11-Deoxycorticosterone

11-Deoxycorticosterone (DOC), or simply deoxycorticosterone, also known as 21-hydroxyprogesterone, as well as desoxycortone (INN), deoxycortone, and cortexone, is a steroid hormone produced by the adrenal gland that possesses mineralocorticoid activity and acts as a precursor to aldosterone. ^[1]

32 relations: Acetate, Adrenal gland, Adrenocorticotropic hormone, Aldosterone, Aldosterone synthase, Angiotensin, Congenital adrenal hyperplasia, Corticosterone, Dehydration, Deoxygenation, Ester, Glossary of biology, Glucocorticoid, Hydroxy group, In vivo, International nonproprietary name, Kallikrein, Mineralocorticoid, Precursor (chemistry), Progesterone, Progestogen, Red blood cell, Renin, Steroid, Steroid 11β-hydroxylase, Steroid hormone, Tubule, Zona fasciculata, Zona glomerulosa, 11-Deoxycortisol, 17α-Hydroxyprogesterone, 21-Hydroxylase.
Mineralocorticoids
Steroid hormones

Acetate

An acetate is a salt formed by the combination of acetic acid with a base (e.g. alkaline, earthy, metallic, nonmetallic or radical base).

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Adrenal gland

The adrenal glands (also known as suprarenal glands) are endocrine glands that produce a variety of hormones including adrenaline and the steroids aldosterone and cortisol.

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Adrenocorticotropic hormone

Adrenocorticotropic hormone (ACTH; also adrenocorticotropin, corticotropin) is a polypeptide tropic hormone produced by and secreted by the anterior pituitary gland.

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Aldosterone

Aldosterone is the main mineralocorticoid steroid hormone produced by the zona glomerulosa of the adrenal cortex in the adrenal gland. 11-Deoxycorticosterone and Aldosterone are mineralocorticoids, Pregnanes and steroid hormones.

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Aldosterone synthase

Aldosterone synthase, also called steroid 18-hydroxylase, corticosterone 18-monooxygenase or P450C18, is a steroid hydroxylase cytochrome P450 enzyme involved in the biosynthesis of the mineralocorticoid aldosterone and other steroids.

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Angiotensin

Angiotensin is a peptide hormone that causes vasoconstriction and an increase in blood pressure.

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Congenital adrenal hyperplasia

Congenital adrenal hyperplasia (CAH) is a group of autosomal recessive disorders characterized by impaired cortisol synthesis.

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Corticosterone

Corticosterone, also known as 17-deoxycortisol and 11β,21-dihydroxyprogesterone, is a 21-carbon steroid hormone of the corticosteroid type produced in the cortex of the adrenal glands. 11-Deoxycorticosterone and Corticosterone are Pregnanes.

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Dehydration

In physiology, dehydration is a lack of total body water, with an accompanying disruption of metabolic processes.

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Deoxygenation

Deoxygenation is a chemical reaction involving the removal of oxygen atoms from a molecule.

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Ester

In chemistry, an ester is a functional group derived from an acid (organic or inorganic) in which the hydrogen atom (H) of at least one acidic hydroxyl group of that acid is replaced by an organyl group.

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Glossary of biology

This glossary of biology terms is a list of definitions of fundamental terms and concepts used in biology, the study of life and of living organisms.

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Glucocorticoid

Glucocorticoids (or, less commonly, glucocorticosteroids) are a class of corticosteroids, which are a class of steroid hormones.

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Hydroxy group

In chemistry, a hydroxy or hydroxyl group is a functional group with the chemical formula and composed of one oxygen atom covalently bonded to one hydrogen atom.

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In vivo

Studies that are in vivo (Latin for "within the living"; often not italicized in English) are those in which the effects of various biological entities are tested on whole, living organisms or cells, usually animals, including humans, and plants, as opposed to a tissue extract or dead organism.

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International nonproprietary name

An international nonproprietary name (INN) is an official generic and nonproprietary name given to a pharmaceutical drug or an active ingredient.

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Kallikrein

Kallikreins are a subgroup of serine proteases, enzymes capable of cleaving peptide bonds in proteins.

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Mineralocorticoid

Mineralocorticoids are a class of corticosteroids, which in turn are a class of steroid hormones. 11-Deoxycorticosterone and Mineralocorticoid are mineralocorticoids.

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Precursor (chemistry)

In chemistry, a precursor is a compound that participates in a chemical reaction that produces another compound.

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Progesterone

Progesterone (P4) is an endogenous steroid and progestogen sex hormone involved in the menstrual cycle, pregnancy, and embryogenesis of humans and other species. 11-Deoxycorticosterone and Progesterone are Glycine receptor antagonists, Pregnanes, progestogens and steroid hormones.

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Progestogen

Progestogens, also sometimes written progestins, progestagens or gestagens, are a class of natural or synthetic steroid hormones that bind to and activate the progesterone receptors (PR). 11-Deoxycorticosterone and Progestogen are progestogens.

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Red blood cell

Red blood cells (RBCs), referred to as erythrocytes (with -cyte translated as 'cell' in modern usage) in academia and medical publishing, also known as red cells, erythroid cells, and rarely haematids, are the most common type of blood cell and the vertebrate's principal means of delivering oxygen to the body tissues—via blood flow through the circulatory system.

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Renin

Renin (etymology and pronunciation), also known as an angiotensinogenase, is an aspartic protease protein and enzyme secreted by the kidneys that participates in the body's renin–angiotensin–aldosterone system (RAAS)—also known as the renin–angiotensin–aldosterone axis—that increases the volume of extracellular fluid (blood plasma, lymph and interstitial fluid) and causes arterial vasoconstriction.

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Steroid

A steroid is an organic compound with four fused rings (designated A, B, C, and D) arranged in a specific molecular configuration.

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Steroid 11β-hydroxylase

Steroid 11β-hydroxylase, also known as steroid 11β-monooxygenase, is a steroid hydroxylase found in the zona glomerulosa and zona fasciculata of the adrenal cortex.

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Steroid hormone

A steroid hormone is a steroid that acts as a hormone. 11-Deoxycorticosterone and steroid hormone are steroid hormones.

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Tubule

In biology, a tubule is a general term referring to small tube or similar type of structure.

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Zona fasciculata

The zona fasciculata (sometimes, fascicular or fasciculate zone) constitutes the middle and also the widest zone of the adrenal cortex, sitting directly beneath the zona glomerulosa.

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Zona glomerulosa

The zona glomerulosa (sometimes, glomerular zone) of the adrenal gland is the most superficial layer of the adrenal cortex, lying directly beneath the renal capsule.

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11-Deoxycortisol

11-Deoxycortisol, also known as cortodoxone (INN), cortexolone as well as 17α,21-dihydroxyprogesterone or 17α,21-dihydroxypregn-4-ene-3,20-dione, is an endogenous glucocorticoid steroid hormone, and a metabolic intermediate toward cortisol. 11-Deoxycorticosterone and 11-Deoxycortisol are mineralocorticoids, Pregnanes and steroid hormones.

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17α-Hydroxyprogesterone

17α-Hydroxyprogesterone (17α-OHP), also known as 17-OH progesterone (17-OHP), or hydroxyprogesterone (OHP), is an endogenous progestogen steroid hormone related to progesterone. 11-Deoxycorticosterone and 17α-Hydroxyprogesterone are Pregnanes and progestogens.

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21-Hydroxylase

Steroid 21-hydroxylase is a protein that in humans is encoded by the CYP21A2 gene.

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References

[1] https://en.wikipedia.org/wiki/11-Deoxycorticosterone

Also known as 11-Desoxycorticosterone, 21-Hydroxyprogesterone, ATC code H02AA03, ATCvet code QH02AA03, Cortexone, Deoxycortone, Desoxycortone, Kendall’s Desoxy Compound B, Percorten, Percoten.

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