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Zinc finger

A zinc finger is a small protein structural motif that is characterized by the coordination of one or more zinc ions in order to stabilize the fold. [1]

62 relations: African clawed frog, B-box zinc finger, Beta hairpin, Beta sheet, Biomolecular structure, Caenorhabditis elegans, Cell adhesion, Chromatin, Conformational change, Coordination complex, Cysteine, Cytoskeleton, DNA, DNA-binding protein, Drosophila melanogaster, EGR1, Epithelium, Eukaryote, Evolution, Extended X-ray absorption fine structure, FokI, GAL4/UAS system, Gene, GTF3A, Histidine, Histone acetyltransferase, HIV/AIDS, Ion, Krüppel associated box, Ligand, Lipid, Maize, Molecular binding, Myelin, Nuclear receptor, Peptide sequence, Phage display, PROSITE, Protein, Protein domain, Protein engineering, Protein folding, Rat, RING finger domain, RNA, Salt bridge, Sequence motif, Steroid hormone receptor, Structural motif, Substrate (chemistry), ..., Supersecondary structure, TAL effector, Tobacco, Transcription (genetics), Transcription activator-like effector nuclease, Transcription factor, Xenopus, Zebrafish, Zinc, Zinc finger inhibitor, Zinc finger nuclease, Zinc finger transcription factor. Expand index (12 more) »

African clawed frog

The African clawed frog (Xenopus laevis, also known as the xenopus, African clawed toad, African claw-toed frog or the platanna) is a species of African aquatic frog of the Pipidae family.

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B-box zinc finger

In molecular biology the B-box-type zinc finger domain is a short protein domain of around 40 amino acid residues in length.

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Beta hairpin

The beta hairpin (sometimes also called beta-ribbon or beta-beta unit) is a simple protein structural motif involving two beta strands that look like a hairpin.

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Beta sheet

The β sheet (also β-pleated sheet) is the second form of regular secondary structure in proteins.

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Biomolecular structure

Biomolecular structure is the intricate folded, three-dimensional shape that is formed by a protein, DNA, or RNA molecule, and that is important to its function.

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Caenorhabditis elegans

Caenorhabditis elegans is a free-living (not parasitic), transparent nematode (roundworm), about 1 mm in length, that lives in temperate soil environments.

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Cell adhesion

Cell adhesion is the binding of a cell to a surface or substrate, such as an extracellular matrix of another cell.

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Chromatin

Chromatin is a complex of macromolecules found in cells, consisting of DNA, protein and RNA.

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Conformational change

In biochemistry, a conformational change is a change in the shape of a macromolecule, often induced by environmental factors.

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Coordination complex

In chemistry, a coordination complex or metal complex consists of a central atom or ion, which is usually metallic and is called the coordination centre, and a surrounding array of bound molecules or ions, that are in turn known as ligands or complexing agents.

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Cysteine

Cysteine (abbreviated as Cys or C) is a semi-essential proteinogenic amino acid with the formula HO2CCH(NH2)CH2SH.

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Cytoskeleton

In eukaryotes, the cytoskeletal matrix is a dynamic structure composed of three main proteins, which are capable of rapid assembly or disassembly dependent on the cell's requirements.

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DNA

Deoxyribonucleic acid (DNA) is a molecule that carries most of the genetic instructions used in the development, functioning and reproduction of all known living organisms and many viruses.

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DNA-binding protein

DNA-binding proteins are proteins that are composed of DNA-binding domains and thus have a specific or general affinity for either single or double stranded DNA.

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Drosophila melanogaster

Drosophila melanogaster is a species of fly (the taxonomic order Diptera) in the family Drosophilidae.

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EGR1

EGR-1 (Early growth response protein 1) also known as Zif268 (zinc finger protein 225) or NGFI-A (nerve growth factor-induced protein A) is a protein that in humans is encoded by the EGR1 gene.

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Epithelium

Epithelium (''epi-'' + ''thele'' + ''-ium'') is one of the four basic types of animal tissue.

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Eukaryote

A eukaryote (or or) is any organism whose cells contain a nucleus and other organelles enclosed within membranes.

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Evolution

Evolution is change in the heritable traits of biological populations over successive generations.

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Extended X-ray absorption fine structure

X-ray Absorption Spectroscopy (XAS) includes both Extended X-Ray Absorption Fine Structure (EXAFS) and X-ray Absorption Near Edge Structure (XANES).

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FokI

The enzyme FokI, naturally found in Flavobacterium okeanokoites, is a bacterial type IIS restriction endonuclease consisting of an N-terminal DNA-binding domain and a non-specific DNA cleavage domain at the C-terminal.

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GAL4/UAS system

The GAL4-UAS system is a biochemical method used to study gene expression and function in organisms such as the fruit fly.

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Gene

A gene is a locus (or region) of DNA that encodes a functional RNA or protein product, and is the molecular unit of heredity.

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GTF3A

Transcription factor IIIA is a protein that in humans is encoded by the GTF3A gene.

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Histidine

Histidine (abbreviated as His or H) is an essential, α-amino acid with an imidazole functional group.

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Histone acetyltransferase

Histone acetyltransferases (HATs) are enzymes that acetylate conserved lysine amino acids on histone proteins by transferring an acetyl group from acetyl CoA to form ε-N-acetyllysine.

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HIV/AIDS

Human immunodeficiency virus infection and acquired immune deficiency syndrome (HIV/AIDS) is a spectrum of conditions caused by infection with the human immunodeficiency virus (HIV).

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Ion

An ion is an atom or a molecule in which the total number of electrons is not equal to the total number of protons, giving the atom or molecule a net positive or negative electrical charge.

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Krüppel associated box

The Krüppel associated box (KRAB) domain is a category of transcriptional repression domains present in approximately 400 human zinc finger protein-based transcription factors (KRAB zinc finger proteins).

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Ligand

In coordination chemistry, a ligand is an ion or molecule (functional group) that binds to a central metal atom to form a coordination complex.

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Lipid

Lipids are a group of naturally occurring molecules that include fats, waxes, sterols, fat-soluble vitamins (such as vitamins A, D, E, and K), monoglycerides, diglycerides, triglycerides, phospholipids, and others.

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Maize

Maize (Zea mays subsp. mays, from maíz after Taíno mahiz), known in some English-speaking countries as corn, is a large grain plant domesticated by indigenous peoples in Mesoamerica in prehistoric times.

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Molecular binding

Molecular binding is an attractive interaction between two molecules that results in a stable association in which the molecules are in close proximity to each other.

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Myelin

Myelin is a fatty white substance that surrounds the axon dielectric (electrically insulating) material that forms a layer, the myelin sheath, usually around only the axon of a neuron.

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Nuclear receptor

In the field of molecular biology, nuclear receptors are a class of proteins found within cells that are responsible for sensing steroid and thyroid hormones and certain other molecules.

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Peptide sequence

Peptide sequence, or amino acid sequence, is the order in which amino acid residues, connected by peptide bonds, lie in the chain in peptides and proteins.

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Phage display

Phage display is a laboratory technique for the study of protein–protein, protein–peptide, and protein–DNA interactions that uses bacteriophages (viruses that infect bacteria) to connect proteins with the genetic information that encodes them.

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PROSITE

PROSITE is a protein database.

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Protein

Proteins are large biomolecules, or macromolecules, consisting of one or more long chains of amino acid residues.

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Protein domain

A protein domain is a conserved part of a given protein sequence and (tertiary) structure that can evolve, function, and exist independently of the rest of the protein chain.

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Protein engineering

Protein engineering is the process of developing useful or valuable proteins.

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Protein folding

Protein folding is the process by which a protein structure assumes its functional shape or conformation.

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Rat

Rats are various medium-sized, long-tailed rodents of the superfamily Muroidea.

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RING finger domain

In molecular biology, a RING (Really Interesting New Gene) finger domain is a protein structural domain of zinc finger type which contains a Cys3HisCys4 amino acid motif which binds two zinc cations.

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RNA

Ribonucleic acid (RNA) is a polymeric molecule implicated in various biological roles in coding, decoding, regulation, and expression of genes.

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Salt bridge

A salt bridge, in electrochemistry, is a laboratory device used to connect the oxidation and reduction half-cells of a galvanic cell (voltaic cell), a type of electrochemical cell.

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Sequence motif

In genetics, a sequence motif is a nucleotide or amino-acid sequence pattern that is widespread and has, or is conjectured to have, a biological significance.

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Steroid hormone receptor

Steroid hormone receptors are found on the plasma membrane, in the cytosol and also in the nucleus of target cells.

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Structural motif

In a chain-like biological molecule, such as a protein or nucleic acid, a structural motif is a supersecondary structure, which also appears in a variety of other molecules.

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Substrate (chemistry)

In chemistry, a substrate is typically the chemical species being observed in a chemical reaction, which reacts with reagent to generate a product.

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Supersecondary structure

A supersecondary structure is a compact three-dimensional protein structure of several adjacent elements of a secondary structure that is smaller than a protein domain or a subunit.

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TAL effector

TAL (transcription activator-like) effectors (often referred to as TALEs but not to be confused with the three amino acid loop extension family of proteins) are proteins secreted by Xanthomonas bacteria via their type III secretion system when they infect various plant species.

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Tobacco

Tobacco is a product prepared from the leaves of the tobacco plant by curing them.

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Transcription (genetics)

Transcription is the first step of gene expression, in which a particular segment of DNA is copied into RNA (mRNA) by the enzyme RNA polymerase.

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Transcription activator-like effector nuclease

Transcription activator-like effector nucleases (TALENs) are artificial restriction enzymes generated by fusing a TAL effector DNA-binding domain to a DNA cleavage domain.

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Transcription factor

In molecular biology and genetics, a transcription factor (sometimes called a sequence-specific DNA-binding factor) is a protein that binds to specific DNA sequences, thereby controlling the rate of transcription of genetic information from DNA to messenger RNA.

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Xenopus

Xenopus (Gk., ξενος, xenos.

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Zebrafish

The zebrafish (Danio rerio) is a tropical freshwater fish belonging to the minnow family (Cyprinidae) of the order Cypriniformes.

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Zinc

Zinc, in commerce also spelter, is a chemical element with symbol Zn and atomic number 30.

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Zinc finger inhibitor

This image shows the typical structure of NCp7, which is targeted by zinc finger inhibitors when combating HIV. Zinc finger inhibitors, or zinc ejectors, are substances or compounds that interact adversely with zinc fingers and cause them to release their zinc from its binding site, disrupting the conformation of the polypeptide chain and rendering the zinc fingers ineffective, thereby preventing them from performing their associated cellular functions.

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Zinc finger nuclease

Zinc-finger nucleases (ZFNs) are artificial restriction enzymes generated by fusing a zinc finger DNA-binding domain to a DNA-cleavage domain.

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Zinc finger transcription factor

Zinc finger transcription factors or ZF-TFs, are transcription factors composed of a zinc finger-binding domain and any of a variety of transcription-factor effector-domains that exert their modulatory effect in the vicinity of any sequence to which the protein domain binds.

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References

[1] https://en.wikipedia.org/wiki/Zinc_finger

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