenous leukemia, Cyanogen bromide, Essential thrombocythemia, Galena Biopharma, Hydroxycarbamide, IC50, Litre, Medical Research Council (United Kingdom), Megakaryocyte, Myelofibrosis, Phosphodiesterase, Phosphodiesterase inhibitor, Platelet, Quinazoline, Shire (pharmaceutical company), Thrombosis, Venous thrombosis.

Adverse drug reaction

An adverse drug reaction (ADR) is an injury caused by taking a medication.

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Artery

An artery (plural arteries) is a blood vessel that takes blood away from the heart to all parts of the body (tissues, lungs, etc).

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Aspirin

Aspirin, also known as acetylsalicylic acid (ASA), is a medication used to treat pain, fever, or inflammation.

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Bleeding

Bleeding, also known as hemorrhaging or haemorrhaging, is blood escaping from the circulatory system.

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Bristol-Myers Squibb

Bristol-Myers Squibb (BMS) is an American pharmaceutical company, headquartered in New York City.

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Chronic myelogenous leukemia

Chronic myelogenous leukemia (CML), also known as chronic myeloid leukemia, is a cancer of the white blood cells.

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Cyanogen bromide

Cyanogen bromide is the inorganic compound with the formula (CN)Br or BrCN.

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Essential thrombocythemia

Essential thrombocythemia (ET) is a rare chronic blood condition characterised by the overproduction of platelets (thrombocytes) by megakaryocytes in the bone marrow.

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Galena Biopharma

Galena Biopharma (originally RXi Pharmaceuticals) is a publicly traded pharmaceutical company based in San Ramon, California.

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Hydroxycarbamide

Hydroxycarbamide, also known as hydroxyurea, is a medication used in sickle-cell disease, chronic myelogenous leukemia, cervical cancer, and polycythemia vera.

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IC50

The half maximal inhibitory concentration (IC50) is a measure of the potency of a substance in inhibiting a specific biological or biochemical function.

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Litre

The litre (SI spelling) or liter (American spelling) (symbols L or l, sometimes abbreviated ltr) is an SI accepted metric system unit of volume equal to 1 cubic decimetre (dm3), 1,000 cubic centimetres (cm3) or 1/1,000 cubic metre. A cubic decimetre (or litre) occupies a volume of 10 cm×10 cm×10 cm (see figure) and is thus equal to one-thousandth of a cubic metre. The original French metric system used the litre as a base unit. The word litre is derived from an older French unit, the litron, whose name came from Greek — where it was a unit of weight, not volume — via Latin, and which equalled approximately 0.831 litres. The litre was also used in several subsequent versions of the metric system and is accepted for use with the SI,, p. 124. ("Days" and "hours" are examples of other non-SI units that SI accepts.) although not an SI unit — the SI unit of volume is the cubic metre (m3). The spelling used by the International Bureau of Weights and Measures is "litre", a spelling which is shared by almost all English-speaking countries. The spelling "liter" is predominantly used in American English. One litre of liquid water has a mass of almost exactly one kilogram, because the kilogram was originally defined in 1795 as the mass of one cubic decimetre of water at the temperature of melting ice. Subsequent redefinitions of the metre and kilogram mean that this relationship is no longer exact.

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Medical Research Council (United Kingdom)

The Medical Research Council (MRC) is responsible for co-coordinating and funding medical research in the United Kingdom.

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Megakaryocyte

A megakaryocyte (mega- + karyo- + -cyte, "large-nucleus cell") is a large bone marrow cell with a lobated nucleus responsible for the production of blood thrombocytes (platelets), which are necessary for normal blood clotting.

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Myelofibrosis

Myelofibrosis, also known as osteomyelofibrosis, is a relatively rare bone marrow cancer.

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Phosphodiesterase

A phosphodiesterase (PDE) is an enzyme that breaks a phosphodiester bond.

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Phosphodiesterase inhibitor

A phosphodiesterase inhibitor is a drug that blocks one or more of the five subtypes of the enzyme phosphodiesterase (PDE), thereby preventing the inactivation of the intracellular second messengers cyclic adenosine monophosphate (cAMP) and cyclic guanosine monophosphate (cGMP) by the respective PDE subtype(s).

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Platelet

Platelets, also called thrombocytes (from Greek θρόμβος, "clot" and κύτος, "cell"), are a component of blood whose function (along with the coagulation factors) is to react to bleeding from blood vessel injury by clumping, thereby initiating a blood clot.

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Quinazoline

Quinazoline is an organic compound with the formula C8H6N2.

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Shire (pharmaceutical company)

Shire Plc is a Jersey-registered, Irish-headquartered global specialty biopharmaceutical company.

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Thrombosis

Thrombosis (from Ancient Greek θρόμβωσις thrómbōsis "clotting”) is the formation of a blood clot inside a blood vessel, obstructing the flow of blood through the circulatory system.

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Venous thrombosis

A venous thrombus is a blood clot (thrombus) that forms within a vein.

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Redirects here:

ATC code L01XX35, ATCvet code QL01XX35, Agrylin, Anagrelide hydrochloride, C10H7Cl2N3O, Xagrid.

References

[1] https://en.wikipedia.org/wiki/Anagrelide

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