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Inflammation

Index Inflammation

Inflammation (from inflammatio) is part of the complex biological response of body tissues to harmful stimuli, such as pathogens, damaged cells, or irritants, and is a protective response involving immune cells, blood vessels, and molecular mediators. [1]

359 relations: Abscess, Acne, Actin, Acute-phase protein, Adaptive immune system, Agglutination (biology), Allergen, Allergic rhinitis, Allergy, Amyloidosis, Anabolism, Anaphylatoxin, Anaphylaxis, Angiopoietin, Anorexia (symptom), Anti-inflammatory, Antibody, Antibody opsonization, Apoptosis, Appendicitis, Arachidonic acid, Arteriole, Asthma, Asymptomatic inflammatory prostatitis, Atherosclerosis, Aulus Cornelius Celsus, Autoimmune disease, Azurophilic granule, Bacteremia, Bacteria, Basement membrane, BECN1, Blister, Blood plasma, Blood pressure, Blood sugar level, Blood vessel, Bone marrow, Bradykinin, Burn, Bursitis, C-reactive protein, C-type lectin, C3b, C8 complex, Calorie, Cancer, Cancer epigenetics, Cancer immunology, Capillary, ..., Carcinogenesis, Cardinal sign (pathology), Caspase 1, Catabolism, CD44, Chédiak–Higashi syndrome, Chemokine, Chemotaxis, Chromatin, Chronic granulomatous disease, Chronic wound, Circulatory system, Class III PI 3-kinase, Coagulation, Coding region, Coeliac disease, Colitis, Collagen, Complement component 3, Complement component 5, Complement component 5a, Complement component 6, Complement component 7, Complement component 9, Complement membrane attack complex, Complement receptor 1, Complement system, Complex regional pain syndrome, Conformational change, Coronary artery disease, Correlation and dependence, CpG site, CXCL1, Cysteine, Cytokine, Cytoskeleton, Damage-associated molecular pattern, Degranulation, Delayed onset muscle soreness, Dendritic cell, Dermatitis, Dermatomyositis, Diverticulitis, DNA methylation in cancer, DNA methyltransferase, E-selectin, Edema, Eicosanoid, Encephalitis, Endothelium, Enzyme, Eosinophil, Eosinophilia, Epithelium, Essential fatty acid interactions, Extracellular matrix, EZH2, Factor XII, Fc receptor, Fever, Fibrin, Fibrinogen, Fibrinolysis, Fibroblast, Fibrosis, Flushing (physiology), Frostbite, Functio laesa, G protein–coupled receptor, Galen, Gallbladder cancer, Giant cell, Gingivitis, Glomerulonephritis, Glucan, Granule (cell biology), Granulocyte, Granuloma, Half-life, Healing, Health professional, Heat, Hemostasis, Hidradenitis suppurativa, Histamine, Histiocyte, HIV/AIDS, Human body temperature, Hyperalgesia, Hyperglycemia, Hypersensitivity, Hypochlorite, ICAM-1, Immune system, In vitro, In vivo, Inclusion body myositis, Infection, Inflammation, Inflammatory bowel disease, Inflammatory reflex, Injury, Innate immune system, Insulin, Insulin resistance, Insulin-like growth factor 1, Integrin, Interferon gamma, Interleukin, Interleukin 1 beta, Interleukin 1 receptor antagonist, Interleukin 10, Interleukin 15, Interleukin 18, Interleukin 6, Interleukin 8, Interleukin-1 family, Interstitial cystitis, Ionizing radiation, Irritation, Ischemia, JAMA (journal), Kinin, Kinin–kallikrein system, Kupffer cell, Lactic acid, Leprosy, Leptin, Leucine, Leukocyte extravasation, Leukocytosis, Leukopenia, Leukotriene, Leukotriene B4, Leukotriene C4, Leukotriene D4, Lichen planus, Ligand, Lipopolysaccharide, Lipoxin, Liver, Lymphadenopathy, Lymphangitis, Lymphatic system, Lymphatic vessel, Lymphocyte, Lysosome, Lysozyme, Macrophage, Malaise, Management of HIV/AIDS, Mannan, Marathon, Maresin, Mast cell, Mast cell activation syndrome, Mastocytosis, Matrix metalloproteinase, Meningitis, Mesothelium, Microbicide, Monoamine neurotransmitter, Monocyte, Mononuclear cell infiltration, MTOR, Multinucleate, Muscle, Muscle contraction, Muscle hypertrophy, Mutation, Myelitis, Myocyte, Myokine, Myopathy, Myosatellite cell, Myosin, Myostatin, National Institute of Allergy and Infectious Diseases, Nature (journal), Necrosis, Nephritis, Neuritis, Neurogenic inflammation, Neuroprotectin, Neutrophil, Neutrophilia, NF-κB, Nitric oxide, Nociceptor, Nonsteroidal anti-inflammatory drug, Obesity, Omega-3 fatty acid, Opsonin, Otitis, Overeating, P-selectin, Pain, Parasitic disease, Parenchyma, Pathogen, Pathogen-associated molecular pattern, Pathology, Pattern recognition receptor, Pelvic inflammatory disease, Peptidoglycan, Periodic fever syndrome, Periodontal disease, Perspectives on Psychological Science, Perspiration, Phagocyte, Phagocytosis, Pharyngitis, Phlebitis, Phosphatidylinositol, PIK3R4, Plasmin, Platelet, Pneumonia, Polymyositis, Powerlifting, Proinflammatory cytokine, Promoter (genetics), Prostaglandin, Prostaglandin E2, Prostatitis, Protease-activated receptor, Protein, Proteoglycan, Protozoa, Pulmonary pleurae, Pus, Pyroptosis, Reactive nitrogen species, Reactive oxygen species, Receptor antagonist, Regulation of transcription in cancer, Reperfusion injury, Resolvin, Rhesus macaque, Rheumatic fever, Rheumatoid arthritis, Rhinitis, Rickettsia, Rudolf Virchow, Sarcoidosis, Sarcopenia, Saturated fat, Scaffolding, Scar, Scavenger receptor (immunology), Science (journal), Selectin, Sepsis, Septic shock, Serotonin, Serous membrane, Serum amyloid A, Serum amyloid P component, Shear stress, Signal transduction, Signal-to-noise ratio, Simian immunodeficiency virus, Sinusitis, Sirtuin 1, Skeletal muscle, Somnolence, Sooty mangabey, Specialized pro-resolving mediators, Specific granule, Splinter, Staphylococcus, Substance P, Superoxide, Swelling (medical), Syphilis, Systemic inflammation, Systemic inflammatory response syndrome, Systemic scleroderma, Tendinitis, Thomas Sydenham, Thrombin, Thrombus, TNF receptor superfamily, Tonsillitis, Toxin, Transforming growth factor beta, Transplant rejection, Tryptase, Tuberculosis, Tumor necrosis factor alpha, Type I hypersensitivity, Type III hypersensitivity, Ulcer (dermatology), Ulcerative colitis, Urethritis, Urinary tract infection, Vaginitis, Vasculitis, Vasoactivity, Vasodilation, VCAM-1, Vein, Viremia, Vitamin A, White adipose tissue, White blood cell, Wound healing, 5-Hydroxyeicosatetraenoic acid, 5-oxo-eicosatetraenoic acid. Expand index (309 more) »

Abscess

An abscess is a collection of pus that has built up within the tissue of the body.

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Acne

Acne, also known as acne vulgaris, is a long-term skin disease that occurs when hair follicles are clogged with dead skin cells and oil from the skin.

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Actin

Actin is a family of globular multi-functional proteins that form microfilaments.

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Acute-phase protein

Acute-phase proteins (APPs) are a class of proteins whose plasma concentrations increase (positive acute-phase proteins) or decrease (negative acute-phase proteins) in response to inflammation.

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Adaptive immune system

The adaptive immune system, also known as the acquired immune system or, more rarely, as the specific immune system, is a subsystem of the overall immune system that is composed of highly specialized, systemic cells and processes that eliminate pathogens or prevent their growth.

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Agglutination (biology)

Agglutination is the clumping of particles.

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Allergen

An allergen is a type of antigen that produces an abnormally vigorous immune response in which the immune system fights off a perceived threat that would otherwise be harmless to the body.

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Allergic rhinitis

Allergic rhinitis, also known as hay fever, is a type of inflammation in the nose which occurs when the immune system overreacts to allergens in the air.

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Allergy

Allergies, also known as allergic diseases, are a number of conditions caused by hypersensitivity of the immune system to typically harmless substances in the environment.

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Amyloidosis

Amyloidosis is a group of diseases in which abnormal protein, known as amyloid fibrils, builds up in tissue.

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Anabolism

Anabolism (from ἁνά, "upward" and βάλλειν, "to throw") is the set of metabolic pathways that construct molecules from smaller units.

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Anaphylatoxin

Anaphylatoxins, or complement peptides, are fragments (C3a, C4a and C5a) that are produced as part of the activation of the complement system.

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Anaphylaxis

Anaphylaxis is a serious allergic reaction that is rapid in onset and may cause death.

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Angiopoietin

Angiopoietin is part of a family of vascular growth factors that play a role in embryonic and postnatal angiogenesis.

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Anorexia (symptom)

Anorexia (from Ancient Greek ανορεξία: 'ἀν-' "without" + 'όρεξις', spelled 'órexis' meaning "appetite") is the decreased sensation of appetite.

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Anti-inflammatory

Anti-inflammatory, or antiinflammatory, refers to the property of a substance or treatment that reduces inflammation or swelling.

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Antibody

An antibody (Ab), also known as an immunoglobulin (Ig), is a large, Y-shaped protein produced mainly by plasma cells that is used by the immune system to neutralize pathogens such as pathogenic bacteria and viruses.

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Antibody opsonization

Antibody opsonization is the process by which the pathogen is marked for ingestion and eliminated by the phagocytes.

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Apoptosis

Apoptosis (from Ancient Greek ἀπόπτωσις "falling off") is a process of programmed cell death that occurs in multicellular organisms.

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Appendicitis

Appendicitis is inflammation of the appendix.

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Arachidonic acid

Arachidonic acid (AA, sometimes ARA) is a polyunsaturated omega-6 fatty acid 20:4(ω-6).

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Arteriole

An arteriole is a small-diameter blood vessel in the microcirculation that extends and branches out from an artery and leads to capillaries.

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Asthma

Asthma is a common long-term inflammatory disease of the airways of the lungs.

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Asymptomatic inflammatory prostatitis

Asymptomatic inflammatory prostatitis is a painless inflammation of the prostate gland where there is no evidence of infection.

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Atherosclerosis

Atherosclerosis is a disease in which the inside of an artery narrows due to the build up of plaque.

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Aulus Cornelius Celsus

Aulus Cornelius Celsus (25 BC 50 AD) was a Roman encyclopaedist, known for his extant medical work, De Medicina, which is believed to be the only surviving section of a much larger encyclopedia.

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Autoimmune disease

An autoimmune disease is a condition arising from an abnormal immune response to a normal body part.

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Azurophilic granule

An azurophilic granule is a cellular object readily stainable with a Romanowsky stain.

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Bacteremia

Bacteremia (also bacteraemia) is the presence of bacteria in the blood.

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Bacteria

Bacteria (common noun bacteria, singular bacterium) is a type of biological cell.

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Basement membrane

The basement membrane is a thin, fibrous, extracellular matrix of tissue that separates the lining of an internal or external body surface from underlying connective tissue in metazoans.

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BECN1

Beclin-1 is a protein that in humans is encoded by the BECN1 gene.

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Blister

A blister is a small pocket of body fluid (lymph, serum, plasma, blood, or pus) within the upper layers of the skin, typically caused by forceful rubbing (friction), burning, freezing, chemical exposure or infection.

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Blood plasma

Blood plasma is a yellowish coloured liquid component of blood that normally holds the blood cells in whole blood in suspension; this makes plasma the extracellular matrix of blood cells.

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Blood pressure

Blood pressure (BP) is the pressure of circulating blood on the walls of blood vessels.

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Blood sugar level

The blood sugar level, blood sugar concentration, or blood glucose level is the amount of glucose present in the blood of humans and other animals.

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Blood vessel

The blood vessels are the part of the circulatory system, and microcirculation, that transports blood throughout the human body.

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Bone marrow

Bone marrow is a semi-solid tissue which may be found within the spongy or cancellous portions of bones.

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Bradykinin

Bradykinin is an inflammatory mediator.

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Burn

A burn is a type of injury to skin, or other tissues, caused by heat, cold, electricity, chemicals, friction, or radiation.

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Bursitis

Bursitis is the inflammation of one or more bursae (small sacs) of synovial fluid in the body.

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C-reactive protein

C-reactive protein (CRP) is an annular (ring-shaped), pentameric protein found in blood plasma, whose levels rise in response to inflammation.

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C-type lectin

A C-type lectin (CLEC) is a type of carbohydrate-binding protein domain known as a lectin.

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C3b

C3b is the larger of two elements formed by the cleavage of complement component 3, and is considered an important part of the innate immune system.

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C8 complex

Complement component 8 is a protein involved in the complement system.

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Calorie

A calorie is a unit of energy.

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Cancer

Cancer is a group of diseases involving abnormal cell growth with the potential to invade or spread to other parts of the body.

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Cancer epigenetics

Cancer epigenetics is the study of epigenetic modifications to the DNA of cancer cells that do not involve a change in the nucleotide sequence.

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Cancer immunology

Cancer immunology is an interdisciplinary branch of biology that is concerned with understanding the role of the immune system in the progression and development of cancer; the most well known application is cancer immunotherapy, which utilises the immune system as a treatment for cancer.

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Capillary

A capillary is a small blood vessel from 5 to 10 micrometres (µm) in diameter, and having a wall one endothelial cell thick.

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Carcinogenesis

Carcinogenesis, also called oncogenesis or tumorigenesis, is the formation of a cancer, whereby normal cells are transformed into cancer cells.

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Cardinal sign (pathology)

In pathology, a cardinal sign or cardinal symptom is the primary or major clinical sign or symptom by which a diagnosis is made.

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Caspase 1

Caspase-1/Interleukin-1 converting enzyme (ICE) is an evolutionarily conserved enzyme that proteolytically cleaves other proteins, such as the precursors of the inflammatory cytokines interleukin 1β and interleukin 18 as well as the pyroptosis inducer Gasdermin D, into active mature peptides.

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Catabolism

Catabolism (from Greek κάτω kato, "downward" and βάλλειν ballein, "to throw") is the set of metabolic pathways that breaks down molecules into smaller units that are either oxidized to release energy or used in other anabolic reactions.

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CD44

The CD44 antigen is a cell-surface glycoprotein involved in cell–cell interactions, cell adhesion and migration.

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Chédiak–Higashi syndrome

Chédiak–Higashi syndrome is a rare autosomal recessive disorder that arises from a mutation of a lysosomal trafficking regulator protein, which leads to a decrease in phagocytosis.

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Chemokine

Chemokines (Greek -kinos, movement) are a family of small cytokines, or signaling proteins secreted by cells.

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Chemotaxis

Chemotaxis (from chemo- + taxis) is the movement of an organism in response to a chemical stimulus.

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Chromatin

Chromatin is a complex of macromolecules found in cells, consisting of DNA, protein, and RNA.

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Chronic granulomatous disease

Chronic granulomatous disease (CGD) (also known as Bridges–Good syndrome, chronic granulomatous disorder, and Quie syndrome) is a diverse group of hereditary diseases in which certain cells of the immune system have difficulty forming the reactive oxygen compounds (most importantly the superoxide radical due to defective phagocyte NADPH oxidase) used to kill certain ingested pathogens.

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Chronic wound

A chronic wound is a wound that does not heal in an orderly set of stages and in a predictable amount of time the way most wounds do; wounds that do not heal within three months are often considered chronic.

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Circulatory system

The circulatory system, also called the cardiovascular system or the vascular system, is an organ system that permits blood to circulate and transport nutrients (such as amino acids and electrolytes), oxygen, carbon dioxide, hormones, and blood cells to and from the cells in the body to provide nourishment and help in fighting diseases, stabilize temperature and pH, and maintain homeostasis.

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Class III PI 3-kinase

Class III PI 3-kinase is a subgroup of the enzyme family, phosphoinositide 3-kinase that share a common protein domain structure, substrate specificity and method of activation.

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Coagulation

Coagulation (also known as clotting) is the process by which blood changes from a liquid to a gel, forming a blood clot.

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Coding region

The coding region of a gene, also known as the CDS (from CoDing Sequence), is that portion of a gene's DNA or RNA that codes for protein.

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Coeliac disease

Coeliac disease, also spelled celiac disease, is a long-term autoimmune disorder that primarily affects the small intestine.

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Colitis

Colitis is an inflammation of the colon.

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Collagen

Collagen is the main structural protein in the extracellular space in the various connective tissues in animal bodies.

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Complement component 3

Complement component 3, often simply called C3, is a protein of the immune system.

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Complement component 5

Complement component 5 is a protein that in humans is encoded by the C5 gene.

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Complement component 5a

C5a is a protein fragment released from cleavage of complement component C5 by protease C5-convertase into C5a and C5b fragments.

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Complement component 6

Complement component 6 is a protein that in humans is encoded by the C6 gene.

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Complement component 7

Complement component 7 is a protein involved in the complement system of the innate immune system.

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Complement component 9

Complement component 9 (C9) is a protein involved in the complement system, which is part of the innate immune system.

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Complement membrane attack complex

The membrane attack complex (MAC) or terminal complement complex (TCC) is a structure typically formed on the surface of pathogen cell membranes as a result of the activation of the host's complement system, and as such is one of the effector proteins of the immune system.

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Complement receptor 1

Complement receptor type 1 (CR1) also known as C3b/C4b receptor or CD35 (cluster of differentiation 35) is a protein that in humans is encoded by the CR1 gene.

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Complement system

The complement system is a part of the immune system that enhances (complements) the ability of antibodies and phagocytic cells to clear microbes and damaged cells from an organism, promotes inflammation, and attacks the pathogen's cell membrane.

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Complex regional pain syndrome

Complex regional pain syndrome (CRPS), also known as reflex sympathetic dystrophy (RSD) or algodystrophy, is a disorder of a portion of the body, usually the arms or legs, which manifests as pain, swelling, limited range of motion, and changes to the skin and bones.

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Conformational change

In biochemistry, a conformational change is a change in the shape of a macromolecule, often induced by environmental factors.

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Coronary artery disease

Coronary artery disease (CAD), also known as ischemic heart disease (IHD), refers to a group of diseases which includes stable angina, unstable angina, myocardial infarction, and sudden cardiac death.

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Correlation and dependence

In statistics, dependence or association is any statistical relationship, whether causal or not, between two random variables or bivariate data.

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CpG site

The CpG sites or CG sites are regions of DNA where a cytosine nucleotide is followed by a guanine nucleotide in the linear sequence of bases along its 5' → 3' direction.

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CXCL1

The chemokine (C-X-C motif) ligand 1 (CXCL1) is a small cytokine belonging to the CXC chemokine family that was previously called GRO1 oncogene, GROα, KC, neutrophil-activating protein 3 (NAP-3) and melanoma growth stimulating activity, alpha (MSGA-α).

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Cysteine

Cysteine (symbol Cys or C) is a semi-essential proteinogenic amino acid with the formula HO2CCH(NH2)CH2SH.

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Cytokine

Cytokines are a broad and loose category of small proteins (~5–20 kDa) that are important in cell signaling.

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Cytoskeleton

A cytoskeleton is present in all cells of all domains of life (archaea, bacteria, eukaryotes).

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Damage-associated molecular pattern

Damage-associated molecular patterns (DAMPs), also known as danger-associated molecular patterns, danger signals, and alarmin, are host biomolecules that can initiate and perpetuate a noninfectious inflammatory response.

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Degranulation

Degranulation is a cellular process that releases antimicrobial cytotoxic or other molecules from secretory vesicles called granules found inside some cells.

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Delayed onset muscle soreness

Delayed onset muscle soreness (DOMS) is the pain and stiffness felt in muscles several hours to days after unaccustomed or strenuous exercise.

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Dendritic cell

Dendritic cells (DCs) are antigen-presenting cells (also known as accessory cells) of the mammalian immune system.

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Dermatitis

Dermatitis, also known as eczema, is a group of diseases that results in inflammation of the skin.

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Dermatomyositis

Dermatomyositis (DM) is a long term inflammatory disorder which affects muscles.

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Diverticulitis

Diverticulitis, specifically colonic diverticulitis, is a gastrointestinal disease characterized by inflammation of abnormal pouches - diverticuli - which can develop in the wall of the large intestine.

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DNA methylation in cancer

DNA methylation in cancer plays a variety of roles, helping to change the healthy regulation of gene expression to a disease pattern.

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DNA methyltransferase

In biochemistry, the DNA methyltransferase (DNA MTase) family of enzymes catalyze the transfer of a methyl group to DNA.

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E-selectin

E-selectin, also known as CD62 antigen-like family member E (CD62E), endothelial-leukocyte adhesion molecule 1 (ELAM-1), or leukocyte-endothelial cell adhesion molecule 2 (LECAM2), is a cell adhesion molecule expressed only on endothelial cells activated by cytokines.

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Edema

Edema, also spelled oedema or œdema, is an abnormal accumulation of fluid in the interstitium, located beneath the skin and in the cavities of the body, which can cause severe pain.

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Eicosanoid

Eicosanoids are signaling molecules made by the enzymatic or non-enzymatic oxidation of arachidonic acid or other polyunsaturated fatty acids (PUFAs) that are, similar to arachidonic acid, 20 carbon units in length.

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Encephalitis

Encephalitis is inflammation of the brain.

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Endothelium

Endothelium refers to cells that line the interior surface of blood vessels and lymphatic vessels, forming an interface between circulating blood or lymph in the lumen and the rest of the vessel wall.

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Enzyme

Enzymes are macromolecular biological catalysts.

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Eosinophil

Eosinophils sometimes called eosinophiles or, less commonly, acidophils, are a variety of white blood cells and one of the immune system components responsible for combating multicellular parasites and certain infections in vertebrates. Along with mast cells and basophils, they also control mechanisms associated with allergy and asthma. They are granulocytes that develop during hematopoiesis in the bone marrow before migrating into blood, after which they are terminally differentiated and do not multiply. These cells are eosinophilic or "acid-loving" due to their large acidophilic cytoplasmic granules, which show their affinity for acids by their affinity to coal tar dyes: Normally transparent, it is this affinity that causes them to appear brick-red after staining with eosin, a red dye, using the Romanowsky method. The staining is concentrated in small granules within the cellular cytoplasm, which contain many chemical mediators, such as eosinophil peroxidase, ribonuclease (RNase), deoxyribonucleases (DNase), lipase, plasminogen, and major basic protein. These mediators are released by a process called degranulation following activation of the eosinophil, and are toxic to both parasite and host tissues. In normal individuals, eosinophils make up about 1–3% of white blood cells, and are about 12–17 micrometres in size with bilobed nuclei. While they are released into the bloodstream as neutrophils are, eosinophils reside in tissue They are found in the medulla and the junction between the cortex and medulla of the thymus, and, in the lower gastrointestinal tract, ovary, uterus, spleen, and lymph nodes, but not in the lung, skin, esophagus, or some other internal organs under normal conditions. The presence of eosinophils in these latter organs is associated with disease. For instance, patients with eosinophilic asthma have high levels of eosinophils that lead to inflammation and tissue damage, making it more difficult for patients to breathe. Eosinophils persist in the circulation for 8–12 hours, and can survive in tissue for an additional 8–12 days in the absence of stimulation. Pioneering work in the 1980s elucidated that eosinophils were unique granulocytes, having the capacity to survive for extended periods of time after their maturation as demonstrated by ex-vivo culture experiments.

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Eosinophilia

Eosinophilia is a condition in which the eosinophil count in the peripheral blood exceeds.

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Epithelium

Epithelium is one of the four basic types of animal tissue, along with connective tissue, muscle tissue and nervous tissue.

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Essential fatty acid interactions

The effects on humans of the ω-3 (omega-3) and ω-6 (omega-6) essential fatty acids (EFAs) are best characterized by their interactions; they cannot be understood separately.

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Extracellular matrix

In biology, the extracellular matrix (ECM) is a collection of extracellular molecules secreted by support cells that provides structural and biochemical support to the surrounding cells.

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EZH2

Enhancer of zeste homolog 2 (EZH2) is a histone-lysine N-methyltransferase enzyme (EC 2.1.1.43) encoded by EZH2 gene, that participates in histone methylation and, ultimately, transcriptional repression.

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Factor XII

Coagulation factor XII, also known as Hageman factor, is a plasma protein.

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Fc receptor

An Fc receptor is a protein found on the surface of certain cells – including, among others, B lymphocytes, follicular dendritic cells, natural killer cells, macrophages, neutrophils, eosinophils, basophils, human platelets, and mast cells – that contribute to the protective functions of the immune system.

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Fever

Fever, also known as pyrexia and febrile response, is defined as having a temperature above the normal range due to an increase in the body's temperature set-point.

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Fibrin

Fibrin (also called Factor Ia) is a fibrous, non-globular protein involved in the clotting of blood.

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Fibrinogen

Fibrinogen (factor I) is a glycoprotein that in vertebrates circulates in the blood.

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Fibrinolysis

Fibrinolysis is a process that prevents blood clots from growing and becoming problematic.

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Fibroblast

A fibroblast is a type of biological cell that synthesizes the extracellular matrix and collagen, the structural framework (stroma) for animal tissues, and plays a critical role in wound healing.

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Fibrosis

Fibrosis is the formation of excess fibrous connective tissue in an organ or tissue in a reparative or reactive process.

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Flushing (physiology)

For a person to flush is to become markedly red in the face and often other areas of the skin, from various physiological conditions.

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Frostbite

Frostbite occurs when exposure to low temperatures causes freezing of the skin or other tissues.

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Functio laesa

Functio laesa is a term used in medicine to refer to a loss of function or a disturbance of function.

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G protein–coupled receptor

G protein–coupled receptors (GPCRs), also known as seven-(pass)-transmembrane domain receptors, 7TM receptors, heptahelical receptors, serpentine receptor, and G protein–linked receptors (GPLR), constitute a large protein family of receptors that detect molecules outside the cell and activate internal signal transduction pathways and, ultimately, cellular responses.

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Galen

Aelius Galenus or Claudius Galenus (Κλαύδιος Γαληνός; September 129 AD – /), often Anglicized as Galen and better known as Galen of Pergamon, was a Greek physician, surgeon and philosopher in the Roman Empire.

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Gallbladder cancer

Gallbladder cancer is a relatively uncommon cancer.

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Giant cell

A giant cell (multinucleated giant cell, multinucleate giant cell) is a mass formed by the union of several distinct cells (usually macrophages), often forming a granuloma.

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Gingivitis

Gingivitis is a non-destructive disease that occurs around the teeth.

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Glomerulonephritis

Glomerulonephritis (GN), also known as glomerular nephritis, is a term used to refer to several kidney diseases (usually affecting both kidneys).

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Glucan

A glucan molecule is a polysaccharide of D-glucose monomers, linked by glycosidic bonds.

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Granule (cell biology)

In cell biology, a granule is a small particle.

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Granulocyte

Granulocytes are a category of white blood cells characterized by the presence of granules in their cytoplasm.

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Granuloma

Granuloma is an inflammation found in many diseases.

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Half-life

Half-life (symbol t1⁄2) is the time required for a quantity to reduce to half its initial value.

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Healing

Healing (literally meaning to make whole) is the process of the restoration of health from an unbalanced, diseased or damaged organism.

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Health professional

A health professional, health practitioner or healthcare provider (sometimes simply "provider") is an individual who provides preventive, curative, promotional or rehabilitative health care services in a systematic way to people, families or communities.

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Heat

In thermodynamics, heat is energy transferred from one system to another as a result of thermal interactions.

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Hemostasis

Hemostasis or haemostasis is a process which causes bleeding to stop, meaning to keep blood within a damaged blood vessel (the opposite of hemostasis is hemorrhage).

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Hidradenitis suppurativa

Hidradenitis suppurativa (HS), also known as acne inversa, is a long term skin disease characterized by the occurrence of inflamed and swollen lumps.

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Histamine

Histamine is an organic nitrogenous compound involved in local immune responses, as well as regulating physiological function in the gut and acting as a neurotransmitter for the brain, spinal cord, and uterus.

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Histiocyte

A histiocyte is an animal cell that is part of the mononuclear phagocyte system (also known as the reticuloendothelial system or lymphoreticular system).

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HIV/AIDS

Human immunodeficiency virus infection and acquired immune deficiency syndrome (HIV/AIDS) is a spectrum of conditions caused by infection with the human immunodeficiency virus (HIV).

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Human body temperature

Normal human body temperature, also known as normothermia or euthermia, is the typical temperature range found in humans.

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Hyperalgesia

Hyperalgesia (or; 'hyper' from Greek ὑπέρ (huper, “over”), '-algesia' from Greek algos, ἄλγος (pain)) is an increased sensitivity to pain, which may be caused by damage to nociceptors or peripheral nerves and can cause hypersensitivity to stimulus, stimuli which would normally not be cause for a pain reaction (ex/ eyes or brain having a painful reaction to daylight).

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Hyperglycemia

Hyperglycemia, or high blood sugar (also spelled hyperglycaemia or hyperglycæmia) is a condition in which an excessive amount of glucose circulates in the blood plasma.

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Hypersensitivity

Hypersensitivity (also called hypersensitivity reaction or intolerance) refers to undesirable reactions produced by the normal immune system, including allergies and autoimmunity.

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Hypochlorite

In chemistry, hypochlorite is an ion with the chemical formula ClO−.

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ICAM-1

ICAM-1 (Intercellular Adhesion Molecule 1) also known as CD54 (Cluster of Differentiation 54) is a protein that in humans is encoded by the ICAM1 gene.

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Immune system

The immune system is a host defense system comprising many biological structures and processes within an organism that protects against disease.

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In vitro

In vitro (meaning: in the glass) studies are performed with microorganisms, cells, or biological molecules outside their normal biological context.

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In vivo

Studies that are in vivo (Latin for "within the living"; often not italicized in English) are those in which the effects of various biological entities are tested on whole, living organisms or cells, usually animals, including humans, and plants, as opposed to a tissue extract or dead organism.

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Inclusion body myositis

Inclusion body myositis (IBM) is the most common inflammatory muscle disease in older adults.

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Infection

Infection is the invasion of an organism's body tissues by disease-causing agents, their multiplication, and the reaction of host tissues to the infectious agents and the toxins they produce.

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Inflammation

Inflammation (from inflammatio) is part of the complex biological response of body tissues to harmful stimuli, such as pathogens, damaged cells, or irritants, and is a protective response involving immune cells, blood vessels, and molecular mediators.

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Inflammatory bowel disease

Inflammatory bowel disease (IBD) is a group of inflammatory conditions of the colon and small intestine.

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Inflammatory reflex

The inflammatory reflex is a neural circuit that regulates the immune response to injury and invasion.

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Injury

Injury, also known as physical trauma, is damage to the body caused by external force.

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Innate immune system

The innate immune system, also known as the non-specific immune system or in-born immunity system, is an important subsystem of the overall immune system that comprises the cells and mechanisms involved in the defense of the host from infection by other organisms.

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Insulin

Insulin (from Latin insula, island) is a peptide hormone produced by beta cells of the pancreatic islets; it is considered to be the main anabolic hormone of the body.

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Insulin resistance

Insulin resistance (IR) is a pathological condition in which cells fail to respond normally to the hormone insulin.

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Insulin-like growth factor 1

Insulin-like growth factor 1 (IGF-1), also called somatomedin C, is a protein that in humans is encoded by the IGF1 gene.

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Integrin

Integrins are transmembrane receptors that facilitate cell-extracellular matrix (ECM) adhesion.

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Interferon gamma

Interferon gamma (IFNγ) is a dimerized soluble cytokine that is the only member of the type II class of interferons.

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Interleukin

Interleukins (ILs) are a group of cytokines (secreted proteins and signal molecules) that were first seen to be expressed by white blood cells (leukocytes).

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Interleukin 1 beta

Interleukin 1 beta (IL1β) also known as leukocytic pyrogen, leukocytic endogenous mediator, mononuclear cell factor, lymphocyte activating factor and other names, is a cytokine protein that in humans is encoded by the IL1B gene.

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Interleukin 1 receptor antagonist

The interleukin-1 receptor antagonist (IL-1RA) is a protein that in humans is encoded by the IL1RN gene.

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Interleukin 10

Interleukin 10 (IL-10), also known as human cytokine synthesis inhibitory factor (CSIF), is an anti-inflammatory cytokine.

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Interleukin 15

Interleukin-15 (IL-15) is a cytokine with structural similarity to Interleukin-2 (IL-2).

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Interleukin 18

Interleukin-18 (IL18, also known as interferon-gamma inducing factor) is a protein which in humans is encoded by the IL18 gene.

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Interleukin 6

Interleukin 6 (IL-6) is an interleukin that acts as both a pro-inflammatory cytokine and an anti-inflammatory myokine.

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Interleukin 8

Interleukin 8 (IL8 or chemokine (C-X-C motif) ligand 8, CXCL8) is a chemokine produced by macrophages and other cell types such as epithelial cells, airway smooth muscle cells and endothelial cells.

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Interleukin-1 family

The Interleukin-1 family (IL-1 family) is a group of 11 cytokines that plays a central role in the regulation of immune and inflammatory responses to infections or sterile insults.

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Interstitial cystitis

Interstitial cystitis (IC), also known as bladder pain syndrome (BPS), is a type of chronic pain that affects the bladder.

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Ionizing radiation

Ionizing radiation (ionising radiation) is radiation that carries enough energy to liberate electrons from atoms or molecules, thereby ionizing them.

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Irritation

Irritation, in biology and physiology, is a state of inflammation or painful reaction to allergy or cell-lining damage.

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Ischemia

Ischemia or ischaemia is a restriction in blood supply to tissues, causing a shortage of oxygen that is needed for cellular metabolism (to keep tissue alive).

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JAMA (journal)

JAMA: The Journal of the American Medical Association is a peer-reviewed medical journal published 48 times a year by the American Medical Association.

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Kinin

A kinin is any of various structurally related polypeptides, such as bradykinin and kallidin.

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Kinin–kallikrein system

The kinin–kallikrein system or simply kinin system is a poorly understood hormonal system with limited available research.

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Kupffer cell

Kupffer cells, also known as stellate macrophages and Kupffer-Browicz cells, are specialized macrophages located in the liver, lining the walls of the sinusoids.

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Lactic acid

Lactic acid is an organic compound with the formula CH3CH(OH)COOH.

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Leprosy

Leprosy, also known as Hansen's disease (HD), is a long-term infection by the bacterium Mycobacterium leprae or Mycobacterium lepromatosis.

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Leptin

Leptin (from Greek λεπτός leptos, "thin"), "the hormone of energy expenditure", is a hormone predominantly made by adipose cells that helps to regulate energy balance by inhibiting hunger.

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Leucine

Leucine (symbol Leu or L) is an essential amino acid that is used in the biosynthesis of proteins.

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Leukocyte extravasation

Leukocyte extravasation, less commonly called diapedesis, is the movement of leukocytes out of the circulatory system and towards the site of tissue damage or infection.

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Leukocytosis

Leukocytosis is white cells (the leukocyte count) above the normal range in the blood.

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Leukopenia

Leukopenia is a decrease in the number of white blood cells (leukocytes) found in the blood, which places individuals at increased risk of infection.

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Leukotriene

Leukotrienes are a family of eicosanoid inflammatory mediators produced in leukocytes by the oxidation of arachidonic acid (AA) and the essential fatty acid eicosapentaenoic acid (EPA) by the enzyme arachidonate 5-lipoxygenase.

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Leukotriene B4

Leukotriene B4 (LTB4) is a leukotriene involved in inflammation.

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Leukotriene C4

Leukotriene C4 (LTC4) is a leukotriene.

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Leukotriene D4

Leukotriene D4 (LTD4) is one of the leukotrienes.

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Lichen planus

Lichen planus (LP) is a disease characterized by itchy reddish-purple polygon-shaped skin lesions on the lower back, wrists, and ankles.

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Ligand

In coordination chemistry, a ligand is an ion or molecule (functional group) that binds to a central metal atom to form a coordination complex.

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Lipopolysaccharide

Lipopolysaccharides (LPS), also known as lipoglycans and endotoxins, are large molecules consisting of a lipid and a polysaccharide composed of O-antigen, outer core and inner core joined by a covalent bond; they are found in the outer membrane of Gram-negative bacteria.

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Lipoxin

Lipoxins (LXs or Lxs), an acronym for lipoxygenase interaction products, are bioactive autacoid metabolites of arachidonic acid made by various cell types.

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Liver

The liver, an organ only found in vertebrates, detoxifies various metabolites, synthesizes proteins, and produces biochemicals necessary for digestion.

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Lymphadenopathy

Lymphadenopathy or adenopathy is disease of the lymph nodes, in which they are abnormal in size, number, or consistency.

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Lymphangitis

Lymphangitis is an inflammation or an infection of the lymphatic channels that occurs as a result of infection at a site distal to the channel.

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Lymphatic system

The lymphatic system is part of the vascular system and an important part of the immune system, comprising a network of lymphatic vessels that carry a clear fluid called lymph (from Latin, lympha meaning "water") directionally towards the heart.

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Lymphatic vessel

The lymphatic vessels (or lymph vessels or lymphatics) are thin-walled vessels structured like blood vessels, that carry lymph.

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Lymphocyte

A lymphocyte is one of the subtypes of white blood cell in a vertebrate's immune system.

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Lysosome

A lysosome is a membrane-bound organelle found in nearly all animal cells.

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Lysozyme

Lysozyme, also known as muramidase or N-acetylmuramide glycanhydrolase is an antimicrobial enzyme produced by animals that forms part of the innate immune system.

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Macrophage

Macrophages (big eaters, from Greek μακρός (makrós).

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Malaise

Malaise is a feeling of general discomfort, uneasiness or pain, often the first indication of an infection or other disease.

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Management of HIV/AIDS

The management of HIV/AIDS normally includes the use of multiple antiretroviral drugs in an attempt to control HIV infection.

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Mannan

Mannan may refer to a plant polysaccharide that is a linear polymer of the sugar mannose.

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Marathon

The marathon is a long-distance race, completed by running, walking, or a run/walk strategy.

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Maresin

Maresin 1 (MaR1 or 7R,14S-dihydroxy-4Z,8E,10E,12Z,16Z,19Z-docosahexaenoic acid) is a macrophage-derived mediator of inflammation resolution coined from macrophage mediator in resolving inflammation.

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Mast cell

A mast cell (also known as a mastocyte or a labrocyte) is a type of white blood cell.

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Mast cell activation syndrome

Mast cell activation syndrome (MCAS) is one type of mast cell activation disorder (MCAD), and is an immunological condition in which mast cells inappropriately and excessively release chemical mediators, resulting in a range of chronic symptoms, sometimes including anaphylaxis or near-anaphylaxis attacks.

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Mastocytosis

Mastocytosis, a type of mast cell disease, is a rare disorder affecting both children and adults caused by the accumulation of functionally defective mast cells (also called mastocytes) and CD34+ mast cell precursors.

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Matrix metalloproteinase

Matrix metalloproteinases (MMPs), also known as matrixins, are calcium-dependent zinc-containing endopeptidases; other family members are adamalysins, serralysins, and astacins.

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Meningitis

Meningitis is an acute inflammation of the protective membranes covering the brain and spinal cord, known collectively as the meninges.

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Mesothelium

The mesothelium is a membrane composed of simple squamous epithelium that forms the lining of several body cavities: the pleura (thoracic cavity), peritoneum (abdominal cavity including the mesentery), mediastinum and pericardium (heart sac).

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Microbicide

A microbicide is any biocidal compound or substance whose purpose is to reduce the infectivity of microbes, such as viruses or bacteria.

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Monoamine neurotransmitter

Monoamine neurotransmitters are neurotransmitters and neuromodulators that contain one amino group that is connected to an aromatic ring by a two-carbon chain (such as -CH2-CH2-). All monoamines are derived from aromatic amino acids like phenylalanine, tyrosine, tryptophan, and the thyroid hormones by the action of aromatic amino acid decarboxylase enzymes.

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Monocyte

Monocytes are a type of leukocyte, or white blood cell.

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Mononuclear cell infiltration

Mononuclear cell infiltrates are characteristic of inflammatory lesions, where white blood cells, mainly macrophages and lymphocytes, collect at the site of injury to help clear away the debris.

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MTOR

The mammalian target of rapamycin (mTOR), also known as the mechanistic target of rapamycin and FK506-binding protein 12-rapamycin-associated protein 1 (FRAP1), is a kinase that in humans is encoded by the MTOR gene.

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Multinucleate

Multinucleate cells (also called multinucleated or polynuclear cells) are eukaryotic cells that have more than one nucleus per cell, i.e., multiple nuclei share one common cytoplasm.

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Muscle

Muscle is a soft tissue found in most animals.

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Muscle contraction

Muscle contraction is the activation of tension-generating sites within muscle fibers.

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Muscle hypertrophy

Muscle hypertrophy involves an increase in size of skeletal muscle through a growth in size of its component cells.

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Mutation

In biology, a mutation is the permanent alteration of the nucleotide sequence of the genome of an organism, virus, or extrachromosomal DNA or other genetic elements.

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Myelitis

Myelitis is inflammation of the spinal cord which can disrupt the normal responses from the brain to the rest of the body, and from the rest of the body to the brain.

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Myocyte

A myocyte (also known as a muscle cell) is the type of cell found in muscle tissue.

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Myokine

A myokine is one of several hundred cytokines or other small proteins (~5–20 kDa) and proteoglycan peptides that are produced and released by muscle cells (myocytes) in response to muscular contractions.

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Myopathy

Myopathy is a disease of the muscle in which the muscle fibers do not function properly.

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Myosatellite cell

Myosatellite cells or satellite cells are small multipotent cells with virtually no cytoplasm found in mature muscle.

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Myosin

Myosins are a superfamily of motor proteins best known for their roles in muscle contraction and in a wide range of other motility processes in eukaryotes.

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Myostatin

Myostatin (also known as growth differentiation factor 8, abbreviated GDF-8) is a myokine, a protein produced and released by myocytes that acts on muscle cells' autocrine function to inhibit myogenesis: muscle cell growth and differentiation.

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National Institute of Allergy and Infectious Diseases

The National Institute of Allergy and Infectious Diseases (NIAID) is one of the 27 institutes and centers that make up the National Institutes of Health (NIH), an agency of the United States Department of Health and Human Services (HHS).

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Nature (journal)

Nature is a British multidisciplinary scientific journal, first published on 4 November 1869.

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Necrosis

Necrosis (from the Greek νέκρωσις "death, the stage of dying, the act of killing" from νεκρός "dead") is a form of cell injury which results in the premature death of cells in living tissue by autolysis.

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Nephritis

Nephritis is inflammation of the kidneys and may involve the glomeruli, tubules, or interstitial tissue surrounding the glomeruli and tubules.

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Neuritis

Neuritis is inflammation of a nerve or the general inflammation of the peripheral nervous system.

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Neurogenic inflammation

Neurogenic inflammation is inflammation arising from the local release by afferent neurons of inflammatory mediators such as Substance P, Calcitonin Gene-Related Peptide (CGRP), neurokinin A (NKA), and endothelin-3 (ET-3).

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Neuroprotectin

Neuroprotectin D1 (NPD1) (10R,17S-dihydroxy-4Z,7Z,11E,13E,15Z,19Z-docosahexaenoic acid) also known as Protectin D1 (PD1) is a docosanoid derived from the polyunsaturated fatty acid (PUFA) docosahexaenoic acid (DHA), which is a component of fish oil and the most important omega-3 PUFA.

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Neutrophil

Neutrophils (also known as neutrocytes) are the most abundant type of granulocytes and the most abundant (40% to 70%) type of white blood cells in most mammals.

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Neutrophilia

Neutrophilia (also called neutrophil leukocytosis or occasionally neutrocytosis) is leukocytosis of neutrophils, that is, a high number of neutrophil granulocytes in the blood.

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NF-κB

NF-κB (nuclear factor kappa-light-chain-enhancer of activated B cells) is a protein complex that controls transcription of DNA, cytokine production and cell survival.

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Nitric oxide

Nitric oxide (nitrogen oxide or nitrogen monoxide) is a colorless gas with the formula NO.

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Nociceptor

A nociceptor is a sensory neuron that responds to damaging or potentially damaging stimuli by sending “possible threat” signals to the spinal cord and the brain.

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Nonsteroidal anti-inflammatory drug

Nonsteroidal anti-inflammatory drugs (NSAIDs) are a drug class that reduce pain, decrease fever, prevent blood clots and, in higher doses, decrease inflammation.

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Obesity

Obesity is a medical condition in which excess body fat has accumulated to the extent that it may have a negative effect on health.

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Omega-3 fatty acid

Omega−3 fatty acids, also called ω−3 fatty acids or n−3 fatty acids, are polyunsaturated fatty acids (PUFAs).

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Opsonin

An opsonin (from the Greek opsōneîn, to prepare for eating) is any molecule that enhances phagocytosis by marking an antigen for an immune response or marking dead cells for recycling (i.e., causes the phagocyte to "relish" the marked cell).

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Otitis

Otitis is a general term for inflammation or infection of the ear, in both humans and other animals.

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Overeating

Overeating is the excess food in relation to the energy that an organism expends (or expels via excretion), leading to weight gaining and often obesity.

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P-selectin

P-selectin is a protein that in humans is encoded by the SELP gene.

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Pain

Pain is a distressing feeling often caused by intense or damaging stimuli.

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Parasitic disease

A parasitic disease, also known as parasitosis, is an infectious disease caused or transmitted by a parasite.

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Parenchyma

Parenchyma is the bulk of a substance.

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Pathogen

In biology, a pathogen (πάθος pathos "suffering, passion" and -γενής -genēs "producer of") or a '''germ''' in the oldest and broadest sense is anything that can produce disease; the term came into use in the 1880s.

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Pathogen-associated molecular pattern

Pathogen-associated molecular patterns, or PAMPs, are molecules associated with groups of pathogens, that are recognized by cells of the innate immune system.

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Pathology

Pathology (from the Ancient Greek roots of pathos (πάθος), meaning "experience" or "suffering" and -logia (-λογία), "study of") is a significant field in modern medical diagnosis and medical research, concerned mainly with the causal study of disease, whether caused by pathogens or non-infectious physiological disorder.

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Pattern recognition receptor

Pattern recognition receptors (PRRs) play a crucial role in the proper function of the innate immune system.

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Pelvic inflammatory disease

Pelvic inflammatory disease or pelvic inflammatory disorder (PID) is an infection of the upper part of the female reproductive system namely the uterus, fallopian tubes, and ovaries, and inside of the pelvis.

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Peptidoglycan

Peptidoglycan, also known as murein, is a polymer consisting of sugars and amino acids that forms a mesh-like layer outside the plasma membrane of most bacteria, forming the cell wall.

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Periodic fever syndrome

Periodic fever syndromes (also known as autoinflammatory diseases or autoinflammatory syndromes) are a set of disorders characterized by recurrent episodes of systemic and organ-specific inflammation.

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Periodontal disease

Periodontal disease, also known as gum disease, is a set of inflammatory conditions affecting the tissues surrounding the teeth.

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Perspectives on Psychological Science

Perspectives on Psychological Science is a bimonthly peer-reviewed academic journal of psychology.

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Perspiration

Perspiration, also known as sweating, is the production of fluids secreted by the sweat glands in the skin of mammals.

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Phagocyte

Phagocytes are cells that protect the body by ingesting harmful foreign particles, bacteria, and dead or dying cells.

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Phagocytosis

In cell biology, phagocytosis is the process by which a cell—often a phagocyte or a protist—engulfs a solid particle to form an internal compartment known as a phagosome.

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Pharyngitis

Pharyngitis is inflammation of the back of the throat, known as the pharynx.

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Phlebitis

Phlebitis or venitis is the inflammation of a vein, usually in the legs.

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Phosphatidylinositol

Phosphatidylinositol consists of a family of lipids as illustrated on the right, a class of the phosphatidylglycerides.

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PIK3R4

Phosphoinositide 3-kinase regulatory subunit 4, also known as PI3-kinase regulatory subunit 4 or PI3-kinase p150 subunit or phosphoinositide 3-kinase adaptor protein, or VPS15 is an enzyme that in humans is encoded by the PIK3R4 gene.

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Plasmin

Plasmin is an important enzyme present in blood that degrades many blood plasma proteins, including fibrin clots.

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Platelet

Platelets, also called thrombocytes (from Greek θρόμβος, "clot" and κύτος, "cell"), are a component of blood whose function (along with the coagulation factors) is to react to bleeding from blood vessel injury by clumping, thereby initiating a blood clot.

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Pneumonia

Pneumonia is an inflammatory condition of the lung affecting primarily the small air sacs known as alveoli.

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Polymyositis

Polymyositis (PM) is a type of chronic inflammation of the muscles (inflammatory myopathy) related to dermatomyositis and inclusion body myositis.

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Powerlifting

Powerlifting is a strength sport that consists of three attempts at maximal weight on three lifts: squat, bench press, and deadlift.

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Proinflammatory cytokine

A proinflammatory cytokine or more simply an inflammatory cytokine is a type of signaling molecule (a cytokine) that is excreted from immune cells like helper T cells (Th) and macrophages, and certain other cell types that promote inflammation.

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Promoter (genetics)

In genetics, a promoter is a region of DNA that initiates transcription of a particular gene.

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Prostaglandin

The prostaglandins (PG) are a group of physiologically active lipid compounds having diverse hormone-like effects in animals.

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Prostaglandin E2

Prostaglandin E2 (PGE2), also known as dinoprostone, is a naturally occurring prostaglandin which is used as a medication.

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Prostatitis

Prostatitis is inflammation of the prostate gland.

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Protease-activated receptor

Protease-activated receptors are a subfamily of related G protein-coupled receptors that are activated by cleavage of part of their extracellular domain.

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Protein

Proteins are large biomolecules, or macromolecules, consisting of one or more long chains of amino acid residues.

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Proteoglycan

Proteoglycans are proteins that are heavily glycosylated.

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Protozoa

Protozoa (also protozoan, plural protozoans) is an informal term for single-celled eukaryotes, either free-living or parasitic, which feed on organic matter such as other microorganisms or organic tissues and debris.

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Pulmonary pleurae

The pulmonary pleurae (sing. pleura) are the two pleurae of the invaginated sac surrounding each lung and attaching to the thoracic cavity.

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Pus

Pus is an exudate, typically white-yellow, yellow, or yellow-brown, formed at the site of inflammation during bacterial or fungal infection.

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Pyroptosis

Pyroptosis is a highly inflammatory form of programmed cell death that occurs most frequently upon infection with intracellular pathogens and is likely to form part of the antimicrobial response.

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Reactive nitrogen species

Reactive nitrogen species (RNS) are a family of antimicrobial molecules derived from nitric oxide (•NO) and superoxide (O2•−) produced via the enzymatic activity of inducible nitric oxide synthase 2 (NOS2) and NADPH oxidase respectively.

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Reactive oxygen species

Reactive oxygen species (ROS) are chemically reactive chemical species containing oxygen.

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Receptor antagonist

A receptor antagonist is a type of receptor ligand or drug that blocks or dampens a biological response by binding to and blocking a receptor rather than activating it like an agonist.

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Regulation of transcription in cancer

Generally, in progression to cancer, hundreds of genes are silenced or activated.

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Reperfusion injury

Reperfusion injury or reperfusion insult, sometimes called ischemia-reperfusion injury (IRI) or reoxygenation injury, is the tissue damage caused when blood supply returns to tissue (re- + perfusion) after a period of ischemia or lack of oxygen (anoxia or hypoxia).

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Resolvin

Resolvins are metabolic byproducts of omega-3 fatty acids, primarily eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), as well as docosapentaenoic acid (DPA) and clupanodonic acid.

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Rhesus macaque

The rhesus macaque (Macaca mulatta) is one of the best-known species of Old World monkeys.

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Rheumatic fever

Rheumatic fever (RF) is an inflammatory disease that can involve the heart, joints, skin, and brain.

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Rheumatoid arthritis

Rheumatoid arthritis (RA) is a long-term autoimmune disorder that primarily affects joints.

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Rhinitis

Rhinitis, also known as coryza, is irritation and inflammation of the mucous membrane inside the nose.

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Rickettsia

Rickettsia is a genus of nonmotile, Gram-negative, nonspore-forming, highly pleomorphic bacteria that can be present as cocci (0.1 μm in diameter), rods (1–4 μm long), or thread-like (10 μm long).

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Rudolf Virchow

Rudolf Ludwig Carl Virchow (13 October 1821 – 5 September 1902) was a German physician, anthropologist, pathologist, prehistorian, biologist, writer, editor, and politician, known for his advancement of public health.

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Sarcoidosis

Sarcoidosis is a disease involving abnormal collections of inflammatory cells that form lumps known as granulomas.

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Sarcopenia

Sarcopenia is the degenerative loss of skeletal muscle mass (0.5–1% loss per year after the age of 50), quality, and strength associated with aging.

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Saturated fat

A saturated fat is a type of fat in which the fatty acid chains have all or predominantly single bonds.

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Scaffolding

Scaffolding, also called scaffold or staging, is a temporary structure used to support a work crew and materials to aid in the construction, maintenance and repair of buildings, bridges and all other man made structures.

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Scar

A scar is an area of fibrous tissue that replaces normal skin after an injury.

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Scavenger receptor (immunology)

Scavenger receptors are receptors on macrophages and other cells that bind to numerous ligands, such as bacterial cell-wall components, and remove them from the blood.

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Science (journal)

Science, also widely referred to as Science Magazine, is the peer-reviewed academic journal of the American Association for the Advancement of Science (AAAS) and one of the world's top academic journals.

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Selectin

The selectins (cluster of differentiation 62 or CD62) are a family of cell adhesion molecules (or CAMs).

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Sepsis

Sepsis is a life-threatening condition that arises when the body's response to infection causes injury to its own tissues and organs.

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Septic shock

Septic shock is a serious medical condition that occurs when sepsis, which is organ injury or damage in response to infection, leads to dangerously low blood pressure and abnormalities in cellular metabolism.

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Serotonin

Serotonin or 5-hydroxytryptamine (5-HT) is a monoamine neurotransmitter.

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Serous membrane

In anatomy, serous membrane (or serosa) is a smooth tissue membrane consisting of two layers of mesothelium, which secrete serous fluid.

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Serum amyloid A

Serum amyloid A (SAA) proteins are a family of apolipoproteins associated with high-density lipoprotein (HDL) in plasma.

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Serum amyloid P component

The serum amyloid P component (SAP) is the identical serum form of amyloid P component (AP), a 25kDa pentameric protein first identified as the pentagonal constituent of in vivo pathological deposits called "amyloid".

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Shear stress

A shear stress, often denoted by (Greek: tau), is the component of stress coplanar with a material cross section.

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Signal transduction

Signal transduction is the process by which a chemical or physical signal is transmitted through a cell as a series of molecular events, most commonly protein phosphorylation catalyzed by protein kinases, which ultimately results in a cellular response.

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Signal-to-noise ratio

Signal-to-noise ratio (abbreviated SNR or S/N) is a measure used in science and engineering that compares the level of a desired signal to the level of background noise.

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Simian immunodeficiency virus

Simian immunodeficiency viruses (SIVs) are retroviruses that cause persistent infections in at least 45 species of African non-human primates.

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Sinusitis

Sinusitis, also known as a sinus infection or rhinosinusitis, is inflammation of the sinuses resulting in symptoms.

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Sirtuin 1

Sirtuin 1, also known as NAD-dependent deacetylase sirtuin-1, is a protein that in humans is encoded by the SIRT1 gene.

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Skeletal muscle

Skeletal muscle is one of three major muscle types, the others being cardiac muscle and smooth muscle.

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Somnolence

Somnolence (alternatively "sleepiness" or "drowsiness") is a state of strong desire for sleep, or sleeping for unusually long periods (compare hypersomnia).

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Sooty mangabey

The sooty mangabey (Cercocebus atys) is an Old World monkey found in forests from Senegal in a margin along the coast down to Ghana.

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Specialized pro-resolving mediators

Specialized pro-resolving mediators (SPM, also termed specialized proresolving mediators) are a large and growing class of cell signaling molecules formed in cells by the metabolism of polyunsaturated fatty acids (PUFA) by one or a combination of lipoxygenase, cyclooxygenase, and cytochrome P450 monooxygenase enzymes.

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Specific granule

Specific granules are secretory vesicles found exclusively in cells of the immune system called granulocytes.

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Splinter

A splinter is a fragment of a larger object (especially wood), or a foreign body that penetrates or is purposely injected into a body.

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Staphylococcus

Staphylococcus (from the σταφυλή, staphylē, "grape" and κόκκος, kókkos, "granule") is a genus of Gram-positive bacteria.

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Substance P

Substance P (SP) is an undecapeptide (a peptide composed of a chain of 11 amino acid residues) member of the tachykinin neuropeptide family. It is a neuropeptide, acting as a neurotransmitter and as a neuromodulator. Substance P and its closely related neurokinin A (NKA) are produced from a polyprotein precursor after differential splicing of the preprotachykinin A gene. The deduced amino acid sequence of substance P is as follows.

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Superoxide

A superoxide is a compound that contains the superoxide anion, which has the chemical formula.

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Swelling (medical)

In medical parlance, swelling, turgescence or tumefaction is a transient abnormal enlargement of a body part or area not caused by proliferation of cells.

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Syphilis

Syphilis is a sexually transmitted infection caused by the bacterium Treponema pallidum subspecies pallidum.

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Systemic inflammation

Chronic systemic inflammation (SI) is the result of release of pro-inflammatory cytokines from immune-related cells and the chronic activation of the innate immune system.

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Systemic inflammatory response syndrome

Systemic inflammatory response syndrome (SIRS) is an inflammatory state affecting the whole body.

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Systemic scleroderma

Systemic scleroderma, also called diffuse scleroderma or systemic sclerosis, is an autoimmune disease of the connective tissue.

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Tendinitis

Tendinitis (also tendonitis), meaning inflammation of a tendon, is a type of tendinopathy often confused with the more common tendinosis, which has similar symptoms but requires different treatment.

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Thomas Sydenham

Thomas Sydenham (10 September 1624 – 29 December 1689) was an English physician.

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Thrombin

Thrombin (fibrinogenase, thrombase, thrombofort, topical, thrombin-C, tropostasin, activated blood-coagulation factor II, blood-coagulation factor IIa, factor IIa, E thrombin, beta-thrombin, gamma-thrombin) is a serine protease, an enzyme that, in humans, is encoded by the F2 gene.

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Thrombus

A thrombus, colloquially called a blood clot, is the final product of the blood coagulation step in hemostasis.

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TNF receptor superfamily

The tumor necrosis factor receptor superfamily (TNFRSF) is a protein superfamily of cytokine receptors characterized by the ability to bind tumor necrosis factors (TNFs) via an extracellular cysteine-rich domain.

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Tonsillitis

Tonsillitis is inflammation of the tonsils, typically of rapid onset.

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Toxin

A toxin (from toxikon) is a poisonous substance produced within living cells or organisms; synthetic toxicants created by artificial processes are thus excluded.

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Transforming growth factor beta

Transforming growth factor beta (TGF-β) is a multifunctional cytokine belonging to the transforming growth factor superfamily that includes four different isoforms (TGF-β 1 to 4, HGNC symbols TGFB1, TGFB2, TGFB3, TGFB4) and many other signaling proteins produced by all white blood cell lineages.

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Transplant rejection

Transplant rejection occurs when transplanted tissue is rejected by the recipient's immune system, which destroys the transplanted tissue.

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Tryptase

Tryptase is the most abundant secretory granule-derived serine proteinase contained in mast cells and has been used as a marker for mast cell activation.

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Tuberculosis

Tuberculosis (TB) is an infectious disease usually caused by the bacterium Mycobacterium tuberculosis (MTB).

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Tumor necrosis factor alpha

Tumor necrosis factor (TNF, tumor necrosis factor alpha, TNFα, cachexin, or cachectin) is a cell signaling protein (cytokine) involved in systemic inflammation and is one of the cytokines that make up the acute phase reaction.

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Type I hypersensitivity

Type I hypersensitivity (or immediate hypersensitivity) is an allergic reaction provoked by reexposure to a specific type of antigen referred to as an allergen.

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Type III hypersensitivity

Type III hypersensitivity occurs when there is accumulation of immune complexes (antigen-antibody complexes) that have not been adequately cleared by innate immune cells, giving rise to an inflammatory response and attraction of leukocytes.

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Ulcer (dermatology)

An ulcer is a sore on the skin or a mucous membrane, accompanied by the disintegration of tissue.

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Ulcerative colitis

Ulcerative colitis (UC) is a long-term condition that results in inflammation and ulcers of the colon and rectum.

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Urethritis

Urethritis is inflammation of the urethra.

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Urinary tract infection

A urinary tract infection (UTI) is an infection that affects part of the urinary tract.

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Vaginitis

Vaginitis is inflammation of the vagina.

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Vasculitis

Vasculitis is a group of disorders that destroy blood vessels by inflammation.

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Vasoactivity

A vasoactive substance is an endogenous agent or pharmaceutical drug that has the effect of either increasing or decreasing blood pressure and/or heart rate through its vasoactivity, that is, vascular activity (effect on blood vessels).

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Vasodilation

Vasodilation is the widening of blood vessels.

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VCAM-1

Vascular cell adhesion protein 1 also known as vascular cell adhesion molecule 1 (VCAM-1) or cluster of differentiation 106 (CD106) is a protein that in humans is encoded by the VCAM1 gene.

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Vein

Veins are blood vessels that carry blood toward the heart.

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Viremia

Viremia (UK: viraemia) is a medical condition where viruses enter the bloodstream and hence have access to the rest of the body.

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Vitamin A

Vitamin A is a group of unsaturated nutritional organic compounds that includes retinol, retinal, retinoic acid, and several provitamin A carotenoids (most notably beta-carotene).

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White adipose tissue

White adipose tissue (WAT) or white fat is one of the two types of adipose tissue found in mammals.

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White blood cell

White blood cells (WBCs), also called leukocytes or leucocytes, are the cells of the immune system that are involved in protecting the body against both infectious disease and foreign invaders.

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Wound healing

Wound healing is an intricate process in which the skin repairs itself after injury.

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5-Hydroxyeicosatetraenoic acid

5-Hydroxyeicosatetraenoic acid (5-HETE, 5(S)-HETE, or 5S-HETE) is an eicosanoid, i.e. a metabolite of arachidonic acid.

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5-oxo-eicosatetraenoic acid

5-Oxo-eicosatetraenoic acid (i.e. 5-oxo-6E,8Z,11Z,14Z-eicosatetraenoic acid; also termed 5-oxo-ETE and 5-oxoETE) is a Nonclassic eicosanoid metabolite of arachidonic acid and the most potent naturally occurring member of the 5-HETE family of cell signaling agents.

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References

[1] https://en.wikipedia.org/wiki/Inflammation

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