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36 relations: Anxiety disorder, Anxiolytic, Benzodiazepine, Bioavailability, Blood pressure, Blood–brain barrier, Cmax (pharmacology), CYP2D6, CYP3A4, Dopamine receptor D1, Dopamine receptor D2, Drug metabolism, Electrocardiography, Enzyme, G protein–coupled receptor, GABA reuptake inhibitor, Generalized anxiety disorder, Half-life, Hamilton Anxiety Rating Scale, Hepatocyte, High-density lipoprotein, Inverse agonist, Low-density lipoprotein, Muscle relaxant, Peritoneum, Pharmacokinetics, Post-translational modification, Receptor (biochemistry), Receptor antagonist, Redox, Residence time, Sedative, Tiagabine, Transport maximum, 5-HT2A receptor, 5-HT2C receptor.
Anxiety disorder
Anxiety disorders are a group of mental disorders characterized by significant feelings of anxiety and fear.
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Anxiolytic
An anxiolytic (also antipanic or antianxiety agent) is a medication or other intervention that inhibits anxiety.
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Benzodiazepine
Benzodiazepines (BZD, BZs), sometimes called "benzos", are a class of psychoactive drugs whose core chemical structure is the fusion of a benzene ring and a diazepine ring.
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Bioavailability
In pharmacology, bioavailability (BA or F) is a subcategory of absorption and is the fraction of an administered dose of unchanged drug that reaches the systemic circulation, one of the principal pharmacokinetic properties of drugs.
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Blood pressure
Blood pressure (BP) is the pressure of circulating blood on the walls of blood vessels.
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Blood–brain barrier
The blood–brain barrier (BBB) is a highly selective semipermeable membrane barrier that separates the circulating blood from the brain and extracellular fluid in the central nervous system (CNS).
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Cmax (pharmacology)
Cmax is the maximum (or peak) serum concentration that a drug achieves in a specified compartment or test area of the body after the drug has been administrated and before the administration of a second dose.
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CYP2D6
Cytochrome P450 2D6 (CYP2D6) is an enzyme that in humans is encoded by the CYP2D6 gene.
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CYP3A4
Cytochrome P450 3A4 (abbreviated CYP3A4) is an important enzyme in the body, mainly found in the liver and in the intestine.
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Dopamine receptor D1
Dopamine receptor D1, also known as DRD1, is a protein that in humans is encoded by the DRD1 gene.
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Dopamine receptor D2
Dopamine receptor D2, also known as D2R, is a protein that, in humans, is encoded by the DRD2 gene.
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Drug metabolism
Drug metabolism is the metabolic breakdown of drugs by living organisms, usually through specialized enzymatic systems.
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Electrocardiography
Electrocardiography (ECG or EKG) is the process of recording the electrical activity of the heart over a period of time using electrodes placed on the skin.
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Enzyme
Enzymes are macromolecular biological catalysts.
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G protein–coupled receptor
G protein–coupled receptors (GPCRs), also known as seven-(pass)-transmembrane domain receptors, 7TM receptors, heptahelical receptors, serpentine receptor, and G protein–linked receptors (GPLR), constitute a large protein family of receptors that detect molecules outside the cell and activate internal signal transduction pathways and, ultimately, cellular responses.
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GABA reuptake inhibitor
A GABA reuptake inhibitor (GRI) is a type of drug which acts as a reuptake inhibitor for the neurotransmitter gamma-Aminobutyric acid (GABA) by blocking the action of the gamma-Aminobutyric acid transporters (GATs).
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Generalized anxiety disorder
Generalized anxiety disorder (GAD) is an anxiety disorder characterized by excessive, uncontrollable and often irrational worry, that is, apprehensive expectation about events or activities.
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Half-life
Half-life (symbol t1⁄2) is the time required for a quantity to reduce to half its initial value.
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Hamilton Anxiety Rating Scale
The Hamilton Anxiety Rating Scale (HAM-A) is a psychological questionnaire used by clinicians to rate the severity of a patient's anxiety.
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Hepatocyte
A hepatocyte is a cell of the main parenchymal tissue of the liver.
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High-density lipoprotein
High-density lipoproteins (HDL) are one of the five major groups of lipoproteins.
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Inverse agonist
In the field of pharmacology, an inverse agonist is an agent that binds to the same receptor as an agonist but induces a pharmacological response opposite to that agonist.
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Low-density lipoprotein
Low-density lipoprotein (LDL) is one of the five major groups of lipoprotein which transport all fat molecules around the body in the extracellular water.
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Muscle relaxant
A muscle relaxant is a drug that affects skeletal muscle function and decreases the muscle tone.
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Peritoneum
The peritoneum is the serous membrane that forms the lining of the abdominal cavity or coelom in amniotes and some invertebrates, such as annelids.
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Pharmacokinetics
Pharmacokinetics (from Ancient Greek pharmakon "drug" and kinetikos "moving, putting in motion"; see chemical kinetics), sometimes abbreviated as PK, is a branch of pharmacology dedicated to determining the fate of substances administered to a living organism.
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Post-translational modification
Post-translational modification (PTM) refers to the covalent and generally enzymatic modification of proteins following protein biosynthesis.
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Receptor (biochemistry)
In biochemistry and pharmacology, a receptor is a protein molecule that receives chemical signals from outside a cell.
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Receptor antagonist
A receptor antagonist is a type of receptor ligand or drug that blocks or dampens a biological response by binding to and blocking a receptor rather than activating it like an agonist.
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Redox
Redox (short for reduction–oxidation reaction) (pronunciation: or) is a chemical reaction in which the oxidation states of atoms are changed.
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Residence time
For material flowing through a volume, the residence time is a measure of how much time the matter spends in it.
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Sedative
A sedative or tranquilliser is a substance that induces sedation by reducing irritability or excitement.
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Tiagabine
Tiagabine (trade name Gabitril) is an anticonvulsant medication used in the treatment of epilepsy that is produced by Cephalon.
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Transport maximum
In physiology, transport maximum (alternatively Tm or Tmax) refers to the point at which increases in concentration of a substance do not result in an increase in movement of a substance across a cell membrane.
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5-HT2A receptor
The mammalian 5-HT2A receptor is a subtype of the 5-HT2 receptor that belongs to the serotonin receptor family and is a G protein-coupled receptor (GPCR).
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5-HT2C receptor
The 5-HT2C receptor is a subtype of 5-HT receptor that binds the endogenous neurotransmitter serotonin (5-hydroxytryptamine, 5-HT).
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References
[1] https://en.wikipedia.org/wiki/Deramciclane
