Force spectrum microscopy

Force Spectrum Microscopy (FSM) is an application of active microrheology developed to measure aggregate random forces in the cytoplasm. ^[1]

23 relations: Actin, Adenosine triphosphate, Bacteria, Brownian motion, Cancer, Cytoplasm, Cytoskeleton, David A. Weitz, Elasticity (physics), Flow tracer, Fourier transform, Hooke's law, List of breast cancer cell lines, Macromolecular crowding, Malignancy, MCF-7, Mean squared displacement, Metastasis, Microrheology, Myosin, Optical tweezers, Polyethylene glycol, Vesicle (biology and chemistry).
Rheology

Actin

Actin is a family of globular multi-functional proteins that form microfilaments in the cytoskeleton, and the thin filaments in muscle fibrils.

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Adenosine triphosphate

Adenosine triphosphate (ATP) is a nucleotide that provides energy to drive and support many processes in living cells, such as muscle contraction, nerve impulse propagation, and chemical synthesis.

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Bacteria

Bacteria (bacterium) are ubiquitous, mostly free-living organisms often consisting of one biological cell.

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Brownian motion

Brownian motion is the random motion of particles suspended in a medium (a liquid or a gas).

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Cancer

Cancer is a group of diseases involving abnormal cell growth with the potential to invade or spread to other parts of the body.

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Cytoplasm

In cell biology, the cytoplasm describes all material within a eukaryotic cell, enclosed by the cell membrane, except for the cell nucleus.

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Cytoskeleton

The cytoskeleton is a complex, dynamic network of interlinking protein filaments present in the cytoplasm of all cells, including those of bacteria and archaea.

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David A. Weitz

David A. Weitz (born October 3, 1951) is a Canadian/American physicist and Mallinckrodt Professor of Physics & Applied Physics at Harvard University.

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Elasticity (physics)

In physics and materials science, elasticity is the ability of a body to resist a distorting influence and to return to its original size and shape when that influence or force is removed.

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Flow tracer

A flow tracer is any fluid property used to track the flow velocity (i.e., flow magnitude and direction) and circulation patterns.

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In physics, engineering and mathematics, the Fourier transform (FT) is an integral transform that takes a function as input and outputs another function that describes the extent to which various frequencies are present in the original function.

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Hooke's law

In physics, Hooke's law is an empirical law which states that the force needed to extend or compress a spring by some distance scales linearly with respect to that distance—that is, where is a constant factor characteristic of the spring (i.e., its stiffness), and is small compared to the total possible deformation of the spring.

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List of breast cancer cell lines

Scientists study the behaviour of isolated cells grown in the laboratory for insights into how cells function in the body in health and disease.

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Macromolecular crowding

The phenomenon of macromolecular crowding alters the properties of molecules in a solution when high concentrations of macromolecules such as proteins are present.

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Malignancy

Malignancy is the tendency of a medical condition to become progressively worse; the term is most familiar as a characterization of cancer.

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MCF-7

MCF-7 is a breast cancer cell line isolated in 1970 from a 69-year-old White woman.

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Mean squared displacement

In statistical mechanics, the mean squared displacement (MSD, also mean square displacement, average squared displacement, or mean square fluctuation) is a measure of the deviation of the position of a particle with respect to a reference position over time.

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Metastasis

Metastasis is a pathogenic agent's spread from an initial or primary site to a different or secondary site within the host's body; the term is typically used when referring to metastasis by a cancerous tumor.

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Microrheology

Microrheology is a technique used to measure the rheological properties of a medium, such as microviscosity, via the measurement of the trajectory of a flow tracer (a micrometre-sized particle). Force spectrum microscopy and Microrheology are rheology.

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Myosin

Myosins are a superfamily of motor proteins best known for their roles in muscle contraction and in a wide range of other motility processes in eukaryotes.

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Optical tweezers

Optical tweezers (originally called single-beam gradient force trap) are scientific instruments that use a highly focused laser beam to hold and move microscopic and sub-microscopic objects like atoms, nanoparticles and droplets, in a manner similar to tweezers.

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Polyethylene glycol

Polyethylene glycol (PEG) is a polyether compound derived from petroleum with many applications, from industrial manufacturing to medicine.

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Vesicle (biology and chemistry)

In cell biology, a vesicle is a structure within or outside a cell, consisting of liquid or cytoplasm enclosed by a lipid bilayer.

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References

[1] https://en.wikipedia.org/wiki/Force_spectrum_microscopy

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