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164 relations: Abacavir, Abacavir/dolutegravir/lamivudine, Abacavir/lamivudine, Abacavir/lamivudine/zidovudine, Abbott Laboratories, Adherence (medicine), Allele, Allosteric regulation, Amprenavir, Anthony S. Fauci, Antiviral drug, Artificial insemination, Assisted reproductive technology, Atazanavir, Atazanavir/cobicistat, Bevirimat, Breakthrough of the Year, Bristol-Myers Squibb, Caesarean section, Cardiovascular disease, CCR5, CD4, Citation impact, Clinical Therapeutics, Clinical trial, Cobicistat, Cochrane (organisation), Competitive inhibition, Computing, Current Opinion (Elsevier), CXCR4, Cytochrome P450, Cytokine, Darunavir, Darunavir/cobicistat, David Ho, Dementia, Didanosine, Direct-to-consumer advertising, Discovery and development of HIV-protease inhibitors, Discovery and development of non-nucleoside reverse-transcriptase inhibitors, Discovery and development of nucleoside and nucleotide reverse-transcriptase inhibitors, DNA, Dolutegravir, Drug holiday, Drug resistance, Drugs (journal), Durban, Efavirenz, Efavirenz/emtricitabine/tenofovir, ..., Elvitegravir, Elvitegravir/cobicistat/emtricitabine/tenofovir, Emtricitabine, Emtricitabine/rilpivirine/tenofovir, Emtricitabine/tenofovir, Enfuvirtide, Entry inhibitor, Enzyme, Etravirine, False advertising, Fatty liver, FDA Consumer, Fixed-dose combination (antiretroviral), Food and Drug Administration, Genotype, Gilead Sciences, GlaxoSmithKline, Hematopoietic stem cell transplantation, Hepatitis B, Hepatitis C, Histone deacetylase, HIV, HIV tropism, HIV-associated lipodystrophy, HIV/AIDS, HPTN 052, Human papillomavirus infection, Hypertriglyceridemia, Immune system, In vitro fertilisation, Indinavir, Integrase, Integrase inhibitor, Interleukin 2, International nonproprietary name, JAMA (journal), Janssen Pharmaceutica, Lactic acidosis, Lamivudine, Lamivudine/raltegravir, Lamivudine/zidovudine, Lipoatrophy, Liver disease, Lopinavir, Lopinavir/ritonavir, Management of HIV/AIDS, Maraviroc, Maturation inhibitor, Medical literature, Memory T cell, Merck & Co., Mitochondrion, Model (person), Mountaineering, Mucous membrane, Mutation, Myocardial infarction, Myopathy, National Institute of Allergy and Infectious Diseases, Natural selection, Nelfinavir, Nevirapine, Non-competitive inhibition, Nucleoside, Nucleotide, Opportunistic infection, Peripheral neuropathy, Phenotype, Post-exposure prophylaxis, Pre-integration complex, Protease inhibitor (pharmacology), Raltegravir, Randomized controlled trial, Renal function, Retronym, Retrovirus, Reverse transcriptase, Reverse-transcriptase inhibitor, Rilpivirine, Ritonavir, RNA, Salvage therapy, Science (journal), Scientific American, Serodiscordant, South Africa, Sperm washing, Stavudine, Structural analog, Synergy, Systematic review, Tat (HIV), Tenofovir alafenamide, Tenofovir disoproxil, The Berlin Patient, The BMJ, The Journal of Infectious Diseases, The Lancet, The New England Journal of Medicine, Tibotec, Treatment and control groups, United States Department of Health and Human Services, United States Public Health Service, USA Today, Valproate, ViiV Healthcare, Viral load, Virology, Virus, Virus latency, Vorinostat, World Health Organization, Zalcitabine, Zidovudine. Expand index (114 more) »
Abacavir
Abacavir (ABC) is a medication used to prevent and treat HIV/AIDS.
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Abacavir/dolutegravir/lamivudine
Abacavir/dolutegravir/lamivudine (brand name Triumeq) is a fixed-dose combination drug for the treatment of HIV/AIDS.
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Abacavir/lamivudine
Abacavir/lamivudine, sold under the brand name Kivexa among others, is a medication used to treat HIV/AIDS.
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Abacavir/lamivudine/zidovudine
Abacavir/lamivudine/zidovudine, sold under the trade name Trizivir, is a medication for HIV infection.
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Abbott Laboratories
Abbott Laboratories is an American health care company with headquarters in Lake Bluff, Illinois, United States.
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Adherence (medicine)
In medicine, compliance (also adherence, capacitance) describes the degree to which a patient correctly follows medical advice.
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Allele
An allele is a variant form of a given gene.
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Allosteric regulation
In biochemistry, allosteric regulation (or allosteric control) is the regulation of an enzyme by binding an effector molecule at a site other than the enzyme's active site.
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Amprenavir
Amprenavir (original brand name Agenerase, GlaxoSmithKline) is a protease inhibitor used to treat HIV infection.
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Anthony S. Fauci
Anthony Stephen "Tony" Fauci (born December 24, 1940) is an American immunologist who has made substantial contributions to HIV/AIDS research and other immunodeficiencies, both as a scientist and as the head of the National Institute of Allergy and Infectious Diseases (NIAID).
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Antiviral drug
Antiviral drugs are a class of medication used specifically for treating viral infections rather than bacterial ones.
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Artificial insemination
Artificial insemination (AI) is the deliberate introduction of sperm into a female's uterus or cervix for the purpose of achieving a pregnancy through in vivo fertilization by means other than sexual intercourse.
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Assisted reproductive technology
Assisted reproductive technology (ART) is the technology used to achieve pregnancy in procedures such as fertility medication, in vitro fertilization and surrogacy.
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Atazanavir
Atazanavir, sold under the trade name Reyataz among others, is an antiretroviral medication used to treat and prevent HIV/AIDS.
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Atazanavir/cobicistat
Atazanavir/cobicistat (trade name Evotaz) is an antiretroviral medication used to treat and prevent HIV/AIDS.
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Bevirimat
Bevirimat (research code MPC-4326) is an anti-HIV drug derived from a betulinic acid-like compound, first isolated from Syzygium claviflorum, a Chinese herb.
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Breakthrough of the Year
The Breakthrough of the Year is an annual award made by the AAAS journal, Science, for the most significant development in scientific research.
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Bristol-Myers Squibb
Bristol-Myers Squibb (BMS) is an American pharmaceutical company, headquartered in New York City.
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Caesarean section
Caesarean section, also known as C-section or caesarean delivery, is the use of surgery to deliver one or more babies.
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Cardiovascular disease
Cardiovascular disease (CVD) is a class of diseases that involve the heart or blood vessels.
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CCR5
C-C chemokine receptor type 5, also known as CCR5 or CD195, is a protein on the surface of white blood cells that is involved in the immune system as it acts as a receptor for chemokines.
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CD4
In molecular biology, CD4 (cluster of differentiation 4) is a glycoprotein found on the surface of immune cells such as T helper cells, monocytes, macrophages, and dendritic cells.
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Citation impact
Citation impact quantifies the citation usage of scholarly works.
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Clinical Therapeutics
Clinical Therapeutics is a monthly peer-reviewed medical journal that was established in 1977 and is published by Elsevier.
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Clinical trial
Clinical trials are experiments or observations done in clinical research.
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Cobicistat
Cobicistat, with trade name Tybost (formerly GS-9350) is a licensed drug for use in the treatment of human immunodeficiency virus infection (HIV/AIDS).
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Cochrane (organisation)
Cochrane is a non-profit, non-governmental organization formed to organize medical research findings so as to facilitate evidence-based choices about health interventions faced by health professionals, patients, and policy makers.
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Competitive inhibition
Competitive inhibition is a form of enzyme inhibition where binding of an inhibitor prevents binding of the target molecule of the enzyme, also known as the substrate.
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Computing
Computing is any goal-oriented activity requiring, benefiting from, or creating computers.
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Current Opinion (Elsevier)
Current Opinion is a collection of review journals on various disciplines of the life sciences published by Elsevier.
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CXCR4
C-X-C chemokine receptor type 4 (CXCR-4) also known as fusin or CD184 (cluster of differentiation 184) is a protein that in humans is encoded by the CXCR4 gene.
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Cytochrome P450
Cytochromes P450 (CYPs) are proteins of the superfamily containing heme as a cofactor and, therefore, are hemoproteins.
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Cytokine
Cytokines are a broad and loose category of small proteins (~5–20 kDa) that are important in cell signaling.
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Darunavir
Darunavir (DRV), sold under the brand name Prezista among others, is an antiretroviral medication used to treat and prevent HIV/AIDS.
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Darunavir/cobicistat
Darunavir/cobicistat (trade name Prezcobix) is an antiretroviral medication used to treat and prevent HIV/AIDS.
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David Ho
David Da-i Ho (born November 3, 1952) is a Taiwanese-American medical doctor and HIV/AIDS researcher who was born in Taiwan and has made many innovative state of the art scientific contributions to the understanding and technological treatment of HIV infection.
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Dementia
Dementia is a broad category of brain diseases that cause a long-term and often gradual decrease in the ability to think and remember that is great enough to affect a person's daily functioning.
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Didanosine
Didanosine (ddI, DDI), marketed under the trade names Videx, is a medication used to treat HIV/AIDS.
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Direct-to-consumer advertising
Direct-to-consumer advertising (DTC advertising) usually refers to the marketing of pharmaceutical products but also applies to the direct marketing of medical devices, consumer diagnostics and sometimes financial services.
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Discovery and development of HIV-protease inhibitors
Many major physiological processes depend on regulation of proteolytic enzyme activity and there can be dramatic consequences when equilibrium between an enzyme and its substrates is disturbed.
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Discovery and development of non-nucleoside reverse-transcriptase inhibitors
Non-nucleoside reverse-transcriptase inhibitors (NNRTIs) are antiretroviral drugs used in the treatment of human immunodeficiency virus (HIV).
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Discovery and development of nucleoside and nucleotide reverse-transcriptase inhibitors
Discovery and development of nucleoside and nucleotide reverse-transcriptase inhibitors (NRTIs and NtRTIs) began in the 1980s when the AIDS epidemic hit Western societies.
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DNA
Deoxyribonucleic acid (DNA) is a thread-like chain of nucleotides carrying the genetic instructions used in the growth, development, functioning and reproduction of all known living organisms and many viruses.
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Dolutegravir
Dolutegravir (DTG), sold under the brand name Tivicay, is an antiretroviral medication used, together with other medication, to treat HIV/AIDS.
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Drug holiday
A drug holiday (sometimes also called a drug vacation, medication vacation, structured treatment interruption, tolerance break, treatment break or strategic treatment interruption) is when a patient stops taking a medication(s) for a period of time; anywhere from a few days to many months or even years if they feel it is in their best interests.
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Drug resistance
Drug resistance is the reduction in effectiveness of a medication such as an antimicrobial or an antineoplastic in curing a disease or condition.
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Drugs (journal)
Drugs is a peer-reviewed medical journal published by Adis International (Springer Science + Business Media) that covers topics in drugs and therapeutics.
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Durban
Durban (eThekwini, from itheku meaning "bay/lagoon") is the largest city in the South African province of KwaZulu-Natal and the third most populous in South Africa after Johannesburg and Cape Town.
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Efavirenz
Efavirenz (EFV), sold under the brand names Sustiva among others, is an antiretroviral medication used to treat and prevent HIV/AIDS.
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Efavirenz/emtricitabine/tenofovir
Efavirenz/emtricitabine/tenofovir, sold under the trade name Atripla among others, is a medication used to treat HIV/AIDS.
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Elvitegravir
Elvitegravir (EVG) is an integrase inhibitor used to treat HIV infection.
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Elvitegravir/cobicistat/emtricitabine/tenofovir
Elvitegravir/cobicistat/emtricitabine/tenofovir (brand name Stribild), also known as the Quad pill, is a fixed dose combination drug for the treatment of HIV/AIDS.
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Emtricitabine
Emtricitabine (commonly called FTC, systematic name 2',3'-dideoxy-5-fluoro-3'-thiacytidine), with trade name Emtriva (formerly Coviracil), is a nucleoside reverse transcriptase inhibitor (NRTI) for the prevention and treatment of HIV infection in adults and children.
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Emtricitabine/rilpivirine/tenofovir
Emtricitabine/rilpivirine/tenofovir (trade names Complera, Eviplera) is a fixed dose combination of antiretroviral drugs for the treatment of HIV.
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Emtricitabine/tenofovir
Emtricitabine/tenofovir, sold under the brand name Truvada among others, is a medication used to treat and prevent HIV/AIDS.
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Enfuvirtide
Enfuvirtide (INN) is an HIV fusion inhibitor, the first of a novel class of antiretroviral drugs used in combination therapy for the treatment of HIV-1 infection.
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Entry inhibitor
Entry inhibitors, also known as fusion inhibitors, are a class of antiretroviral drugs, used in combination therapy for the treatment of HIV infection.
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Enzyme
Enzymes are macromolecular biological catalysts.
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Etravirine
Etravirine (ETR, brand name Intelence, formerly known as TMC125) is a drug used for the treatment of HIV.
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False advertising
False advertising is the use of false, misleading, or unproven information to advertise products to consumers or advertising that does not disclose its source.
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Fatty liver
Fatty liver is a reversible condition wherein large vacuoles of triglyceride fat accumulate in liver cells via the process of steatosis (i.e., abnormal retention of lipids within a cell).
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FDA Consumer
FDA Consumer was a magazine published from 1967 through 2007 by the U.S. Food and Drug Administration (FDA).
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Fixed-dose combination (antiretroviral)
Fixed-dose combinations of antiretrovirals are multiple antiretroviral drugs combined into a single pill, which helps reduce pill burden.
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Food and Drug Administration
The Food and Drug Administration (FDA or USFDA) is a federal agency of the United States Department of Health and Human Services, one of the United States federal executive departments.
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Genotype
The genotype is the part of the genetic makeup of a cell, and therefore of an organism or individual, which determines one of its characteristics (phenotype).
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Gilead Sciences
Gilead Sciences, Inc., commonly known as Gilead Sciences or Gilead (also styled GILEAD), is an American biopharmaceutical company that researches, develops and commercializes drugs.
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GlaxoSmithKline
GlaxoSmithKline plc (GSK) is a British pharmaceutical company headquartered in Brentford, London.
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Hematopoietic stem cell transplantation
Hematopoietic stem cell transplantation (HSCT) is the transplantation of multipotent hematopoietic stem cells, usually derived from bone marrow, peripheral blood, or umbilical cord blood.
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Hepatitis B
Hepatitis B is an infectious disease caused by the hepatitis B virus (HBV) that affects the liver.
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Hepatitis C
Hepatitis C is an infectious disease caused by the hepatitis C virus (HCV) that primarily affects the liver.
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Histone deacetylase
Histone deacetylases (HDAC) are a class of enzymes that remove acetyl groups (O.
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HIV
The human immunodeficiency virus (HIV) is a lentivirus (a subgroup of retrovirus) that causes HIV infection and over time acquired immunodeficiency syndrome (AIDS).
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HIV tropism
HIV tropism refers to the cell type that the human immunodeficiency virus (HIV) infects and replicates in.
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HIV-associated lipodystrophy
HIV-associated lipodystrophy, also known as lipodystrophy in HIV-infected patients (LD-HIV), is a condition characterized by loss of subcutaneous fat associated with infection with HIV.
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HIV/AIDS
Human immunodeficiency virus infection and acquired immune deficiency syndrome (HIV/AIDS) is a spectrum of conditions caused by infection with the human immunodeficiency virus (HIV).
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HPTN 052
HPTN 052 is the name of a clinical trial conducted in nine countries which examined whether starting people living with HIV on antiretroviral therapy (ART) can reduce the chance that they will pass HIV on to their sexual partners who do not have HIV.
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Human papillomavirus infection
Human papillomavirus infection is an infection by human papillomavirus (HPV).
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Hypertriglyceridemia
Hypertriglyceridemia denotes high (hyper-) blood levels (-emia) of triglycerides, the most abundant fatty molecule in most organisms.
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Immune system
The immune system is a host defense system comprising many biological structures and processes within an organism that protects against disease.
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In vitro fertilisation
In vitro fertilisation (IVF) is a process of fertilisation where an egg is combined with sperm outside the body, in vitro ("in glass").
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Indinavir
Indinavir (IDV; trade name Crixivan, manufactured by Merck) is a protease inhibitor used as a component of highly active antiretroviral therapy to treat HIV/AIDS.
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Integrase
Retroviral integrase (IN) is an enzyme produced by a retrovirus (such as HIV) that enables its genetic material to be integrated into the DNA of the infected cell.
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Integrase inhibitor
Integrase inhibitors (INIs) are a class of antiretroviral drug designed to block the action of integrase, a viral enzyme that inserts the viral genome into the DNA of the host cell.
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Interleukin 2
Interleukin-2 (IL-2) is an interleukin, a type of cytokine signaling molecule in the immune system.
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International nonproprietary name
The International Nonproprietary Name (INN) is an official generic and non-proprietary name given to a pharmaceutical drug or an active ingredient.
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JAMA (journal)
JAMA: The Journal of the American Medical Association is a peer-reviewed medical journal published 48 times a year by the American Medical Association.
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Janssen Pharmaceutica
Janssen Pharmaceutica is a pharmaceutical company headquartered in Beerse, Belgium.
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Lactic acidosis
Lactic acidosis is a medical condition characterized by the buildup of lactate (especially L-lactate) in the body, which results in an excessively low pH in the bloodstream.
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Lamivudine
Lamivudine, commonly called 3TC, is an antiretroviral medication used to prevent and treat HIV/AIDS.
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Lamivudine/raltegravir
Lamivudine/raltegravir, sold under the brand name Dutrebis, is a combination medication of lamivudine and raltegravir which is used in the treatment of HIV/AIDS.
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Lamivudine/zidovudine
Lamivudine/zidovudine, sold under the brand name Combivir among others, is a medication used to treat HIV/AIDS.
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Lipoatrophy
Lipoatrophy is the term describing the localized loss of fat tissue.
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Liver disease
Liver disease (also called hepatic disease) is a type of damage to or disease of the liver.
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Lopinavir
Lopinavir (ABT-378) is an antiretroviral of the protease inhibitor class.
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Lopinavir/ritonavir
Lopinavir/ritonavir (LPV/r), sold under the brand name Kaletra among others, is a fixed dose combination medication for the treatment and prevention of HIV/AIDS.
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Management of HIV/AIDS
The management of HIV/AIDS normally includes the use of multiple antiretroviral drugs in an attempt to control HIV infection.
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Maraviroc
Maraviroc (INN, brand-named Selzentry, or Celsentri outside the U.S.) is an antiretroviral drug in the CCR5 receptor antagonist class used in the treatment of HIV infection.
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Maturation inhibitor
The maturation inhibitors are a class of antiviral drugs for the treatment of infection with HIV.
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Medical literature
Medical literature is the scientific literature of medicine: articles in journals and texts in books devoted to the field of medicine.
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Memory T cell
Memory T cells are a subset of infection- and cancer-fighting T cells (also known as a T lymphocyte) that have previously encountered and responded to their cognate antigen; thus, the term antigen-experienced T cell is often applied.
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Merck & Co.
Merck & Company, Inc., d.b.a. Merck Sharp & Dohme (MSD) outside the United States and Canada, is an American pharmaceutical company and one of the largest pharmaceutical companies in the world.
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Mitochondrion
The mitochondrion (plural mitochondria) is a double-membrane-bound organelle found in most eukaryotic organisms.
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Model (person)
A model is a person with a role either to promote, display or advertise commercial products (notably fashion clothing in fashion shows), or to serve as a visual aid for people who are creating works of art or to pose for photography.
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Mountaineering
Mountaineering is the sport of mountain climbing.
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Mucous membrane
A mucous membrane or mucosa is a membrane that lines various cavities in the body and covers the surface of internal organs.
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Mutation
In biology, a mutation is the permanent alteration of the nucleotide sequence of the genome of an organism, virus, or extrachromosomal DNA or other genetic elements.
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Myocardial infarction
Myocardial infarction (MI), commonly known as a heart attack, occurs when blood flow decreases or stops to a part of the heart, causing damage to the heart muscle.
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Myopathy
Myopathy is a disease of the muscle in which the muscle fibers do not function properly.
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National Institute of Allergy and Infectious Diseases
The National Institute of Allergy and Infectious Diseases (NIAID) is one of the 27 institutes and centers that make up the National Institutes of Health (NIH), an agency of the United States Department of Health and Human Services (HHS).
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Natural selection
Natural selection is the differential survival and reproduction of individuals due to differences in phenotype.
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Nelfinavir
Nelfinavir (brand name Viracept) is an antiretroviral drug used in the treatment of the human immunodeficiency virus (HIV).
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Nevirapine
Nevirapine (NVP), marketed under the trade name Viramune among others, is a medication used to treat and prevent HIV/AIDS, specifically HIV-1.
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Non-competitive inhibition
Non-competitive inhibition is a type of enzyme inhibition where the inhibitor reduces the activity of the enzyme and binds equally well to the enzyme whether or not it has already bound the substrate.
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Nucleoside
Nucleosides are glycosylamines that can be thought of as nucleotides without a phosphate group.
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Nucleotide
Nucleotides are organic molecules that serve as the monomer units for forming the nucleic acid polymers deoxyribonucleic acid (DNA) and ribonucleic acid (RNA), both of which are essential biomolecules within all life-forms on Earth.
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Opportunistic infection
An opportunistic infection is an infection caused by pathogens (bacteria, viruses, fungi, or protozoa) that take advantage of an opportunity not normally available, such as a host with a weakened immune system, an altered microbiota (such as a disrupted gut microbiota), or breached integumentary barriers.
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Peripheral neuropathy
Peripheral neuropathy (PN) is damage to or disease affecting nerves, which may impair sensation, movement, gland or organ function, or other aspects of health, depending on the type of nerve affected.
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Phenotype
A phenotype is the composite of an organism's observable characteristics or traits, such as its morphology, development, biochemical or physiological properties, behavior, and products of behavior (such as a bird's nest).
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Post-exposure prophylaxis
Post-exposure prophylaxis, also known as post-exposure prevention (PEP), is any preventive medical treatment started after exposure to a pathogen (such as a disease-causing virus), in order to prevent the infection from occurring.
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Pre-integration complex
The pre-integration complex (PIC) is a nucleoprotein complex of viral genetic material and associated viral and host proteins which is capable of inserting a viral genome into a host genome.
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Protease inhibitor (pharmacology)
Protease inhibitors (PIs) are a class of antiviral drugs that are widely used to treat HIV/AIDS and hepatitis C. Protease inhibitors prevent viral replication by selectively binding to viral proteases (e.g. HIV-1 protease) and blocking proteolytic cleavage of protein precursors that are necessary for the production of infectious viral particles.
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Raltegravir
Raltegravir (RAL), sold under the brand name Isentress, is an antiretroviral medication used, together with other medication, to treat HIV/AIDS.
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Randomized controlled trial
A randomized controlled trial (or randomized control trial; RCT) is a type of scientific (often medical) experiment which aims to reduce bias when testing a new treatment.
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Renal function
Renal function, in nephrology, is an indication of the kidney's condition and its role in renal physiology.
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Retronym
A retronym is a newer name for an existing thing that differentiates the original form or version from a more recent one.
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Retrovirus
A retrovirus is a single-stranded positive-sense RNA virus with a DNA intermediate and, as an obligate parasite, targets a host cell.
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Reverse transcriptase
A reverse transcriptase (RT) is an enzyme used to generate complementary DNA (cDNA) from an RNA template, a process termed reverse transcription.
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Reverse-transcriptase inhibitor
Reverse-transcriptase inhibitors (RTIs) are a class of antiretroviral drugs used to treat HIV infection or AIDS, and in some cases hepatitis B. RTIs inhibit activity of reverse transcriptase, a viral DNA polymerase that is required for replication of HIV and other retroviruses.
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Rilpivirine
Rilpivirine (TMC278, trade name Edurant) is a pharmaceutical drug, developed by Tibotec, for the treatment of HIV infection.
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Ritonavir
Ritonavir, sold under the trade name Norvir, is an antiretroviral medication used along with other medications to treat HIV/AIDS.
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RNA
Ribonucleic acid (RNA) is a polymeric molecule essential in various biological roles in coding, decoding, regulation, and expression of genes.
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Salvage therapy
Salvage therapy, also known as rescue therapy, is a form of therapy given after an ailment does not respond to standard therapy.
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Science (journal)
Science, also widely referred to as Science Magazine, is the peer-reviewed academic journal of the American Association for the Advancement of Science (AAAS) and one of the world's top academic journals.
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Scientific American
Scientific American (informally abbreviated SciAm) is an American popular science magazine.
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Serodiscordant
A serodiscordant relationship, also known as or mixed-status, is one in which one partner is infected by HIV and the other is not.
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South Africa
South Africa, officially the Republic of South Africa (RSA), is the southernmost country in Africa.
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Sperm washing
Sperm washing is the process in which individual sperms are separated from the semen.
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Stavudine
Stavudine (d4T), sold under the brand name Zerit among others, is an antiretroviral medication used to prevent and treat HIV/AIDS.
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Structural analog
A structural analog, also known as a chemical analog or simply an analog, is a compound having a structure similar to that of another compound, but differing from it in respect to a certain component.
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Synergy
Synergy is the creation of a whole that is greater than the simple sum of its parts.
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Systematic review
Systematic reviews are a type of literature review that uses systematic methods to collect secondary data, critically appraise research studies, and synthesize studies.
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Tat (HIV)
In molecular biology, Tat is a protein that is encoded for by the tat gene in HIV-1.
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Tenofovir alafenamide
Tenofovir alafenamide (INN/USAN; trade name Vemlidy) is a nucleotide reverse transcriptase inhibitor and a prodrug of tenofovir. It was developed by Gilead Sciences for use in the treatment of HIV infection and chronic hepatitis B, and is applied in the form of tenofovir alafenamide fumarate (TAF). Closely related to the commonly used reverse-transcriptase inhibitor tenofovir disoproxil fumarate (TDF), TAF has greater antiviral activity and better distribution into lymphoid tissues than that agent. Gilead was awarded FDA approval in November 2016 for the drug Vemlidy. Gilead announced a phase 3 clinical trial evaluating a single-tablet regimen combining tenofovir alafenamide with cobicistat, emtricitabine and elvitegravir and developed a coformulation of the drug with cobicistat, emtricitabine and the protease inhibitor darunavir. In a 48-week study comparing elvitegravir/cobicistat/emtricitabine/tenofovir disoproxil (trade name Stribild) to elvitegravir/cobicistat/emtricitabine/tenofovir alafenamide (trade name Genvoya), the results showed the newer drug to be noninferior to the established agent, but at much lower dosages and with lower incidence of adverse side effects such as impaired kidney function. The FDA approved the TAF-based treatment regimen for treatment of HIV-1 in November 2015. Genvoya is the first TAF-based regimen to receive approval.
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Tenofovir disoproxil
Tenofovir disoproxil, sold under the trade name Viread among others, is a medication used to treat chronic hepatitis B and to prevent and treat HIV/AIDS.
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The Berlin Patient
The Berlin patient is a phrase that has been used on two distinct and unrelated occasions: in the first case, to describe a person who has exhibited prolonged "post treatment control" of HIV viral load after HIV treatments were interrupted, and in the second case to describe the one individual who is considered to have been cured of HIV infection.
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The BMJ
The BMJ is a weekly peer-reviewed medical journal.
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The Journal of Infectious Diseases
The Journal of Infectious Diseases is a peer-reviewed biweekly medical journal published by Oxford University Press on behalf of the Infectious Diseases Society of America.
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The Lancet
The Lancet is a weekly peer-reviewed general medical journal.
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The New England Journal of Medicine
The New England Journal of Medicine (NEJM) is a weekly medical journal published by the Massachusetts Medical Society.
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Tibotec
Tibotec was a pharmaceutical company with a focus on research and development for the treatment of infectious diseases such as HIV/AIDS and hepatitis C. The company was founded in 1994 and then acquired by and Johnson & Johnson and merged into its Janssen Pharmaceutica division in 2002.
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Treatment and control groups
In the design of experiments, treatments are applied to experimental units in the treatment group(s).
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United States Department of Health and Human Services
The United States Department of Health and Human Services (HHS), also known as the Health Department, is a cabinet-level department of the U.S. federal government with the goal of protecting the health of all Americans and providing essential human services.
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United States Public Health Service
The Public Health Service Act of 1944 structured the United States Public Health Service (PHS), founded in 1798, as the primary division of the U.S. Department of Health, Education and Welfare (HEW; which was established in 1953), which later became the United States Department of Health and Human Services in 1979–1980 (when the Education agencies were separated into their own U.S. Department of Education).
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USA Today
USA Today is an internationally distributed American daily, middle-market newspaper that serves as the flagship publication of its owner, the Gannett Company.
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Valproate
Valproate (VPA), and its valproic acid, sodium valproate, and valproate semisodium forms, are medications primarily used to treat epilepsy and bipolar disorder and to prevent migraine headaches.
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ViiV Healthcare
ViiV Healthcare is a pharmaceutical company specialising in the development of therapies for HIV infection that was created as a joint venture by Pfizer and GlaxoSmithKline in November 2009 with both companies transferring their HIV assets to the new company.
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Viral load
Viral load, also known as viral burden, viral titre or viral titer, is a numerical expression of the quantity of virus in a given volume.
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Virology
Virology is the study of viruses – submicroscopic, parasitic particles of genetic material contained in a protein coat – and virus-like agents.
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Virus
A virus is a small infectious agent that replicates only inside the living cells of other organisms.
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Virus latency
Virus latency (or viral latency) is the ability of a pathogenic virus to lie dormant (latent) within a cell, denoted as the lysogenic part of the viral life cycle.
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Vorinostat
Vorinostat (rINN) also known as suberanilohydroxamic acid (suberoyl+anilide+hydroxamic acid abbreviated as SAHA) is a member of a larger class of compounds that inhibit histone deacetylases (HDAC).
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World Health Organization
The World Health Organization (WHO; French: Organisation mondiale de la santé) is a specialized agency of the United Nations that is concerned with international public health.
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Zalcitabine
Zalcitabine (2′-3′-dideoxycytidine, ddC), also called dideoxycytidine, is a nucleoside analog reverse transcriptase inhibitor (NRTI) sold under the trade name Hivid.
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Zidovudine
Zidovudine (ZDV), also known as azidothymidine (AZT), is an antiretroviral medication used to prevent and treat HIV/AIDS.
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References
[1] https://en.wikipedia.org/wiki/Management_of_HIV/AIDS
