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Index 11-Ketoprogesterone

11-Ketoprogesterone (brand name Ketogestin; former developmental code names Bio 66, U-1258), or 11-oxoprogesterone, also known as pregn-4-ene-3,11,20-trione, is a pregnane steroid related to cortisone (11-keto-17α,21-dihydroxyprogesterone) that was formerly used in veterinary medicine in the treatment of bovine ketosis. [1]

30 relations: Adrenal cortex, Allosteric modulator, Androgen, Biological activity, Bovinae, Carbohydrate metabolism, Chemical synthesis, Cortisone, Enzyme, Enzyme inhibitor, Estrogen, GABAA receptor, Glucocorticoid, Halogen, Hormone, Ketosis, Membrane glucocorticoid receptor, Mineralocorticoid, Pregnane, Progesterone (medication), Progestogen, Steroid, Toxicity, Veterinary medicine, 11-Dehydrocorticosterone, 11α-Hydroxyprogesterone, 11β-Hydroxyprogesterone, 11β-Hydroxysteroid dehydrogenase, 21-Deoxycortisone, 9α-Bromo-11-ketoprogesterone.

Adrenal cortex

Situated along the perimeter of the adrenal gland, the adrenal cortex mediates the stress response through the production of mineralocorticoids and glucocorticoids, such as aldosterone and cortisol, respectively.

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Allosteric modulator

In biochemistry and pharmacology, an allosteric modulator (allo- from the Greek meaning "other") is a substance which indirectly influences (modulates) the effects of a primary ligand that directly activates or deactivates the function of a target protein.

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An androgen (from Greek andr-, the stem of the word meaning "man") is any natural or synthetic steroid hormone which regulates the development and maintenance of male characteristics in vertebrates by binding to androgen receptors.

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Biological activity

In pharmacology, biological activity or pharmacological activity describes the beneficial or adverse effects of a drug on living matter.

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The biological subfamily Bovinae includes a diverse group of 10 genera of medium to large-sized ungulates, including domestic cattle, bison, African buffalo, the water buffalo, the yak, and the four-horned and spiral-horned antelopes.

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Carbohydrate metabolism

Carbohydrate metabolism denotes the various biochemical processes responsible for the formation, breakdown, and interconversion of carbohydrates in living organisms.

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Chemical synthesis

Chemical synthesis is a purposeful execution of chemical reactions to obtain a product, or several products.

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Cortisone, also known as 17α,21-dihydroxypregn-4-ene-3,11,20-trione, is a pregnane (21-carbon) steroid hormone.

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Enzymes are macromolecular biological catalysts.

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Enzyme inhibitor

4QI9) An enzyme inhibitor is a molecule that binds to an enzyme and decreases its activity.

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Estrogen, or oestrogen, is the primary female sex hormone.

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GABAA receptor

The GABAA receptor (GABAAR) is an ionotropic receptor and ligand-gated ion channel.

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Glucocorticoids are a class of corticosteroids, which are a class of steroid hormones.

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The halogens are a group in the periodic table consisting of five chemically related elements: fluorine (F), chlorine (Cl), bromine (Br), iodine (I), and astatine (At).

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A hormone (from the Greek participle “ὁρμῶ”, "to set in motion, urge on") is any member of a class of signaling molecules produced by glands in multicellular organisms that are transported by the circulatory system to target distant organs to regulate physiology and behaviour.

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Ketosis is a metabolic state in which some of the body's energy supply comes from ketone bodies in the blood, in contrast to a state of glycolysis in which blood glucose provides energy.

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Membrane glucocorticoid receptor

Membrane glucocorticoid receptors (mGRs) are a group of receptors which bind and are activated by glucocorticoids such as cortisol and corticosterone, as well as certain exogenous glucocorticoids such as dexamethasone.

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Mineralocorticoids are a class of corticosteroids, which in turn are a class of steroid hormones.

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Pregnane is a C21 steroid and, indirectly, a parent of progesterone.

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Progesterone (medication)

Progesterone is a medication and naturally occurring steroid hormone.

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Progestogens, also sometimes spelled progestagens or gestagens, are a class of steroid hormones that bind to and activate the progesterone receptor (PR).

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A steroid is a biologically active organic compound with four rings arranged in a specific molecular configuration.

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Toxicity is the degree to which a chemical substance or a particular mixture of substances can damage an organism.

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Veterinary medicine

Veterinary medicine is the branch of medicine that deals with the prevention, diagnosis and treatment of disease, disorder and injury in non-human animals.

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11-Dehydrocorticosterone (11-DHC), also known as 11-oxocorticosterone or 17-deoxycortisone, as well as 21-hydroxypregn-4-ene-3,11,20-trione, is a naturally occurring, endogenous corticosteroid related to cortisone and corticosterone.

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11α-Hydroxyprogesterone (11α-OHP), or 11α-hydroxypregn-4-ene-3,20-dione is an endogenous steroid and metabolite of progesterone.

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11β-Hydroxyprogesterone (11β-OHP), also known as 21-deoxycorticosterone, as well as 11β-hydroxypregn-4-ene-3,20-dione, is a naturally occurring, endogenous steroid and derivative of progesterone.

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11β-Hydroxysteroid dehydrogenase

11β-Hydroxysteroid dehydrogenase (HSD-11β or 11β-HSD) is a family of enzymes that catalyze the conversion of inert 11 keto-products (cortisone) to active cortisol, or vice versa, thus regulating the access of glucocorticoids to the steroid receptors: Thus, the two substrates of this enzyme are 11beta-hydroxysteroid and NADP+, whereas its 3 products are 11-oxosteroid, NADPH, and H+.

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21-Deoxycortisone, also known as 21-desoxycortisone, 11-keto-17α-hydroxyprogesterone, or 17α-hydroxypregn-4-ene-3,11,20-trione, is a naturally occurring, endogenous steroid and minor intermediate and metabolite in corticosteroid metabolism.

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9α-Bromo-11-ketoprogesterone (BKP), or 9α-bromo-11-oxoprogesterone (BOP), also known as braxarone, is an orally active steroidal progestin that was never marketed.

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Redirects here:

11-Oxoprogesterone, 11-ketoprogesterone, 11-oxoprogesterone, Bio 66, Bio. 66, Ketogestin, Pregn-4-ene-3,11,20-trione, U 1258, U-1258, U1258.


[1] https://en.wikipedia.org/wiki/11-Ketoprogesterone

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