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75 relations: ACE inhibitor, Aloe, Amino acid, Aminopeptidase, Angiotensin II receptor blocker, Angiotensin-converting enzyme, Arginine, Asthma, Astrocyte, Autopharmacology, Blood plasma, Blood pressure, Blood vessel, Bothrops, Bothrops jararaca, Bradykinin receptor B1, Brazil, Bristol-Myers Squibb, Bromelain, Bronchus, Calcium, Captopril, Carboxypeptidase, Carcinoid, CXCL5, Ductus arteriosus, Endothelium, Endothelium-derived hyperpolarizing factor, Enzyme, Faculdade de Medicina de Ribeirão Preto, G protein–coupled receptor, Gastão Rosenfeld, Glutamic acid, Glycine, Hereditary angioedema, High-molecular-weight kininogen, Hypotension, Hypotensive transfusion reaction, Icatibant, Inflammation, Instituto Biológico, Instituto Butantan, Kallikrein, Kinin, Kinin–kallikrein system, Kininogen, Kininogen 1, Maurício Rocha e Silva, Model organism, Natriuresis, ..., Neocortex, Neutrophil, Nitric oxide, Pain, Peptide, Phenylalanine, Plasmin, Polyphenol, Proline, Prostacyclin, Protein, Proteolysis, Receptor antagonist, São Paulo, Sérgio Henrique Ferreira, Serine, Shock (circulatory), Smooth muscle tissue, Snake, Toxicology, Translation (biology), Vascular permeability, Vasodilation, Venom, Wilson Teixeira Beraldo. Expand index (25 more) »
ACE inhibitor
An angiotensin-converting-enzyme inhibitor (ACE inhibitor) is a pharmaceutical drug used primarily for the treatment of hypertension (elevated blood pressure) and congestive heart failure.
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Aloe
Aloe, also written Aloë, is a genus containing over 500 species of flowering succulent plants.
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Amino acid
Amino acids are organic compounds containing amine (-NH2) and carboxyl (-COOH) functional groups, along with a side chain (R group) specific to each amino acid.
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Aminopeptidase
Aminopeptidases are enzymes that catalyze the cleavage of amino acids from the amino terminus (N-terminus) of proteins or peptides.
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Angiotensin II receptor blocker
Angiotensin II receptor blockers (ARBs), also known as angiotensin II receptor antagonists, AT1 receptor antagonists or sartans, are a group of pharmaceuticals that modulate the renin–angiotensin system.
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Angiotensin-converting enzyme
Angiotensin-converting enzyme, or ACE, is a central component of the renin–angiotensin system (RAS), which controls blood pressure by regulating the volume of fluids in the body.
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Arginine
Arginine (symbol Arg or R) is an α-amino acid that is used in the biosynthesis of proteins.
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Asthma
Asthma is a common long-term inflammatory disease of the airways of the lungs.
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Astrocyte
Astrocytes (Astro from Greek astron.
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Autopharmacology
Autopharmacology relates to the scientific study of the regulation of body functions by the activity of its naturally existent (or endogenous) chemical factors of the tissues.
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Blood plasma
Blood plasma is a yellowish coloured liquid component of blood that normally holds the blood cells in whole blood in suspension; this makes plasma the extracellular matrix of blood cells.
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Blood pressure
Blood pressure (BP) is the pressure of circulating blood on the walls of blood vessels.
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Blood vessel
The blood vessels are the part of the circulatory system, and microcirculation, that transports blood throughout the human body.
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Bothrops
Bothrops is a genus of pit vipers endemic to Central and South America.
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Bothrops jararaca
Bothrops jararaca — known as the jararaca (or the yarara) — is a species of pit viper endemic to southern Brazil, Paraguay, and northern Argentina.
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Bradykinin receptor B1
Bradykinin receptor B1 (B1) is a G-protein coupled receptor encoded by the BDKRB1 gene in humans.
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Brazil
Brazil (Brasil), officially the Federative Republic of Brazil (República Federativa do Brasil), is the largest country in both South America and Latin America.
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Bristol-Myers Squibb
Bristol-Myers Squibb (BMS) is an American pharmaceutical company, headquartered in New York City.
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Bromelain
Bromelain is an enzyme extract derived from the stems of pineapples, although it exists in all parts of the fresh plant and fruit.
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Bronchus
A bronchus, is a passage of airway in the respiratory system that conducts air into the lungs.
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Calcium
Calcium is a chemical element with symbol Ca and atomic number 20.
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Captopril
Captopril, sold under the trade name Capoten, is an angiotensin-converting enzyme (ACE) inhibitor used for the treatment of hypertension and some types of congestive heart failure.
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Carboxypeptidase
A carboxypeptidase (EC number 3.4.16 - 3.4.18) is a protease enzyme that hydrolyzes (cleaves) a peptide bond at the carboxy-terminal (C-terminal) end of a protein or peptide.
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Carcinoid
Carcinoid (also carcinoid tumor) is a slow-growing type of neuroendocrine tumor originating in the cells of the neuroendocrine system.
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CXCL5
C-X-C motif chemokine 5 (CXCL5 or ENA78) is a protein that in humans is encoded by the CXCL5 gene.
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Ductus arteriosus
In the developing fetus, the ductus arteriosus, also called the ductus Botalli, is a blood vessel connecting the main pulmonary artery to the proximal descending aorta.
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Endothelium
Endothelium refers to cells that line the interior surface of blood vessels and lymphatic vessels, forming an interface between circulating blood or lymph in the lumen and the rest of the vessel wall.
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Endothelium-derived hyperpolarizing factor
In blood vessels Endothelium-Derived Hyperpolarizing Factor or EDHF is proposed to be a substance and/or electrical signal that is generated or synthesized in and released from the endothelium; its action is to hyperpolarize vascular smooth muscle cells, causing these cells to relax, thus allowing the blood vessel to expand in diameter.
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Enzyme
Enzymes are macromolecular biological catalysts.
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Faculdade de Medicina de Ribeirão Preto
Faculdade de Medicina de Ribeirão Preto (Ribeirão Preto Medical School in Portuguese) is a medical school of the University of São Paulo (USP) located in the city of Ribeirão Preto, state of São Paulo, Brazil, founded 1952.
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G protein–coupled receptor
G protein–coupled receptors (GPCRs), also known as seven-(pass)-transmembrane domain receptors, 7TM receptors, heptahelical receptors, serpentine receptor, and G protein–linked receptors (GPLR), constitute a large protein family of receptors that detect molecules outside the cell and activate internal signal transduction pathways and, ultimately, cellular responses.
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Gastão Rosenfeld
Gastão Rosenfeld (born Budapest, July 26, 1912; died São Paulo, July 15, 1990), was a Brazilian physician and biomedical scientist, one of the co-discoverers of bradykinin, together with Maurício Rocha e Silva and Wilson Teixeira Beraldo, in 1949.
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Glutamic acid
Glutamic acid (symbol Glu or E) is an α-amino acid with formula.
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Glycine
Glycine (symbol Gly or G) is the amino acid that has a single hydrogen atom as its side chain.
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Hereditary angioedema
Hereditary angioedema (HAE) is a disorder that results in recurrent attacks of severe swelling.
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High-molecular-weight kininogen
High-molecular-weight kininogen (HMWK or HK) is a circulating plasma protein which participates in the initiation of blood coagulation, and in the generation of the vasodilator bradykinin via the Kallikrein-kinin system.
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Hypotension
Hypotension is low blood pressure, especially in the arteries of the systemic circulation.
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Hypotensive transfusion reaction
A Hypotensive transfusion reaction or HTR is a rare condition that presents with low blood pressure associated with administration of blood products.
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Icatibant
Icatibant, trade name Firazyr, is medication that has been approved by the European Commission for the symptomatic treatment of acute attacks of hereditary angioedema (HAE) in adults with C1-esterase-inhibitor deficiency.
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Inflammation
Inflammation (from inflammatio) is part of the complex biological response of body tissues to harmful stimuli, such as pathogens, damaged cells, or irritants, and is a protective response involving immune cells, blood vessels, and molecular mediators.
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Instituto Biológico
Biological Institute (Instituto Biológico in Portuguese) is an applied research center organised in 1924 in São Paulo, Brazil.
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Instituto Butantan
Instituto Butantan (in modern Portuguese, Instituto Butantã) is a Brazilian biologic research center affiliated to the São Paulo State Secretariat of Health.
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Kallikrein
Kallikreins are a subgroup of serine proteases, enzymes capable of cleaving peptide bonds in proteins.
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Kinin
A kinin is any of various structurally related polypeptides, such as bradykinin and kallidin.
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Kinin–kallikrein system
The kinin–kallikrein system or simply kinin system is a poorly understood hormonal system with limited available research.
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Kininogen
Kininogens are proteins that are defined by their role as precursors for kinins, but that also can have additional roles.
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Kininogen 1
Kininogen-1 (KNG1), also known as alpha-2-thiol proteinase inhibitor, Williams-Fitzgerald-Flaujeac factor or the HMWK-kallikrein factor is a proteinUniProt: that in humans is encoded by the KNG1 gene.
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Maurício Rocha e Silva
Maurício Oscar da Rocha e Silva (19 September 1910, Rio de Janeiro – 19 December 1983, Ribeirão Preto, Brazil) was a Brazilian physician, biomedical scientist and pharmacologist.
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Model organism
A model organism is a non-human species that is extensively studied to understand particular biological phenomena, with the expectation that discoveries made in the organism model will provide insight into the workings of other organisms.
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Natriuresis
Natriuresis is the process of sodium excretion in the urine through the action of the kidneys.
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Neocortex
The neocortex, also called the neopallium and isocortex, is the part of the mammalian brain involved in higher-order brain functions such as sensory perception, cognition, generation of motor commands, spatial reasoning and language.
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Neutrophil
Neutrophils (also known as neutrocytes) are the most abundant type of granulocytes and the most abundant (40% to 70%) type of white blood cells in most mammals.
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Nitric oxide
Nitric oxide (nitrogen oxide or nitrogen monoxide) is a colorless gas with the formula NO.
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Pain
Pain is a distressing feeling often caused by intense or damaging stimuli.
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Peptide
Peptides (from Gr.: πεπτός, peptós "digested"; derived from πέσσειν, péssein "to digest") are short chains of amino acid monomers linked by peptide (amide) bonds.
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Phenylalanine
Phenylalanine (symbol Phe or F) is an α-amino acid with the formula.
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Plasmin
Plasmin is an important enzyme present in blood that degrades many blood plasma proteins, including fibrin clots.
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Polyphenol
Polyphenols (also known as polyhydroxyphenols) are a structural class of mainly natural, but also synthetic or semisynthetic, organic chemicals characterized by the presence of large multiples of phenol structural units.
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Proline
Proline (symbol Pro or P) is a proteinogenic amino acid that is used in the biosynthesis of proteins.
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Prostacyclin
Prostacyclin (also called prostaglandin I2 or PGI2) is a prostaglandin member of the eicosanoid family of lipid molecules.
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Protein
Proteins are large biomolecules, or macromolecules, consisting of one or more long chains of amino acid residues.
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Proteolysis
Proteolysis is the breakdown of proteins into smaller polypeptides or amino acids.
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Receptor antagonist
A receptor antagonist is a type of receptor ligand or drug that blocks or dampens a biological response by binding to and blocking a receptor rather than activating it like an agonist.
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São Paulo
São Paulo is a municipality in the southeast region of Brazil.
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Sérgio Henrique Ferreira
Sérgio Henrique Ferreira (October 4, 1934 – July 17, 2016) was a Brazilian physician and pharmacologist noted for the discovery of the bradykinin potentiating factor, which led to new and widely used anti-hypertension drugs — the ACE inhibitors.
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Serine
Serine (symbol Ser or S) is an ɑ-amino acid that is used in the biosynthesis of proteins.
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Shock (circulatory)
Shock is the state of low blood perfusion to tissues resulting in cellular injury and inadequate tissue function.
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Smooth muscle tissue
Smooth muscle is an involuntary non-striated muscle.
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Snake
Snakes are elongated, legless, carnivorous reptiles of the suborder Serpentes.
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Toxicology
Toxicology is a discipline, overlapping with biology, chemistry, pharmacology, and medicine, that involves the study of the adverse effects of chemical substances on living organisms and the practice of diagnosing and treating exposures to toxins and toxicants.
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Translation (biology)
In molecular biology and genetics, translation is the process in which ribosomes in the cytoplasm or ER synthesize proteins after the process of transcription of DNA to RNA in the cell's nucleus.
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Vascular permeability
Vascular permeability, often in the form of capillary permeability or microvascular permeability, characterizes the capacity of a blood vessel wall to allow for the flow of small molecules (drugs, nutrients, water, ions) or even whole cells (lymphocytes on their way to the site of inflammation) in and out of the vessel.
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Vasodilation
Vasodilation is the widening of blood vessels.
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Venom
Venomous Animals Venom is a form of toxin secreted by an animal for the purpose of causing harm to another.
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Wilson Teixeira Beraldo
Wilson Teixeira Beraldo (April 20, 1917, Silvanópolis, state of Minas Gerais, Brazil – July 28, 1998, Belo Horizonte, Minas Gerais) was a Brazilian physician and physiologist, a co-discoverer of bradykinin.
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References
[1] https://en.wikipedia.org/wiki/Bradykinin
