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19 relations: Amsterdam criteria, BRCA1, Cancer epigenetics, CpG site, DNA methylation, DNA mismatch repair, Endometrial cancer, Gene, Hereditary nonpolyposis colorectal cancer, Microsatellite instability, MiR-155, MIRN21, MSH2, National Institutes of Health, Penetrance, Proliferating cell nuclear antigen, Promoter (genetics), Protein–protein interaction, Saccharomyces cerevisiae.
Amsterdam criteria
The Amsterdam criteria are a set of diagnostic criteria used by doctors to help identify families which are likely to have Lynch syndrome, also known as hereditary nonpolyposis colorectal cancer (HNPCC).
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BRCA1
BRCA1 and BRCA1 are a human gene and its protein product, respectively.
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Cancer epigenetics
Cancer epigenetics is the study of epigenetic modifications to the DNA of cancer cells that do not involve a change in the nucleotide sequence.
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CpG site
The CpG sites or CG sites are regions of DNA where a cytosine nucleotide is followed by a guanine nucleotide in the linear sequence of bases along its 5' → 3' direction.
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DNA methylation
DNA methylation is a process by which methyl groups are added to the DNA molecule.
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DNA mismatch repair
DNA mismatch repair (MMR) is a system for recognizing and repairing erroneous insertion, deletion, and mis-incorporation of bases that can arise during DNA replication and recombination, as well as repairing some forms of DNA damage.
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Endometrial cancer
Endometrial cancer is a cancer that arises from the endometrium (the lining of the uterus or womb).
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Gene
In biology, a gene is a sequence of DNA or RNA that codes for a molecule that has a function.
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Hereditary nonpolyposis colorectal cancer
Hereditary nonpolyposis colorectal cancer (HNPCC) or Lynch syndrome is an autosomal dominant genetic condition that has a high risk of colon cancer as well as other cancers including endometrial cancer (second most common), ovary, stomach, small intestine, hepatobiliary tract, upper urinary tract, brain, and skin.
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Microsatellite instability
Microsatellite instability (MSI) is the condition of genetic hypermutability (predisposition to mutation) that results from impaired DNA mismatch repair (MMR).
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MiR-155
MiR-155 is a microRNA that in humans is encoded by the MIR155 host gene or MIR155HG.
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MIRN21
microRNA 21 also known as hsa-mir-21 or miRNA21 is a mammalian microRNA that is encoded by the MIR21 gene.
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MSH2
DNA mismatch repair protein Msh2 also known as MutS protein homolog 2 or MSH2 is a protein that in humans is encoded by the MSH2 gene, which is located on chromosome 2.
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National Institutes of Health
The National Institutes of Health (NIH) is the primary agency of the United States government responsible for biomedical and public health research, founded in the late 1870s.
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Penetrance
Penetrance in genetics is the proportion of individuals carrying a particular variant (or allele) of a gene (the genotype) that also express an associated trait (the phenotype).
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Proliferating cell nuclear antigen
Proliferating cell nuclear antigen (PCNA) is a DNA clamp that acts as a processivity factor for DNA polymerase δ in eukaryotic cells and is essential for replication.
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Promoter (genetics)
In genetics, a promoter is a region of DNA that initiates transcription of a particular gene.
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Protein–protein interaction
Protein–protein interactions (PPIs) are the physical contacts of high specificity established between two or more protein molecules as a result of biochemical events steered by electrostatic forces including the hydrophobic effect.
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Saccharomyces cerevisiae
Saccharomyces cerevisiae is a species of yeast.
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GTBP, Gtbp, HNPCC5, HSAP, Hnpcc5, Hsap, MSH6 (gene), MutS homolog 6.
